Textural content in 3T MR: an image-based marker for Alzheimer's disease

In this paper, we propose a study, which investigates the first-order and second-order distributions of T2 images from a magnetic resonance (MR) scan for an age-matched data set of 24 Alzheimer's disease and 17 normal patients. The study is motivated by the desire to analyze the brain iron uptake in the hippocampus of Alzheimer's patients, which is captured by low T2 values. Since, excess iron deposition occurs locally in certain regions of the brain, we are motivated to investigate the spatial distribution of T2, which is captured by higher-order statistics. Based on the first-order and second-order distributions (involving gray level co-occurrence matrix) of T2, we show that the second-order statistics provide features with sensitivity >90% (at 80% specificity), which in turn capture the textural content in T2 data. Hence, we argue that different texture characteristics of T2 in the hippocampus for Alzheimer's and normal patients could be used as an early indicator of Alzheimer's disease.

[1]  Robert M. Haralick,et al.  Textural Features for Image Classification , 1973, IEEE Trans. Syst. Man Cybern..

[2]  F. Kruggel,et al.  Three-dimensional texture analysis of MRI brain datasets , 2001, IEEE Transactions on Medical Imaging.

[3]  M.,et al.  Statistical and Structural Approaches to Texture , 2022 .

[4]  James M. Keller,et al.  Texture description and segmentation through fractal geometry , 1989, Comput. Vis. Graph. Image Process..

[5]  M. R. Turner,et al.  Texture discrimination by Gabor functions , 1986, Biological Cybernetics.

[6]  R W Cox,et al.  AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. , 1996, Computers and biomedical research, an international journal.

[7]  C.-C. Jay Kuo,et al.  Texture analysis and classification with tree-structured wavelet transform , 1993, IEEE Trans. Image Process..

[8]  Nick C. Fox,et al.  MR image texture analysis applied to the diagnosis and tracking of Alzheimer's disease , 1998, IEEE Transactions on Medical Imaging.

[9]  Anil K. Jain,et al.  Markov Random Field Texture Models , 1983, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[10]  Jacob D. Furst,et al.  CO-OCCURRENCE MATRICES FOR VOLUMETRIC DATA , 2004 .