Pre-clinical studies of toxin-specific nanobodies: evidence of in vivo efficacy to prevent fatal disturbances provoked by scorpion envenoming.
暂无分享,去创建一个
S. Muyldermans | S. Boubaker | V. Caveliers | T. Lahoutte | B. Cosyns | M. El Ayeb | B. Bouhaouala-Zahar | I. Hmila | H. Tounsi | B. Roosens | R. B. Abderrazek | M. el Ayeb
[1] C. Vanhove,et al. Localization, mechanism and reduction of renal retention of technetium-99m labeled epidermal growth factor receptor-specific nanobody in mice. , 2011, Contrast media & molecular imaging.
[2] S. Muyldermans,et al. A bispecific nanobody to provide full protection against lethal scorpion envenoming , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[3] V. Petricevich. Scorpion Venom and the Inflammatory Response , 2010, Mediators of inflammation.
[4] S. Muyldermans,et al. Identification of potent nanobodies to neutralize the most poisonous polypeptide from scorpion venom. , 2009, The Biochemical journal.
[5] R. Vieira,et al. Effects of Tityus serrulatus scorpion venom on lung mechanics and inflammation in mice. , 2009, Toxicon : official journal of the International Society on Toxinology.
[6] F. Laraba-Djebari,et al. Combination of two antibody fragments F(ab')(2)/Fab: an alternative for scorpion envenoming treatment. , 2008, International immunopharmacology.
[7] F. Laraba-Djebari,et al. Pathophysiological effects of Androctonus australis hector scorpion venom: tissue damages and inflammatory response. , 2008, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
[8] S. Muyldermans,et al. VHH, bivalent domains and chimeric Heavy chain-only antibodies with high neutralizing efficacy for scorpion toxin AahI'. , 2008, Molecular immunology.
[9] Christian Vanhove,et al. Comparison of the Biodistribution and Tumor Targeting of Two 99mTc-Labeled Anti-EGFR Nanobodies in Mice, Using Pinhole SPECT/Micro-CT , 2008, Journal of Nuclear Medicine.
[10] G. Slegers,et al. Biodistribution and planar gamma camera imaging of (123)I- and (131)I-labeled F(ab')(2) and Fab fragments of monoclonal antibody 14C5 in nude mice bearing an A549 lung tumor. , 2007, Nuclear medicine and biology.
[11] C. Rougeot,et al. Toxicokinetic and toxicodynamic analyses of Androctonus australis hector venom in rats: optimization of antivenom therapy. , 2007, Toxicology and applied pharmacology.
[12] J. D’hooge,et al. Doppler myocardial imaging in adult male rats: reference values and reproducibility of velocity and deformation parameters. , 2006, European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology.
[13] M. Jalali,et al. In vitro and in vivo studies on some toxic effects of the venom from Hemiscorpious lepturus scorpion. , 2006, Toxicon : official journal of the International Society on Toxinology.
[14] B. Cornelissen,et al. In vitro and In vivo Targeting Properties of Iodine-123- or Iodine-131–Labeled Monoclonal Antibody 14C5 in a Non–Small Cell Lung Cancer and Colon Carcinoma Model , 2005, Clinical Cancer Research.
[15] H. Rochat,et al. Quantitative variability in the biodistribution and in toxinokinetic studies of the three main alpha toxins from the Androctonus australis hector scorpion venom. , 2004, Toxicon : official journal of the International Society on Toxinology.
[16] Serge Muyldermans,et al. Efficient cancer therapy with a nanobody-based conjugate. , 2004, Cancer research.
[17] David E Dostal,et al. Baseline echocardiographic values for adult male rats. , 2004, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.
[18] A. Carayon,et al. Candidemia in critically ill patients: difference of outcome between medical and surgical patients , 2003, Intensive Care Medicine.
[19] Sanjiv Sam Gambhir,et al. AMIDE: a free software tool for multimodality medical image analysis. , 2003, Molecular imaging.
[20] A. R. Meki,et al. Significance of assessment of serum cardiac troponin I and interleukin-8 in scorpion envenomed children. , 2003, Toxicon : official journal of the International Society on Toxinology.
[21] T. Quinn,et al. In vivo evaluation of 188Re‐labeled alpha‐melanocyte stimulating hormone peptide analogs for melanoma therapy , 2002, International journal of cancer.
[22] D. Dávila,et al. Sympathetic nervous system activation, antivenin administration and cardiovascular manifestations of scorpion envenomation. , 2002, Toxicon : official journal of the International Society on Toxinology.
[23] S. E. Hering,et al. Cardiac troponin I release after severe scorpion envenoming by Tityus serrulatus. , 2002, Toxicon : official journal of the International Society on Toxinology.
[24] Serge Muyldermans,et al. Efficient tumor targeting by single‐domain antibody fragments of camels , 2002, International journal of cancer.
[25] M. Brechbiel,et al. Rapid accumulation and internalization of radiolabeled herceptin in an inflammatory breast cancer xenograft with vasculogenic mimicry predicted by the contrast-enhanced dynamic MRI with the macromolecular contrast agent G6-(1B4M-Gd)(256). , 2002, Cancer research.
[26] F. Van de Werf,et al. Noninvasive Quantification of the Contractile Reserve of Stunned Myocardium by Ultrasonic Strain Rate and Strain , 2001, Circulation.
[27] M. El Ayeb,et al. Evaluation of antivenom therapy in children severely envenomed by Androctonus australis garzonii (Aag) and Buthus occitanus tunetanus (Bot) scorpions. , 1999, Toxicon : official journal of the International Society on Toxinology.
[28] F. Abroug,et al. Serotherapy in scorpion envenomation: a randomised controlled trial , 1999, The Lancet.
[29] G W Beresford,et al. Pharmacokinetics and biodistribution of engineered single-chain antibody constructs of MAb CC49 in colon carcinoma xenografts. , 1999, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
[30] M. Delepierre,et al. Scorpion toxins specific for Na+-channels. , 1999, European journal of biochemistry.
[31] L. Possani,et al. Pharmacokinetics of the toxic fraction of Centruroides limpidus limpidus venom in experimentally envenomed rabbits and effects of immunotherapy with specific F(ab')2. , 1999, Toxicon : official journal of the International Society on Toxinology.
[32] M. Teixeira,et al. Pharmacological evidence that neuropeptides mediate part of the actions of scorpion venom on the guinea pig ileum. , 1999, European journal of pharmacology.
[33] M. Ismail,et al. Pharmacokinetics of 125I-labelled IgG, F(ab')2 and Fab fractions of scorpion and snake antivenins: merits and potential for therapeutic use. , 1998, Toxicon : official journal of the International Society on Toxinology.
[34] A. Tarasiuk,et al. Effects of antivenom serotherapy on hemodynamic pathophysiology in dogs injected with L. quinquestriatus scorpion venom. , 1998, Toxicon : official journal of the International Society on Toxinology.
[35] S. Sampaio,et al. Biochemical and histopathological alterations induced in rats by Tityus serrulatus scorpion venom and its major neurotoxin tityustoxin-I. , 1997, Toxicon : official journal of the International Society on Toxinology.
[36] R. Apte,et al. Interleukin-6 release following scorpion sting in children. , 1996, Toxicon : official journal of the International Society on Toxinology.
[37] M. Ismail. The scorpion envenoming syndrome. , 1995, Toxicon : official journal of the International Society on Toxinology.
[38] M. Ismail. The treatment of the scorpion envenoming syndrome: the Saudi experience with serotherapy. , 1994, Toxicon : official journal of the International Society on Toxinology.
[39] L L Houston,et al. Highly specific in vivo tumor targeting by monovalent and divalent forms of 741F8 anti-c-erbB-2 single-chain Fv. , 1993, Cancer research.
[40] I. M. de Matos,et al. Heparin or a PAF antagonist (BN-52021) prevents the acute pulmonary edema induced by Tityus serrulatus scorpion venom in the rat. , 1993, Toxicon : official journal of the International Society on Toxinology.
[41] C. Rochat,et al. Purification of animal neurotoxins. Isolation and characterization of eleven neurotoxins from the venoms of the scorpions Androctonus australis hector, Buthus occitanus tunetanus and Leiurus quinquestriatus quinquestriatus. , 1970, European journal of biochemistry.
[42] N. Lago,et al. A new venomous scorpion responsible for severe envenomation in Argentina: Tityus confluens. , 2009, Toxicon : official journal of the International Society on Toxinology.
[43] E. Donadi,et al. Increased plasma levels of IL-1β, IL-6, IL-8, IL-10 and TNF-α in patients moderately or severely envenomed by Tityus serrulatus scorpion sting , 2003 .
[44] H. Daisley,et al. Acute myocarditis following Tityus trinitatis envenoming: morphological and pathophysiological characteristics. , 1999, Toxicon : official journal of the International Society on Toxinology.
[45] S. E. Hering,et al. Severe scorpion envenomation in Brazil. Clinical, laboratory and anatomopathological aspects. , 1994, Revista do Instituto de Medicina Tropical de Sao Paulo.
[46] S. Sofer,et al. The cardiovascular system after scorpion envenomation. A review. , 1992, Journal of toxicology. Clinical toxicology.
[47] L. Freire-Maia. Pharmacology of Tityus serrulatus scorpion venom. , 1990 .
[48] S. Sofer,et al. Respiratory failure in children following envenomation by the scorpion Leiurus quinquestriatus: hemodynamic and neurological aspects. , 1988, Toxicon : official journal of the International Society on Toxinology.
[49] M. Ismail,et al. Are the toxicological effects of scorpion envenomation related to tissue venom concentration? , 1988, Toxicon : official journal of the International Society on Toxinology.