Microtubule-stabilizing agents as potential therapeutics for neurodegenerative disease.
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[1] Arthur W Toga,et al. Association of cerebrospinal fluid β-amyloid 1-42, T-tau, P-tau181, and α-synuclein levels with clinical features of drug-naive patients with early Parkinson disease. , 2013, JAMA neurology.
[2] J. Trojanowski,et al. MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications. , 2013, ACS medicinal chemistry letters.
[3] Erin B D Clabough. Huntington’s Disease: The Past, Present, and Future Search for Disease Modifiers , 2013, The Yale journal of biology and medicine.
[4] T. Foltynie,et al. Parkinson’s disease: an update on pathogenesis and treatment , 2013, Journal of Neurology.
[5] Wim Robberecht,et al. The changing scene of amyotrophic lateral sclerosis , 2013, Nature Reviews Neuroscience.
[6] Marileen Dogterom,et al. Microtubule organization in vitro. , 2013, Current opinion in cell biology.
[7] Y. Jan,et al. Golgi Outposts Shape Dendrite Morphology by Functioning as Sites of Acentrosomal Microtubule Nucleation in Neurons , 2012, Neuron.
[8] J. Trojanowski,et al. Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies. , 2012, Journal of medicinal chemistry.
[9] R. Nussbaum,et al. Cerebrospinal fluid-based kinetic biomarkers of axonal transport in monitoring neurodegeneration. , 2012, The Journal of clinical investigation.
[10] T. Ishikawa. Structural biology of cytoplasmic and axonemal dyneins. , 2012, Journal of structural biology.
[11] K. Altmann,et al. Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubules. , 2012, Chemistry & biology.
[12] E. Reddy,et al. (Z)-1-aryl-3-arylamino-2-propen-1-ones, highly active stimulators of tubulin polymerization: synthesis, structure-activity relationship (SAR), tubulin polymerization, and cell growth inhibition studies. , 2012, Journal of medicinal chemistry.
[13] F. Lee,et al. Hyperdynamic Microtubules, Cognitive Deficits, and Pathology Are Improved in Tau Transgenic Mice with Low Doses of the Microtubule-Stabilizing Agent BMS-241027 , 2012, The Journal of Neuroscience.
[14] S. Steinberg,et al. TPI-287, a New Taxane Family Member, Reduces the Brain Metastatic Colonization of Breast Cancer Cells , 2012, Molecular Cancer Therapeutics.
[15] J. Trojanowski,et al. The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice , 2012, The Journal of Neuroscience.
[16] Mark Ellisman,et al. LRRK2 Parkinson disease mutations enhance its microtubule association. , 2011, Human molecular genetics.
[17] F. Obata,et al. LRRK2 Phosphorylates Tubulin-Associated Tau but Not the Free Molecule: LRRK2-Mediated Regulation of the Tau-Tubulin Association and Neurite Outgrowth , 2012, PloS one.
[18] C. Hoogenraad,et al. Centrosomes, microtubules and neuronal development , 2011, Molecular and Cellular Neuroscience.
[19] Lihong Hu,et al. Potent taccalonolides, AF and AJ, inform significant structure-activity relationships and tubulin as the binding site of these microtubule stabilizers. , 2011, Journal of the American Chemical Society.
[20] B. Stockwell,et al. Identification of Simple Compounds with Microtubule-Binding Activity That Inhibit Cancer Cell Growth with High Potency , 2011, ACS medicinal chemistry letters.
[21] G. Helms,et al. Identification and biological activities of new taccalonolide microtubule stabilizers. , 2011, Journal of medicinal chemistry.
[22] E. Masliah,et al. Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease , 2011, BMC Neuroscience.
[23] E. Masliah,et al. Hyperphosphorylated Tau in an α‐synuclein‐overexpressing transgenic model of Parkinson’s disease , 2011, The European journal of neuroscience.
[24] J. Trojanowski,et al. The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies. , 2011, Pharmacological research.
[25] A. Sidhu,et al. Tauopathic Changes in the Striatum of A53T α-Synuclein Mutant Mouse Model of Parkinson's Disease , 2011, PloS one.
[26] R. Palmiter,et al. Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson’s disease model , 2011, The Journal of cell biology.
[27] C. B. Kunst,et al. Effect of genetic background on phenotype variability in transgenic mouse models of amyotrophic lateral sclerosis: A window of opportunity in the search for genetic modifiers , 2011, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.
[28] H. Paudel,et al. Parkinsonian Neurotoxin 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and α-Synuclein Mutations Promote Tau Protein Phosphorylation at Ser262 and Destabilize Microtubule Cytoskeleton in Vitro* , 2010, The Journal of Biological Chemistry.
[29] J. Trojanowski,et al. Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy , 2010, The Journal of Neuroscience.
[30] C. Ronchi,et al. Microtubule dysfunction precedes transport impairment and mitochondria damage in MPP+‐induced neurodegeneration , 2010, Journal of neurochemistry.
[31] C. Galmarini,et al. Cabazitaxel, a new taxane with favorable properties. , 2010, Drugs of today.
[32] David C Schriemer,et al. Discovery and characterization of the laulimalide-microtubule binding mode by mass shift perturbation mapping. , 2010, Chemistry & biology.
[33] Eran Perlson,et al. Retrograde axonal transport: pathways to cell death? , 2010, Trends in Neurosciences.
[34] Frank Bradke,et al. Axon Extension Occurs Independently of Centrosomal Microtubule Nucleation , 2010, Science.
[35] J. Trojanowski,et al. Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies , 2009, Nature Reviews Drug Discovery.
[36] R. Gross,et al. Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models? , 2009, Trends in pharmacological sciences.
[37] Concepción Lillo,et al. Axonal Stress Kinase Activation and Tau Misbehavior Induced by Kinesin-1 Transport Defects , 2009, The Journal of Neuroscience.
[38] P. Lienau,et al. Sagopilone crosses the blood-brain barrier in vivo to inhibit brain tumor growth and metastases. , 2009, Neuro-oncology.
[39] U. Klar,et al. Sagopilone (ZK-EPO): from a natural product to a fully synthetic clinical development candidate , 2008, Expert opinion on investigational drugs.
[40] D. Mavroudis,et al. Paclitaxel and docetaxel in the treatment of breast cancer , 2008 .
[41] A. Grierson,et al. Role of axonal transport in neurodegenerative diseases. , 2008, Annual review of neuroscience.
[42] C. Discafani,et al. TTI-237: a novel microtubule-active compound with in vivo antitumor activity. , 2008, Cancer research.
[43] Ram Dixit,et al. Differential Regulation of Dynein and Kinesin Motor Proteins by Tau , 2008, Science.
[44] C. Shaw,et al. Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content. , 2007, Human molecular genetics.
[45] M. Goedert,et al. Interaction of tau protein with the dynactin complex , 2007, The EMBO journal.
[46] J. Trojanowski,et al. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders , 2007, Nature Reviews Neuroscience.
[47] M. Hellerstein,et al. Stabilization of Hyperdynamic Microtubules Is Neuroprotective in Amyotrophic Lateral Sclerosis* , 2007, Journal of Biological Chemistry.
[48] N. Zhang,et al. 2-cyanoaminopyrimidines as a class of antitumor agents that promote tubulin polymerization. , 2007, Bioorganic & medicinal chemistry letters.
[49] J. Baselga,et al. Targeting the microtubules in breast cancer beyond taxanes: the epothilones. , 2007, The oncologist.
[50] Nan Zhang,et al. Synthesis and SAR of [1,2,4]triazolo[1,5-a]pyrimidines, a class of anticancer agents with a unique mechanism of tubulin inhibition. , 2007, Journal of medicinal chemistry.
[51] I. Barasoain,et al. Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites. , 2007, Nature chemical biology.
[52] B. C. Carter,et al. Multiple-motor based transport and its regulation by Tau , 2007, Proceedings of the National Academy of Sciences.
[53] Arun K. Ghosh,et al. Synergistic Effects of Peloruside A and Laulimalide with Taxoid Site Drugs, but Not with Each Other, on Tubulin Assembly , 2006, Molecular Pharmacology.
[54] Ian J. Reynolds,et al. Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons , 2006, Neurobiology of Disease.
[55] Xiao-Jiang Li,et al. Interaction of Huntingtin-associated Protein-1 with Kinesin Light Chain , 2006, Journal of Biological Chemistry.
[56] Dan L Sackett,et al. A thalidomide analogue with in vitro antiproliferative, antimitotic, and microtubule-stabilizing activities , 2006, Molecular Cancer Therapeutics.
[57] S. Reske,et al. Heterozygous R1101K mutation of the DCTN1 gene in a family with ALS and FTD , 2005, Annals of neurology.
[58] S. Rundlett,et al. Identification of novel and improved antimitotic agents derived from noscapine. , 2005, Journal of medicinal chemistry.
[59] Wenhua Liu,et al. Selective Vulnerability of Dopaminergic Neurons to Microtubule Depolymerization* , 2005, Journal of Biological Chemistry.
[60] T. Surrey,et al. The parkinsonism producing neurotoxin MPP+ affects microtubule dynamics by acting as a destabilising factor , 2005, FEBS letters.
[61] R. Andersen,et al. Ceratamines, structurally simple microtubule-stabilizing antimitotic agents with unusual cellular effects. , 2005, Cancer research.
[62] J. M. Lee,et al. Tau phosphorylation increases in symptomatic mice overexpressing A30P α-synuclein , 2005, Experimental Neurology.
[63] Bin Zhang,et al. Axonal transport defects: a common theme in neurodegenerative diseases , 2005, Acta Neuropathologica.
[64] Chi Li,et al. Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[65] J. Kuret,et al. Pseudophosphorylation and Glycation of Tau Protein Enhance but Do Not Trigger Fibrillization in Vitro* , 2004, Journal of Biological Chemistry.
[66] E. Seeberg,et al. Mutant Huntingtin Impairs Axonal Trafficking in Mammalian Neurons In Vivo and In Vitro , 2004, Molecular and Cellular Biology.
[67] L. Amos,et al. Microtubule structure and its stabilisation. , 2004, Organic & biomolecular chemistry.
[68] M. Jordan,et al. Microtubules as a target for anticancer drugs , 2004, Nature Reviews Cancer.
[69] Richard G. Brusch,et al. Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila , 2003, Neuron.
[70] Leslie Wilson,et al. Differential regulation of microtubule dynamics by three- and four-repeat tau: Implications for the onset of neurodegenerative disease , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[71] S. Pomponi,et al. Tubulin polymerizing activity of dictyostatin-1, a polyketide of marine sponge origin. , 2003, Biochemical pharmacology.
[72] T. Hemscheidt,et al. Taccalonolides E and A: Plant-derived steroids with microtubule-stabilizing activity. , 2003, Cancer research.
[73] H. Neumann. Molecular mechanisms of axonal damage in inflammatory central nervous system diseases. , 2003, Current opinion in neurology.
[74] George Perry,et al. Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation. , 2003, The American journal of pathology.
[75] J. Trojanowski,et al. Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein , 2003, Science.
[76] Shin J. Oh,et al. Mutant dynactin in motor neuron disease , 2003, Nature Genetics.
[77] N. Rusan,et al. Noscapine alters microtubule dynamics in living cells and inhibits the progression of melanoma. , 2002, Cancer research.
[78] M. Zucchetti,et al. A novel taxane active against an orthotopically growing human glioma xenograft , 2001, Cancer.
[79] K. Altmann. Microtubule-stabilizing agents: a growing class of important anticancer drugs. , 2001, Current opinion in chemical biology.
[80] J. Trojanowski,et al. Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice. , 2001, The American journal of pathology.
[81] E. Mandelkow,et al. Structure, microtubule interactions, and paired helical filament aggregation by tau mutants of frontotemporal dementias. , 2000, Biochemistry.
[82] A. Cáceres,et al. 2,4-Dichlorophenoxyacetic acid disrupts the cytoskeleton and disorganizes the Golgi apparatus of cultured neurons. , 2000, Toxicological sciences : an official journal of the Society of Toxicology.
[83] S. Haggarty,et al. Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis. , 2000, Chemistry & biology.
[84] Bin Zhang,et al. Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform , 1999, Neuron.
[85] M. Hutton,et al. ACCELERATED FILAMENT FORMATION FROM TAU PROTEIN WITH SPECIFIC FTDP-17 MISSENSE MUTATIONS , 1999 .
[86] S. Lovestone,et al. Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation , 1999, FEBS letters.
[87] L. Amos,et al. How Taxol stabilises microtubule structure. , 1999, Chemistry & biology.
[88] John X. Morris,et al. Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17. , 1998, Science.
[89] M. Goedert,et al. Tau proteins with FTDP‐17 mutations have a reduced ability to promote microtubule assembly , 1998, FEBS letters.
[90] J. Holy. Chlorpropham [isopropyl N-(3-chlorophenyl) carbamate] disrupts microtubule organization, cell division, and early development of sea urchin embryos. , 1998, Journal of toxicology and environmental health. Part A.
[91] Ronald C. Petersen,et al. Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17 , 1998, Nature.
[92] C. Fairchild,et al. Eleutherobin, a novel cytotoxic agent that induces tubulin polymerization, is similar to paclitaxel (Taxol). , 1998, Cancer research.
[93] K. Ye,et al. Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cells. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[94] S. Hersch,et al. Interaction of Huntingtin-Associated Protein with Dynactin P150Glued , 1998, The Journal of Neuroscience.
[95] P. Worley,et al. Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin. , 1997, Human molecular genetics.
[96] J. Trojanowski,et al. Neurofilaments and Orthograde Transport Are Reduced in Ventral Root Axons of Transgenic Mice that Express Human SOD1 with a G93A Mutation , 1997, The Journal of cell biology.
[97] J. Trojanowski,et al. Selective Destruction of Stable Microtubules and Axons by Inhibitors of Protein Serine/Threonine Phosphatases in Cultured Human Neurons (NT2N Cells) , 1997, The Journal of Neuroscience.
[98] J. Brion,et al. Reduction of acetylated alpha-tubulin immunoreactivity in neurofibrillary tangle-bearing neurons in Alzheimer's disease. , 1996, Journal of neuropathology and experimental neurology.
[99] Alejandra del C. Alonso,et al. Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules , 1996, Nature Medicine.
[100] U. Wagner,et al. Cellular phosphorylation of tau by GSK-3 beta influences tau binding to microtubules and microtubule organisation. , 1996, Journal of cell science.
[101] S. Schreiber,et al. (+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest. , 1996, Chemistry & biology.
[102] H. Rosenkranz,et al. Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol. , 1996, Biochemistry.
[103] E. Mandelkow,et al. Domains of tau protein, differential phosphorylation, and dynamic instability of microtubules. , 1995, Molecular biology of the cell.
[104] J. Trojanowski,et al. Microtubule stabilizing drugs for the treatment of Alzheimer's disease , 1994, Neurobiology of Aging.
[105] E D Salmon,et al. Brain microtubule-associated proteins modulate microtubule dynamic instability in vitro. Real-time observations using video microscopy. , 1992, Journal of cell science.
[106] A. Hyman,et al. Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau. , 1992, Molecular biology of the cell.
[107] J. Trojanowski,et al. A68: a major subunit of paired helical filaments and derivatized forms of normal Tau. , 1991, Science.
[108] R. A. Crowther,et al. Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease , 1989, Neuron.
[109] P. Schiff,et al. Promotion of microtubule assembly in vitro by taxol , 1979, Nature.
[110] R. Himes,et al. Rotenone inhibition of tubulin self-assembly. , 1978, Biochimica et biophysica acta.
[111] B. Brinkley,et al. Rotenone inhibition of spindle microtubule assembly in mammalian cells. , 1974, Experimental cell research.
[112] A. McPhail,et al. Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. , 1971, Journal of the American Chemical Society.
[113] M. Kidd. Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease , 1963, Nature.
[114] Christine Klein,et al. Genetics of Parkinson's disease. , 2012, Cold Spring Harbor perspectives in medicine.
[115] M. Piccart-Gebhart,et al. Taxanes: optimizing adjuvant chemotherapy for early-stage breast cancer , 2010, Nature Reviews Clinical Oncology.
[116] K. Altmann. The epothilones : an outstanding family of anti-tumor agents : from soil to the clinic , 2009 .
[117] A. F. Soleng,et al. A thorny question: how does activity maintain dendritic spines? , 1999, Nature Neuroscience.
[118] Toshimasa Tanaka,et al. GS-164, a small synthetic compound, stimulates tubulin polymerization by a similar mechanism to that of Taxol , 1997, Cancer Chemotherapy and Pharmacology.
[119] T. Mitchison,et al. Microtubule polymerization dynamics. , 1997, Annual review of cell and developmental biology.
[120] B. Hyman,et al. Differential effect of three‐repeat and four‐repeat tau on mitochondrial axonal transport , 2009, Journal of neurochemistry.