The emerging roles of N6-methyladenosine RNA methylation in human cancers

[1]  Chuan He,et al.  RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia. , 2020, Cell stem cell.

[2]  Shaoguang Li,et al.  Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis. , 2020, Cell stem cell.

[3]  S. Yamashita,et al.  Mechanistic insights into m6A modification of U6 snRNA by human METTL16 , 2020, Nucleic acids research.

[4]  E. Martens-Uzunova,et al.  VIRMA-Dependent N6-Methyladenosine Modifications Regulate the Expression of Long Non-Coding RNAs CCAT1 and CCAT2 in Prostate Cancer , 2020, Cancers.

[5]  Yingke Xu,et al.  Long non-coding RNA RHPN1-AS1 promotes tumorigenesis and metastasis of ovarian cancer by acting as a ceRNA against miR-596 and upregulating LETM1 , 2020, Aging.

[6]  Xiangyi Zheng,et al.  METTL3/YTHDF2 m6A axis promotes tumorigenesis by degrading SETD7 and KLF4 mRNAs in bladder cancer , 2020, Journal of cellular and molecular medicine.

[7]  Jie Zhu,et al.  Deciphering N6-Methyladenosine-Related Genes Signature to Predict Survival in Lung Adenocarcinoma , 2020, BioMed research international.

[8]  M. Zheng,et al.  METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST , 2020, Molecular Cancer.

[9]  Yun Wang,et al.  METTL3 Promotes the Progression of Gastric Cancer via Targeting the MYC Pathway , 2020, Frontiers in Oncology.

[10]  G. Kristiansen,et al.  The N6‐methyladenosine (m6A) erasers alkylation repair homologue 5 (ALKBH5) and fat mass and obesity‐associated protein (FTO) are prognostic biomarkers in patients with clear cell renal carcinoma , 2020 .

[11]  Yiming Huang,et al.  FTO Facilitates Lung Adenocarcinoma Cell Progression by Activating Cell Migration Through mRNA Demethylation , 2020, OncoTargets and therapy.

[12]  G. Kristiansen,et al.  The N6‐methyladenosine (m6A) erasers alkylation repair homologue 5 (ALKBH5) and fat mass and obesity‐associated protein (FTO) are prognostic biomarkers in patients with clear cell renal carcinoma , 2020, BJU international.

[13]  R. Sun,et al.  Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma , 2020, Medical science monitor : international medical journal of experimental and clinical research.

[14]  Xuehao Wang,et al.  M6A-mediated upregulation of LINC00958 increases lipogenesis and acts as a nanotherapeutic target in hepatocellular carcinoma , 2020, Journal of Hematology & Oncology.

[15]  W. Ji,et al.  ALKBH5-m6A-FOXM1 signaling axis promotes proliferation and invasion of lung adenocarcinoma cells under intermittent hypoxia. , 2020, Biochemical and biophysical research communications.

[16]  Hong Wang,et al.  N6-methyladenosine METTL3 promotes the breast cancer progression via targeting Bcl-2. , 2020, Gene.

[17]  A. Jemal,et al.  Cancer statistics, 2020 , 2020, CA: a cancer journal for clinicians.

[18]  Xiaozhou He,et al.  m6A RNA modification modulates gene expression and cancer-related pathways in clear cell renal cell carcinoma. , 2019, Epigenomics.

[19]  Ling Lin,et al.  Immune signature of T follicular helper cells predicts clinical prognostic and therapeutic impact in lung squamous cell carcinoma. , 2019, International immunopharmacology.

[20]  Hui Cao,et al.  m6A RNA methylation regulators can contribute to malignant progression and impact the prognosis of bladder cancer , 2019, Bioscience reports.

[21]  Y. Mo,et al.  IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader , 2019, Cell Death & Differentiation.

[22]  Hong Wu,et al.  KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3 , 2019, Molecular Cancer.

[23]  Hongsheng Wang,et al.  N6-methyladenosine induced miR-143-3p promotes the brain metastasis of lung cancer via regulation of VASH1 , 2019, Molecular Cancer.

[24]  Jinjian Yang,et al.  Mettl14 inhibits bladder TIC self-renewal and bladder tumorigenesis through N6-methyladenosine of Notch1 , 2019, Molecular Cancer.

[25]  Zhike Lu,et al.  YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma , 2019, Molecular Cancer.

[26]  Su Yao,et al.  Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m6A reader YTHDF3 , 2019, Molecular Cancer.

[27]  Q. Ding,et al.  METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance , 2019, Gut.

[28]  Wei Wu,et al.  MiR-4429 prevented gastric cancer progression through targeting METTL3 to inhibit m6A-caused stabilization of SEC62. , 2019, Biochemical and biophysical research communications.

[29]  Q. Cao,et al.  N6-methyladenosine Modulates Nonsense-mediated mRNA Decay in Human Glioblastoma. , 2019, Cancer research.

[30]  Lin Lin,et al.  m6A demethylase FTO promotes hepatocellular carcinoma tumorigenesis via mediating PKM2 demethylation. , 2019, American journal of translational research.

[31]  Haiyang Xie,et al.  WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1 , 2019, Molecular Cancer.

[32]  Yan Wang,et al.  Long noncoding RNA GAS5-AS1 suppresses growth and metastasis of cervical cancer by increasing GAS5 stability. , 2019, American journal of translational research.

[33]  W. Min,et al.  N6-methyladenosine modification of ITGA6 mRNA promotes the development and progression of bladder cancer , 2019, EBioMedicine.

[34]  Shuai Guo,et al.  ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1 , 2019, Journal of Physiology and Biochemistry.

[35]  Mengda Cao,et al.  KIAA1429 acts as an oncogenic factor in breast cancer by regulating CDK1 in an N6-methyladenosine-independent manner , 2019, Oncogene.

[36]  D. Lin,et al.  METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma , 2019, Molecular cancer.

[37]  Jake June-Koo Lee,et al.  Tracing Oncogene Rearrangements in the Mutational History of Lung Adenocarcinoma , 2019, Cell.

[38]  P. Lan,et al.  m6A methyltransferase METTL3 suppresses colorectal cancer proliferation and migration through p38/ERK pathways , 2019, OncoTargets and therapy.

[39]  Long-Bang Chen,et al.  FOX-A1 contributes to acquisition of chemoresistance in human lung adenocarcinoma via transactivation of SOX5 , 2019, EBioMedicine.

[40]  Liang Wang,et al.  KIAA1429 regulates the migration and invasion of hepatocellular carcinoma by altering m6A modification of ID2 mRNA , 2019, OncoTargets and therapy.

[41]  Chuan He,et al.  RETRACTED ARTICLE: RNA m6A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail , 2019, Nature Communications.

[42]  Chunxing Yang,et al.  YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma , 2019, Front. Oncol..

[43]  Haibiao Xie,et al.  Gene signatures and prognostic values of m6A regulators in clear cell renal cell carcinoma – a retrospective study using TCGA database , 2019, Aging.

[44]  Wen Jiang,et al.  METTL3 Promotes the Proliferation and Mobility of Gastric Cancer Cells , 2019, Open medicine.

[45]  Zhenguo Zhao,et al.  The role of the fat mass and obesity-associated protein in the proliferation of pancreatic cancer cells. , 2018, Oncology letters.

[46]  Qiulian Wu,et al.  N 6 -methyladenine DNA Modification in Glioblastoma , 2018, Cell.

[47]  A. Jemal,et al.  Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries , 2018, CA: a cancer journal for clinicians.

[48]  Hongjun Song,et al.  Fragile X mental retardation protein modulates the stability of its m6A‐marked messenger RNA targets , 2018, Human molecular genetics.

[49]  Chuan He,et al.  m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer , 2018, Nature Cell Biology.

[50]  Kwok-Kin Wong,et al.  mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis , 2018, Nature.

[51]  D. Freyer,et al.  Treatment strategies for adolescent and young adult patients with acute myeloid leukemia. , 2018, Blood.

[52]  Lai Wei,et al.  RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2 , 2018, Hepatology.

[53]  S. Egawa,et al.  Epidemiology of prostate cancer in Asian countries , 2018, International journal of urology : official journal of the Japanese Urological Association.

[54]  H. Zhe,et al.  FTO regulates the chemo‐radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting β‐catenin through mRNA demethylation , 2018, Molecular carcinogenesis.

[55]  Z. Dauter,et al.  Structural insights into the RNA methyltransferase domain of METTL16 , 2018, Scientific Reports.

[56]  Yang Shi,et al.  Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal. , 2018, Molecular cell.

[57]  Mark Helm,et al.  Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d , 2018, Genes & development.

[58]  Yuen Gao,et al.  HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g. , 2018, Cancer letters.

[59]  Chuan He,et al.  VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation , 2018, Cell Discovery.

[60]  Stefan Hüttelmaier,et al.  Recognition of RNA N6-methyladenosine by IGF2BP Proteins Enhances mRNA Stability and Translation , 2018, Nature Cell Biology.

[61]  K. Somasundaram,et al.  Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance , 2018, Oncogene.

[62]  Charlotte Kuperwasser,et al.  Premature polyadenylation of MAGI3 is associated with diminished N6-methyladenosine in its large internal exon , 2018, Scientific Reports.

[63]  James E. Bradner,et al.  R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling , 2018, Cell.

[64]  K. Somasundaram,et al.  mRNA Traffic Control Reviewed: N6‐Methyladenosine (m6A) Takes the Driver's Seat , 2018, BioEssays : news and reviews in molecular, cellular and developmental biology.

[65]  Yue Sheng,et al.  METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification. , 2017, Cell stem cell.

[66]  Wei Yan,et al.  ALKBH5-dependent m6A demethylation controls splicing and stability of long 3′-UTR mRNAs in male germ cells , 2017, Proceedings of the National Academy of Sciences.

[67]  Liping Xie,et al.  Downregulation of N6-methyladenosine binding YTHDF2 protein mediated by miR-493-3p suppresses prostate cancer by elevating N6-methyladenosine levels , 2017, Oncotarget.

[68]  Junwei Shi,et al.  Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control , 2017, Nature.

[69]  Ralph E. Kleiner,et al.  RNA Chemical Proteomics Reveals the N6-Methyladenosine (m6A)-Regulated Protein-RNA Interactome. , 2017, Journal of the American Chemical Society.

[70]  F. Du,et al.  YTH domain family 2 orchestrates epithelial-mesenchymal transition/proliferation dichotomy in pancreatic cancer cells , 2017, Cell cycle.

[71]  Ji Wan,et al.  m6A Facilitates eIF4F-Independent mRNA Translation. , 2017, Molecular cell.

[72]  Chuan He,et al.  YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs , 2017, eLife.

[73]  Y. Liu,et al.  FTO expression is associated with the occurrence of gastric cancer and prognosis. , 2017, Oncology reports.

[74]  Xuerui Yang,et al.  Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis , 2017, Cell Research.

[75]  Francine E. Garrett-Bakelman,et al.  The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal and leukemia cells , 2017, Nature Medicine.

[76]  Chuan He,et al.  N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis , 2017, Nature Structural &Molecular Biology.

[77]  S. Pignata,et al.  Immunotherapy in ovarian, endometrial and cervical cancer: State of the art and future perspectives. , 2017, Cancer treatment reviews.

[78]  Howard Y. Chang,et al.  The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline , 2017, eLife.

[79]  Chuan He,et al.  Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis , 2017, Cell Research.

[80]  Christopher E Mason,et al.  ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2 , 2017, bioRxiv.

[81]  Yuval Kluger,et al.  m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway , 2017, Nature.

[82]  Jean-Yves Roignant,et al.  m6A in mRNA: An Ancient Mechanism for Fine-Tuning Gene Expression. , 2017, Trends in genetics : TIG.

[83]  Yang Xie,et al.  The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention , 2017, Cell.

[84]  P. V. Van Schil,et al.  Circulating cell-free nucleic acids and platelets as a liquid biopsy in the provision of personalized therapy for lung cancer patients. , 2017, Lung cancer.

[85]  Chuan He,et al.  m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program. , 2017, Cancer cell.

[86]  Gang Chen,et al.  Implication of downregulation and prospective pathway signaling of microRNA-375 in lung squamous cell carcinoma. , 2017, Pathology, research and practice.

[87]  Zhike Lu,et al.  m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells , 2017, Cell reports.

[88]  Nian Liu,et al.  N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein , 2017, Nucleic acids research.

[89]  K. Harada,et al.  AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells , 2017, Scientific Reports.

[90]  John E. J. Rasko,et al.  Genetic alterations of m6A regulators predict poorer survival in acute myeloid leukemia , 2017, Journal of Hematology & Oncology.

[91]  Feng Liu,et al.  METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N6‐methyladenosine‐dependent primary MicroRNA processing , 2017, Hepatology.

[92]  Chuan He,et al.  YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA , 2017, Cell Research.

[93]  Yun-Gui Yang,et al.  Cytoplasmic m6A reader YTHDF3 promotes mRNA translation , 2017, Cell Research.

[94]  Yuan Wang,et al.  MicroRNA-145 Modulates N6-Methyladenosine Levels by Targeting the 3′-Untranslated mRNA Region of the N6-Methyladenosine Binding YTH Domain Family 2 Protein* , 2017, The Journal of Biological Chemistry.

[95]  Jie Jin,et al.  FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase. , 2017, Cancer cell.

[96]  Samie R. Jaffrey,et al.  m6A RNA methylation promotes XIST-mediated transcriptional repression , 2016, Nature.

[97]  Ligang Wu,et al.  YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex , 2016, Nature Communications.

[98]  W. Gilbert,et al.  Messenger RNA modifications: Form, distribution, and function , 2016, Science.

[99]  Qiang Wang,et al.  Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex , 2016, Nature.

[100]  Wanjin Hong,et al.  N6-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5 , 2016, Scientific Reports.

[101]  R. Gregory,et al.  The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. , 2016, Molecular cell.

[102]  Chuanzhao Zhang,et al.  Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA , 2016, Proceedings of the National Academy of Sciences.

[103]  Samir Adhikari,et al.  Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing. , 2016, Molecular cell.

[104]  Rong Wang,et al.  Coordination of m(6)A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming. , 2015, Cell stem cell.

[105]  Saeed Tavazoie,et al.  HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events , 2015, Cell.

[106]  Shu-Bing Qian,et al.  Dynamic m6A mRNA methylation directs translational control of heat shock response , 2015, Nature.

[107]  Chuan He,et al.  RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation , 2015, Genes & development.

[108]  Chuan He,et al.  N 6 -methyladenosine Modulates Messenger RNA Translation Efficiency , 2015, Cell.

[109]  H. Brody.  Colorectal cancer , 2015, Nature.

[110]  A. Jemal,et al.  Global cancer statistics, 2012 , 2015, CA: a cancer journal for clinicians.

[111]  Chuan He,et al.  N6-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions , 2015, Nature.

[112]  H. Moch,et al.  A clearer view of the molecular complexity of clear cell renal cell carcinoma. , 2015, Annual review of pathology.

[113]  R. Kalkan.  Glioblastoma Stem Cells as a New Therapeutic Target for Glioblastoma , 2015, Clinical Medicine Insights. Oncology.

[114]  Cheng Luo,et al.  Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5 , 2014, Nucleic acids research.

[115]  E. Hirsch,et al.  PI3K/AKT signaling pathway and cancer: an updated review , 2014, Annals of medicine.

[116]  Schraga Schwartz,et al.  Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. , 2014, Cell reports.

[117]  E. Estey,et al.  Management of older or unfit patients with acute myeloid leukemia , 2014, Leukemia.

[118]  M. Walsh,et al.  The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma. , 2014, Cancer cell.

[119]  Samir Adhikari,et al.  Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase , 2014, Cell Research.

[120]  Yang Wang,et al.  N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells , 2014, Nature Cell Biology.

[121]  Miao Yu,et al.  A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation , 2013, Nature chemical biology.

[122]  Zhike Lu,et al.  m6A-dependent regulation of messenger RNA stability , 2013, Nature.

[123]  Arne Klungland,et al.  ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. , 2013, Molecular cell.

[124]  O. Elemento,et al.  Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons , 2012, Cell.

[125]  M. Kupiec,et al.  Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq , 2012, Nature.

[126]  Chengqi Yi,et al.  N6-Methyladenosine in Nuclear RNA is a Major Substrate of the Obesity-Associated FTO , 2011, Nature chemical biology.

[127]  Michael Hiller,et al.  The YTH Domain Is a Novel RNA Binding Domain* , 2010, The Journal of Biological Chemistry.

[128]  L. Aravind,et al.  Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids , 2009, Cell cycle.

[129]  Santosh Kesari,et al.  Malignant gliomas in adults. , 2008, The New England journal of medicine.

[130]  Chris P. Ponting,et al.  The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase , 2007, Science.

[131]  F. Rottman,et al.  Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. , 1997, RNA.

[132]  S. Kane,et al.  Precise localization of m6A in Rous sarcoma virus RNA reveals clustering of methylation sites: implications for RNA processing , 1985, Molecular and cellular biology.

[133]  B. Moss,et al.  Nucleotide sequences at the N6-methyladenosine sites of HeLa cell messenger ribonucleic acid. , 1977, Biochemistry.

[134]  B. Moss,et al.  Methylated nucleotides block 5′ terminus of HeLa cell messenger RNA , 1975, Cell.

[135]  M. Bühler,et al.  Zc 3 h 13 / Flacc is required for adenosine methylation by bridging the mRNA binding factor Rbm 15 / Spenito to the m 6 A machinery component Wtap / Fl ( 2 ) , 2018 .

[136]  A. Jemal,et al.  Global Cancer Statistics , 2011 .

[137]  A. Jemal,et al.  Global cancer statistics , 2011, CA: a cancer journal for clinicians.

[138]  J. Hardcastle,et al.  Colorectal cancer , 1993, Europe Against Cancer European Commission Series for General Practitioners.