G-protein signaling: back to the future
暂无分享,去创建一个
D. Siderovski | F. Willard | R. Kimple | C. McCudden | C. R. McCudden | M. D. Hains | R. J. Kimple | D. P. Siderovski | F. S. Willard | M. Hains
[1] Y. Jan,et al. Evidence that direct binding of G beta gamma to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation. , 1995, Neuron.
[2] L. Buck,et al. The Molecular Architecture of Odor and Pheromone Sensing in Mammals , 2000, Cell.
[3] Yohanns Bellaïche,et al. Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymmetric cell division , 2000, Nature Cell Biology.
[4] C. Ponting. Raf-like Ras/Rap-binding domains in RGS12- and still-life-like signalling proteins , 1999, Journal of Molecular Medicine.
[5] Y. Peterson,et al. AGS3 Inhibits GDP Dissociation from Gα Subunits of the Gi Family and Rhodopsin-dependent Activation of Transducin* , 2000, The Journal of Biological Chemistry.
[6] S. Ferguson,et al. Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. , 2001, Pharmacological reviews.
[7] M. E. Lewis,et al. Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases. , 2001, Structure.
[8] E. Talley,et al. Activation and inhibition of G protein-coupled inwardly rectifying potassium (Kir3) channels by G protein beta gamma subunits. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[9] H. Hamm,et al. GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4. , 1995, Nature.
[10] H. Nakagoshi,et al. Asymmetric segregation of the homeodomain protein Prospero duringDrosophila development , 1995, Nature.
[11] E. Ross,et al. GTPase activity of the stimulatory GTP-binding regulatory protein of adenylate cyclase, Gs. Accumulation and turnover of enzyme-nucleotide intermediates. , 1985, The Journal of biological chemistry.
[12] P. Hawkins,et al. The Gβγ Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor, p101 , 1997, Cell.
[13] S. Duensing,et al. Participation of Survivin in mitotic and apoptotic activities of normal and tumor‐derived cells * , 2001, Journal of cellular biochemistry.
[14] M. Berridge,et al. Inositol trisphosphate and diacylglycerol: two interacting second messengers. , 1987, Annual review of biochemistry.
[15] C. Goodman,et al. loco encodes an RGS protein required for Drosophila glial differentiation. , 1999, Development.
[16] F. Nicoletti,et al. Regulation of mGlu4 metabotropic glutamate receptor signaling by type-2 G-protein coupled receptor kinase (GRK2). , 2004, Molecular pharmacology.
[17] C. Der,et al. Rho GTPase-dependent transformation by G protein-coupled receptors , 2001, Oncogene.
[18] F. Roegiers. Insights into mRNA transport in neurons , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[19] C. Doe,et al. Extrinsic cues, intrinsic cues and microfilaments regulate asymmetric protein localization in Drosophila neuroblasts , 1997, Current Biology.
[20] Y. Jan,et al. Evidence that the nucleotide exchange and hydrolysis cycle of G proteins causes acute desensitization of G-protein gated inward rectifier K+ channels. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[21] Liquan Huang,et al. Gγ13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium , 1999, Nature Neuroscience.
[22] M. Mark,et al. G-protein mediated gating of inward-rectifier K+ channels. , 2000, European journal of biochemistry.
[23] A. Wittinghofer,et al. The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with RaplA and a GTP analogue , 1995, Nature.
[24] Y. Jan,et al. Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells , 1994, Cell.
[25] Y. Jan,et al. The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[26] P. Bryant,et al. The Partner of Inscuteable/Discs-Large Complex Is Required to Establish Planar Polarity during Asymmetric Cell Division in Drosophila , 2001, Cell.
[27] M. Gotta,et al. Control of Embryonic Spindle Positioning and Gα Activity by C. elegans RIC-8 , 2004, Current Biology.
[28] D. Rosskopf,et al. Rap2B-Dependent Stimulation of Phospholipase C-ε by Epidermal Growth Factor Receptor Mediated by c-Src Phosphorylation of RasGRP3 , 2004, Molecular and Cellular Biology.
[29] A. Gilman,et al. Effects of Mg2+ and the beta gamma-subunit complex on the interactions of guanine nucleotides with G proteins. , 1987, The Journal of biological chemistry.
[30] V. Arshavsky,et al. Specific Binding of RGS9-Gβ5L to Protein Anchor in Photoreceptor Membranes Greatly Enhances Its Catalytic Activity* , 2002, The Journal of Biological Chemistry.
[31] J. Gutkind,et al. Leukemia‐associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G12 family to Rho , 2000, FEBS letters.
[32] P. Hawkins,et al. P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. , 2002, Cell.
[33] L. Limbird,et al. Evidence that human platelet alpha-adrenergic receptors coupled to inhibition of adenylate cyclase are not associated with the subunit of adenylate cyclase ADP-ribosylated by cholera toxin. , 1982, The Journal of biological chemistry.
[34] T. L. Jones. Role of palmitoylation in RGS protein function. , 2004, Methods in enzymology.
[35] P. Hawkins,et al. The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. , 1997, Cell.
[36] A. Gilman,et al. A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[37] M. Rasenick,et al. G Protein β1γ2 Subunits Promote Microtubule Assembly* , 1997, The Journal of Biological Chemistry.
[38] T. Ohhata,et al. Mouse dexamethasone-induced RAS protein 1 gene is expressed in a circadian rhythmic manner in the suprachiasmatic nucleus. , 2003, Brain research. Molecular brain research.
[39] M. Moran,et al. Phospholipase C-gamma1: a phospholipase and guanine nucleotide exchange factor. , 2002, Molecular interventions.
[40] Y. Mori,et al. Differential Interactions of the C terminus and the Cytoplasmic I-II Loop of Neuronal Ca2+ Channels with G-protein α and βγ Subunits , 1998, The Journal of Biological Chemistry.
[41] D. Bayliss,et al. Activation and inhibition of G protein-coupled inwardly rectifying potassium (Kir3) channels by G protein βγ subunits , 2000 .
[42] I. Macara. Parsing the Polarity Code , 2004, Nature Reviews Molecular Cell Biology.
[43] J. Sondek,et al. Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[44] T. Kataoka,et al. Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras. , 2001, The Journal of biological chemistry.
[45] E. Duzic,et al. Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling , 1999, Nature Biotechnology.
[46] J. Boyer,et al. Beta gamma-subunit activation of G-protein-regulated phospholipase C. , 1992, The Journal of biological chemistry.
[47] H. Dohlman,et al. G proteins and pheromone signaling. , 2002, Annual review of physiology.
[48] X. Morin,et al. Analysis of partner of inscuteable, a Novel Player of Drosophila Asymmetric Divisions, Reveals Two Distinct Steps in Inscuteable Apical Localization , 2000, Cell.
[49] T. K. Harden,et al. A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q. , 2002, Nature structural biology.
[50] H. Horvitz,et al. EGL-10 Regulates G Protein Signaling in the C. elegans Nervous System and Shares a Conserved Domain with Many Mammalian Proteins , 1996, Cell.
[51] S. Lanier,et al. Analysis and Subcellular Distribution of the Two G-protein Regulators AGS 3 and LGN Indicate Distinct Functionality LOCALIZATION OF LGN TO THE MIDBODY DURING CYTOKINESIS * , 2002 .
[52] R. K. Chan,et al. Isolation and genetic analysis of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones , 1982, Molecular and cellular biology.
[53] Richard R. Neubig,et al. Regulators of G-Protein signalling as new central nervous system drug targets , 2002, Nature Reviews Drug Discovery.
[54] Kevin R. Lynch,et al. International Union of Pharmacology. XXXIV. Lysophospholipid Receptor Nomenclature , 2002, Pharmacological Reviews.
[55] Y. Jan,et al. Partner of Numb Colocalizes with Numb during Mitosis and Directs Numb Asymmetric Localization in Drosophila Neural and Muscle Progenitors , 1998, Cell.
[56] Y. Jan,et al. Miranda Is Required for the Asymmetric Localization of Prospero during Mitosis in Drosophila , 1997, Cell.
[57] E. Neer,et al. Specificity of G protein beta and gamma subunit interactions. , 1992, The Journal of biological chemistry.
[58] Alan Wise,et al. The identification of ligands at orphan G-protein coupled receptors. , 2004, Annual review of pharmacology and toxicology.
[59] K. Blumer,et al. Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family , 1996, Nature.
[60] D. Cleveland,et al. NuMA: a protein involved in nuclear structure, spindle assembly, and nuclear re-formation. , 1995, Trends in cell biology.
[61] C. Hansen,et al. Ribozyme-mediated Suppression of the G Protein γ7Subunit Suggests a Role in Hormone Regulation of Adenylylcyclase Activity* , 1997, The Journal of Biological Chemistry.
[62] W. Chia,et al. Subcellular localization of LGN during mitosis: evidence for its cortical localization in mitotic cell culture systems and its requirement for normal cell cycle progression. , 2003, Molecular biology of the cell.
[63] Xuemin Wang,et al. Arabidopsis phospholipase Dalpha1 interacts with the heterotrimeric G-protein alpha-subunit through a motif analogous to the DRY motif in G-protein-coupled receptors. , 2004, The Journal of biological chemistry.
[64] G. Schultz,et al. Selectivity in signal transduction determined by gamma subunits of heterotrimeric G proteins. , 1993, Science.
[65] C. Malbon,et al. Frizzleds: new members of the superfamily of G-protein-coupled receptors. , 2004, Frontiers in bioscience : a journal and virtual library.
[66] K. Lorenz,et al. Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2 , 2003, Nature.
[67] J. Ahringer,et al. CDC-42 controls early cell polarity and spindle orientation in C. elegans , 2001, Current Biology.
[68] T. Gudermann,et al. Receptors and G proteins as primary components of transmembrane signal transduction , 1995, Journal of Molecular Medicine.
[69] K. Baek,et al. Phospholipase Cδ1 Is a Guanine Nucleotide Exchanging Factor for Transglutaminase II (Gαh) and Promotes α1B-Adrenoreceptor-mediated GTP Binding and Intracellular Calcium Release* , 2001, The Journal of Biological Chemistry.
[70] R. Neubig,et al. Receptor-selective Effects of Endogenous RGS3 and RGS5 to Regulate Mitogen-activated Protein Kinase Activation in Rat Vascular Smooth Muscle Cells* , 2002, The Journal of Biological Chemistry.
[71] Robert F Margolskee,et al. Molecular Mechanisms of Bitter and Sweet Taste Transduction* , 2002, The Journal of Biological Chemistry.
[72] A. Gilman,et al. The GTPase-activating Protein RGS4 Stabilizes the Transition State for Nucleotide Hydrolysis* , 1996, The Journal of Biological Chemistry.
[73] H. Bourne,et al. cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells. , 1994, The Journal of biological chemistry.
[74] C. Der,et al. Activation of phospholipase C-epsilon by heterotrimeric G protein betagamma-subunits. , 2001, The Journal of biological chemistry.
[75] P. Barrett,et al. T-type calcium channel regulation by specific G-protein betagamma subunits. , 2003, Nature.
[76] C. Carman,et al. Selective Regulation of Gαq/11 by an RGS Domain in the G Protein-coupled Receptor Kinase, GRK2* , 1999, The Journal of Biological Chemistry.
[77] Heidi E. Hamm,et al. Structural determinants for activation of the α-subunit of a heterotrimeric G protein , 1994, Nature.
[78] J. Knoblich,et al. Heterotrimeric G Proteins Direct Two Modes of Asymmetric Cell Division in the Drosophila Nervous System , 2001, Cell.
[79] E. Duzic,et al. Activator of G-protein Signaling 1 Blocks GIRK Channel Activation by a G-protein-coupled Receptor , 2002, The Journal of Biological Chemistry.
[80] R. M. Peitzsch,et al. Binding of acylated peptides and fatty acids to phospholipid vesicles: pertinence to myristoylated proteins. , 1993, Biochemistry.
[81] M. Rasenick,et al. G Protein α Subunits Activate Tubulin GTPase and Modulate Microtubule Polymerization Dynamics* , 1999, The Journal of Biological Chemistry.
[82] Temple F. Smith,et al. Sites for Gα Binding on the G Protein β Subunit Overlap with Sites for Regulation of Phospholipase Cβ and Adenylyl Cyclase* , 1998, The Journal of Biological Chemistry.
[83] F. Piano,et al. Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans. , 1998, Development.
[84] C. Berlot,et al. Mutations at the Domain Interface of Gsα Impair Receptor-mediated Activation by Altering Receptor and Guanine Nucleotide Binding* , 1998, The Journal of Biological Chemistry.
[85] E M Ross,et al. GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. , 2000, Annual review of biochemistry.
[86] A. Gilman,et al. Receptor regulation of G-protein palmitoylation. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[87] Alan M. Jones,et al. G Protein Regulation of Ion Channels and Abscisic Acid Signaling in Arabidopsis Guard Cells , 2001, Science.
[88] J. Bonner,et al. Identification of Adenosine-3′,5′-Monophosphate as the Bacterial Attractant for Myxamoebae of Dictyostelium discoideum , 1969, Journal of bacteriology.
[89] Melvin I. Simon,et al. Diversity of G proteins in signal transduction , 1991, Science.
[90] H. Lester,et al. RGS proteins reconstitute the rapid gating kinetics of Gβγ-activated inwardly rectifying K+ channels , 1997 .
[91] P. H. Anborgh,et al. G Protein-coupled Receptor Kinase 2 Regulator of G Protein Signaling Homology Domain Binds to Both Metabotropic Glutamate Receptor 1a and Gαq to Attenuate Signaling* , 2004, Journal of Biological Chemistry.
[92] J. Ruppersberg,et al. New roles for RGS2, 5 and 8 on the ratio‐dependent modulation of recombinant GIRK channels expressed in Xenopus oocytes , 1999, The Journal of physiology.
[93] H. Hamm,et al. Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein. , 1994, Nature.
[94] P. Crespo,et al. Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits , 1994, Nature.
[95] M. Camps,et al. Isozyme-selective stimulation of phospholipase C-β2 by G protein βγ-subunits , 1992, Nature.
[96] B. Hille,et al. G-Protein β-Subunit Specificity in the Fast Membrane-Delimited Inhibition of Ca2+ Channels , 1998, The Journal of Neuroscience.
[97] J. Thorner,et al. Sst2, a negative regulator of pheromone signaling in the yeast Saccharomyces cerevisiae: expression, localization, and genetic interaction and physical association with Gpa1 (the G-protein alpha subunit) , 1996, Molecular and cellular biology.
[98] P. Chidiac,et al. Recruitment of RGS2 and RGS4 to the plasma membrane by G proteins and receptors reflects functional interactions. , 2003, Molecular pharmacology.
[99] H. Hamm,et al. A Specific Domain of Giα Required for the Transactivation of Giα by Tubulin Is Implicated in the Organization of Cellular Microtubules* , 2003, The Journal of Biological Chemistry.
[100] C. Doe,et al. Staufen-dependent localization of prospero mRNA contributes to neuroblast daughter-cell fate , 1998, Nature.
[101] A. Smrcka,et al. Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins. , 2004, The Biochemical journal.
[102] P. Gierschik,et al. Stimulation of phospholipase C‐β2 by the Rho GTPases Cdc42Hs and Rac1 , 1998, The EMBO journal.
[103] W. Weis,et al. Structural basis of the Axin–adenomatous polyposis coli interaction , 2000, The EMBO journal.
[104] Nobuaki Yoshida,et al. Role of Phospholipase C-L2, a Novel Phospholipase C-Like Protein That Lacks Lipase Activity, in B-Cell Receptor Signaling , 2003, Molecular and Cellular Biology.
[105] D. Spriggs,et al. Non‐kinase second‐messenger signaling: new pathways with new promise , 2004, BioEssays : news and reviews in molecular, cellular and developmental biology.
[106] Xuemin Wang,et al. Arabidopsis Phospholipase Dα1 Interacts with the Heterotrimeric G-protein α-Subunit through a Motif Analogous to the DRY Motif in G-protein-coupled Receptors* , 2004, Journal of Biological Chemistry.
[107] W. Huttner,et al. Asymmetric cell division during neurogenesis in Drosophila and vertebrates , 2003, Mechanisms of Development.
[108] T. Hébert,et al. Gbetagamma subunit combinations differentially modulate receptor and effector coupling in vivo. , 2000, Cellular signalling.
[109] V. Slepak,et al. Gβ5 prevents the RGS7-Gαo interaction through binding to a distinct Gγ-like domain found in RGS7 and other RGS proteins , 1999 .
[110] M. Cismowski,et al. Identification and Characterization of AGS4 , 2004, Journal of Biological Chemistry.
[111] D. Evanko,et al. Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq. , 2001, The Journal of biological chemistry.
[112] M. Scott,et al. The prospero gene specifies cell fates in the drosophila central nervous system , 1991, Cell.
[113] K. Jakobs,et al. A new phospholipase-C–calcium signalling pathway mediated by cyclic AMP and a Rap GTPase , 2001, Nature Cell Biology.
[114] L. Birnbaumer,et al. Inhibitory regulation of adenylyl cyclase in the absence of stimulatory regulation. Requirements and kinetics of guanine nucleotide-induced inhibition of the cyc- S49 adenylyl cyclase. , 1983, The Journal of biological chemistry.
[115] J. Knoblich,et al. Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts , 1999, Nature.
[116] P. Casey,et al. Functional Interaction between Gαz and Rap1GAP Suggests a Novel Form of Cellular Cross-talk* , 1999, The Journal of Biological Chemistry.
[117] J. Campos-Ortega,et al. inscuteable, a neural precursor gene of Drosophila, encodes a candidate for a cytoskeleton adaptor protein. , 1996, Developmental biology.
[118] David E. Clapham,et al. G PROTEIN BETA GAMMA SUBUNITS , 1997 .
[119] M. Matsuda,et al. Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with G alpha(i) , 1999, Nature.
[120] T. K. Harden,et al. Purification of an AlF4- and G-protein beta gamma-subunit-regulated phospholipase C-activating protein. , 1991, The Journal of biological chemistry.
[121] P. H. Anborgh,et al. G Protein-coupled receptor kinase 2 regulator of G protein signaling homology domain binds to both metabotropic glutamate receptor 1a and Galphaq to attenuate signaling. , 2004, The Journal of biological chemistry.
[122] Y. Jan,et al. prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila , 1991, Cell.
[123] T. Traut. The functions and consensus motifs of nine types of peptide segments that form different types of nucleotide-binding sites. , 1994, European journal of biochemistry.
[124] D. Siderovski,et al. Purification and in vitro functional analysis of the Arabidopsis thaliana regulator of G-protein signaling-1. , 2004, Methods in enzymology.
[125] J. Jordan,et al. Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel , 2000, Nature.
[126] E. Sutherland,et al. The relationship of epinephrine and glucagon to liver phosphorylase. IV. Effect of epinephrine and glucagon on the reactivation of phosphorylase in liver homogenates. , 1957, The Journal of biological chemistry.
[127] E. Sutherland,et al. Fractionation and characterization of a cyclic adenine ribonucleotide formed by tissue particles. , 1958, The Journal of biological chemistry.
[128] S. Sprang,et al. Structural basis of activity and subunit recognition in G protein heterotrimers. , 1998, Structure.
[129] D. Siderovski,et al. Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: alanine-to-aspartate mutation restores function to an inactive second GoLoco motif. , 2004, The Biochemical journal.
[130] T. Kataoka,et al. Identification of PLC210, a Caenorhabditis elegansPhospholipase C, as a Putative Effector of Ras* , 1998, The Journal of Biological Chemistry.
[131] Y. Jan,et al. Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels. , 1997, FEBS letters.
[132] M. Scott,et al. The prospero gene specifies cell fates in the Drosophila central nervous system. , 1991, Cell.
[133] S. Snyder,et al. Dexras1 A G Protein Specifically Coupled to Neuronal Nitric Oxide Synthase via CAPON , 2000, Neuron.
[134] T. K. Harden,et al. RhoA Activates Purified Phospholipase C-ϵ by a Guanine Nucleotide-dependent Mechanism* , 2004, Journal of Biological Chemistry.
[135] Martin Raff,et al. Asymmetric segregation of Numb: a mechanism for neural specification from Drosophila to mammals , 2002, Nature Neuroscience.
[136] R. Sunahara,et al. Isoforms of mammalian adenylyl cyclase: multiplicities of signaling. , 2002, Molecular interventions.
[137] M. Gho,et al. Revisiting the Drosophila microchaete lineage: a novel intrinsically asymmetric cell division generates a glial cell. , 1999, Development.
[138] G beta gamma directly binds to the carboxyl terminus of the G protein-gated muscarinic K+ channel, GIRK1. , 1995, Biochemical and biophysical research communications.
[139] Raman Nambudripad,et al. The ancient regulatory-protein family of WD-repeat proteins , 1994, Nature.
[140] D. Siderovski,et al. The G betagamma dimer as a novel source of selectivity in G-protein signaling: GGL-ing at convention. , 2004, Molecular interventions.
[141] J. Knoblich,et al. Protein localization during asymmetric cell division. , 2001, Experimental cell research.
[142] M. Ichikawa,et al. RGS7 and RGS8 Differentially Accelerate G Protein-mediated Modulation of K+ Currents* , 1999, The Journal of Biological Chemistry.
[143] Zhong-Ping Feng,et al. Syntaxin 1A Supports Voltage-Dependent Inhibition of α1B Ca2+ Channels by Gβγ in Chick Sensory Neurons , 2001, The Journal of Neuroscience.
[144] J. Sondek,et al. Structural determinants for GoLoco-induced inhibition of nucleotide release by Gα subunits , 2002, Nature.
[145] D. Siderovski,et al. Return of the GDI: the GoLoco motif in cell division. , 2004, Annual review of biochemistry.
[146] P. Gönczy. Mechanisms of spindle positioning: focus on flies and worms. , 2002, Trends in cell biology.
[147] S. van den Heuvel,et al. A complex of LIN-5 and GPR proteins regulates G protein signaling and spindle function in C elegans. , 2003, Genes & development.
[148] R. Sunahara,et al. Differentially Regulated Expression of Endogenous RGS4 and RGS7* , 2004, Journal of Biological Chemistry.
[149] P C Sternweis,et al. p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13. , 1998, Science.
[150] Edward N Pugh,et al. G proteins and phototransduction. , 2002, Annual review of physiology.
[151] David P. Siderovski,et al. Gβγ Isoforms Selectively Rescue Plasma Membrane Localization and Palmitoylation of Mutant Gαs and Gαq * , 2001, The Journal of Biological Chemistry.
[152] B. Nürnberg,et al. Specificity and Structural Requirements of Phospholipase C-β Stimulation by Rho GTPases Versus G Protein βγ Dimers* , 2003, The Journal of Biological Chemistry.
[153] M. Bünemann,et al. Regulators of G Protein Signaling (RGS) Proteins Constitutively Activate Gβγ-gated Potassium Channels* , 1998, The Journal of Biological Chemistry.
[154] D. Manning,et al. Regulation of G proteins by covalent modification , 2001, Oncogene.
[155] Lesilee S. Rose,et al. LET-99 opposes Gα/GPR signaling to generate asymmetry for spindle positioning in response to PAR and MES-1/SRC-1 signaling , 2003, Development.
[156] S. Lanier,et al. Expression Analysis and Subcellular Distribution of the Two G-protein Regulators AGS3 and LGN Indicate Distinct Functionality , 2002, The Journal of Biological Chemistry.
[157] M. Lohse,et al. Interactions of Phosducin with Defined G Protein -Subunits (*) , 1996, The Journal of Biological Chemistry.
[158] H. Hamm,et al. A specific domain of Gialpha required for the transactivation of Gialpha by tubulin is implicated in the organization of cellular microtubules. , 2003, Journal of Biological Chemistry.
[159] S. Offermanns,et al. Mouse models to study G-protein-mediated signaling. , 2004, Pharmacology & therapeutics.
[160] A. Wittinghofer,et al. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP , 1998, Nature.
[161] L. Jan,et al. Molecular basis for interactions of G protein betagamma subunits with effectors. , 1998, Science.
[162] M. Lindorfer,et al. The G Protein β5 Subunit Interacts Selectively with the Gq α Subunit* , 1998, The Journal of Biological Chemistry.
[163] Heidi E. Hamm,et al. The 2.2 Å crystal structure of transducin-α complexed with GTPγS , 1993, Nature.
[164] E. Duzic,et al. Receptor-independent Activators of Heterotrimeric G-protein Signaling Pathways* , 1999, The Journal of Biological Chemistry.
[165] J. Blank,et al. Activation of cytosolic phosphoinositide phospholipase C by G-protein beta gamma subunits. , 1992, The Journal of biological chemistry.
[166] P. Hawkins,et al. A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits. , 1994, Cell.
[167] D. Logothetis,et al. Distinct sites on G protein beta gamma subunits regulate different effector functions. , 2002, The Journal of biological chemistry.
[168] N. Dascal. Signalling via the G protein-activated K+ channels. , 1997, Cellular signalling.
[169] J. Ahringer,et al. Distinct roles for Gα and Gβγ in regulating spindle position and orientation in Caenorhabditis elegans embryos , 2001, Nature Cell Biology.
[170] C. Der,et al. The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways , 2001, Oncogene.
[171] T. Wensel,et al. R9AP, a membrane anchor for the photoreceptor GTPase accelerating protein, RGS9-1 , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[172] P C Sternweis,et al. Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq. , 1991, Science.
[173] Randall J. Kimple,et al. RGS12 and RGS14 GoLoco Motifs Are GαiInteraction Sites with Guanine Nucleotide Dissociation Inhibitor Activity* , 2001, The Journal of Biological Chemistry.
[174] Dennis Brown,et al. Expression of GTPase-deficient Giα2 Results in Translocation of Cytoplasmic RGS4 to the Plasma Membrane* , 1998, The Journal of Biological Chemistry.
[175] M. Rasenick,et al. G protein beta1gamma2 subunits promote microtubule assembly. , 1997, The Journal of biological chemistry.
[176] K. Miller,et al. A role for RIC-8 (Synembryn) and GOA-1 (G(o)alpha) in regulating a subset of centrosome movements during early embryogenesis in Caenorhabditis elegans. , 2000, Genetics.
[177] R. Lefkowitz,et al. Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ , 2003, Science.
[178] Alan M. Jones,et al. A Seven-Transmembrane RGS Protein That Modulates Plant Cell Proliferation , 2003, Science.
[179] Peng Li,et al. Inscuteable and Staufen Mediate Asymmetric Localization and Segregation of prospero RNA during Drosophila Neuroblast Cell Divisions , 1997, Cell.
[180] J. Gutkind,et al. A Novel PDZ Domain Containing Guanine Nucleotide Exchange Factor Links Heterotrimeric G Proteins to Rho* , 1999, The Journal of Biological Chemistry.
[181] Y. Peterson,et al. Receptor- and Nucleotide Exchange-independent Mechanisms for Promoting G Protein Subunit Dissociation* , 2003, Journal of Biological Chemistry.
[182] A. Levey,et al. RGS2 Binds Directly and Selectively to the M1 Muscarinic Acetylcholine Receptor Third Intracellular Loop to Modulate Gq/11α Signaling* , 2004, Journal of Biological Chemistry.
[183] D. Clapham,et al. The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart. , 1987, Nature.
[184] T. Hunter,et al. Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro , 1989, Cell.
[185] Henry R. Bourne,et al. Lipid Modifications of Trimeric G Proteins (*) , 1995, The Journal of Biological Chemistry.
[186] C. Myung,et al. Role of Isoprenoid Lipids on the Heterotrimeric G Protein γ Subunit in Determining Effector Activation* , 1999, The Journal of Biological Chemistry.
[187] N. Artemyev,et al. Inhibition of GDP/GTP exchange on G alpha subunits by proteins containing G-protein regulatory motifs. , 2001, Biochemistry.
[188] S. Ikeda,et al. A voltage-independent calcium current inhibitory pathway activated by muscarinic agonists in rat sympathetic neurons requires both Galpha q/11 and Gbeta gamma. , 2000, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[189] D. Clapham,et al. The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart , 1987, Nature.
[190] S H Kim,et al. Crystal structures at 2.2 A resolution of the catalytic domains of normal ras protein and an oncogenic mutant complexed with GDP. , 1991, Journal of molecular biology.
[191] D. Clapham,et al. G PROTEIN BETA GAMMA SUBUNITS , 1997 .
[192] C. Doe,et al. The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila. , 1995, Development.
[193] S. Sprang,et al. Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis. , 1994, Science.
[194] K. Jakobs,et al. Inhibition of phospholipase C-epsilon by Gi-coupled receptors. , 2004, Cellular signalling.
[195] K. Rossman,et al. Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1 , 2000, Nature.
[196] D. Siderovski,et al. D2 dopamine receptor activation of potassium channels is selectively decoupled by Gαi‐specific GoLoco motif peptides , 2005, Journal of neurochemistry.
[197] T. Kataoka,et al. Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling. , 2001, The Journal of biological chemistry.
[198] P. Sternberg,et al. Inositol Trisphosphate Mediates a RAS-Independent Response to LET-23 Receptor Tyrosine Kinase Activation in C. elegans , 1998, Cell.
[199] P. Sternberg,et al. Caenorhabditis elegans inositol 5-phosphatase homolog negatively regulates inositol 1,4,5-triphosphate signaling in ovulation. , 2002, Molecular biology of the cell.
[200] G. Carpenter,et al. Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[201] P. Hawkins,et al. A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits , 1994, Cell.
[202] Y. Jan,et al. Evidence that direct binding of Gβγ to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation , 1995, Neuron.
[203] A. Gilman,et al. Synthesis in Escherichia coli of GTPase-deficient mutants of Gs alpha. , 1989, The Journal of biological chemistry.
[204] J. Ahringer,et al. Asymmetrically Distributed C. elegans Homologs of AGS3/PINS Control Spindle Position in the Early Embryo , 2003, Current Biology.
[205] A. Shevchenko,et al. A protein complex containing Inscuteable and the Gα-binding protein Pins orients asymmetric cell divisions in Drosophila , 2000, Current Biology.
[206] K. Baek,et al. Phospholipase Cdelta1 is a guanine nucleotide exchanging factor for transglutaminase II (Galpha h) and promotes alpha 1B-adrenoreceptor-mediated GTP binding and intracellular calcium release. , 2001, The Journal of biological chemistry.
[207] R. Kemppainen,et al. Dexamethasone Rapidly Induces a Novel Ras Superfamily Member-related Gene in AtT-20 Cells* , 1998, The Journal of Biological Chemistry.
[208] D. Morton,et al. The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry. , 2000, Development.
[209] P B Sigler,et al. Sst2 is a GTPase-activating protein for Gpa1: purification and characterization of a cognate RGS-Galpha protein pair in yeast. , 1998, Biochemistry.
[210] P B Sigler,et al. The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S. , 1994, Nature.
[211] Y. Kaziro,et al. Activation of p38 Mitogen-activated Protein Kinase by Signaling through G Protein-coupled Receptors , 1997, The Journal of Biological Chemistry.
[212] W. Simonds,et al. Signaling from G protein-coupled receptors to c-Jun kinase involves beta gamma subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway. , 1996, The Journal of biological chemistry.
[213] S. Ryu,et al. Phospholipase C isozymes selectively couple to specific neurotransmitter receptors , 1997, Nature.
[214] J. Sondek,et al. Fidelity of G protein β-subunit association by the G protein γ-subunit-like domains of RGS6, RGS7, and RGS11 , 1999 .
[215] W. Chia,et al. A family of Snail‐related zinc finger proteins regulates two distinct and parallel mechanisms that mediate Drosophila neuroblast asymmetric divisions , 2001, The EMBO journal.
[216] E. Ross,et al. Palmitoylation of a Conserved Cysteine in the Regulator of G Protein Signaling (RGS) Domain Modulates the GTPase-activating Activity of RGS4 and RGS10* , 1999, The Journal of Biological Chemistry.
[217] W. Kolch,et al. Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP , 1999, Nature.
[218] J. Ahringer,et al. Distinct roles for Galpha and Gbetagamma in regulating spindle position and orientation in Caenorhabditis elegans embryos. , 2001, Nature cell biology.
[219] A. Smrcka. G Protein Signaling , 2003 .
[220] P. Sternberg,et al. Phospholipase Cepsilon regulates ovulation in Caenorhabditis elegans. , 2004, Developmental biology.
[221] D. St Johnston,et al. Miranda mediates asymmetric protein and RNA localization in the developing nervous system. , 1998, Genes & development.
[222] M. Camps,et al. Isozyme-selective stimulation of phospholipase C-beta 2 by G protein beta gamma-subunits. , 1992, Nature.
[223] G. Zamponi,et al. Syntaxin 1A supports voltage-dependent inhibition of alpha1B Ca2+ channels by Gbetagamma in chick sensory neurons. , 2001, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[224] S. Rhee,et al. Regulation of inositol phospholipid-specific phospholipase C isozymes. , 1992, The Journal of biological chemistry.
[225] S. Sprang,et al. Structure of RGS4 Bound to AlF4 −-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis , 1997, Cell.
[226] Claudia Walliser,et al. Specificity and structural requirements of phospholipase C-beta stimulation by Rho GTPases versus G protein beta gamma dimers. , 2003, The Journal of biological chemistry.
[227] U. Maier,et al. Roles of Non-catalytic Subunits in Gβγ-induced Activation of Class I Phosphoinositide 3-Kinase Isoforms β and γ* , 1999, The Journal of Biological Chemistry.
[228] M. Rasenick,et al. Tubulin binds specifically to the signal-transducing proteins, Gs alpha and Gi alpha 1. , 1990, The Journal of biological chemistry.
[229] M. Gonzalez-Gaitan,et al. The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila. , 2002, Developmental cell.
[230] D. Morton,et al. Identification of genes required for cytoplasmic localization in early C. elegans embryos , 1988, Cell.
[231] S. Rhee,et al. Regulation of phosphoinositide-specific phospholipase C. , 2001, Annual review of biochemistry.
[232] A. Smrcka,et al. Phospholipase C(epsilon): a novel Ras effector. , 2001, The EMBO journal.
[233] Y. Jan,et al. Binding of the G protein βγ subunit to multiple regions of G protein‐gated inward‐rectifying K+ channels , 1997 .
[234] Y. Luo,et al. Interaction of heterotrimeric G protein Galphao with Purkinje cell protein-2. Evidence for a novel nucleotide exchange factor. , 1999, The Journal of biological chemistry.
[235] Alan M. Jones,et al. Modulation of Cell Proliferation by Heterotrimeric G Protein in Arabidopsis , 2001, Science.
[236] S. Ryu,et al. Phospholipase C-delta1 is activated by capacitative calcium entry that follows phospholipase C-beta activation upon bradykinin stimulation. , 1999, The Journal of biological chemistry.
[237] S. J. Taylor,et al. Activation of the beta 1 isozyme of phospholipase C by alpha subunits of the Gq class of G proteins. , 1991, Nature.
[238] A. Gilman,et al. Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits. , 1991, Science.
[239] Jack E. Dixon,et al. Sorting out the cellular functions of sorting nexins , 2003, Nature Reviews Molecular Cell Biology.
[240] M. Tyers,et al. A new family of regulators of G-protein-coupled receptors? , 1996, Current Biology.
[241] T. Hunter,et al. Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro. , 1989, Cell.
[242] J. Falck,et al. Ca2+/Calmodulin Reverses Phosphatidylinositol 3,4,5-Trisphosphate-dependent Inhibition of Regulators of G Protein-signaling GTPase-activating Protein Activity* , 2000, The Journal of Biological Chemistry.
[243] J. Labbé,et al. PAR Proteins Regulate Microtubule Dynamics at the Cell Cortex in C. elegans , 2003, Current Biology.
[244] P. Delmas,et al. Calcium channel gating and modulation by transmitters depend on cellular compartmentalization , 2000, Nature Neuroscience.
[245] Y. Jan,et al. Control of Daughter Cell Fates during Asymmetric Division: Interaction of Numb and Notch , 1996, Neuron.
[246] K. Yan,et al. A Domain on the G Protein β Subunit Interacts with Both Adenylyl Cyclase 2 and the Muscarinic Atrial Potassium Channel* , 1996, The Journal of Biological Chemistry.
[247] Chin-Tong Ong,et al. Membrane Targeting and Asymmetric Localization of Drosophila Partner of Inscuteable Are Discrete Steps Controlled by Distinct Regions of the Protein , 2002, Molecular and Cellular Biology.
[248] J. Surmeier,et al. Differential Dependence of the D1 and D5Dopamine Receptors on the G Protein γ7 Subunit for Activation of Adenylylcyclase* , 2001, The Journal of Biological Chemistry.
[249] S Thirup,et al. Helix unwinding in the effector region of elongation factor EF-Tu-GDP. , 1996, Structure.
[250] M. Gotta,et al. Control of embryonic spindle positioning and Galpha activity by C. elegans RIC-8. , 2004, Current biology : CB.
[251] V. Slepak,et al. Gbeta5 prevents the RGS7-Galphao interaction through binding to a distinct Ggamma-like domain found in RGS7 and other RGS proteins. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[252] P C Sternweis,et al. Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13. , 1998, Science.
[253] C. Kunsch,et al. Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. , 1995, The Journal of biological chemistry.
[254] Jonathon Howard,et al. The Distribution of Active Force Generators Controls Mitotic Spindle Position , 2003, Science.
[255] N. Davidson,et al. Time resolved kinetics of direct G beta 1 gamma 2 interactions with the carboxyl terminus of Kir3.4 inward rectifier K+ channel subunits. , 1996, Neuropharmacology.
[256] A. Gilman,et al. Cloning and expression of a widely distributed (type IV) adenylyl cyclase. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[257] S. Bronson,et al. Loss of G Protein γ7 Alters Behavior and Reduces Striatal αolf Level and cAMP Production* , 2003, The Journal of Biological Chemistry.
[258] E. Hewlett,et al. ADP-ribosylation of adenylate cyclase by pertussis toxin. Effects on inhibitory agonist binding. , 1984, The Journal of biological chemistry.
[259] I. Macara,et al. A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization , 2001, Nature Cell Biology.
[260] Masaru Ishii,et al. PIP3 inhibition of RGS protein and its reversal by Ca2+/calmodulin mediate voltage-dependent control of the G protein cycle in a cardiac K+ channel , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[261] M. Whiteway,et al. Dominant‐negative mutants of a yeast G‐protein beta subunit identify two functional regions involved in pheromone signalling. , 1992, The EMBO journal.
[262] S. Sprang,et al. The structure of the G protein heterotrimer Giα1 β 1 γ 2 , 1995, Cell.
[263] A. Gilman,et al. A G protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gβ5 subunits , 1998 .
[264] F. Apone,et al. The G-Protein-Coupled Receptor GCR1 Regulates DNA Synthesis through Activation of Phosphatidylinositol-Specific Phospholipase C , 2003, Plant Physiology.
[265] C. Der,et al. G2A is an oncogenic G protein-coupled receptor , 2000, Oncogene.
[266] H. Lester,et al. Time Resolved Kinetics of Direct Gβ1γ2 Interactions with the Carboxyl Terminus of Kir3.4 Inward Rectifier K+ Channel Subunits , 1996, Neuropharmacology.
[267] W. Chia,et al. Distinct roles of Gαi and Gβ13F subunits of the heterotrimeric G protein complex in the mediation of Drosophila neuroblast asymmetric divisions , 2003, The Journal of cell biology.
[268] A. Gilman,et al. Mammalian Ric-8A (Synembryn) Is a Heterotrimeric Gα Protein Guanine Nucleotide Exchange Factor* , 2003, The Journal of Biological Chemistry.
[269] P. Insel,et al. Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2. , 1996, Gene.
[270] G. Schultz,et al. Receptor-dependent RhoA Activation in G12/G13-deficient Cells , 2003, Journal of Biological Chemistry.
[271] Y. Jan,et al. Role of inscuteable in orienting asymmetric cell divisions in Drosophila , 1996, Nature.
[272] A. Smrcka,et al. Phospholipase Cϵ: a novel Ras effector , 2001 .
[273] C. Doe,et al. Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisions , 1997, Nature.
[274] K. Kemphues,et al. Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos , 1995, Cell.
[275] P. Gönczy,et al. Spindle positioning during the asymmetric first cell division of Caenorhabditis elegans embryos. , 2001, Novartis Foundation symposium.
[276] Jun Yokota,et al. Identification and Characterization of a New Phospholipase C-like Protein, PLC-L2 , 1999 .
[277] P. Barrett,et al. T-type calcium channel regulation by specific G-protein βγ subunits , 2003, Nature.
[278] T. Hébert,et al. Gβγ subunit combinations differentially modulate receptor and effector coupling in vivo , 2000 .
[279] P. Sternberg,et al. Phospholipase Cɛ regulates ovulation in Caenorhabditis elegans , 2004 .
[280] S. Goderie,et al. Intrinsic programs of patterned cell lineages in isolated vertebrate CNS ventricular zone cells. , 1998, Development.
[281] G. Milligan,et al. N-terminal fatty acylation of the alpha-subunit of the G-protein Gi1: only the myristoylated protein is a substrate for palmitoylation. , 1994, Biochemical Journal.
[282] Channing J Der,et al. Leukemia-Associated Rho Guanine Nucleotide Exchange Factor Promotes Gαq-Coupled Activation of RhoA , 2002, Molecular and Cellular Biology.
[283] Pierre Gönczy,et al. Translation of Polarity Cues into Asymmetric Spindle Positioning in Caenorhabditis elegans Embryos , 2003, Science.
[284] T. Kataoka,et al. Neuronal lineage‐specific induction of phospholipase Cε expression in the developing mouse brain , 2003 .
[285] K. Jakobs,et al. Inhibition of phospholipase C-ε by Gi-coupled receptors , 2004 .
[286] J. Ahringer,et al. G Proteins Are Required for Spatial Orientation of Early Cell Cleavages in C. elegans Embryos , 1996, Cell.
[287] M. Ishii,et al. Assays of RGS protein modulation by phosphatidylinositides and calmodulin. , 2004, Methods in enzymology.
[288] T. Kataoka,et al. Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase Cε , 2002, Oncogene.
[289] D. Compton,et al. LGN Blocks the Ability of NuMA to Bind and Stabilize Microtubules A Mechanism for Mitotic Spindle Assembly Regulation , 2002, Current Biology.
[290] Peter J Woolf,et al. A Spatial Focusing Model for G Protein Signals , 2003, The Journal of Biological Chemistry.
[291] M. Rasenick,et al. Gβγ Mediates the Interplay between Tubulin Dimers and Microtubules in the Modulation of Gq Signaling* , 2003, Journal of Biological Chemistry.
[292] C. Der,et al. Activation of Phospholipase C-ε by Heterotrimeric G Protein βγ-Subunits* , 2001, The Journal of Biological Chemistry.
[293] J. Yokota,et al. Identification and characterization of a new phospholipase C-like protein, PLC-L(2). , 1999, Biochemical and biophysical research communications.
[294] N. Fuse,et al. Differential functions of G protein and Baz–aPKC signaling pathways in Drosophila neuroblast asymmetric division , 2004, The Journal of cell biology.
[295] T. Gudermann,et al. Receptors and G proteins as primary components of transmembrane signal transduction , 1995, Journal of Molecular Medicine.
[296] G. Milligan,et al. The palmitoylation status of the G-protein G(o)1 alpha regulates its activity of interaction with the plasma membrane. , 1994, The Biochemical journal.
[297] Sara Jacob,et al. Mammalian NUMB is an evolutionarily conserved signaling adapter protein that specifies cell fate , 1996, Current Biology.
[298] P. Crespo,et al. Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits. , 1994, Nature.
[299] Y. Jan,et al. Asymmetric segregation of Numb and Prospero during cell division , 1995, Nature.
[300] L. Jan,et al. Molecular Basis for Interactions of G Protein βγ Subunits with Effectors , 1998 .
[301] R. Lefkowitz,et al. GTPase Activating Specificity of RGS12 and Binding Specificity of an Alternatively Spliced PDZ (PSD-95/Dlg/ZO-1) Domain* , 1998, The Journal of Biological Chemistry.
[302] S. Sprang,et al. Thermodynamic Characterization of the Binding of Activator of G Protein Signaling 3 (AGS3) and Peptides Derived from AGS3 with Gαi1* , 2003, Journal of Biological Chemistry.
[303] A. Gilman,et al. Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride. , 1982, Proceedings of the National Academy of Sciences of the United States of America.
[304] T. Kurosaki,et al. Regulation of the phospholipase C‐γ2 pathway in B cells , 2000, Immunological reviews.
[305] P. Devreotes,et al. Temporal and spatial regulation of chemotaxis. , 2002, Developmental cell.
[306] D. Siderovski,et al. The GoLoco motif: a Galphai/o binding motif and potential guanine-nucleotide exchange factor. , 1999, Trends in biochemical sciences.
[307] J. Knoblich,et al. Mechanisms of asymmetric cell division during animal development. , 1997, Current opinion in cell biology.
[308] S. Muallem,et al. RGS Proteins Determine Signaling Specificity of Gq-coupled Receptors* , 1999, The Journal of Biological Chemistry.
[309] H. Lester,et al. RGS proteins reconstitute the rapid gating kinetics of gbetagamma-activated inwardly rectifying K+ channels. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[310] T. Katada,et al. Gβγ Directly Binds to the Carboxyl Terminus of the G Protein-Gated Muscarinic K+ Channel, GIRK1 , 1995 .
[311] W. Chia,et al. Asymmetric division of Drosophila neural progenitors. , 2002, Current opinion in genetics & development.
[312] B. Bowerman,et al. Cell polarity and the cytoskeleton in the Caenorhabditis elegans zygote. , 2003, Annual review of genetics.
[313] N. Gautam,et al. Efficient Interaction with a Receptor Requires a Specific Type of Prenyl Group on the G Protein γ Subunit (*) , 1995, The Journal of Biological Chemistry.
[314] P. Bryant,et al. Asymmetric localization of LGN but not AGS3, two homologs of Drosophila pins, in dividing human neural progenitor cells , 2004, Journal of neuroscience research.
[315] J. Gutkind,et al. RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho? , 2001, Oncogene.
[316] Deborah A. Brown,et al. Lipid-dependent Targeting of G Proteins into Rafts* , 2000, The Journal of Biological Chemistry.
[317] T. K. Harden,et al. Application of RGS box proteins to evaluate G-protein selectivity in receptor-promoted signaling. , 2004, Methods in enzymology.
[318] M. Cismowski,et al. Identification and characterization of AGS4: a protein containing three G-protein regulatory motifs that regulate the activation state of Gialpha. , 2004, The Journal of biological chemistry.
[319] T. Kohout,et al. Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization. , 2003, Molecular pharmacology.
[320] K. Jakobs,et al. Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B. , 2002, The Journal of biological chemistry.
[321] E. Ross,et al. Phospholipase C-β1 is a GTPase-activating protein for Gq/11, its physiologic regulator , 1992, Cell.
[322] S R Sprang,et al. G protein mechanisms: insights from structural analysis. , 1997, Annual review of biochemistry.
[323] J. Oberdick,et al. Conservation of the developmentally regulated dendritic localization of a Purkinje cell-specific mRNA that encodes a G-protein modulator: comparison of rodent and human Pcp2(L7) gene structure and expression. , 2002, Brain research. Molecular brain research.
[324] Y. Tu,et al. Allosteric regulation of GAP activity by phospholipids in regulators of G-protein signaling. , 2004, Methods in enzymology.
[325] H. Hamm,et al. The 2.0 Å crystal structure of a heterotrimeric G protein , 1996, Nature.
[326] T Kendall Harden,et al. PLC-epsilon: a shared effector protein in Ras-, Rho-, and G alpha beta gamma-mediated signaling. , 2003, Molecular interventions.
[327] F. A. Lai,et al. PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development. , 2002, Development.
[328] D. Leopoldt,et al. Gβ5γ2 Is a Highly Selective Activator of Phospholipid-dependent Enzymes* , 2000, The Journal of Biological Chemistry.
[329] A. Gilman,et al. Resolution of some components of adenylate cyclase necessary for catalytic activity. , 1977, The Journal of biological chemistry.
[330] K. Jakobs,et al. Stimulation of Phospholipase C-ε by the M3Muscarinic Acetylcholine Receptor Mediated by Cyclic AMP and the GTPase Rap2B* , 2002, The Journal of Biological Chemistry.
[331] H. Hamm,et al. A Novel Bifunctional Phospholipase C That Is Regulated by Gα12 and Stimulates the Ras/Mitogen-activated Protein Kinase Pathway* , 2001, The Journal of Biological Chemistry.
[332] J. Hanoune,et al. Regulation and role of adenylyl cyclase isoforms. , 2001, Annual review of pharmacology and toxicology.
[333] S. Snyder,et al. Brain phospholipase C isozymes: differential mRNA localizations by in situ hybridization. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[334] H. Hamm,et al. Crystal structure of a G-protein beta gamma dimer at 2.1A resolution. , 1996, Nature.
[335] T. Kataoka,et al. Regulation of a Novel Human Phospholipase C, PLCε, through Membrane Targeting by Ras* , 2001, The Journal of Biological Chemistry.
[336] K. Kemphues,et al. PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos. , 1999, Development.
[337] S. Grill,et al. RGS-7 Completes a Receptor-Independent Heterotrimeric G Protein Cycle to Asymmetrically Regulate Mitotic Spindle Positioning in C. elegans , 2004, Cell.
[338] J. Sondek,et al. A unique fold of phospholipase C-β mediates dimerization and interaction with Gαq , 2002, Nature Structural Biology.
[339] T. Hope,et al. Heterotrimeric G‐proteins associate with microtubules during differentiation in PC12 pheochromocytoma cells , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[340] T. Li,et al. The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein beta subunit. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[341] R. Taussig,et al. Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases. , 1994, The Journal of biological chemistry.
[342] B. Mullah,et al. Ribozyme Approach Identifies a Functional Association between the G Protein β1γ7 Subunits in the β-Adrenergic Receptor Signaling Pathway* , 1999, The Journal of Biological Chemistry.
[343] H. Hamm,et al. The myristoylated amino terminus of Galpha(i)(1) plays a critical role in the structure and function of Galpha(i)(1) subunits in solution. , 2003, Biochemistry.
[344] J. Penninger,et al. RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote. , 2004, Developmental cell.
[345] E. Prossnitz,et al. Dexras1/AGS-1 Inhibits Signal Transduction from the Gi-coupled Formyl Peptide Receptor to Erk-1/2 MAP Kinases* , 2002, The Journal of Biological Chemistry.
[346] W. Chia,et al. Apical Complex Genes Control Mitotic Spindle Geometry and Relative Size of Daughter Cells in Drosophila Neuroblast and pI Asymmetric Divisions , 2003, Cell.
[347] M. Lindorfer,et al. The G protein beta5 subunit interacts selectively with the Gq alpha subunit. , 1998, Journal of Biological Chemistry.
[348] D. Leopoldt,et al. Gbeta 5gamma 2 is a highly selective activator of phospholipid-dependent enzymes. , 2000, The Journal of biological chemistry.
[349] T. Kataoka,et al. Neuronal lineage-specific induction of phospholipase Cepsilon expression in the developing mouse brain. , 2003, The European journal of neuroscience.
[350] R. Iyengar,et al. Stimulation and inhibition of adenylyl cyclases mediated by distinct regulatory proteins , 1983, Nature.
[351] P. Gönczy,et al. RIC-8 Is Required for GPR-1/2-Dependent Gα Function during Asymmetric Division of C. elegans Embryos , 2004, Cell.
[352] S. Spiegel,et al. Sphingolipid signalling in Arabidopsis guard cells involves heterotrimeric G proteins , 2003, Nature.
[353] S. Muallem,et al. The N-terminal Domain of RGS4 Confers Receptor-selective Inhibition of G Protein Signaling* , 1998, The Journal of Biological Chemistry.
[354] M. Simon,et al. Activation of phospholipase C by the alpha subunits of the Gq and G11 proteins in transfected Cos-7 cells. , 1992, Journal of Biological Chemistry.
[355] N. Fuse,et al. Heterotrimeric G Proteins Regulate Daughter Cell Size Asymmetry in Drosophila Neuroblast Divisions , 2003, Current Biology.
[356] M. Rasenick,et al. G protein alpha subunits activate tubulin GTPase and modulate microtubule polymerization dynamics. , 1999, The Journal of biological chemistry.
[357] Y. Kubo,et al. RGS8 accelerates G-protein-mediated modulation of K+currents , 1997, Nature.
[358] Temple F. Smith,et al. The ancient regulatory-protein family of WD-repeat proteins , 1994, Nature.
[359] V. Hartenstein,et al. Development of adult sensilla on the wing and notum of Drosophila melanogaster. , 1989, Development.
[360] T. K. Harden,et al. Direct Activation of Phospholipase C-ϵ by Rho* , 2003, Journal of Biological Chemistry.
[361] M. Kunkel,et al. Identification of domains conferring G protein regulation on inward rectifier potassium channels , 1995, Cell.
[362] Alan M. Jones,et al. G-protein-coupled signaling in Arabidopsis. , 2002, Current opinion in plant biology.
[363] C. Fraser,et al. Translation of Polarity Cues into Asymmetric Spindle Positioning in Caenorhabditis elegans Embryos , 2022 .
[364] A. Gilman,et al. p115 RhoGEF, a GTPase activating protein for Gα12 and Gα13 , 1998 .
[365] Alan M. Jones,et al. AtRGS1 function in Arabidopsis thaliana. , 2004, Methods in enzymology.
[366] E. Duzic,et al. Activation of Heterotrimeric G-protein Signaling by a Ras-related Protein , 2000, The Journal of Biological Chemistry.
[367] D. Siderovski,et al. Analysis of interactions between regulator of G-protein signaling-14 and microtubules. , 2004, Methods in enzymology.
[368] J. Penninger,et al. Dexras1 Potentiates Photic and Suppresses Nonphotic Responses of the Circadian Clock , 2004, Neuron.
[369] T. Kataoka,et al. Role of the CDC25 Homology Domain of Phospholipase Cε in Amplification of Rap1-dependent Signaling* , 2001, The Journal of Biological Chemistry.
[370] D. Logothetis,et al. Distinct Sites on G Protein βγ Subunits Regulate Different Effector Functions* , 2002, The Journal of Biological Chemistry.