The particle has landed--characterizing the fate of inhaled pharmaceuticals.
暂无分享,去创建一个
M. Gumbleton | J. Patton | C. Ehrhardt | M. Sakagami | L. Davies | R. Vanbever | J. Brain | J. Fiegel | Kwang-Jin Kim
[1] C. Bosquillon,et al. Drug transporters in the lung--do they play a role in the biopharmaceutics of inhaled drugs? , 2010, Journal of pharmaceutical sciences.
[2] T. Nakanishi,et al. Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption. , 2010, Molecular pharmaceutics.
[3] Myrna C B Godoy,et al. Subsolid pulmonary nodules and the spectrum of peripheral adenocarcinomas of the lung: recommended interim guidelines for assessment and management. , 2009, Radiology.
[4] J. Christopher Post,et al. Biofilms in pediatric respiratory and related infections , 2009, Current allergy and asthma reports.
[5] B. G. Sanders,et al. Aerosol Delivery of Liposomal Formulated Paclitaxel and Vitamin E Analog Reduces Murine Mammary Tumor Burden and Metastases , 2009, Experimental biology and medicine.
[6] Q. Shen,et al. Microdialysis: a technique for pharmacokinetic-pharmacodynamic studies of oncological drugs. , 2009, Current pharmaceutical biotechnology.
[7] R. Williams,et al. Advances in the pulmonary delivery of poorly water-soluble drugs: influence of solubilization on pharmacokinetic properties , 2009, Drug development and industrial pharmacy.
[8] P. Sinn,et al. Progress and Prospects: prospects of repeated pulmonary administration of viral vectors , 2009, Gene Therapy.
[9] S. Hammerschmidt,et al. Inhaled iloprost for the control of pulmonary hypertension , 2009, Vascular health and risk management.
[10] Michael P Boyle,et al. The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles. , 2009, Biomaterials.
[11] H. Maeda,et al. Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect. , 2009, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
[12] Ben Forbes,et al. In‐vitro respiratory drug absorption models possess nominal functional P‐glycoprotein activity , 2009, The Journal of pharmacy and pharmacology.
[13] E. Alton,et al. Gene transfer to the lung: lessons learned from more than 2 decades of CF gene therapy. , 2009, Advanced drug delivery reviews.
[14] S. Bates,et al. ABCG2: a perspective. , 2009, Advanced drug delivery reviews.
[15] G. Scheuch,et al. Inhaled insulin--does it become reality? , 2008, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
[16] Po‐Chang Chiang,et al. Fluticasone and budesonide nanosuspensions for pulmonary delivery: preparation, characterization, and pharmacokinetic studies. , 2008, Journal of pharmaceutical sciences.
[17] T. Gedrange,et al. Long term evaluation of biomaterial application in surgical treatment of periodontitis , 2008 .
[18] B. Forbes,et al. Lack of difference in pulmonary absorption of digoxin, a P‐glycoprotein substrate, in mdr1a‐deficient and mdr1a‐competent mice , 2008, The Journal of pharmacy and pharmacology.
[19] D. Meyerholz,et al. Disruption of the CFTR Gene Produces a Model of Cystic Fibrosis in Newborn Pigs , 2008, Science.
[20] N. Voelkel,et al. The cancer paradigm of severe pulmonary arterial hypertension. , 2008, American journal of respiratory and critical care medicine.
[21] P. Sinn,et al. Lentivirus Vector Can Be Readministered to Nasal Epithelia without Blocking Immune Responses , 2008, Journal of Virology.
[22] F. Bosch,et al. The Contributions of Paul Ehrlich to Pharmacology: A Tribute on the Occasion of the Centenary of His Nobel Prize , 2008, Pharmacology.
[23] D. Baram,et al. Aerosolized antibiotics and ventilator-associated tracheobronchitis in the intensive care unit* , 2008, Critical care medicine.
[24] G. James,et al. Biofilm penetration, triggered release and in vivo activity of inhaled liposomal amikacin in chronic Pseudomonas aeruginosa lung infections. , 2008, The Journal of antimicrobial chemotherapy.
[25] A. Clark,et al. A Comparison of the Pulmonary Bioavailability of Powder and Liquid Aerosol Formulations of Salmon Calcitonin , 2008, Pharmaceutical Research.
[26] T. Pieber,et al. The effect of exercise on the absorption of inhaled human insulin in healthy volunteers. , 2008, British journal of clinical pharmacology.
[27] P. Holt,et al. Regulation of immunological homeostasis in the respiratory tract , 2008, Nature Reviews Immunology.
[28] R. Kim,et al. Pharmacogenomics of MRP Transporters (ABCC1-5) and BCRP (ABCG2) , 2008, Drug metabolism reviews.
[29] G. Scheuch,et al. Novel approaches to enhance pulmonary delivery of proteins and peptides. , 2007, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
[30] S. Hyde,et al. Lack of Repeat Transduction by Recombinant Adeno-Associated Virus Type 5/5 Vectors in the Mouse Airway , 2007, Journal of Virology.
[31] Thomas Ferkol,et al. Repeated aerosolized AAV-CFTR for treatment of cystic fibrosis: a randomized placebo-controlled phase 2B trial. , 2007, Human gene therapy.
[32] J. Brain. Inhalation, deposition, and fate of insulin and other therapeutic proteins. , 2007, Diabetes technology & therapeutics.
[33] Per Wollmer,et al. Site of deposition and absorption of an inhaled hydrophilic solute. , 2007, British journal of clinical pharmacology.
[34] H. Koepsell,et al. Polyspecific Organic Cation Transporters: Structure, Function, Physiological Roles, and Biopharmaceutical Implications , 2007, Pharmaceutical Research.
[35] P. Stumbles,et al. Mouse respiratory tract dendritic cell subsets and the immunological fate of inhaled antigens , 2007, Immunology and cell biology.
[36] M. Gumbleton,et al. P-glycoprotein (MDR1) functional activity in human alveolar epithelial cell monolayers , 2007, Cell and Tissue Research.
[37] M. Matthay,et al. Nonventilatory treatments for acute lung injury and ARDS. , 2007, Chest.
[38] D. Porteous,et al. Optimizing aerosol gene delivery and expression in the ovine lung. , 2007, Molecular therapy : the journal of the American Society of Gene Therapy.
[39] A. Wanner,et al. Epithelial organic cation transporters ensure pH-dependent drug absorption in the airway. , 2007, American journal of respiratory cell and molecular biology.
[40] Sai T Reddy,et al. Targeting dendritic cells with biomaterials: developing the next generation of vaccines. , 2006, Trends in immunology.
[41] S. Cole,et al. Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. , 2006, Physiological reviews.
[42] C. Ehrhardt,et al. Assessment of transport rates of proteins and peptides across primary human alveolar epithelial cell monolayers. , 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[43] C. Johansson,et al. Airway selectivity: an update of pharmacokinetic factors affecting local and systemic disposition of inhaled steroids. , 2006, Basic & clinical pharmacology & toxicology.
[44] T. Litman,et al. Localization of the ABCG2 mitoxantrone resistance-associated protein in normal tissues. , 2006, Cancer letters.
[45] Bart N Lambrecht,et al. Alveolar macrophage in the driver's seat. , 2006, Immunity.
[46] Scott H Randell,et al. Effective mucus clearance is essential for respiratory health. , 2006, American journal of respiratory cell and molecular biology.
[47] A. Coates,et al. How many infective viral particles are necessary for successful mass measles immunization by aerosol? , 2006, Vaccine.
[48] J. Castle,et al. Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: A resource for investigations into drug disposition , 2006, Xenobiotica; the fate of foreign compounds in biological systems.
[49] N. Müller,et al. Idiopathic pulmonary fibrosis: spectrum of high-resolution CT findings. , 2005, AJR. American journal of roentgenology.
[50] M. Conese,et al. Serum albumin enhances polyethylenimine‐mediated gene delivery to human respiratory epithelial cells , 2005, The journal of gene medicine.
[51] Diane P. Martin,et al. Incidence and outcomes of acute lung injury. , 2005, The New England journal of medicine.
[52] R. A. Coffee,et al. Electrohydrodynamic Comminution: A Novel Technique for the Aerosolisation of Plasmid DNA , 2005, Pharmaceutical Research.
[53] C. Ehrhardt,et al. Salbutamol is actively absorbed across human bronchial epithelial cell layers. , 2005, Pulmonary pharmacology & therapeutics.
[54] Wolfgang Kreyling,et al. Ultrafine Particles Cross Cellular Membranes by Nonphagocytic Mechanisms in Lungs and in Cultured Cells , 2005, Environmental health perspectives.
[55] H. Koepsell,et al. Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium. , 2005, American journal of respiratory cell and molecular biology.
[56] A. Kirschbaum,et al. Monitoring the initial pulmonary absorption of two different beclomethasone dipropionate aerosols employing a human lung reperfusion model , 2005, Respiratory research.
[57] Shohei Sugimoto,et al. Surface-modified PLGA nanosphere with chitosan improved pulmonary delivery of calcitonin by mucoadhesion and opening of the intercellular tight junctions. , 2005, Journal of controlled release : official journal of the Controlled Release Society.
[58] V. H. Lee,et al. Net absorption of IgG via FcRn-mediated transcytosis across rat alveolar epithelial cell monolayers. , 2004, American journal of physiology. Lung cellular and molecular physiology.
[59] Takashi Suzuki,et al. Heterogeneous increase in CD34-positive alveolar capillaries in idiopathic pulmonary fibrosis. , 2004, American journal of respiratory and critical care medicine.
[60] Véronique Préat,et al. Alveolar macrophages are a primary barrier to pulmonary absorption of macromolecules. , 2004, American journal of physiology. Lung cellular and molecular physiology.
[61] L. Davies,et al. The development of gene therapy for diseases of the lung , 2004, Cellular and Molecular Life Sciences CMLS.
[62] D. Wirtz,et al. Enhanced Viscoelasticity of Human Cystic Fibrotic Sputum Correlates with Increasing Microheterogeneity in Particle Transport* , 2003, Journal of Biological Chemistry.
[63] K. Braeckmans,et al. Three-dimensional fluorescence recovery after photobleaching with the confocal scanning laser microscope. , 2003, Biophysical journal.
[64] M. Newhouse,et al. Inhalation of a dry powder tobramycin PulmoSphere formulation in healthy volunteers. , 2003, Chest.
[65] Hans Lennernäs,et al. Pulmonary absorption rate and bioavailability of drugs in vivo in rats: structure-absorption relationships and physicochemical profiling of inhaled drugs. , 2003, Journal of pharmaceutical sciences.
[66] Marianne Geiser,et al. Influence of surface chemistry and topography of particles on their immersion into the lung's surface-lining layer. , 2003, Journal of applied physiology.
[67] N. Davies,et al. A novel method for assessing dissolution of aerosol inhaler products. , 2003, International journal of pharmaceutics.
[68] A. Malik,et al. Protein transport across the lung epithelial barrier. , 2003, American journal of physiology. Lung cellular and molecular physiology.
[69] P. Meier,et al. The superfamily of organic anion transporting polypeptides. , 2003, Biochimica et biophysica acta.
[70] Hans Lennernäs,et al. Drug Absorption from the Isolated Perfused Rat Lung–Correlations with Drug Physicochemical Properties and Epithelial Permeability , 2003, Journal of drug targeting.
[71] L. Campbell,et al. Constitutive Expression of P-Glycoprotein in Normal Lung Alveolar Epithelium and Functionality in Primary Alveolar Epithelial Cultures , 2003, Journal of Pharmacology and Experimental Therapeutics.
[72] I. Pajeva,et al. Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis). , 2002, Journal of medicinal chemistry.
[73] Robert Gelein,et al. EXTRAPULMONARY TRANSLOCATION OF ULTRAFINE CARBON PARTICLES FOLLOWING WHOLE-BODY INHALATION EXPOSURE OF RATS , 2002, Journal of toxicology and environmental health. Part A.
[74] Ning Li,et al. Tissue distribution and chemical induction of multiple drug resistance genes in rats. , 2002, Drug metabolism and disposition: the biological fate of chemicals.
[75] D. Postma,et al. Multidrug resistance related molecules in human and murine lung. , 2002, Journal of clinical pathology.
[76] S. D. De Smedt,et al. On the Transport of Lipoplexes Through Cystic Fibrosis Sputum , 2002, Pharmaceutical Research.
[77] Terry R Stouch,et al. Progress in understanding the structure-activity relationships of P-glycoprotein. , 2002, Advanced drug delivery reviews.
[78] K. Chung,et al. Distribution and function of the peptide transporter PEPT2 in normal and cystic fibrosis human lung , 2002, Thorax.
[79] Y. Makino,et al. Enhanced pulmonary absorption following aerosol administration of mucoadhesive powder microspheres. , 2001, Journal of controlled release : official journal of the Controlled Release Society.
[80] J. Morris,et al. Aerosol and lobar administration of a recombinant adenovirus to individuals with cystic fibrosis. II. Transfection efficiency in airway epithelium. , 2001, Human gene therapy.
[81] M D Donovan,et al. Drug transfer through mucus. , 2001, Advanced drug delivery reviews.
[82] S. Smedt,et al. Cystic fibrosis sputum: a barrier to the transport of nanospheres. , 2000, American journal of respiratory and critical care medicine.
[83] R W Glenny,et al. Hemodynamic effects of 15-microm-diameter microspheres on the rat pulmonary circulation. , 2000, Journal of applied physiology.
[84] J. Nezu,et al. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. , 2000, Biochemical and biophysical research communications.
[85] S. Schürch,et al. Particles at the airway interfaces of the lung , 1999 .
[86] S. Durham,et al. Cationic lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis: a double-blind placebo-controlled trial , 1999, The Lancet.
[87] J. Bernaudin,et al. Different Pattern of MRP Localization in Ciliated and Basal Cells from Human Bronchial Epithelium , 1998, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
[88] J. Widdicombe. Airway liquid: a barrier to drug diffusion? , 1997, The European respiratory journal.
[89] G. Wolff,et al. Role of alveolar macrophages in rapid elimination of adenovirus vectors administered to the epithelial surface of the respiratory tract. , 1997, Human gene therapy.
[90] B. Milleron,et al. MDR1-Pgp 170 expression in human bronchus. , 1997, The European respiratory journal.
[91] J. Patton,et al. Mechanisms of macromolecule absorption by the lungs , 1996 .
[92] M. Flens,et al. Tissue distribution of the multidrug resistance protein. , 1996, The American journal of pathology.
[93] J. Dorin. Development of mouse models for cystic fibrosis , 1995, Journal of Inherited Metabolic Disease.
[94] J. Mcghee,et al. Intratracheal gene delivery with adenoviral vector induces elevated systemic IgG and mucosal IgA antibodies to adenovirus and beta-galactosidase. , 1995, Human gene therapy.
[95] R. Kradin,et al. The antigen-presenting activities of Ia+ dendritic cells shift dynamically from lung to lymph node after an airway challenge with soluble antigen , 1995, The Journal of experimental medicine.
[96] G. Freeman,et al. Human alveolar macrophages present antigen ineffectively due to defective expression of B7 costimulatory cell surface molecules. , 1995, The Journal of clinical investigation.
[97] J. Godleski,et al. Chronic bronchitis alters the pattern of aerosol deposition in the lung. , 1995, American journal of respiratory and critical care medicine.
[98] J. Wright,et al. Immunomodulatory Functions of Surfactant , 1995, Physiological reviews.
[99] B. Lehnert,et al. Correlation between particle size, in vivo particle persistence, and lung injury. , 1994, Environmental health perspectives.
[100] M. Tsan,et al. Depletion of alveolar macrophages by liposome-encapsulated dichloromethylene diphosphonate. , 1993, Journal of applied physiology.
[101] P. Holt,et al. Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages , 1993, The Journal of experimental medicine.
[102] N. Rooijen,et al. Selective Depletion of Liver and Splenic Macrophages Using Liposomes Encapsulating the Drug Dichloromethylene Diphosphonate: Effects on Antimicrobial Resistance , 1991, Journal of leukocyte biology.
[103] M. Melamed,et al. Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues. , 1990, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
[104] S. Schürch,et al. Surfactant displaces particles toward the epithelium in airways and alveoli. , 1990, Respiration physiology.
[105] J. Godleski,et al. Emphysema alters the deposition pattern of inhaled particles in hamsters. , 1987, The American journal of pathology.
[106] R. Rhoades. Handbook of Physiology: The Respiratory System, Circulation and Nonrespiratory Functions , 1985 .
[107] J. Godleski,et al. Short-term regional clearance of an inhaled submicrometric aerosol in pulmonary fibrosis. , 1985, The American review of respiratory disease.
[108] J. Shelhamer,et al. Human respiratory mucus. , 1984, The American review of respiratory disease.
[109] A. Watson,et al. Uptake of iron aerosols by mouse airway epithelium. , 1979, Laboratory investigation; a journal of technical methods and pathology.
[110] Z. Chowhan,et al. Pulmonary absorption studies utilizing in situ rat lung model: designing dosage regimen for bronchial delivery of new drug entities. , 1976, Journal of pharmaceutical sciences.
[111] M. Gumbleton,et al. RT-PCR analysis of ABC, SLC and SLCO drug transporters in human lung epithelial cell models. , 2009, The Journal of pharmacy and pharmacology.
[112] V. Shah,et al. The Inhalation Ad Hoc Advisory Panel for the USP Performance Tests of Inhalation Dosage Forms , 2008 .
[113] R. Vanbever,et al. Crucial Biopharmaceutical Issues Facing Macromolecular Candidates for Inhalation: The Role of Macrophages in Pulmonary Protein Clearance , 2007 .
[114] Peter R. Byron,et al. Inhaling medicines: delivering drugs to the body through the lungs , 2007, Nature Reviews Drug Discovery.
[115] Thomas J. Raub,et al. P-glycoprotein recognition of substrates and circumvention through rational drug design. , 2006, Molecular pharmaceutics.
[116] Y. Kanai,et al. Organic anion transporter family: current knowledge. , 2006, Journal of pharmacological sciences.
[117] M. van der Deen,et al. ATP-binding cassette (ABC) transporters in normal and pathological lung , 2005, Respiratory research.
[118] M. Sakagami. Insulin Disposition in the Lung Following Oral Inhalation in Humans , 2004, Clinical pharmacokinetics.
[119] P. Allavena,et al. From pattern recognition receptor to regulator of homeostasis: the double-faced macrophage mannose receptor. , 2004, Critical reviews in immunology.
[120] J. Patton,et al. Clinical Pharmacokinetics and Pharmacodynamics of Inhaled Insulin , 2004, Clinical pharmacokinetics.
[121] T. Rochat,et al. Gene therapy for cystic fibrosis by means of aerosol. , 2002, Journal of Aerosol Medicine.
[122] C. Janeway,et al. ImmunoBiology: The Immune System in Health and Diseases , 1996 .
[123] V. H. Lee,et al. Fate of insulin during transit across rat alveolar epithelial cell monolayers , 1994 .
[124] T. Tsuruo,et al. Distribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues. Analysis with 3 monoclonal antibodies recognizing different epitopes of the P-glycoprotein molecule. , 1990, Annals of oncology : official journal of the European Society for Medical Oncology.
[125] T. Tsuruo,et al. Distribution of multidrug resistance-associated P-glycoprotein in normal and neoplastic human tissue , 1990 .
[126] J. Godleski,et al. Effects of pulmonary fibrosis on aerosol deposition in hamsters , 1984 .
[127] P. Valberg,et al. Deposition of aerosol in the respiratory tract. , 1979, The American review of respiratory disease.