Tim Protein Structures Reveal a Unique Face for Ligand Binding

[1]  Steven C Almo,et al.  T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface. , 2007, Immunity.

[2]  J. Casasnovas,et al.  Structures of T Cell Immunoglobulin Mucin Receptors 1 and 2 Reveal Mechanisms for Regulation of Immune Responses by the TIM Receptor Family , 2007, Immunity.

[3]  David E. Anderson,et al.  TIM-3 in autoimmunity. , 2006, Current opinion in immunology.

[4]  L. Kane,et al.  Cutting Edge: Inhibition of T Cell Activation by TIM-21 , 2006, The Journal of Immunology.

[5]  L. Kane,et al.  T cell Ig and mucin 1 (TIM-1) is expressed on in vivo-activated T cells and provides a costimulatory signal for T cell activation. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[6]  V. Kuchroo,et al.  The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity , 2005, Nature Immunology.

[7]  F. Brodsky,et al.  TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis , 2005, The Journal of experimental medicine.

[8]  V. Kuchroo,et al.  The TIM gene family regulates autoimmune and allergic diseases. , 2005, Trends in molecular medicine.

[9]  V. Kuchroo,et al.  Tim-2 regulates T helper type 2 responses and autoimmunity , 2005, The Journal of experimental medicine.

[10]  G. Freeman,et al.  The TIM gene family: emerging roles in immunity and disease , 2003, Nature Reviews Immunology.

[11]  G. Barsh,et al.  Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family , 2001, Nature Immunology.