Nephrotic syndrome as a result of membranous nephropathy caused by renal cell carcinoma

A 77‐year‐old woman was admitted for a renal biopsy to evaluate a case of nephrotic syndrome. In the course of the examination, a right renal tumor was incidentally found. We performed a right radical nephrectomy in advance of the renal biopsy. Histologically, the tumor was diagnosed as a renal cell carcinoma (clear cell carcinoma) and the non‐neoplastic renal cell tissue showed membranous nephropathy (MN). After surgery, the nephrotic syndrome remitted without any further medical treatment and the MN was considered to be a malignancy associated syndrome. There have been few case reports in the literature regarding this association and we wish to describe another case.

[1]  A. Hishida,et al.  Membranous Glomerulonephritis Associated with Renal Cell Carcinoma: Failure to Detect a Nephritogenic Tumor Antigen , 2002, Nephron.

[2]  Sanjay Jain,et al.  CRESCENTIC GLOMERULONEPHRITIS ASSOCIATED WITH RENAL CELL CARCINOMA , 2001, Renal failure.

[3]  S. Adler,et al.  Nephrotic syndrome, renal failure, and renal malignancy: an unusual tumor-associated glomerulonephritis. , 1997, Journal of the American Society of Nephrology : JASN.

[4]  Y. Ikeda,et al.  Nephrotic syndrome due to membranous nephropathy associated with renal cell carcinoma. , 1996, Clinical nephrology.

[5]  J. Gronich,et al.  Membranous nephropathy associated with renal cell carcinoma. , 1993, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[6]  M. Cudkowicz,et al.  Membranous nephropathy in a patient with renal cell carcinoma. , 1991, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[7]  C. Alpers,et al.  Neoplasia and glomerular injury. , 1986, Kidney international.

[8]  R. B. Colvin,et al.  Case 42-1980 , 1980 .

[9]  W. Couser Book ReviewCurrent Nephrology , 1980 .

[10]  H. Feiner,et al.  Membranous Nephropathy Associated with Renal Cell Carcinoma Evidence Against a Role of Renal Tubular or Tumor Antibodies in Pathogenesis , 1978 .

[11]  J. Lee,et al.  The association of cancer and the nephrotic syndrome. , 1966, Annals of internal medicine.