Activation of Fas death receptor pathway and Bid in hepatocytes is involved in saikosaponin D induction of hepatotoxicity.

[1]  F. Gonzalez,et al.  Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling. , 2014, Chemico-biological interactions.

[2]  Feng Zhang,et al.  Saikosaponin D disrupts platelet-derived growth factor-β receptor/p38 pathway leading to mitochondrial apoptosis in human LO2 hepatocyte cells: a potential mechanism of hepatotoxicity. , 2013, Chemico-biological interactions.

[3]  Pei-Shan Liu,et al.  Saikosaponin a and saikosaponin d inhibit proliferation and migratory activity of rat HSC-T6 cells. , 2013, Journal of medicinal food.

[4]  Mitchell R. McGill,et al.  Fas receptor-deficient lpr mice are protected against acetaminophen hepatotoxicity due to higher glutathione synthesis and enhanced detoxification of oxidant stress. , 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[5]  C. Bunchorntavakul,et al.  Review article: herbal and dietary supplement hepatotoxicity , 2013, Alimentary pharmacology & therapeutics.

[6]  H. Devarbhavi.  An Update on Drug-induced Liver Injury. , 2012, Journal of clinical and experimental hepatology.

[7]  D. Pessayre,et al.  Central role of mitochondria in drug-induced liver injury , 2012, Drug metabolism reviews.

[8]  A. Strasser,et al.  Fas death receptor signalling: roles of Bid and XIAP , 2011, Cell Death and Differentiation.

[9]  H. Walczak,et al.  Caspase-8 and bid: caught in the act between death receptors and mitochondria. , 2011, Biochimica et biophysica acta.

[10]  Pau-Chung Chen,et al.  Risk of Liver Injury Associated with Chinese Herbal Products Containing Radix bupleuri in 639,779 Patients with Hepatitis B Virus Infection , 2011, PloS one.

[11]  Michael Ederer,et al.  Tumor necrosis factor α sensitizes primary murine hepatocytes to Fas/CD95‐induced apoptosis in a Bim‐ and Bid‐dependent manner , 2011, Hepatology.

[12]  M. Manns,et al.  The strength of the Fas ligand signal determines whether hepatocytes act as type 1 or type 2 cells in murine livers , 2009, Hepatology.

[13]  Liang Liu,et al.  Mechanistic study of saikosaponin‐d (Ssd) on suppression of murine T lymphocyte activation , 2009, Journal of cellular biochemistry.

[14]  Kathrin Schmich,et al.  Switch from type II to I Fas/CD95 death signaling on in vitro culturing of primary hepatocytes , 2008, Hepatology.

[15]  D. Andrews,et al.  Bid: a Bax-like BH3 protein , 2008, Oncogene.

[16]  Xi Zhang,et al.  Characterization and identification of saikosaponins in crude extracts from three Bupleurum species using LC-ESI-MS. , 2008, Journal of separation science.

[17]  G. Gores,et al.  Death receptor-mediated liver injury. , 2007, Seminars in liver disease.

[18]  Liang Liu,et al.  Saikosaponin-d inhibits T cell activation through the modulation of PKCθ, JNK, and NF-κB transcription factor , 2005 .

[19]  R. Khosravi‐Far.  Death receptor signals to the mitochondria , 2004, Cancer biology & therapy.

[20]  A. Thorburn,et al.  Death receptor-induced cell killing. , 2004, Cellular signalling.

[21]  T. Kuwana,et al.  Bcl-2-family proteins and the role of mitochondria in apoptosis. , 2003, Current opinion in cell biology.

[22]  Xiao-Ming Yin,et al.  Death receptor activation-induced hepatocyte apoptosis and liver injury. , 2003, Current molecular medicine.

[23]  Junying Yuan,et al.  Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis , 1998, Cell.