Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status

[1]  J. Corren,et al.  Tezepelumab in Adults with Uncontrolled Asthma. , 2019, The New England journal of medicine.

[2]  S. Yancey,et al.  Mepolizumab or Placebo for Eosinophilic Granulomatosis with Polyangiitis , 2017, The New England journal of medicine.

[3]  Cisca Wijmenga,et al.  The MHC locus and genetic susceptibility to autoimmune and infectious diseases , 2017, Genome Biology.

[4]  P. Donnelly,et al.  Practical Use of Methods for Imputation of HLA Alleles from SNP Genotype Data , 2016, bioRxiv.

[5]  Szilard Voros,et al.  Variation in PCSK9 and HMGCR and Risk of Cardiovascular Disease and Diabetes. , 2016, The New England journal of medicine.

[6]  Jonathan M. Cairns,et al.  Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters , 2016, Cell.

[7]  William J. Astle,et al.  Allelic Landscape of Human Blood Cell Trait Variation and Links , 2016 .

[8]  J. Rinn,et al.  The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan , 2016, Nature.

[9]  Stephen Burgess,et al.  PhenoScanner: a database of human genotype–phenotype associations , 2016, Bioinform..

[10]  Tim J. Carver,et al.  CHiCP: a web-based tool for the integrative and interactive visualization of promoter capture Hi-C datasets , 2016, Bioinform..

[11]  David L. Vaux,et al.  Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies , 2016, Nature Reviews Cancer.

[12]  N. Hanania,et al.  Role of T2 inflammation biomarkers in severe asthma , 2016, Current opinion in pulmonary medicine.

[13]  P. Merkel,et al.  Rituximab for the treatment of eosinophilic granulomatosis with polyangiitis (Churg–Strauss) , 2014, Annals of the rheumatic diseases.

[14]  Judy H. Cho,et al.  Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations , 2015, Nature Genetics.

[15]  J. Denburg,et al.  Thymic stromal lymphopoietin (TSLP) secretion from human nasal epithelium is a function of TSLP genotype , 2014, Mucosal Immunology.

[16]  A. Scott,et al.  Glycoprotein A33 deficiency: a new mouse model of impaired intestinal epithelial barrier function and inflammatory disease , 2015, Disease Models & Mechanisms.

[17]  Philip A. Ewels,et al.  Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C , 2015, Nature Genetics.

[18]  G. Kempermann Faculty Opinions recommendation of Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. , 2015 .

[19]  Jun S. Liu,et al.  The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans , 2015, Science.

[20]  N. Wray,et al.  Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance components analysis , 2015, Nature Genetics.

[21]  G. Sobue,et al.  [Central nervous system vasculitis according to the 2012 revise international Chapel Hill consensus conference nomenclature of vasculitides]. , 2015, Brain and nerve = Shinkei kenkyu no shinpo.

[22]  Chris Wallace,et al.  A Pleiotropy-Informed Bayesian False Discovery Rate Adapted to a Shared Control Design Finds New Disease Associations From GWAS Summary Statistics , 2015, bioRxiv.

[23]  Carson C Chow,et al.  Second-generation PLINK: rising to the challenge of larger and richer datasets , 2014, GigaScience.

[24]  B. Berger,et al.  Efficient Bayesian mixed model analysis increases association power in large cohorts , 2014, Nature Genetics.

[25]  M. Daly,et al.  LD Score regression distinguishes confounding from polygenicity in genome-wide association studies , 2014, Nature Genetics.

[26]  Super-enhancers delineate disease-associated regulatory nodes in T cells , 2015 .

[27]  A. McKenzie Type-2 innate lymphoid cells in asthma and allergy. , 2014, Annals of the American Thoracic Society.

[28]  A. Bredenoord,et al.  GWAS identifies four novel eosinophilic esophagitis loci , 2014, Nature Communications.

[29]  Ian D Pavord,et al.  Mepolizumab treatment in patients with severe eosinophilic asthma. , 2014, The New England journal of medicine.

[30]  P. Visscher,et al.  Estimation and partitioning of (co)heritability of inflammatory bowel disease from GWAS and immunochip data. , 2014, Human molecular genetics.

[31]  R. Uehara,et al.  A nationwide survey on the epidemiology and clinical features of eosinophilic granulomatosis with polyangiitis (Churg-Strauss) in Japan , 2014, Modern rheumatology.

[32]  Andrew M. Rupert,et al.  Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease , 2014, Nature Genetics.

[33]  Manuel A. R. Ferreira,et al.  Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. , 2014, The Journal of allergy and clinical immunology.

[34]  J. Svaren,et al.  Bach2 Regulates Homeostasis of Foxp3+ Regulatory T Cells and Protects against Fatal Lung Disease in Mice , 2014, The Journal of Immunology.

[35]  A. Vaglio,et al.  Eosinophilic granulomatosis with polyangiitis (Churg–Strauss): evolutions in classification, etiopathogenesis, assessment and management , 2014, Current opinion in rheumatology.

[36]  Kari Stefansson,et al.  Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization , 2013, Nature Genetics.

[37]  Chuong B. Do,et al.  A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci , 2013, Nature Genetics.

[38]  L. Mouthon,et al.  Antineutrophil cytoplasmic antibody-associated vasculitides: is it time to split up the group? , 2013, Annals of the rheumatic diseases.

[39]  D. Rujescu,et al.  Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate , 2013, PLoS genetics.

[40]  Satoru Takahashi,et al.  Transcription Factors GATA-3 and RORγt Are Important for Determining the Phenotype of Allergic Airway Inflammation in a Murine Model of Asthma , 2013, The Journal of Immunology.

[41]  P. Merkel,et al.  2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. , 2013, Arthritis and rheumatism.

[42]  L. Mouthon,et al.  Eosinophilic granulomatosis with polyangiitis (Churg-Strauss): clinical characteristics and long-term followup of the 383 patients enrolled in the French Vasculitis Study Group cohort. , 2013, Arthritis and rheumatism.

[43]  O. Delaneau,et al.  Supplementary Information for ‘ Improved whole chromosome phasing for disease and population genetic studies ’ , 2012 .

[44]  Jake K. Byrnes,et al.  Bayesian refinement of association signals for 14 loci in 3 common diseases , 2012, Nature Genetics.

[45]  P. Khoury,et al.  Serum biomarkers are similar in Churg–Strauss syndrome and hypereosinophilic syndrome , 2012, Allergy.

[46]  J. Marchini,et al.  Fast and accurate genotype imputation in genome-wide association studies through pre-phasing , 2012, Nature Genetics.

[47]  Panos Deloukas,et al.  Genetically distinct subsets within ANCA-associated vasculitis. , 2012, The New England journal of medicine.

[48]  David J Balding,et al.  A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order. , 2011, The Journal of allergy and clinical immunology.

[49]  Florence Demenais,et al.  A large-scale, consortium-based genomewide association study of asthma. , 2010, The New England journal of medicine.

[50]  G. Nilsson,et al.  The BH3-Mimetic ABT-737 Induces Mast Cell Apoptosis In Vitro and In Vivo: Potential for Therapeutics , 2010, The Journal of Immunology.

[51]  P. van Paassen,et al.  Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis. , 2010, The New England journal of medicine.

[52]  D. Huang,et al.  BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs , 2010, Proceedings of the National Academy of Sciences.

[53]  Joseph T. Glessner,et al.  Common variants at 5q22 associate with pediatric eosinophilic esophagitis , 2010, Nature Genetics.

[54]  Saskia M Pasedag,et al.  Cell Adhesion and Transcriptional Activity - Defining the Role of the Novel Protooncogene LPP. , 2009, Translational oncology.

[55]  P. Donnelly,et al.  A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies , 2009, PLoS genetics.

[56]  D. Postma,et al.  Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction , 2009, Nature Genetics.

[57]  S. Pai,et al.  GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation , 2009, Nature Reviews Immunology.

[58]  Jon Wakefield,et al.  Bayes factors for genome‐wide association studies: comparison with P‐values , 2009, Genetic epidemiology.

[59]  Takahiko Sugihara,et al.  Successful Treatment of Animal Models of Rheumatoid Arthritis with Small-Molecule Cyclin-Dependent Kinase Inhibitors1 , 2008, The Journal of Immunology.

[60]  J. Epplen,et al.  Associations of Churg-Strauss syndrome with the HLA-DRB1 locus, and relationship to the genetics of antineutrophil cytoplasmic antibody-associated vasculitides: comment on the article by Vaglio et al. , 2008, Arthritis and rheumatism.

[61]  U. Maggiore,et al.  HLA-DRB4 as a genetic risk factor for Churg-Strauss syndrome. , 2007, Arthritis and rheumatism.

[62]  Tetsuo Noda,et al.  Plasmacytic Transcription Factor Blimp-1 Is Repressed by Bach2 in B Cells* , 2006, Journal of Biological Chemistry.

[63]  G. Besra,et al.  GATA-3 Regulates the Development and Function of Invariant NKT Cells1 , 2006, The Journal of Immunology.

[64]  L. Mouthon,et al.  Antineutrophil Cytoplasmic Antibodies and the ChurgStrauss Syndrome , 2005, Annals of Internal Medicine.

[65]  Laura Pavone,et al.  Prevalence and clinical significance of antineutrophil cytoplasmic antibodies in Churg-Strauss syndrome. , 2005, Arthritis and rheumatism.

[66]  G. Nilsson,et al.  Proapoptotic Bcl-2 family member Bim is involved in the control of mast cell survival and is induced together with Bcl-XL upon IgE-receptor activation , 2005, Cell Death and Differentiation.

[67]  Booki Min,et al.  Conditional deletion of Gata3 shows its essential function in TH1-TH2 responses , 2004, Nature Immunology.

[68]  J. Lötvall,et al.  Regulation of bone marrow and airway CD34+ eosinophils by interleukin-5. , 2004, American journal of respiratory cell and molecular biology.

[69]  S. Pai,et al.  GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[70]  A. Strasser,et al.  Loss of the Pro-Apoptotic BH3-only Bcl-2 Family Member Bim Inhibits BCR Stimulation–induced Apoptosis and Deletion of Autoreactive B Cells , 2003, The Journal of experimental medicine.

[71]  A. Strasser,et al.  BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes , 2002, Nature.

[72]  A. Strasser,et al.  Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. , 1999, Science.

[73]  N. Day,et al.  EPIC-Norfolk: study design and characteristics of the cohort. European Prospective Investigation of Cancer. , 1999, British journal of cancer.

[74]  T. Pincus,et al.  Limitations of the 1990 American College of Rheumatology Classification Criteria in the Diagnosis of Vasculitis , 1998, Annals of Internal Medicine.

[75]  D. Scott,et al.  Churg-Strauss syndrome in a district hospital. , 1998, QJM : monthly journal of the Association of Physicians.

[76]  Richard A Flavell,et al.  The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells , 1997, Cell.

[77]  L. Staudt,et al.  Control of inflammation, cytokine expression, and germinal center formation by BCL-6. , 1997, Science.

[78]  R. Matsumura,et al.  IL‐5 but not interferon‐gamma (IFN‐γ) inhibits eosinophil apoptosis by up‐regulation of bcl‐2 expression , 1997, Clinical and experimental immunology.

[79]  J. Leiden,et al.  Transcription factor GATA-3 is required for development of the T-cell lineage , 1996, Nature.

[80]  A. Wardlaw,et al.  Interleukin-5 selectively enhances the chemotactic response of eosinophils obtained from normal but not eosinophilic subjects. , 1992, Blood.

[81]  D A Bloch,et al.  The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis). , 2010, Arthritis and rheumatism.

[82]  G. Hughes,et al.  Systemic Vasculitis with Asthma and Eosinophilia: A Clinical Approach to the Churg‐Strauss Syndrome , 1984, Medicine.

[83]  J. Churg,et al.  Allergic granulomatosis, allergic angiitis, and periarteritis nodosa. , 1951, The American journal of pathology.