The Prediction of Complicated Clostridium difficile Infections in Children

We validated proposed definitions for severe Clostridium difficile infection (CDI) in adults for prediction of complicated CDI in children. Complicated CDI occurred in 9 of 202 cases. Definitions for severe CDI in adults showed poor measures for discrimination of complicated CDI in children, which calls into question the usefulness of such definitions in pediatric cohorts. Infect Control Hosp Epidemiol 2014;35(7):901–903

[1]  M. P. Bauer,et al.  European Society of Clinical Microbiology and Infectious Diseases: update of the treatment guidance document for Clostridium difficile infection. , 2014, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[2]  M. Mulvey,et al.  Severe clinical outcome is uncommon in Clostridium difficile infection in children: a retrospective cohort study , 2014, BMC Pediatrics.

[3]  P. Tamma,et al.  Distinguishing community-associated from hospital-associated Clostridium difficile infections in children: implications for public health surveillance. , 2013, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[4]  S. Coffin,et al.  Clostridium difficile infection is associated with increased risk of death and prolonged hospitalization in children. , 2013, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[5]  A. Zinsmeister,et al.  The epidemiology of Clostridium difficile infection in children: a population-based study. , 2013, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[6]  D. Enoch,et al.  Five Years Experience of Clostridium difficile Infection in Children at a UK Tertiary Hospital: Proposed Criteria for Diagnosis and Management , 2012, PloS one.

[7]  P. Tamma,et al.  Clostridium difficile Infection in Children: Current State and Unanswered Questions. , 2012, Journal of the Pediatric Infectious Diseases Society.

[8]  S. Coffin,et al.  Risk Factors and Outcomes Associated With Severe Clostridium difficile Infection in Children , 2012, The Pediatric infectious disease journal.

[9]  E. Kuijper,et al.  Clostridium difficile infection in Europe: a hospital-based survey , 2011, The Lancet.

[10]  Guang-xi Li,et al.  Clinical practice guidelines for Clostridium difficile infection in adults:2010 update by the Society for Healthcare Epidemiology of America(SHEA)and the Infectious Diseases Society of America(IDSA) , 2011 .