Using Resistin, Glucose, Age and BMI and Pruning Fuzzy Neural Network for the Construction of Expert Systems in the Prediction of Breast Cancer

Research on predictions of breast cancer grows in the scientific community, providing data on studies in patient surveys. Predictive models link areas of medicine and artificial intelligence to collect data and improve disease assessments that affect a large part of the population, such as breast cancer. In this work, we used a hybrid artificial intelligence model based on concepts of neural networks and fuzzy systems to assist in the identification of people with breast cancer through fuzzy rules. The hybrid model can manipulate the data collected in medical examinations and identify patterns between healthy people and people with breast cancer with an acceptable level of accuracy. These intelligent techniques allow the creation of expert systems based on logical rules of the IF/THEN type. To demonstrate the feasibility of applying fuzzy neural networks, binary pattern classification tests were performed where the dimensions of the problem are used for a model, and the answers identify whether or not the patient has cancer. In the tests, experiments were replicated with several characteristics collected in the examinations done by medical specialists. The results of the tests, compared to other models commonly used for this purpose in the literature, confirm that the hybrid model has a tremendous predictive capacity in the prediction of people with breast cancer maintaining acceptable levels of accuracy with good ability to act on false positives and false negatives, assisting the scientific milieu with its forecasts with the significant characteristic of interpretability of breast cancer. In addition to coherent predictions, the fuzzy neural network enables the construction of systems in high level programming languages to build support systems for physicians’ actions during the initial stages of treatment of the disease with the fuzzy rules found, allowing the construction of systems that replicate the knowledge of medical specialists, disseminating it to other professionals.

[1]  Kevin Smith,et al.  Digital image analysis in breast pathology-from image processing techniques to artificial intelligence. , 2017, Translational research : the journal of laboratory and clinical medicine.

[2]  M. Mapelli,et al.  A Numb–Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer , 2018, The Journal of cell biology.

[3]  Ian H. Witten,et al.  Weka: Practical machine learning tools and techniques with Java implementations , 1999 .

[4]  Yong Yu,et al.  Sales forecasting using extreme learning machine with applications in fashion retailing , 2008, Decis. Support Syst..

[5]  Thiago Silva Rezende,et al.  Using Fuzzy Neural Networks to the Prediction of Improvement in Expert Systems for Treatment of Immunotherapy , 2018, IBERAMIA.

[6]  Luca Maria Gambardella,et al.  Mitosis Detection in Breast Cancer Histology Images with Deep Neural Networks , 2013, MICCAI.

[7]  Hongming Zhou,et al.  Extreme Learning Machine for Regression and Multiclass Classification , 2012, IEEE Transactions on Systems, Man, and Cybernetics, Part B (Cybernetics).

[8]  S. Rubin,et al.  Efficacy of screening mammography. A meta-analysis. , 1995, JAMA.

[9]  Paulo Vitor C. Souza,et al.  Regularized Fuzzy Neural Networks for Pattern Classification Problems , 2018 .

[10]  H. Iwase,et al.  [Breast cancer]. , 2006, Nihon rinsho. Japanese journal of clinical medicine.

[11]  Yiming Yang,et al.  A Comparative Study on Feature Selection in Text Categorization , 1997, ICML.

[12]  Qin Hu,et al.  Fault Diagnosis Based on Weighted Extreme Learning Machine With Wavelet Packet Decomposition and KPCA , 2018, IEEE Sensors Journal.

[13]  Heang-Ping Chan,et al.  Deep Learning for Mammographic Breast Density Assessment and Beyond. , 2019, Radiology.

[14]  Yixuan Li,et al.  Performance Evaluation of Machine Learning Methods for Breast Cancer Prediction , 2018 .

[15]  E J Lusk,et al.  Contemporary unorthodox treatments in cancer medicine. A study of patients, treatments, and practitioners. , 1984, Annals of internal medicine.

[16]  Alexandre Mendes,et al.  Evolutionary Wavelet Neural Network ensembles for breast cancer and Parkinson’s disease prediction , 2018, PloS one.

[17]  Hussein A. Abbass,et al.  An evolutionary artificial neural networks approach for breast cancer diagnosis , 2002, Artif. Intell. Medicine.

[18]  Pradipta Kishore Dash,et al.  Data decomposition based fast reduced kernel extreme learning machine for currency exchange rate forecasting and trend analysis , 2018, Expert Syst. Appl..

[19]  Ioannis E. Livieris,et al.  Improving the Classification Efficiency of an ANN Utilizing a New Training Methodology , 2018, Informatics.

[20]  Lotfi A. Zadeh,et al.  A fuzzy-algorithmic approach to the definition of complex or imprecise concepts , 1976 .

[21]  Ivan Nunes da Silva,et al.  Inferência fuzzy para o problema de corte de estoque com sobras aproveitáveis de material , 2011 .

[22]  A. Jemal,et al.  Breast cancer statistics, 2013 , 2014, CA: a cancer journal for clinicians.

[23]  E. Mizutani,et al.  Neuro-Fuzzy and Soft Computing-A Computational Approach to Learning and Machine Intelligence [Book Review] , 1997, IEEE Transactions on Automatic Control.

[24]  Kemal Polat,et al.  A Novel ML Approach to Prediction of Breast Cancer: Combining of mad normalization, KMC based feature weighting and AdaBoostM1 classifier , 2018, 2018 2nd International Symposium on Multidisciplinary Studies and Innovative Technologies (ISMSIT).

[25]  Paulo Vitor de Campos Souza,et al.  Pruning fuzzy neural networks based on unineuron for problems of classification of patterns , 2018, J. Intell. Fuzzy Syst..

[26]  Thiago Silva Rezende,et al.  Method of pruning the hidden layer of the extreme learning machine based on correlation coefficient , 2018, 2018 IEEE Latin American Conference on Computational Intelligence (LA-CCI).

[27]  Thomas Kirchner,et al.  Migrating cancer stem cells — an integrated concept of malignant tumour progression , 2005, Nature Reviews Cancer.

[28]  George E. Dahl,et al.  Artificial Intelligence-Based Breast Cancer Nodal Metastasis Detection: Insights Into the Black Box for Pathologists. , 2018, Archives of pathology & laboratory medicine.

[29]  Ian H. Witten,et al.  The WEKA data mining software: an update , 2009, SKDD.

[30]  G. Hortobagyi,et al.  Breast Cancer in Men , 2002, Annals of Internal Medicine.

[31]  Li Li,et al.  A new method based on Type-2 fuzzy neural network for accurate wind power forecasting under uncertain data , 2018, Renewable Energy.

[32]  Dursun Delen,et al.  Predicting breast cancer survivability: a comparison of three data mining methods , 2005, Artif. Intell. Medicine.

[33]  Jyh-Shing Roger Jang,et al.  ANFIS: adaptive-network-based fuzzy inference system , 1993, IEEE Trans. Syst. Man Cybern..

[34]  A. Jemal,et al.  Breast Cancer Statistics , 2013 .

[35]  Mehmet Fatih Akay,et al.  Support vector machines combined with feature selection for breast cancer diagnosis , 2009, Expert Syst. Appl..

[36]  Carlos E. Pedreira,et al.  Neural networks for short-term load forecasting: a review and evaluation , 2001 .

[37]  Chee Kheong Siew,et al.  Extreme learning machine: Theory and applications , 2006, Neurocomputing.

[38]  Witold Pedrycz,et al.  Fuzzy neural networks and neurocomputations , 1993 .

[39]  Witold Pedrycz,et al.  Evaluation of fuzzy linear regression models , 1991 .

[40]  Rudy Setiono,et al.  Generating concise and accurate classification rules for breast cancer diagnosis , 2000, Artif. Intell. Medicine.

[41]  Kemal Polat,et al.  Multi-class f-score feature selection approach to classification of obstructive sleep apnea syndrome , 2010, Expert Syst. Appl..

[42]  Fernando Gomide,et al.  New uninorm-based neuron model and fuzzy neural networks , 2010, 2010 Annual Meeting of the North American Fuzzy Information Processing Society.

[43]  Chih-Jen Lin,et al.  Combining SVMs with Various Feature Selection Strategies , 2006, Feature Extraction.

[44]  Irina Rish,et al.  An empirical study of the naive Bayes classifier , 2001 .

[45]  F. Caramelo,et al.  Using Resistin, glucose, age and BMI to predict the presence of breast cancer , 2018, BMC Cancer.

[46]  M. Giger,et al.  Computer vision and artificial intelligence in mammography. , 1994, AJR. American journal of roentgenology.

[47]  Hossam Faris,et al.  Improving Extreme Learning Machine by Competitive Swarm Optimization and its application for medical diagnosis problems , 2018, Expert Syst. Appl..

[48]  Junfeng Gao,et al.  A Novel Approach for Lie Detection Based on F-Score and Extreme Learning Machine , 2013, PloS one.

[49]  Lian Li,et al.  Wavelet transform and Kernel-based extreme learning machine for electricity price forecasting , 2018 .

[50]  Arthur Albert,et al.  Regression and the Moore-Penrose Pseudoinverse , 2012 .

[51]  Umberto Veronesi,et al.  Sentinel‐Node Biopsy to Avoid Axillary Dissection in Breast Cancer with Clinically Negative Lymph‐Nodes , 1998 .

[52]  Kurt Hornik,et al.  Multilayer feedforward networks are universal approximators , 1989, Neural Networks.

[53]  Witold Pedrycz,et al.  Neurocomputations in Relational Systems , 1991, IEEE Trans. Pattern Anal. Mach. Intell..

[54]  P J Webros BACKPROPAGATION THROUGH TIME: WHAT IT DOES AND HOW TO DO IT , 1990 .

[55]  Farah Hani Nordin,et al.  Extreme Learning Machine and Particle Swarm Optimization in optimizing CNC turning operation , 2018 .

[56]  Taher Niknam,et al.  Probabilistic Load Forecasting Using an Improved Wavelet Neural Network Trained by Generalized Extreme Learning Machine , 2018, IEEE Transactions on Smart Grid.

[57]  S. Morrison,et al.  Prospective identification of tumorigenic breast cancer cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[58]  Jürgen Schmidhuber,et al.  Multi-column deep neural networks for image classification , 2012, 2012 IEEE Conference on Computer Vision and Pattern Recognition.

[59]  Yu Zhang,et al.  Multi-kernel extreme learning machine for EEG classification in brain-computer interfaces , 2018, Expert Syst. Appl..

[60]  Faa-Jeng Lin,et al.  Intelligent Backstepping Control Using Recurrent Feature Selection Fuzzy Neural Network for Synchronous Reluctance Motor Position Servo Drive System , 2019, IEEE Transactions on Fuzzy Systems.

[61]  Jorge Moreno,et al.  Energy-management system for a hybrid electric vehicle, using ultracapacitors and neural networks , 2006, IEEE Transactions on Industrial Electronics.

[62]  Moshe Sipper,et al.  A fuzzy-genetic approach to breast cancer diagnosis , 1999, Artif. Intell. Medicine.

[63]  Lin Chen,et al.  Novel battery state-of-health online estimation method using multiple health indicators and an extreme learning machine , 2018, Energy.

[64]  Yudong D. He,et al.  Gene expression profiling predicts clinical outcome of breast cancer , 2002, Nature.

[65]  A. Vlahou,et al.  A novel approach toward development of a rapid blood test for breast cancer. , 2003, Clinical breast cancer.

[66]  Lucas Oliveira Batista,et al.  Using Fuzzy Neural Networks to Improve Prediction of Expert Systems for Detection of Breast Cancer , 2018, Anais do XV Encontro Nacional de Inteligência Artificial e Computacional (ENIAC 2018).

[67]  Long Jin,et al.  Fuzzy neural network and LLE Algorithm for forecasting precipitation in tropical cyclones: comparisons with interpolation method by ECMWF and stepwise regression method , 2018, Natural Hazards.

[68]  J. Thompson,et al.  Mammary lymphoscintigraphy in breast cancer. , 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[69]  H. Hakimzadeh,et al.  Part 1 , 2011 .

[70]  S. LaValle Rapidly-exploring random trees : a new tool for path planning , 1998 .

[71]  G. Giuntia,et al.  A biopsy of Breast Cancer mobile applications : state of the practice review , 2017 .

[72]  Yan-Lin He,et al.  A novel prediction intervals method integrating an error & self-feedback extreme learning machine with particle swarm optimization for energy consumption robust prediction , 2018, Energy.

[73]  Ahmed Hosny,et al.  Artificial intelligence in radiology , 2018, Nature Reviews Cancer.

[74]  Javier Oliver,et al.  HYBRID FUZZY NEURAL NETWORK TO PREDICT PRICE DIRECTION IN THE GERMAN DAX-30 INDEX , 2018, Technological and Economic Development of Economy.

[75]  Kemal Polat,et al.  Breast cancer diagnosis using least square support vector machine , 2007, Digit. Signal Process..

[76]  Joel Quintanilla-Domínguez,et al.  WBCD breast cancer database classification applying artificial metaplasticity neural network , 2011, Expert Syst. Appl..

[77]  Paulo Vitor de Campos Souza,et al.  Regularized Fuzzy Neural Network Based on Or Neuron for Time Series Forecasting , 2018, NAFIPS.

[78]  Ibrahim Khalil,et al.  Collaborative extreme learning machine with a confidence interval for P2P learning in healthcare , 2019, Comput. Networks.

[79]  Lotfi A. Zadeh,et al.  The Concepts of a Linguistic Variable and its Application to Approximate Reasoning , 1975 .