Harpagophytum procumbens Extract Ameliorates Allodynia and Modulates Oxidative and Antioxidant Stress Pathways in a Rat Model of Spinal Cord Injury

[1]  D. Beversdorf,et al.  Yin-Yang Mechanisms Regulating Lipid Peroxidation of Docosahexaenoic Acid and Arachidonic Acid in the Central Nervous System , 2019, Front. Neurol..

[2]  O. Pol,et al.  Analgesic and Antidepressant Effects of Oltipraz on Neuropathic Pain in Mice by Modulating Microglial Activation , 2019, Journal of clinical medicine.

[3]  Jiankun Cui,et al.  Maternal Dietary Docosahexaenoic Acid Alters Lipid Peroxidation Products and (n-3)/(n-6) Fatty Acid Balance in Offspring Mice , 2019, Metabolites.

[4]  E. Bacchelli,et al.  Analysis of a Sardinian Multiplex Family with Autism Spectrum Disorder Points to Post-Synaptic Density Gene Variants and Identifies CAPG as a Functionally Relevant Candidate Gene , 2019, Journal of clinical medicine.

[5]  Zhiqiang Zhang,et al.  Polydatin attenuates spinal cord injury in rats by inhibiting oxidative stress and microglia apoptosis via Nrf2/HO‐1 pathway , 2019, Life sciences.

[6]  Bin Wang,et al.  Celastrol inhibits microglial pyroptosis and attenuates inflammatory reaction in acute spinal cord injury rats , 2019, International immunopharmacology.

[7]  Ryota Mabuchi,et al.  Metabolic Profiling of Fish Meat by GC-MS Analysis, and Correlations with Taste Attributes Obtained Using an Electronic Tongue , 2018, Metabolites.

[8]  Christine L. Weisshaar,et al.  Pre-treatment with Meloxicam Prevents the Spinal Inflammation and Oxidative Stress in DRG Neurons that Accompany Painful Cervical Radiculopathy , 2018, Neuroscience.

[9]  Mingtai Chen,et al.  Sulfasalazine attenuates chronic constriction injury-induced neuroinflammation and mechanical hypersensitivity in rats , 2018, Neuroscience Letters.

[10]  Jiankun Cui,et al.  Unveiling anti-oxidative and anti-inflammatory effects of docosahexaenoic acid and its lipid peroxidation product on lipopolysaccharide-stimulated BV-2 microglial cells , 2018, Journal of Neuroinflammation.

[11]  Manjari Singh,et al.  Modulation of oxidative stress response by flaxseed oil: Role of lipid peroxidation and underlying mechanisms. , 2018, Prostaglandins & other lipid mediators.

[12]  H. Hosseinzadeh,et al.  Rosmarinic acid attenuates development and existing pain in a rat model of neuropathic pain: An evidence of anti-oxidative and anti-inflammatory effects. , 2018, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[13]  O. Pol,et al.  Mechanism implicated in the anti‐allodynic and anti‐hyperalgesic effects induced by the activation of heme oxygenase 1/carbon monoxide signaling pathway in the central nervous system of mice with neuropathic pain , 2018, Biochemical pharmacology.

[14]  D. Nosi,et al.  Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice , 2017, Nature Communications.

[15]  H. Willemen,et al.  Divergent roles of immune cells and their mediators in pain , 2017, Rheumatology.

[16]  M. Schaefer,et al.  Inflammatory pain control by blocking oxidized phospholipid-mediated TRP channel activation , 2017, Scientific Reports.

[17]  D. Beversdorf,et al.  Docosahexaenoic acid (DHA): An essential nutrient and a nutraceutical for brain health and diseases. , 2017, Prostaglandins, leukotrienes, and essential fatty acids.

[18]  S. Maier,et al.  Nitroxidative Signaling Mechanisms in Pathological Pain , 2016, Trends in Neurosciences.

[19]  Jiankun Cui,et al.  Effects of aged garlic extract and FruArg on gene expression and signaling pathways in lipopolysaccharide-activated microglial cells , 2016, Scientific Reports.

[20]  D. Jiang,et al.  Lipopolysaccharide-induced preconditioning protects against traumatic spinal cord injury by upregulating Nrf2 expression in rats. , 2016, Life sciences.

[21]  R. Moore,et al.  Oxycodone for neuropathic pain in adults. , 2016, The Cochrane database of systematic reviews.

[22]  D. Lubahn,et al.  Phytochemicals and botanical extracts regulate NF-κB and Nrf2/ARE reporter activities in DI TNC1 astrocytes , 2016, Neurochemistry International.

[23]  Jiankun Cui,et al.  Botanical Polyphenols Mitigate Microglial Activation and Microglia-Induced Neurotoxicity: Role of Cytosolic Phospholipase A2 , 2016, NeuroMolecular Medicine.

[24]  H. Bayır,et al.  Therapies targeting lipid peroxidation in traumatic brain injury , 2016, Brain Research.

[25]  Alexander Sasha Rabchevsky,et al.  Cellular and subcellular oxidative stress parameters following severe spinal cord injury , 2015, Redox biology.

[26]  Á. Simonyi,et al.  Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway , 2015, Journal of Neuroinflammation.

[27]  Á. Simonyi,et al.  Quercetin Attenuates Inflammatory Responses in BV-2 Microglial Cells: Role of MAPKs on the Nrf2 Pathway and Induction of Heme Oxygenase-1 , 2015, PloS one.

[28]  R. Parenti,et al.  Involvement of the Heme-Oxygenase Pathway in the Antiallodynic and Antihyperalgesic Activity of Harpagophytum procumbens in Rats , 2015, Molecules.

[29]  J. Mandl,et al.  On the role of 4-hydroxynonenal in health and disease. , 2015, Biochimica et biophysica acta.

[30]  D. Sengelaub,et al.  Inhibition of cPLA2 has neuroprotective effects on motoneuron and muscle atrophy following spinal cord injury. , 2014, Journal of neurotrauma.

[31]  Andrew L. Thomas,et al.  Dietary Sutherlandia and Elderberry Mitigate Cerebral Ischemia-Induced Neuronal Damage and Attenuate p47phox and Phospho-ERK1/2 Expression in Microglial Cells , 2014, ASN neuro.

[32]  J. S. Quintans,et al.  Natural Products Evaluated in Neuropathic Pain Models ‐ A Systematic Review , 2014, Basic & clinical pharmacology & toxicology.

[33]  J. Bonventre,et al.  Cytosolic Phospholipase A2 Protein as a Novel Therapeutic Target for Spinal Cord Injury , 2014, Annals of neurology.

[34]  Á. Simonyi,et al.  Role of Cytosolic Phospholipase A2 in Oxidative and Inflammatory Signaling Pathways in Different Cell Types in the Central Nervous System , 2014, Molecular Neurobiology.

[35]  Jianlin Cheng,et al.  NitroDIGE analysis reveals inhibition of protein S-nitrosylation by epigallocatechin gallates in lipopolysaccharide-stimulated microglial cells , 2014, Journal of Neuroinflammation.

[36]  Yun-Tai Kim,et al.  Analgesic Effect of Harpagophytum procumbens on Postoperative and Neuropathic Pain in Rats , 2014, Molecules.

[37]  G. Plazzi,et al.  Neuropathic pain following spinal cord injury: what we know about mechanisms, assessment and management. , 2013, European review for medical and pharmacological sciences.

[38]  N. Finnerup.  Pain in patients with spinal cord injury , 2013, PAIN®.

[39]  X. Wen,et al.  A contusion model of severe spinal cord injury in rats. , 2013, Journal of visualized experiments : JoVE.

[40]  Milen I Georgiev,et al.  Harpagoside: from Kalahari Desert to pharmacy shelf. , 2013, Phytochemistry.

[41]  M. Moradi-Lakeh,et al.  Epidemiology of Traumatic Spinal Cord Injury in Developing Countries: A Systematic Review , 2013, Neuroepidemiology.

[42]  E. Wischmeyer,et al.  The Connection of Monocytes and Reactive Oxygen Species in Pain , 2013, PloS one.

[43]  M Fitzharris,et al.  The global map for traumatic spinal cord injury epidemiology: update 2011, global incidence rate , 2013, Spinal Cord.

[44]  Jiankun Cui,et al.  Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells , 2013, Journal of Neuroinflammation.

[45]  I. Vermaak,et al.  Devil's Claw-a review of the ethnobotany, phytochemistry and biological activity of Harpagophytum procumbens. , 2012, Journal of ethnopharmacology.

[46]  E. Widerström-Noga.  Multidimensional clinical pain phenotypes after spinal cord injury. , 2012, Pain management.

[47]  B. Fiebich,et al.  Molecular Targets of the Antiinflammatory Harpagophytum procumbens (Devil's claw): Inhibition of TNFα and COX‐2 Gene Expression by Preventing Activation of AP‐1 , 2012, Phytotherapy research : PTR.

[48]  H. Zhu,et al.  Oxidative stress in spinal cord injury and antioxidant-based intervention , 2011, Spinal Cord.

[49]  E. Kalso,et al.  A new definition of neuropathic pain , 2011, PAIN®.

[50]  Jiankun Cui,et al.  Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA2-IIA expression in astrocytes and microglia , 2011, Journal of Neuroinflammation.

[51]  Xianzhong Zhao,et al.  Transcription factor Nrf2 protects the spinal cord from inflammation produced by spinal cord injury. , 2011, The Journal of surgical research.

[52]  Yiming Li,et al.  Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro. , 2011, Bioorganic & medicinal chemistry.

[53]  M. Fehlings,et al.  A systematic review of non-invasive pharmacologic neuroprotective treatments for acute spinal cord injury. , 2011, Journal of neurotrauma.

[54]  I. Decosterd,et al.  Glial Cells and Chronic Pain , 2010, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[55]  Edward E Knaus,et al.  Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond. , 2008, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

[56]  C. Heard,et al.  Effect of the major glycosides of Harpagophytum procumbens (Devil's Claw) on epidermal cyclooxygenase-2 (COX-2) in vitro. , 2008, Journal of natural products.

[57]  S. Chrubasik,et al.  Systematic review on the safety of Harpagophytum preparations for osteoarthritic and Low back pain , 2008, Phytotherapy research : PTR.

[58]  D. Amtmann,et al.  Symptom burden in persons with spinal cord injury. , 2007, Archives of physical medicine and rehabilitation.

[59]  S. Chrubasik,et al.  Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kappa B activation. , 2006, Journal of ethnopharmacology.

[60]  M. Hannink,et al.  Distinct signaling pathways for induction of type II NOS by IFNγ and LPS in BV-2 microglial cells , 2005, Neurochemistry International.

[61]  J. Pfeilschifter,et al.  Downregulation of iNOS expression in rat mesangial cells by special extracts of Harpagophytum procumbens derives from harpagoside-dependent and independent effects. , 2004, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[62]  C H Tator,et al.  Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. , 1991, Journal of neurosurgery.

[63]  N. Finnerup,et al.  Pain in spinal cord injury. , 2012, Pain management.

[64]  D. Basso,et al.  Descending systems contributing to locomotor recovery after mild or moderate spinal cord injury in rats: experimental evidence and a review of literature. , 2002, Restorative neurology and neuroscience.