The influence of the dental papilla on the development of tooth shape in embryonic mouse tooth germs.

Studies of epithelio-mesenchymal interactions during embryonic organogenesis have led to a number of conclusions regarding the nature of cellular and tissue differentiation (McLoughlin, 1963; Grobstein, 1967). For example, the importance of both the epithelium and the mesenchyme and the dependence of some systems on a limited number of specific mesenchymal tissues have been pointed out (Hilfer, 1968). Intimately connected with the analysis of the factors that elicit differentiation during such interactions is the question of structural specificity of the differentiated structure. Is the directive for the final form of the structure resident in the epithelium, in the mesoderm, or in both? Can a seemingly stable epithelium undergo transformation to a more labile state and respond to a new interaction with the result that a new epithelial structure is formed (Billingham & Silvers, 1963, 1968)?

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