Latent pulmonary involvement in Crohn's disease: biological, functional, bronchoalveolar lavage and scintigraphic studies.

We have investigated the following pulmonary related parameters in 22 patients with Crohn's disease who were free of clinical pulmonary symptoms and had normal chest roentgenograms and in 25 controls: serum angiotensin converting enzyme, pulmonary function tests, bronchoalveolar lavage (lymphocyte count and subpopulations, macrophage viability and superoxide anion release by macrophages) and pulmonary scannings. Serum angiotensin converting enzyme was lower in Crohn's disease (14.1 +/- 5.1) than in controls (25.2 +/- 4.7) (p less than 0.001). Twelve of 22 Crohn's disease (54%) had a bronchoalveolar lavage lymphocytosis (greater than 18% alveolar lymphocytes). Bronchoalveolar lavage lymphocytes subpopulations were quite variable. Twelve of 17 Crohn's disease (71%) had an increase spontaneous and/or stimulated superoxide anion production by alveolar macrophages. Six of 12 Crohn's disease (50%) had an increase physiologic dead space in the upper part of their lung against one of 11 controls (9%). These data suggest that most patients with Crohn's disease have a latent pulmonary involvement.

[1]  B. Wallaert,et al.  Release of Superoxide Anion by Alveolar Macrophages in Pulmonary Sarcoidosis , 1986, Annals of the New York Academy of Sciences.

[2]  B. Wallaert,et al.  Evidence of lymphocyte alveolitis in Crohn's disease. , 1985, Chest.

[3]  B. Wallaert,et al.  Insulin in the Somogyi Phenomenon , 1985 .

[4]  K. Finucane,et al.  Lung function in diffuse interstitial lung disease of unknown cause. , 1984, Australian and New Zealand journal of medicine.

[5]  R. Crystal,et al.  Interstitial lung diseases of unknown cause. Disorders characterized by chronic inflammation of the lower respiratory tract (first of two parts). , 1984, The New England journal of medicine.

[6]  C. Pitchumoni,et al.  Severe interstitial pulmonary fibrosis in a patient with chronic ulcerative colitis. , 1983, The American journal of gastroenterology.

[7]  J. Gauldie,et al.  Pulmonary function abnormalities in patients with inflammatory bowel disease. , 1982, The Quarterly journal of medicine.

[8]  P. Thomas,et al.  Fibrosing alveolitis, bronchiolitis obliterans, and sulfasalazine therapy. , 1982, Chest.

[9]  F. Henrion,et al.  [Pulmonary and cutaneous lesions and terminal ileitis in a 11-year-old child: an exceptional case (author's transl)]. , 1982, Journal de radiologie.

[10]  T. Clark,et al.  Bronchial disease in ulcerative colitis. , 1980, Thorax.

[11]  D. Jewell,et al.  Monocytes in inflammatory bowel disease: monocyte and serum lysosomal enzyme activity. , 1980, Clinical science.

[12]  P. Whorwell,et al.  Pulmonary function in patients with inflammatory bowel disease. , 1980, The American journal of gastroenterology.

[13]  W. Taylor,et al.  Pulmonary vasculitis complicating childhood ulcerative colitis. , 1979, Gastroenterology.

[14]  H. Watts,et al.  National Cooperative Crohn's Disease Study: extraintestinal manifestations and perianal complications. , 1979, Gastroenterology.

[15]  W. Best,et al.  Rederived values of the eight coefficients of the Crohn's Disease Activity Index (CDAI). , 1979, Gastroenterology.

[16]  C. Price,et al.  ACID HYDROLASES IN MONOCYTES FROM PATIENTS WITH INFLAMMATORY BOWEL DISEASE, CHRONIC LIVER DISEASE, AND RHEUMATOID ARTHRITIS , 1978, The Lancet.

[17]  E. C. Texter,et al.  Inflammatory bowel disease associated with granulomatous lung disease: report of a case with endoscopic findings. , 1976, Gastrointestinal endoscopy.

[18]  K. Constantinidis.  Eosinophilic Pneumonia: An Unusual Side Effect of Therapy with Salicylazosulfapyridine , 1976 .

[19]  R. H. Earle,et al.  Unexplained bronchopulmonary disease with inflammatory bowel disease. , 1976, Archives of internal medicine.

[20]  J. Lieberman.  Elevation of serum angiotensin-converting-enzyme (ACE) level in sarcoidosis. , 1975, The American journal of medicine.

[21]  D. Shearman,et al.  Pulmonary vasculitis and ulcerative colitis , 1975, The American journal of digestive diseases.

[22]  E. Hills,et al.  Ulcerative Colitis, Colitic Spondylitis and Associated Apical Pulmonary Fibrosis , 1974, Proceedings of the Royal Society of Medicine.

[23]  D. Davies,et al.  Fibrosing alveolitis and treatment with sulphasalazine , 1974, Gut.

[24]  J. Edwards,et al.  Respiratory disease due to sulphasalazine , 1974, Clinical allergy.

[25]  G. Jones,et al.  Sulphasalazine induced lung disease , 1972, Thorax.

[26]  J. Kirsner,et al.  The epidemiologic and demographic characteristics of inflammatory bowel disease: an analysis of a computerized file of 1400 patients. , 1971, Journal of chronic diseases.

[27]  J. Isenberg,et al.  Pulmonary vasculitis--an uncommon complication of ulcerative colitis. Report of a case. , 1968, The New England journal of medicine.

[28]  D. Bates,et al.  FACTORS AFFECTING REGIONAL DISTRIBUTION OF VENTILATION AND PERFUSION IN THE LUNG. , 1964, Journal of applied physiology.

[29]  T. King.  Principles in the treatment of hand fractures as shown in the technique for a closed fracture of the metacarpal neck. , 1962, The Medical journal of Australia.

[30]  B. Wallaert,et al.  Superoxide anion generation by alveolar macrophages in Crohn's disease. , 1985, The New England journal of medicine.

[31]  Standardized lung function testing. Report working party. , 1983, Bulletin europeen de physiopathologie respiratoire.

[32]  B. H. Yaffe,et al.  Sulfasalazine pneumonitis. , 1983, The American journal of gastroenterology.

[33]  R. J. Butland,et al.  Chronic bronchial suppuration and inflammatory bowel disease. , 1981, The Quarterly journal of medicine.

[34]  P. Pasquis,et al.  Transient pulmonary impairment during attacks of Crohn's disease. , 1981, Respiration; international review of thoracic diseases.

[35]  M. Eldar,et al.  Salazopyrin-induced eosinophilic pneumonia. , 1980, Respiration; international review of thoracic diseases.

[36]  D. Jewell,et al.  Pulmonary function in inflammatory bowel disease. , 1978, Digestion.