Hypoxia inducible factor-1α correlates with VEGF-C expression and lymphangiogenesis in breast cancer

[1]  M. Gnant,et al.  VEGF-C expressing tumor-associated macrophages in lymph node positive breast cancer: impact on lymphangiogenesis and survival. , 2006, Surgery.

[2]  T. Tajiri,et al.  Correlation of hypoxia inducible factor-1alpha with lymphatic metastasis via vascular endothelial growth factor-C in human esophageal cancer. , 2005, Experimental and molecular pathology.

[3]  Zhaobin Zhang,et al.  Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway. , 2005, Cancer research.

[4]  P. V. van Diest,et al.  Hypoxia‐inducible factor‐1α is associated with angiogenesis, and expression of bFGF, PDGF‐BB, and EGFR in invasive breast cancer , 2005 .

[5]  M. Shibuya,et al.  Differential activation of vascular genes by hypoxia in primary endothelial cells. , 2004, Experimental cell research.

[6]  C. Schofield,et al.  The HIF pathway as a therapeutic target. , 2004, Drug discovery today.

[7]  Michael Gnant,et al.  Prognostic Value of Lymphangiogenesis and Lymphovascular Invasion in Invasive Breast Cancer , 2004, Annals of surgery.

[8]  S. Fox,et al.  Expression of vascular endothelial growth factor D is associated with hypoxia inducible factor (HIF-1α) and the HIF-1α target gene DEC1, but not lymph node metastasis in primary human breast carcinomas , 2004, Journal of Clinical Pathology.

[9]  A. Shvarts,et al.  Lack of lymphangiogenesis during breast carcinogenesis , 2004, Journal of Clinical Pathology.

[10]  G. Semenza.  Targeting HIF-1 for cancer therapy , 2003, Nature Reviews Cancer.

[11]  J. Simons,et al.  2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. , 2003, Cancer cell.

[12]  M. Gnant,et al.  Significant Increase in Breast Conservation in 16 Years of Trials Conducted by the Austrian Breast & Colorectal Cancer Study Group , 2003, Annals of surgery.

[13]  P. V. van Diest,et al.  Levels of hypoxia‐inducible factor‐1α independently predict prognosis in patients with lymph node negative breast carcinoma , 2003, Cancer.

[14]  L. Coussens,et al.  Epithelial carcinogenesis: dynamic interplay between neoplastic cells and their microenvironment. , 2002, Differentiation; research in biological diversity.

[15]  K. Alitalo,et al.  Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis. , 2002, The American journal of pathology.

[16]  L. Neckers,et al.  Hsp90 Regulates a von Hippel Lindau-independent Hypoxia-inducible Factor-1α-degradative Pathway* , 2002, The Journal of Biological Chemistry.

[17]  M. Schindl,et al.  Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph node-positive breast cancer. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

[18]  Rakesh K Jain,et al.  Lymphatic Metastasis in the Absence of Functional Intratumor Lymphatics , 2002, Science.

[19]  R. Johns,et al.  Hypoxia up-regulates mouse vascular endothelial growth factor D promoter activity in rat pulmonary microvascular smooth-muscle cells. , 2002, Chest.

[20]  M. Schindl,et al.  Inflammatory stromal reaction correlates with lymphatic microvessel density in early-stage cervival cancer. , 2001, Anticancer research.

[21]  M. Gnant,et al.  Evaluation of the United States Food and Drug Administration-approved scoring and test system of HER-2 protein expression in breast cancer. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

[22]  M. Karkkainen,et al.  Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth. , 2001, Cancer research.

[23]  M. Pepper,et al.  Lymphangiogenesis and tumor metastasis: myth or reality? , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

[24]  P. Carmeliet,et al.  Molecular mechanisms of blood vessel growth. , 2001, Cardiovascular research.

[25]  M. Schindl,et al.  Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. , 2000, Cancer research.

[26]  G. Semenza,et al.  HIF-1 and human disease: one highly involved factor. , 2000, Genes & development.

[27]  D A Hilton,et al.  Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. , 1999, Cancer research.

[28]  M. Gnant,et al.  Randomized trial of low-dose chemotherapy added to tamoxifen in patients with receptor-positive and lymph node-positive breast cancer. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[29]  G. Semenza,et al.  Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension. , 1996, The American journal of physiology.

[30]  G. Semenza,et al.  Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[31]  I. Ellis,et al.  Method for grading breast cancer. , 1993, Journal of clinical pathology.

[32]  F Pozza,et al.  Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. , 1992, Journal of the National Cancer Institute.

[33]  E. Keshet,et al.  Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis , 1992, Nature.

[34]  G. Dekan,et al.  Endothelial cell membranes contain podocalyxin--the major sialoprotein of visceral glomerular epithelial cells , 1986, The Journal of cell biology.

[35]  M. Schemper,et al.  Simultaneous and Sequential Determinations of Steroid Hormone Receptors in Human Breast Cancer: Influence of Intervening Therapy , 1985, Annals of surgery.

[36]  E. Kaplan,et al.  Nonparametric Estimation from Incomplete Observations , 1958 .

[37]  P. V. van Diest,et al.  Hypoxia-inducible factor-1alpha is associated with angiogenesis, and expression of bFGF, PDGF-BB, and EGFR in invasive breast cancer. , 2005, Histopathology.

[38]  S. Fox,et al.  Expression of vascular endothelial growth factor D is associated with hypoxia inducible factor (HIF-1alpha) and the HIF-1alpha target gene DEC1, but not lymph node metastasis in primary human breast carcinomas. , 2004, Journal of clinical pathology.

[39]  N. Weidner,et al.  Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors , 2004, Breast Cancer Research and Treatment.

[40]  L. Neckers,et al.  Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway. , 2002, The Journal of biological chemistry.

[41]  I. M. Neiman,et al.  [Inflammation and cancer]. , 1974, Patologicheskaia fiziologiia i eksperimental'naia terapiia.