CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages.

[1]  P. Allavena,et al.  Cancer-related inflammation , 2008, Nature.

[2]  T. Lawrence,et al.  “Re-educating” tumor-associated macrophages by targeting NF-κB , 2008, The Journal of experimental medicine.

[3]  Chen Dong,et al.  TH17 cells in development: an updated view of their molecular identity and genetic programming , 2008, Nature Reviews Immunology.

[4]  F. Pépin,et al.  Stromal gene expression predicts clinical outcome in breast cancer , 2008, Nature Medicine.

[5]  Roger R. Gomis,et al.  TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4 , 2008, Cell.

[6]  M. Todaro,et al.  Apoptosis resistance in epithelial tumors is mediated by tumor-cell-derived interleukin-4 , 2008, Cell Death and Differentiation.

[7]  D. Carbone,et al.  Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. , 2008, Cancer cell.

[8]  Lloyd J. Old,et al.  Adaptive immunity maintains occult cancer in an equilibrium state , 2007, Nature.

[9]  S. John,et al.  CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages , 2007, Proceedings of the National Academy of Sciences.

[10]  L. Coussens,et al.  Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression , 2007, Breast Cancer Research.

[11]  J. Pollard,et al.  Tumor-associated macrophages press the angiogenic switch in breast cancer. , 2007, Cancer research.

[12]  C. Aspord,et al.  Breast cancer instructs dendritic cells to prime interleukin 13–secreting CD4+ T cells that facilitate tumor development , 2007, The Journal of experimental medicine.

[13]  Genee Y. Lee,et al.  Three-dimensional culture models of normal and malignant breast epithelial cells , 2007, Nature Methods.

[14]  Yarong Wang,et al.  Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. , 2007, Cancer research.

[15]  A. Sica,et al.  New vistas on macrophage differentiation and activation , 2007, European journal of immunology.

[16]  Stephen B Fox,et al.  Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[17]  A. Sica,et al.  p50 nuclear factor-kappaB overexpression in tumor-associated macrophages inhibits M1 inflammatory responses and antitumor resistance. , 2006, Cancer research.

[18]  Robert D. Schreiber,et al.  Interferons, immunity and cancer immunoediting , 2006, Nature Reviews Immunology.

[19]  L. Coussens,et al.  Analysis of immune cell infiltrates during squamous carcinoma development. , 2006, The journal of investigative dermatology. Symposium proceedings.

[20]  J. Myśliwska,et al.  CD4+CD25+ T regulatory cells inhibit cytotoxic activity of CTL and NK cells in humans-impact of immunosenescence. , 2006, Clinical immunology.

[21]  Acknowledgments , 2006, Molecular and Cellular Endocrinology.

[22]  John Condeelis,et al.  Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis , 2006, Cell.

[23]  Susan Holmes,et al.  Profile of Immune Cells in Axillary Lymph Nodes Predicts Disease-Free Survival in Breast Cancer , 2005, PLoS medicine.

[24]  L. Coussens,et al.  De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent. , 2005, Cancer cell.

[25]  D. Hanahan,et al.  CD4+ T cell-mediated antigen-specific immunotherapy in a mouse model of cervical cancer. , 2005, Cancer research.

[26]  J. Pollard,et al.  A Paracrine Loop between Tumor Cells and Macrophages Is Required for Tumor Cell Migration in Mammary Tumors , 2004, Cancer Research.

[27]  Masahiro Inoue,et al.  An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis. , 2004, The Journal of clinical investigation.

[28]  B. Uzzan,et al.  Microvessel density as a prognostic factor in women with breast cancer: a systematic review of the literature and meta-analysis. , 2004, Cancer research.

[29]  A. Balmain,et al.  Characterizing the Protective Component of the αβ T Cell Response to Transplantable Squamous Cell Carcinoma , 2004 .

[30]  E. Hersh,et al.  Naturally occurring B-cell responses to breast cancer , 2003, Cancer Immunology, Immunotherapy.

[31]  Jayanta Debnath,et al.  Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. , 2003, Methods.

[32]  D. Hanahan,et al.  Immune Enhancement of Skin Carcinogenesis by CD4+ T Cells , 2003, The Journal of experimental medicine.

[33]  C. June,et al.  Cutting Edge: Regulatory T Cells from Lung Cancer Patients Directly Inhibit Autologous T Cell Proliferation1 , 2002, The Journal of Immunology.

[34]  Andrew V. Nguyen,et al.  Colony-Stimulating Factor 1 Promotes Progression of Mammary Tumors to Malignancy , 2001, The Journal of experimental medicine.

[35]  J. Pollard,et al.  Postnatal mammary gland development requires macrophages and eosinophils. , 2000, Development.

[36]  A. Harris,et al.  Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer , 2000, The Journal of pathology.

[37]  R. Cardiff,et al.  Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease , 1992, Molecular and cellular biology.

[38]  M J Bissell,et al.  How does the extracellular matrix direct gene expression? , 1982, Journal of theoretical biology.

[39]  L. Coussens,et al.  Paradoxical roles of the immune system during cancer development , 2006, Nature Reviews Cancer.

[40]  A. Balmain,et al.  Characterizing the protective component of the alphabeta T cell response to transplantable squamous cell carcinoma. , 2004, The Journal of investigative dermatology.

[41]  J. Pollard Tumour-educated macrophages promote tumour progression and metastasis , 2004, Nature Reviews Cancer.

[42]  D. Yee,et al.  STAT6 mediates interleukin-4 growth inhibition in human breast cancer cells. , 2002, Neoplasia.

[43]  Masakazu Toi,et al.  Interleukin-4 and breast cancer , 2000, Breast cancer.

[44]  C. Streuli,et al.  The mammary gland epithelial cell , 1996 .

[45]  A. Harris Epithelial cell culture , 1996 .