The TGFβ-SMAD3 pathway inhibits IL-1α induced interactions between human pancreatic stellate cells and pancreatic carcinoma cells and restricts cancer cell migration
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D. Sandnes | T. Christoffersen | I. Gladhaug | E. Pomianowska | M. Aasrum | I. Brusevold | Vegard Tjomsland | Smiljana Torbica Cizmovic | Ewa Pomianowska
[1] S. Pothula,et al. Key role of pancreatic stellate cells in pancreatic cancer. , 2016, Cancer letters.
[2] Umar Mahmood,et al. Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival. , 2015, Cancer cell.
[3] D. Tuveson,et al. Stromal biology and therapy in pancreatic cancer: a changing paradigm , 2015, Gut.
[4] A. Carrato,et al. A Systematic Review of the Burden of Pancreatic Cancer in Europe: Real-World Impact on Survival, Quality of Life and Costs , 2015, Journal of Gastrointestinal Cancer.
[5] Maria Fichera,et al. Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's disease. , 2015, The New England journal of medicine.
[6] E. Witkowski,et al. Outcomes in operative management of pancreatic cancer , 2014, Journal of surgical oncology.
[7] L. Howells,et al. Pancreatic stellate cells and pancreas cancer: current perspectives and future strategies. , 2014, European journal of cancer.
[8] Kunio Matsumoto,et al. Inhibition of transforming growth factor-β signaling potentiates tumor cell invasion into collagen matrix induced by fibroblast-derived hepatocyte growth factor. , 2014, Experimental cell research.
[9] Daniel Öhlund,et al. Fibroblast heterogeneity in the cancer wound , 2014, The Journal of experimental medicine.
[10] M. Korc,et al. Pancreatic cancer stroma: friend or foe? , 2014, Cancer cell.
[11] Stephen A. Sastra,et al. Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. , 2014, Cancer cell.
[12] D. Sandnes,et al. Inhibitory effects of prostaglandin E2 on collagen synthesis and cell proliferation in human stellate cells from pancreatic head adenocarcinoma , 2014, BMC Cancer.
[13] P. Moynagh. The roles of Pellino E3 ubiquitin ligases in immunity , 2014, Nature Reviews Immunology.
[14] E. Raymond,et al. Perspectives of TGF-β inhibition in pancreatic and hepatocellular carcinomas , 2013, Oncotarget.
[15] L. Bojmar,et al. IL-1α Expression in Pancreatic Ductal Adenocarcinoma Affects the Tumor Cell Migration and Is Regulated by the p38MAPK Signaling Pathway , 2013, PloS one.
[16] C. Logsdon,et al. Roles for KRAS in pancreatic tumor development and progression. , 2013, Gastroenterology.
[17] K. Olive,et al. Pancreatic cancer: why is it so hard to treat? , 2013, Therapeutic advances in gastroenterology.
[18] Y. Miao,et al. Persistent activation of pancreatic stellate cells creates a microenvironment favorable for the malignant behavior of pancreatic ductal adenocarcinoma , 2013, International journal of cancer.
[19] J. Massagué. TGFβ signalling in context , 2012, Nature Reviews Molecular Cell Biology.
[20] A. Hezel,et al. TGF-β and αvβ6 integrin act in a common pathway to suppress pancreatic cancer progression. , 2012, Cancer research.
[21] Derek S. Chan,et al. The Pancreas Cancer Microenvironment , 2012, Clinical Cancer Research.
[22] Johannes E. Schindelin,et al. Fiji: an open-source platform for biological-image analysis , 2012, Nature Methods.
[23] Jian Ye,et al. Primer-BLAST: A tool to design target-specific primers for polymerase chain reaction , 2012, BMC Bioinformatics.
[24] Bond-Smith Giles,et al. Only women with symptoms need to have their breast implants removed, says government , 2012 .
[25] Douglas Hanahan,et al. Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment Prospects and Obstacles for Therapeutic Targeting of Function-enabling Stromal Cell Types , 2022 .
[26] Ruiying Zhao,et al. KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. , 2012, Cancer cell.
[27] H. Druid,et al. Interleukin 1α sustains the expression of inflammatory factors in human pancreatic cancer microenvironment by targeting cancer-associated fibroblasts. , 2011, Neoplasia.
[28] Malte Buchholz,et al. Stromal biology and therapy in pancreatic cancer , 2010, Gut.
[29] H. Funahashi,et al. Cancer cell‐derived IL‐1α promotes HGF secretion by stromal cells and enhances metastatic potential in pancreatic cancer cells , 2010, Journal of surgical oncology.
[30] S. Park,et al. Smad7 and Smad6 bind to discrete regions of Pellino-1 via their MH2 domains to mediate TGF-beta1-induced negative regulation of IL-1R/TLR signaling. , 2010, Biochemical and biophysical research communications.
[31] Peter Olson,et al. Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner. , 2010, Cancer cell.
[32] Dirk E. Smith,et al. The IL-1 family: regulators of immunity , 2010, Nature Reviews Immunology.
[33] Hiroki Takahashi,et al. Interleukin-1alpha secreted by pancreatic cancer cells promotes angiogenesis and its therapeutic implications. , 2009, The Journal of surgical research.
[34] Douglas B. Evans,et al. Secreted Interleukin-1α Induces a Metastatic Phenotype in Pancreatic Cancer by Sustaining a Constitutive Activation of Nuclear Factor-κB , 2009, Molecular Cancer Research.
[35] C. Hill,et al. Tgf-beta superfamily signaling in embryonic development and homeostasis. , 2009, Developmental cell.
[36] L. O’Neill,et al. The interleukin‐1 receptor/Toll‐like receptor superfamily: 10 years of progress , 2008, Immunological reviews.
[37] J. Massagué,et al. TGFβ in Cancer , 2008, Cell.
[38] G. Tortora,et al. LY2109761, a novel transforming growth factor β receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis , 2008, Molecular Cancer Therapeutics.
[39] M. Sporn,et al. The tumour microenvironment as a target for chemoprevention , 2007, Nature Reviews Cancer.
[40] C. Liang,et al. In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro , 2007, Nature Protocols.
[41] M. Omary,et al. The pancreatic stellate cell: a star on the rise in pancreatic diseases. , 2007, The Journal of clinical investigation.
[42] Y. Carmi,et al. The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions , 2006, Cancer and Metastasis Reviews.
[43] S. Wahl,et al. TGF‐β: a mobile purveyor of immune privilege , 2006 .
[44] Brian Bierie,et al. Tumour microenvironment: TGFβ: the molecular Jekyll and Hyde of cancer , 2006, Nature Reviews Cancer.
[45] Robert Jaster,et al. Molecular regulation of pancreatic stellate cell function , 2004, Molecular Cancer.
[46] J S Wilson,et al. Desmoplastic Reaction in Pancreatic Cancer: Role of Pancreatic Stellate Cells , 2004, Pancreas.
[47] C. Thorn,et al. TGF‐β down‐regulates IL‐1α‐induced TLR2 expression in murine hepatocytes , 2004, Journal of leukocyte biology.
[48] P. Chiao,et al. Identification of an Autoregulatory Feedback Pathway Involving Interleukin-1α in Induction of Constitutive NF-κB Activation in Pancreatic Cancer Cells* , 2004, Journal of Biological Chemistry.
[49] Thomas D. Schmittgen,et al. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.
[50] T. Macdonald,et al. Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease. , 2001, The Journal of clinical investigation.
[51] H. Friess,et al. The TGF-β signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer , 1999, Oncogene.
[52] K. Chung,et al. Inflammatory mediators of asthma: an update. , 1998, Pharmacological reviews.
[53] R. Schmid,et al. Identification, culture, and characterization of pancreatic stellate cells in rats and humans. , 1998, Gastroenterology.
[54] T. Shimosegawa,et al. Expression of Transforming Growth Factor β1 (TGFβ1) and Its Receptors in Pancreatic Duct Cell Carcinoma and in Chronic Pancreatitis , 1998 .
[55] H. Friess,et al. Enhanced expression of transforming growth factor β isoforms in pancreatic cancer correlates with decreased survival , 1993 .
[56] C. Dubois,et al. Transforming growth factor beta is a potent inhibitor of interleukin 1 (IL-1) receptor expression: proposed mechanism of inhibition of IL-1 action , 1990, The Journal of experimental medicine.
[57] S. Dower,et al. T-cell interleukin 1 receptor cDNA expressed in Chinese hamster ovary cells regulates functional responses to interleukin 1. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[58] Zhiwei Wang,et al. Pancreatic cancer: understanding and overcoming chemoresistance , 2011, Nature Reviews Gastroenterology &Hepatology.
[59] David Padua,et al. Roles of TGFβ in metastasis , 2009, Cell Research.
[60] S. Wahl,et al. TGF-beta: a mobile purveyor of immune privilege. , 2006, Immunological reviews.
[61] Wolfgang Schima,et al. Pancreatic adenocarcinoma , 2006, European Radiology.
[62] P. Chiao,et al. Identification of an autoregulatory feedback pathway involving interleukin-1alpha in induction of constitutive NF-kappaB activation in pancreatic cancer cells. , 2004, The Journal of biological chemistry.
[63] C. Thorn,et al. TGF-beta down-regulates IL-1alpha-induced TLR2 expression in murine hepatocytes. , 2004, Journal of leukocyte biology.
[64] J. Ringel,et al. Transforming growth factor-beta1 induces desmoplasia in an experimental model of human pancreatic carcinoma. , 2001, Cancer research.
[65] J. Ringel,et al. Transforming Growth Factor-β1 Induces Desmoplasia in an Experimental Model of Human Pancreatic Carcinoma , 2001 .
[66] H. Friess,et al. The TGF-beta signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer. , 1999, Oncogene.
[67] K. Satoh,et al. Expression of transforming growth factor beta1 (TGFbeta1) and its receptors in pancreatic duct cell carcinoma and in chronic pancreatitis. , 1998, Pancreas.