Serum leptin levels in women throughout pregnancy and the postpartum period and in women suffering spontaneous abortion

In pregnancy, important changes occur in the body weight of the mother, caused by sodium and water retention and by an increase in body fat tissue, but the mechanisms that regulate maternal and foetal changes in fat mass are poorly understood. Leptin is a hormone produced by adipocytes in order to regulate food intake and energy expenditure at the hypothalamic level in man. In order to verify whether leptin participates in the changes in body composition during pregnancy and postpartum, 630 healthy women were studied at specific time periods and leptin and auxological parameters were determined.

[1]  F. Lönnqvist,et al.  Overexpression of the obese (ob) gene in adipose tissue of human obese subjects , 1995, Nature Medicine.

[2]  J. Camiña,et al.  Sex-based differences in serum leptin concentrations from umbilical cord blood at delivery. , 1997, European journal of endocrinology.

[3]  R. Considine,et al.  Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance , 1996, The Lancet.

[4]  D. Porte,et al.  Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans , 1996, Nature Medicine.

[5]  F. Casanueva,et al.  Serum immunoreactive-leptin levels are increased in patients with Cushing's syndrome. , 1996, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[6]  S. Apte,et al.  Composition of the human foetus , 1972, British Journal of Nutrition.

[7]  J. Little,et al.  Leptin levels do not change acutely with food administration in normal or obese subjects, but are negatively correlated with pituitary‐adrenal activity , 1997, Clinical endocrinology.

[8]  R. Considine,et al.  Serum immunoreactive-leptin concentrations in normal-weight and obese humans. , 1996, The New England journal of medicine.

[9]  Steven L. Cohen,et al.  Weight-reducing effects of the plasma protein encoded by the obese gene. , 1995, Science.

[10]  M. Saad,et al.  Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1997 by The Endocrine Society Sexual Dimorphism in Plasma Leptin Concentration* , 2022 .

[11]  J. Dötsch,et al.  Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1997 by The Endocrine Society Levels of Leptin in Maternal Serum, Amniotic Fluid, and Arterial and Venous Cord Blood: Relation to Neonatal and Placental Weight , 2022 .

[12]  C. Mantzoros,et al.  Role of leptin in the neuroendocrine response to fasting , 1996, Nature.

[13]  Y. Krausz,et al.  [Postpartum thyroid dysfunction]. , 1990, Harefuah.

[14]  F. Casanueva,et al.  Serum leptin concentrations in patients with anorexia nervosa, bulimia nervosa and non‐specific eating disorders correlate with the body mass index but are independent of the respective disease , 1997, Clinical endocrinology.

[15]  D. Glinoer,et al.  Risk of subclinical hypothyroidism in pregnant women with asymptomatic autoimmune thyroid disorders. , 1994, The Journal of clinical endocrinology and metabolism.

[16]  F. Casanueva,et al.  Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1997 by The Endocrine Society Serum Leptin Levels in Normal Children: Relationship to Age, Gender, Body Mass Index, Pituitary-Gonadal Hormones, and Pubertal Stage* , 2022 .

[17]  J. Lazarus,et al.  Thyroid disease in relation to pregnancy. , 1991, Clinical endocrinology.

[18]  R. Devos,et al.  Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. , 1995, Science.

[19]  F. Casanueva,et al.  Serum immunoreactive leptin concentrations in patients with anorexia nervosa before and after partial weight recovery. , 1997, Biochemical and molecular medicine.

[20]  J. Lazarus,et al.  Review Thyroid disease in relation to pregnancy , 1991 .

[21]  W. Warwick.  The unborn patient. , 1969, JAMA.

[22]  I. Yokota,et al.  Serum leptin concentration in cord blood: relationship to birth weight and gender. , 1997, The Journal of clinical endocrinology and metabolism.

[23]  A. Goldberg,et al.  Racial differences in plasma leptin concentrations in obese postmenopausal women. , 1997, Journal of Clinical Endocrinology and Metabolism.

[24]  Postpartum thyroid dysfunction. , 1986, Archives of internal medicine.

[25]  Rene Devos,et al.  Identification and expression cloning of a leptin receptor, OB-R , 1995, Cell.

[26]  M. Maffei,et al.  Positional cloning of the mouse obese gene and its human homologue , 1995, Nature.

[27]  C. Mantzoros,et al.  Human leptin levels are pulsatile and inversely related to pituitary–ardenal function , 1997, Nature Medicine.

[28]  M. Deitel,et al.  Increased obese mRNA expression in omental fat cells from massively obese humans , 1995, Nature Medicine.

[29]  Dennis J. Rivet,et al.  Multiple Cytokines and Acute Inflammation Raise Mouse Leptin Levels: Potential Role in Inflammatory Anorexia , 1997, The Journal of experimental medicine.

[30]  L. Vignati,et al.  Serum leptin levels in women with anorexia nervosa. , 1996, The Journal of clinical endocrinology and metabolism.

[31]  J. Friedman,et al.  Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. , 1996, The Journal of clinical investigation.

[32]  R. Considine,et al.  Nocturnal rise of leptin in normal prepubertal and pubertal children and in patients with perinatal stalk-transection syndrome. , 1997, The Journal of clinical endocrinology and metabolism.

[33]  F. Casanueva,et al.  Synthesis of leptin in human placenta. , 1997, Endocrinology.

[34]  E. Ravussin,et al.  Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects , 1995, Nature Medicine.

[35]  Mason.  Methods for Voluntary Weight Loss and Control , 1993, Annals of Internal Medicine.

[36]  K. Kotani,et al.  Changes of serum anti-thyroid antibodies during and after pregnancy in autoimmune thyroid diseases. , 1978, Clinical and experimental immunology.

[37]  M. Pelleymounter,et al.  Effects of the obese gene product on body weight regulation in ob/ob mice. , 1995, Science.