A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

[1]  E. Birney,et al.  Pfam: the protein families database , 2013, Nucleic Acids Res..

[2]  R. Nussbaum,et al.  Early embryonic lethality in mice deficient in the p110β catalytic subunit of PI 3-kinase , 2002, Mammalian Genome.

[3]  William A Weiss,et al.  A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. , 2006, Cancer cell.

[4]  K. Okkenhaug,et al.  Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. , 2005, Blood.

[5]  J. Engelman,et al.  The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex , 2005, The Journal of cell biology.

[6]  Kevan M Shokat,et al.  Features of selective kinase inhibitors. , 2005, Chemistry & biology.

[7]  S. Jackson,et al.  Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase , 2005, Nature Cell Biology.

[8]  A. Robertson,et al.  PI 3-kinase p110β: a new target for antithrombotic therapy , 2005, Nature Medicine.

[9]  Kevan M Shokat,et al.  Targeting the gatekeeper residue in phosphoinositide 3-kinases. , 2005, Bioorganic & medicinal chemistry.

[10]  A. Bilancio,et al.  Signalling by PI3K isoforms: insights from gene-targeted mice. , 2005, Trends in biochemical sciences.

[11]  J. Engelman,et al.  Phosphoinositide 3-Kinase Catalytic Subunit Deletion and Regulatory Subunit Deletion Have Opposite Effects on Insulin Sensitivity in Mice , 2005, Molecular and Cellular Biology.

[12]  M. Lavin,et al.  Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM. , 2005, Cancer research.

[13]  L. Álvarez-Vallina,et al.  Full Activation of PKB/Akt in Response to Insulin or Ionizing Radiation Is Mediated through ATM* , 2005, Journal of Biological Chemistry.

[14]  L. S. Harrington,et al.  Restraining PI3K: mTOR signalling goes back to the membrane. , 2005, Trends in biochemical sciences.

[15]  A. Robertson,et al.  PI 3-kinase p110beta: a new target for antithrombotic therapy. , 2005, Nature medicine.

[16]  N. Curtin,et al.  Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM , 2004, Cancer Research.

[17]  B. Hemmings,et al.  Identification of a PKB/Akt Hydrophobic Motif Ser-473 Kinase as DNA-dependent Protein Kinase*♦ , 2004, Journal of Biological Chemistry.

[18]  Peter J. Alaimo,et al.  Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold. , 2004, Bioorganic & medicinal chemistry.

[19]  L. Silengo,et al.  PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects , 2004, Cell.

[20]  N. Argade,et al.  Regioselective quinazolinone-directed ortho lithiation of quinazolinoylquinoline: practical synthesis of naturally occurring human DNA topoisomerase I poison luotonin a and luotonins B and E. , 2004, The Journal of organic chemistry.

[21]  Richard D. Byrne,et al.  Bisperoxovanadium compounds are potent PTEN inhibitors , 2004, FEBS letters.

[22]  J. Ptak,et al.  High Frequency of Mutations of the PIK3CA Gene in Human Cancers , 2004, Science.

[23]  J. Klein,et al.  Positive and Negative Roles of p85α and p85β Regulatory Subunits of Phosphoinositide 3-Kinase in Insulin Signaling* , 2003, Journal of Biological Chemistry.

[24]  ヴィスニック，メリーン,et al.  Benzoxazin-3-ones and derivatives thereof as inhibitors of Pi3k , 2003 .

[25]  ウアバーンス，クラウス,et al.  Fused azole pyrimidine derivatives , 2003 .

[26]  D. Staunton,et al.  Essential Role of Phosphoinositide 3-Kinase δ in Neutrophil Directional Movement , 2003, The Journal of Immunology.

[27]  P. Finan,et al.  Therapeutic potential of phosphoinositide 3-kinase inhibitors. , 2003, Chemistry & biology.

[28]  캐서린 레블랑,et al.  5-phenylthiazole derivatives and use as ??3 kinase inhibitors , 2003 .

[29]  D. Staunton,et al.  Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement. , 2003, Journal of immunology.

[30]  J. Lakshmanan,et al.  Analysis of insulin-stimulated glucose uptake in differentiated 3T3-L1 adipocytes. , 2003, Methods in molecular medicine.

[31]  J. Klein,et al.  Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling. , 2003, The Journal of biological chemistry.

[32]  N. Tonks,et al.  A Function for Phosphoinositide 3-Kinase β Lipid Products in Coupling βγ to Ras Activation in Response to Lysophosphatidic Acid* , 2002, The Journal of Biological Chemistry.

[33]  N. Tonks,et al.  A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid. , 2002, The Journal of biological chemistry.

[34]  Kohjiro Ueki,et al.  Increased insulin sensitivity in mice lacking p85β subunit of phosphoinositide 3-kinase , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[35]  딕켄,et al.  Inhibitors of human phosphatidyl-inositol 3-kinase delta , 2001 .

[36]  John F. Timms,et al.  Cellular function of phosphoinositide 3-kinases: Implications for development, immunity, homeostasis, and cancer , 2001 .

[37]  K. Okkenhaug,et al.  Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. , 2001, Annual review of cell and developmental biology.

[38]  Roger L. Williams,et al.  Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. , 2000, Molecular cell.

[39]  P. Seeburg,et al.  Structural mechanism for STI-571 inhibition of abelson tyrosine kinase. , 2000, Science.

[40]  Y. Yazaki,et al.  p110β Is Up-regulated during Differentiation of 3T3-L1 Cells and Contributes to the Highly Insulin-responsive Glucose Transport Activity* , 2000, The Journal of Biological Chemistry.

[41]  Christian Ried,et al.  Structural insights into phosphoinositide 3-kinase catalysis and signalling , 1999, Nature.

[42]  J. Kuriyan,et al.  Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor. , 1999, Molecular cell.

[43]  R. Nussbaum,et al.  Proliferative Defect and Embryonic Lethality in Mice Homozygous for a Deletion in the p110α Subunit of Phosphoinositide 3-Kinase* , 1999, The Journal of Biological Chemistry.

[44]  L. Cantley,et al.  New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[45]  J. Backer,et al.  Regulation of the p85/p110 Phosphatidylinositol 3′-Kinase: Stabilization and Inhibition of the p110α Catalytic Subunit by the p85 Regulatory Subunit , 1998, Molecular and Cellular Biology.

[46]  L. Cantley,et al.  Phosphoinositide kinases. , 1998, Annual review of biochemistry.

[47]  M. Waterfield,et al.  Using structure to define the function of phosphoinositide 3‐kinase family members , 1997, FEBS letters.

[48]  Joel Morris,et al.  A Cyclodehydration Route to 2-Aminochromones , 1994 .

[49]  Susan S. Taylor,et al.  cAMP‐dependent protein kinase: Crystallographic insights into substrate recognition and phosphotransfer , 1994, Protein science : a publication of the Protein Society.

[50]  L. Cantley,et al.  Identification and quantification of polyphosphoinositides produced in response to platelet-derived growth factor stimulation. , 1991, Methods in enzymology.

[51]  L. Cantley,et al.  Activation of phosphatidylinositol 3-kinase by insulin. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[52]  M. Iradyan,et al.  Imidazole derivatives , 1977 .

[53]  V. Armstrong,et al.  A new brominating reagent: 2-Carboxyethyltriphenylphosphonium perbromide , 1975 .

[54]  J. Lombardino.  Preparation and New Reactions of Imidazo[1,2-a]pyridines , 1965 .