Spectrum of mutations in leiomyosarcomas identified by clinical targeted next-generation sequencing.

[1]  T. Heikkinen,et al.  Exome Sequencing of Uterine Leiomyosarcomas Identifies Frequent Mutations in TP53, ATRX, and MED12 , 2016, PLoS genetics.

[2]  Tania L. Slatter,et al.  Loss of ATRX and DAXX expression identifies poor prognosis for smooth muscle tumours of uncertain malignant potential and early stage uterine leiomyosarcoma , 2015, The journal of pathology. Clinical research.

[3]  Y. Jeng,et al.  Leiomyosarcoma With Alternative Lengthening of Telomeres Is Associated With Aggressive Histologic Features, Loss of ATRX Expression, and Poor Clinical Outcome , 2015, The American journal of surgical pathology.

[4]  H. Wakimoto,et al.  Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors , 2015, Science.

[5]  J. Fletcher,et al.  MED12 mutations in leiomyosarcoma and extrauterine leiomyoma , 2013, Modern Pathology.

[6]  Kenny Q. Ye,et al.  An integrated map of genetic variation from 1,092 human genomes , 2012, Nature.

[7]  L. Layfield,et al.  Classification, Molecular Characterization, and the Significance of Pten Alteration in Leiomyosarcoma , 2012, Sarcoma.

[8]  J. Seddon,et al.  Increased risk of secondary uterine leiomyosarcoma in hereditary retinoblastoma. , 2012, Gynecologic oncology.

[9]  F. Chibon,et al.  New insights in sarcoma oncogenesis: a comprehensive analysis of a large series of 160 soft tissue sarcomas with complex genomics , 2011, The Journal of pathology.

[10]  Mingming Jia,et al.  COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer , 2010, Nucleic Acids Res..

[11]  F. Chibon,et al.  Constant p53 pathway inactivation in a large series of soft tissue sarcomas with complex genetics. , 2010, The American journal of pathology.

[12]  Derek Y. Chiang,et al.  Subtype-specific genomic alterations define new targets for soft tissue sarcoma therapy , 2010, Nature Genetics.

[13]  Jean Y. J. Wang,et al.  Targeting the RB-pathway in Cancer Therapy , 2010, Clinical Cancer Research.

[14]  L. Guillou,et al.  Soft tissue sarcomas with complex genomic profiles , 2010, Virchows Archiv.

[15]  M. Reed,et al.  Common genetic changes in leiomyosarcoma and gastrointestinal stromal tumour: implication for ataxia telangiectasia mutated involvement , 2009, International journal of experimental pathology.

[16]  J. Coindre.  Grading of soft tissue sarcomas: review and update. , 2009, Archives of pathology & laboratory medicine.

[17]  Trevor Hastie,et al.  Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling , 2009, Oncogene.

[18]  L. Jacks,et al.  Stage-specific outcomes of patients with uterine leiomyosarcoma: a comparison of the international Federation of gynecology and obstetrics and american joint committee on cancer staging systems. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[19]  K. Hunt,et al.  Genetic aberrations in soft tissue leiomyosarcoma. , 2009, Cancer letters.

[20]  A. Tolcher,et al.  The role of mTOR inhibitors for treatment of sarcomas , 2007, Current oncology reports.

[21]  P. Pandolfi,et al.  The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas , 2007, Nature Medicine.

[22]  M. Hollstein,et al.  p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM , 2007, Nature Cell Biology.

[23]  S. Knuutila,et al.  Gene copy number profiling of soft-tissue leiomyosarcomas by array-comparative genomic hybridization. , 2006, Cancer genetics and cytogenetics.

[24]  F. Alt,et al.  Functional Interaction of H2AX, NBS1, and p53 in ATM-Dependent DNA Damage Responses and Tumor Suppression , 2005, Molecular and Cellular Biology.

[25]  Y. Yu,et al.  Gene expression analysis of human soft tissue leiomyosarcomas. , 2003, Human pathology.

[26]  S. Weiss.  Smooth Muscle Tumors of Soft Tissue , 2002, Advances in anatomic pathology.

[27]  N. Kinukawa,et al.  Clinicopathological prognostic factors in soft tissue leiomyosarcoma: a multivariate analysis , 2002, Histopathology.

[28]  Yong-jie Lu,et al.  Characterization of chromosome aberrations associated with soft‐tissue leiomyosarcomas by twenty‐four‐color karyotyping and comparative genomic hybridization analysis , 2001, Genes, chromosomes & cancer.

[29]  A. Nicolas,et al.  Leiomyosarcomas and Most Malignant Fibrous Histiocytomas Share Very Similar Comparative Genomic Hybridization Imbalances: An Analysis of a Series of 27 Leiomyosarcomas , 2001, Laboratory Investigation.

[30]  S. Knuutila,et al.  DNA copy number changes in development and progression in leiomyosarcomas of soft tissues. , 1998, The American journal of pathology.

[31]  F. Mitelman,et al.  Cytogenetic analysis of 46 pleomorphic soft tissue sarcomas and correlation with morphologic and clinical features: A report of the CHAMP study group , 1998, Genes, chromosomes & cancer.

[32]  N. Normanno,et al.  Epidermal growth factor-related peptides and their receptors in human malignancies. , 1995, Critical reviews in oncology/hematology.

[33]  Chin-Lee Wu,et al.  Copyright � 1995, American Society for Microbiology In Vivo Association of E2F and DP Family Proteins , 1995 .

[34]  S. Raab,et al.  p53 protein overexpression in smooth muscle tumors of the uterus. , 1995, Human pathology.

[35]  Mårten Fernö,et al.  Soft tissue leiomyosarcoma. A population‐based epidemiologic and prognostic study of 48 patients, including cellular dna content , 1992, Cancer.

[36]  M. Stratton,et al.  Structural alterations of the RB1 gene in human soft tissue tumours. , 1989, British Journal of Cancer.

[37]  M. Tsuneyoshi,et al.  Leiomyosarcoma of the external soft tissues. A clinicopathologic, immunohistochemical, and electron microscopic study , 1986, Cancer.

[38]  A. Wile,et al.  Leiomyosarcoma of soft tissue: A clinicopathologic study , 1981, Cancer.

[39]  A. Jemal,et al.  Cancer statistics, 2015 , 2015, CA: a cancer journal for clinicians.

[40]  M. Miettinen.  Modern Soft Tissue Pathology: SMOOTH MUSCLE TUMORS , 2010 .

[41]  Elizabeth M. Smigielski,et al.  dbSNP: the NCBI database of genetic variation , 2001, Nucleic Acids Res..