Systemic morphine produce antinociception mediated by spinal 5‐HT7, but not 5‐HT1A and 5‐HT2 receptors in the spinal cord

The serotonergic system within the spinal cord have been proposed to play an important role in the analgesic effects of systemic morphine. Currently, seven groups of 5‐HT receptors (5‐HT1–7) have been characterized. One of the most recently identified subtypes of 5 HT receptor is the 5‐HT7 receptor. We aimed to examine the role of spinal 5‐HT7 receptors in the antinociceptive effects of systemic morphine.

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