Effects of adsorbed proteins and surface chemistry on foreign body giant cell formation, tumor necrosis factor alpha release and procoagulant activity of monocytes.

The adhesion and activation of monocytes and macrophages are thought to affect the foreign body response to implanted medical devices. However, these cells interact with devices indirectly, because of the prior adsorption of proteins. Therefore, we preadsorbed several "model" biomaterial surfaces with proteins and then measured foreign body giant cell (FBGC) formation, tumor necrosis factor alpha (TNFalpha) release, and procoagulant activity. The model surfaces were tissue culture polystyrene (TCPS), untreated polystyrene (PS), and Primaria, whereas the proteins used were albumin, fibronectin, fibrinogen, and immunoglobulin. FBGC formation, TNFalpha release, and procoagulant activity of monocytes were the highest for surfaces preadsorbed with IgG. FBGC formation was lower on surfaces with adsorbed fibrinogen and fibronectin than on uncoated surfaces. TNFalpha release and procoagulant activity of monocytes were similar on surface adsorbed with fibrinogen, fibronectin, or albumin. Monocyte activation was also affected by the surface chemistry of the substrates, because FBGC formation was the highest on PS and the lowest on TCPS. Monocyte procoagulant activity was the highest on Primaria. Adsorbed proteins and surface chemistry were found to have strong effects on FBGC formation, monocyte TNFalpha release, and procoagulant activity in vitro, providing support for the idea that these same variables could affect macrophage-mediated foreign body response to biomaterials in vivo.

[1]  C. Anderson,et al.  Phagocytosis mediated by three distinct Fc gamma receptor classes on human leukocytes , 1990, The Journal of experimental medicine.

[2]  W. Tsai,et al.  Human plasma fibrinogen adsorption and platelet adhesion to polystyrene. , 1999, Journal of biomedical materials research.

[3]  J. Anderson,et al.  Interleukin-4 induces foreign body giant cells from human monocytes/macrophages. Differential lymphokine regulation of macrophage fusion leads to morphological variants of multinucleated giant cells. , 1995, The American journal of pathology.

[4]  J M Anderson,et al.  Protein and surface effects on monocyte and macrophage adhesion, maturation, and survival. , 2002, Journal of biomedical materials research.

[5]  D. Castner,et al.  Multivariate surface analysis of plasma-deposited tetraglyme for reduction of protein adsorption and monocyte adhesion , 2003 .

[6]  J. Anderson,et al.  Cytokine and growth factor production by monocytes/macrophages on protein preadsorbed polymers. , 1992, Journal of biomedical materials research.

[7]  R. Maier,et al.  Calcium and calmodulin regulate lipopolysaccharide-induced alveolar macrophage production of tumor necrosis factor and procoagulant activity. , 1996, Archives of surgery.

[8]  M. Backus,et al.  Microprobe analysis of Tc-MIBI in heart cells: calculation of mitochondrial membrane potential. , 1993, The American journal of physiology.

[9]  Y. Nakayama,et al.  Spatial regulation and surface chemistry control of monocyte/macrophage adhesion and foreign body giant cell formation by photochemically micropatterned surfaces. , 1999, Journal of biomedical materials research.

[10]  D. Williams,et al.  Hydrophilicity of polymers and soft tissue responses: a quantitative analysis. , 1997, Journal of biomedical materials research.

[11]  M. Pauly,et al.  Predictors of type of vascular access in hemodialysis patients. , 1996, JAMA.

[12]  J. Anderson,et al.  Alkylsilane-modified surfaces: inhibition of human macrophage adhesion and foreign body giant cell formation. , 1999, Journal of biomedical materials research.

[13]  E. Chan,et al.  TNF-α-induced Regulation and Signalling in Macrophages , 1996 .

[14]  J W Eaton,et al.  Fibrin(ogen) mediates acute inflammatory responses to biomaterials , 1993, The Journal of experimental medicine.

[15]  C. Behling,et al.  Quantitative characterization of cells at the interface of long-term implants of selected polymers. , 1986, Journal of biomedical materials research.

[16]  M. Rosengart,et al.  INTERACTIONS OF CALCIUM/CALMODULIN‐DEPENDENT PROTEIN KINASES (CaMK) AND EXTRACELLULAR‐REGULATED KINASE (ERK) IN MONOCYTE ADHERENCE AND TNF&agr; PRODUCTION , 2000, Shock.

[17]  A. Schmierer.  Macrophage interactions with biomaterial surfaces and their effects on endothelial cell activation , 1998 .

[18]  G. Gallagher,et al.  Immuno-localisation of tumour necrosis factor and its receptors in temporal arteritis , 1997, Rheumatology International.

[19]  M. Tsurudome,et al.  Expression of fusion regulatory proteins (FRPs) on human peripheral blood monocytes. Induction of homotypic cell aggregation and formation of multinucleated giant cells by anti-FRP-1 monoclonal antibodies. , 1994, Journal of immunology.

[20]  James M. Anderson,et al.  β1 and β2 Integrins Mediate Adhesion during Macrophage Fusion and Multinucleated Foreign Body Giant Cell Formation , 2002 .

[21]  Palermo,et al.  Lipopolysaccharide enhances FcγR‐dependent functions in vivo through CD11b/CD18 up‐regulation , 1999, Immunology.

[22]  A. Hiltner,et al.  Role for interleukin-4 in foreign-body giant cell formation on a poly(etherurethane urea) in vivo. , 1995, Journal of biomedical materials research.

[23]  J. Anderson,et al.  Human monocyte/macrophage adhesion and cytokine production on surface-modified poly(tetrafluoroethylene/hexafluoropropylene) polymers with and without protein preadsorption. , 1995, Journal of biomedical materials research.

[24]  J. Anderson,et al.  Human monocyte/macrophage adhesion, macrophage motility, and IL-4-induced foreign body giant cell formation on silane-modified surfaces in vitro. Student Research Award in the Master's Degree Candidate Category, 24th Annual Meeting of the Society for Biomaterials, San Diego, CA, April 22-26, 1998. , 1998, Journal of biomedical materials research.

[25]  C. Damsky,et al.  Synthesis and expression of the fibroblast fibronectin receptor in human monocytes. , 1989, The Journal of clinical investigation.

[26]  D. Ficheux,et al.  Aggregation of mononucleated precursors triggers cell surface expression of alphavbeta3 integrin, essential to formation of osteoclast-like multinucleated cells. , 1998, Journal of cell science.

[27]  M. Rothstein,et al.  Vascular access thrombosis in new hemodialysis patients. , 1995, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[28]  B D Ratner,et al.  Inhibition of monocyte adhesion and fibrinogen adsorption on glow discharge plasma deposited tetraethylene glycol dimethyl ether , 2001, Journal of biomaterials science. Polymer edition.

[29]  D. Altieri,et al.  Occupancy of CD11b/CD18 (Mac-1) divalent ion binding site(s) induces leukocyte adhesion. , 1991, Journal of immunology.

[30]  J. Anderson,et al.  Interleukin-13 induces human monocyte/macrophage fusion and macrophage mannose receptor expression. , 1997, Journal of immunology.

[31]  I. Keidan,et al.  Activation of monocytes via their Fc alpha R increases procoagulant activity. , 1995, The Journal of laboratory and clinical medicine.

[32]  P. Rieu,et al.  Identification of the complement iC3b binding site in the beta 2 integrin CR3 (CD11b/CD18). , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[33]  C. Anderson,et al.  Monoclonal antibodies to Fc receptors for IgG on human mononuclear phagocytes. Antibody characterization and induction of superoxide production in a monocyte cell line. , 1986, The Journal of biological chemistry.

[34]  J. Anderson,et al.  Plasma protein adsorbed biomedical polymers: activation of human monocytes and induction of interleukin 1. , 1989, Journal of biomedical materials research.

[35]  S. Zuckerman,et al.  A novel microtiter plate assay for the quantitation of procoagulant activity on adherent monocytes, macrophage and endothelial cells. , 1989, Thrombosis research.

[36]  K. Ishihara,et al.  Adhesion and cytokine production by monocytes on poly(2-methacryloyloxyethyl phosphorylcholine-co-alkyl methacrylate)-coated polymers. , 1995, Journal of biomedical materials research.

[37]  J M Anderson,et al.  Effects of surface-coupled polyethylene oxide on human macrophage adhesion and foreign body giant cell formation in vitro. , 1999, Journal of biomedical materials research.

[38]  T. Toyota,et al.  Monocyte aggregation and multinucleated giant-cell formation in vitro in Crohn's disease. The effect of cell adhesion molecules. , 1996, Scandinavian journal of gastroenterology.

[39]  S. Haskill,et al.  Adherence induces selective mRNA expression of monocyte mediators and proto-oncogenes. , 1988, Journal of immunology.

[40]  N. Ferreri,et al.  beta-Glucuronidase release from human monocytes induced with aggregated immunoglobulins of different classes. , 1986, Cellular immunology.

[41]  M. Shen,et al.  The effects of surface chemistry and adsorbed proteins on monocyte/macrophage adhesion to chemically modified polystyrene surfaces. , 2001, Journal of biomedical materials research.

[42]  Janet M. Allen,et al.  A molecular switch changes the signalling pathway used by the FcγRI antibody receptor to mobilise calcium , 1998, Current Biology.

[43]  L. Orci,et al.  Human endothelial cell cultures: Phenotypic modulation by leukocyte interleukins , 1985, Journal of cellular physiology.

[44]  J M Anderson,et al.  Foreign-body giant cells and polyurethane biostability: in vivo correlation of cell adhesion and surface cracking. , 1991, Journal of biomedical materials research.

[45]  C. Nathan,et al.  Secretory products of macrophages. , 1987, The Journal of clinical investigation.

[46]  J M Anderson,et al.  Adsorbed serum proteins responsible for surface dependent human macrophage behavior. , 2000, Journal of biomedical materials research.

[47]  J. Anderson,et al.  Adsorbed IgG: a potent adhesive substrate for human macrophages. , 2000, Journal of biomedical materials research.

[48]  P. Singhal,et al.  Leukocyte-polytetrafluoroethylene interaction enhances proliferation of vascular smooth muscle cells via tumor necrosis factor-alpha secretion. , 1997, Kidney international.

[49]  J. Anderson,et al.  Biomaterial biocompatibility and the macrophage. , 1984, Biomaterials.

[50]  A. Hiltner,et al.  In vivo leucocyte interactions with the NHLBI-DTB primary reference materials: polyethylene and silica-free polydimethylsiloxane. , 1987, Biomaterials.

[51]  J. Anderson,et al.  Human monocyte/macrophage activation and interleukin 1 generation by biomedical polymers. , 1988, Journal of biomedical materials research.

[52]  W. Buurman,et al.  Fc-receptor cross-linking induces rapid secretion of tumor necrosis factor (cachectin) by human peripheral blood monocytes. , 1988, Journal of immunology.

[53]  J. Vilček,et al.  Tumor necrosis factor. New insights into the molecular mechanisms of its multiple actions. , 1991, The Journal of biological chemistry.

[54]  P. Kalman,et al.  Differential stimulation of macrophage procoagulant activity by vascular grafts. , 1993, Journal of vascular surgery.

[55]  D. S. Webb,et al.  LFA-3, CD44, and CD45: physiologic triggers of human monocyte TNF and IL-1 release. , 1990, Science.

[56]  M. Grounds,et al.  Direct evidence that inflammatory multinucleate giant cells form by fusion , 1982, The Journal of pathology.

[57]  J. Anderson,et al.  Functional versus quantitative comparison of IL-1 beta from monocytes/macrophages on biomedical polymers. , 1993, Journal of biomedical materials research.

[58]  Buddy D. Ratner,et al.  PEO-like plasma polymerized tetraglyme surface interactions with leukocytes and proteins: in vitro and in vivo studies , 2002, Journal of biomaterials science. Polymer edition.

[59]  R. Dean,et al.  Induction of macrophage lysosomal enzyme secretion by agents acting at the plasma membrane. , 1979, Experimental cell biology.

[60]  T. Chambers,et al.  Inflammatory giant cells. , 1982, Immunobiology.