Forecasting one-day-forward wellness conditions for community-dwelling elderly with single lead short electrocardiogram signals

BackgroundThe accelerated growth of elderly population is creating a heavy burden to the healthcare system in many developed countries and regions. Electrocardiogram (ECG) analysis has been recognized as effective approach to cardiovascular disease diagnosis and widely utilized for monitoring personalized health conditions.MethodIn this study, we present a novel approach to forecasting one-day-forward wellness conditions for community-dwelling elderly by analyzing single lead short ECG signals acquired from a station-based monitoring device. More specifically, exponentially weighted moving-average (EWMA) method is employed to eliminate the high-frequency noise from original signals at first. Then, Fisher-Yates normalization approach is used to adjust the self-evaluated wellness score distribution since the scores among different individuals are skewed. Finally, both deep learning-based and traditional machine learning-based methods are utilized for building wellness forecasting models.ResultsThe experiment results show that the deep learning-based methods achieve the best fitted forecasting performance, where the forecasting accuracy and F value are 93.21% and 91.98% respectively. The deep learning-based methods, with the merit of non-hand-crafted engineering, have superior wellness forecasting performance towards the competitive traditional machine learning-based methods.ConclusionThe developed approach in this paper is effective in wellness forecasting for community-dwelling elderly, which can provide insights in terms of implementing a cost-effective approach to informing healthcare provider about health conditions of elderly in advance and taking timely interventions to reduce the risk of malignant events.

[1]  Christopher D. Manning,et al.  Effective Approaches to Attention-based Neural Machine Translation , 2015, EMNLP.

[2]  George Kurian,et al.  Google's Neural Machine Translation System: Bridging the Gap between Human and Machine Translation , 2016, ArXiv.

[3]  Chia-Chin Chong,et al.  From Mobile Phones to Personal Wellness Dashboards , 2010, IEEE Pulse.

[4]  Wei Xiang,et al.  An IoT-cloud Based Wearable ECG Monitoring System for Smart Healthcare , 2016, Journal of Medical Systems.

[5]  Kwok-Leung Tsui,et al.  Personalized Health Monitoring System of Elderly Wellness at the Community Level in Hong Kong , 2018, IEEE Access.

[6]  Jimeng Sun,et al.  Using recurrent neural network models for early detection of heart failure onset , 2016, J. Am. Medical Informatics Assoc..

[7]  Mark Dredze,et al.  Combining Search, Social Media, and Traditional Data Sources to Improve Influenza Surveillance , 2015, PLoS Comput. Biol..

[8]  A. Govardhan,et al.  Analysis of coronary heart disease and prediction of heart attack in coal mining regions using data mining techniques , 2010, 2010 5th International Conference on Computer Science & Education.

[9]  Shivkumar Sabesan,et al.  Improving long‐term management of epilepsy using a wearable multimodal seizure detection system , 2015, Epilepsy & Behavior.

[10]  Fenglong Ma,et al.  Dipole: Diagnosis Prediction in Healthcare via Attention-based Bidirectional Recurrent Neural Networks , 2017, KDD.

[11]  Navdeep Jaitly,et al.  Hybrid speech recognition with Deep Bidirectional LSTM , 2013, 2013 IEEE Workshop on Automatic Speech Recognition and Understanding.

[12]  Gunasekaran Manogaran,et al.  A new architecture of Internet of Things and big data ecosystem for secured smart healthcare monitoring and alerting system , 2017, Future Gener. Comput. Syst..

[13]  S. C. Mukhopadhyay,et al.  Wireless Sensor Network Based Home Monitoring System for Wellness Determination of Elderly , 2012, IEEE Sensors Journal.

[14]  Elliott Brent,et al.  An Inventory of Evidence-Based Health and Wellness Assessments for Community-Dwelling Older Adults , 2014 .

[15]  Rita Paradiso,et al.  A wearable health care system based on knitted integrated sensors , 2005, IEEE Transactions on Information Technology in Biomedicine.

[16]  Ilya Kashnitsky,et al.  Decomposition of regional convergence in population aging across Europe , 2017, Genus.

[17]  Kuldip K. Paliwal,et al.  Bidirectional recurrent neural networks , 1997, IEEE Trans. Signal Process..

[18]  Priyanka Kakria,et al.  A Real-Time Health Monitoring System for Remote Cardiac Patients Using Smartphone and Wearable Sensors , 2015, International journal of telemedicine and applications.

[19]  Ilkka Korhonen,et al.  Mobile Diary for Wellness Management—Results on Usage and Usability in Two User Studies , 2008, IEEE Transactions on Information Technology in Biomedicine.

[20]  Sally C Stearns,et al.  Time to include time to death? The future of health care expenditure predictions. , 2004, Health economics.

[21]  Shuvo Roy,et al.  A Wearable Patch to Enable Long-Term Monitoring of Environmental, Activity and Hemodynamics Variables , 2016, IEEE Transactions on Biomedical Circuits and Systems.

[22]  Agnes Tiwari,et al.  A Systematic Review of Prevalence and Risk Factors for Elder Abuse in Asia , 2015, Trauma, violence & abuse.

[23]  U. Rajendra Acharya,et al.  Application of deep convolutional neural network for automated detection of myocardial infarction using ECG signals , 2017, Inf. Sci..

[24]  Erick A. Perez Alday,et al.  A New Algorithm to Diagnose Atrial Ectopic Origin from Multi Lead ECG Systems - Insights from 3D Virtual Human Atria and Torso , 2015, PLoS Comput. Biol..

[25]  Andrew W. Senior,et al.  Long short-term memory recurrent neural network architectures for large scale acoustic modeling , 2014, INTERSPEECH.

[26]  Dominican Scholar An Inventory of Evidence-Based Health and Wellness Assessments for Community-Dwelling Older Adults , 2014 .

[27]  Yayan Zhang,et al.  Data normalization and clustering for big and small data and an application to clinical trials , 2015 .

[28]  Jason Roy,et al.  Prediction Modeling Using EHR Data: Challenges, Strategies, and a Comparison of Machine Learning Approaches , 2010, Medical care.

[29]  Hassan Ghasemzadeh,et al.  WANDA: an end-to-end remote health monitoring and analytics system for heart failure patients , 2012, Wireless Health.

[30]  Ye Li,et al.  Multiscaled Fusion of Deep Convolutional Neural Networks for Screening Atrial Fibrillation From Single Lead Short ECG Recordings , 2018, IEEE Journal of Biomedical and Health Informatics.

[31]  Branko G. Celler,et al.  Telehealth Monitoring of Patients in the Community , 2016, J. Intell. Syst..

[32]  Julius Georgiou,et al.  A hardware-efficient lowpass filter design for biomedical applications , 2010, Biomedical Circuits and Systems Conference.

[33]  Johan Schalkwyk,et al.  Learning acoustic frame labeling for speech recognition with recurrent neural networks , 2015, 2015 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP).

[34]  Tim J Gabbett,et al.  Calculating acute:chronic workload ratios using exponentially weighted moving averages provides a more sensitive indicator of injury likelihood than rolling averages , 2016, British Journal of Sports Medicine.

[35]  Chenguang He,et al.  HCloud: A novel application-oriented cloud platform for preventive healthcare , 2012, 4th IEEE International Conference on Cloud Computing Technology and Science Proceedings.

[36]  Geoffrey E. Hinton,et al.  Speech recognition with deep recurrent neural networks , 2013, 2013 IEEE International Conference on Acoustics, Speech and Signal Processing.

[37]  J. Levis,et al.  ECG diagnosis: hypokalemia. , 2012, The Permanente journal.

[38]  Marcus B. Perry,et al.  The Exponentially Weighted Moving Average , 2010 .

[39]  Subhas Mukhopadhyay,et al.  Forecasting the behavior of an elderly using wireless sensors data in a smart home , 2013, Eng. Appl. Artif. Intell..

[40]  Chenguang He,et al.  Toward Ubiquitous Healthcare Services With a Novel Efficient Cloud Platform , 2013, IEEE Transactions on Biomedical Engineering.

[41]  Jina Huh,et al.  Perspectives on wellness self-monitoring tools for older adults , 2013, Int. J. Medical Informatics.

[42]  Jimeng Sun,et al.  RETAIN: An Interpretable Predictive Model for Healthcare using Reverse Time Attention Mechanism , 2016, NIPS.