Organ-Based Chronological Age Estimation Based on 3D MRI Scans

Individuals age differently depending on a multitude of different factors such as lifestyle, medical history and genetics. Often, the global chronological age is not indicative of the true ageing process. An organ-based age estimation would yield a more accurate health state assessment. In this work, we propose a new deep learning architecture for organ-based age estimation based on magnetic resonance images (MRI). The proposed network is a 3D convolutional neural network (CNN) with increased depth and width made possible by the hybrid utilization of inception and fire modules. We apply the proposed framework for the tasks of brain and knee age estimation. Quantitative comparisons against concurrent MR-based regression networks and different 2D and 3D data feeding strategies illustrated the superior performance of the proposed work.

[1]  Jing Hua,et al.  Age estimation using cortical surface pattern combining thickness with curvatures , 2013, Medical & Biological Engineering & Computing.

[2]  Daniel Franklin,et al.  Forensic age estimation in human skeletal remains: current concepts and future directions. , 2010, Legal medicine.

[3]  Kazunori Sato,et al.  Performance Evaluation of Age Estimation from T1-Weighted Images Using Brain Local Features and CNN , 2018, 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[4]  Eve Tausche,et al.  Combining wrist age and third molars in forensic age estimation: how to calculate the joint age estimate and its error rate in age diagnostics* , 2015, Annals of human biology.

[5]  Christian Payer,et al.  Automated age estimation from MRI volumes of the hand , 2019, Medical Image Anal..

[6]  John Ashburner,et al.  A fast diffeomorphic image registration algorithm , 2007, NeuroImage.

[7]  Jeffrey B Driban,et al.  Is Participation in Certain Sports Associated With Knee Osteoarthritis? A Systematic Review. , 2017, Journal of athletic training.

[8]  Kazunori Sato,et al.  An Age Estimation Method Using 3D-CNN From Brain MRI Images , 2019, 2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019).

[9]  Andrew Zisserman,et al.  Quo Vadis, Action Recognition? A New Model and the Kinetics Dataset , 2017, 2017 IEEE Conference on Computer Vision and Pattern Recognition (CVPR).

[10]  Kazunori Sato,et al.  Age estimation from brain MRI images using deep learning , 2017, 2017 IEEE 14th International Symposium on Biomedical Imaging (ISBI 2017).

[11]  Statistical Parameter Mapping , 2020, Definitions.

[12]  Karl J. Friston,et al.  A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains , 2001, NeuroImage.

[13]  Bin Yang,et al.  Person Identification and Body Mass Index: A Deep Learning-Based Study on Micro-Dopplers , 2018, 2019 IEEE Radar Conference (RadarConf).

[14]  Dinggang Shen,et al.  Morphological classification of brains via high-dimensional shape transformations and machine learning methods , 2004, NeuroImage.

[15]  Guodong Guo,et al.  Age Estimation , 2015, Encyclopedia of Biometrics.

[16]  G. Frisoni,et al.  Detection of grey matter loss in mild Alzheimer's disease with voxel based morphometry , 2002, Journal of neurology, neurosurgery, and psychiatry.

[17]  Benjamin Thyreau,et al.  Correlations among Brain Gray Matter Volumes, Age, Gender, and Hemisphere in Healthy Individuals , 2011, PloS one.

[18]  Ariane Maggio,et al.  The skeletal age estimation potential of the knee: Current scholarship and future directions for research , 2017 .

[19]  Stefan Klöppel,et al.  Estimating the age of healthy subjects from T1-weighted MRI scans using kernel methods: Exploring the influence of various parameters , 2010, NeuroImage.

[20]  D. Turnbull,et al.  Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?☆ , 2014, Ageing Research Reviews.

[21]  Pascal Vincent,et al.  fastMRI: An Open Dataset and Benchmarks for Accelerated MRI , 2018, ArXiv.

[22]  Giovanni Montana,et al.  Predicting brain age with deep learning from raw imaging data results in a reliable and heritable biomarker , 2016, NeuroImage.

[23]  Alessandro Gialluisi,et al.  Machine Learning Approaches for the Estimation of Biological Aging: The Road Ahead for Population Studies , 2019, Front. Med..

[24]  Forrest N. Iandola,et al.  SqueezeNet: AlexNet-level accuracy with 50x fewer parameters and <1MB model size , 2016, ArXiv.