Synthesis of 1-azaxanthones and 1-azathioxanthones by Yb(OTf)3/TfOH co-catalyzed intramolecular friedel-crafts reaction

Intramolecular Friedel-Crafts cyclization of phenoxypyridine acids (3a-3j) and phenythiopyridine acids (4a-4i) to form 1-azaxanthones (1a-1j) and 1-azathioxanthones (2a-2i), respectively, was efficiently promoted by Yb(OTf) 3 /TfOH as co-catalysts. And a number of substrates could be cyclized in moderate to good yields.

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