论文信息 - Merkel cell carcinoma arising in immunosuppressed patients treated with high‐dose ultraviolet A1 (320–400 nm) phototherapy: a report of two cases

Merkel cell carcinoma arising in immunosuppressed patients treated with high‐dose ultraviolet A1 (320–400 nm) phototherapy: a report of two cases

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumour of the skin. Though immunodeficiency is the most relevant risk factor, ultraviolet (UV) radiation is also involved, but as of yet we do not know the action spectrum, pattern or dose which would produce a dangerous exposure. A retrospective study of two immunosuppressed patients who developed MCC during, or soon after a treatment cycle with high dose UVA1 exposures was conducted, in order to understand wether repeated exposures to suberythemogenic UVA1 radiation may have a cancerogenic activity provoking MCC in immunosuppressed patients.

[1] Merve Meinhardt,et al. Absorption Spectra of Human Skin In Vivo in the Ultraviolet Wavelength Range Measured by Optoacoustics , 2009, Photochemistry and photobiology.

[2] H. Sandler,et al. Merkel cell carcinoma: Critical review with guidelines for multidisciplinary management , 2007, Cancer.

[3] A. Riggs,et al. DNA lesions induced by UV A1 and B radiation in human cells: comparative analyses in the overall genome and in the p53 tumor suppressor gene. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[4] P. Boukamp,et al. UV‐B‐type mutations and chromosomal imbalances indicate common pathways for the development of Merkel and skin squamous cell carcinomas , 2002, International journal of cancer.

[5] R. Stern,et al. Merkel-cell carcinomas in patients treated with methoxsalen and ultraviolet A radiation. , 1998, The New England journal of medicine.