The Potential Role of Sensory Testing, Skin Biopsy, and Functional Brain Imaging as Biomarkers in Chronic Pain Clinical Trials: IMMPACT Considerations.

[1]  Carol Martin Watts.  Insula , 2019, Encyclopedic Dictionary of Archaeology.

[2]  Richard E. Harris,et al.  Brain white matter changes associated with urological chronic pelvic pain syndrome: multisite neuroimaging from a MAPP case–control study , 2016, Pain.

[3]  M. Caterina,et al.  Peripheral neuropathic changes in pachyonychia congenita , 2016, Pain.

[4]  R. Treede,et al.  Peripheral neuropathic pain: a mechanism-related organizing principle based on sensory profiles , 2016, Pain.

[5]  K. Davis,et al.  Abnormal cross-network functional connectivity in chronic pain and its association with clinical symptoms , 2016, Brain Structure and Function.

[6]  M. Karsdal,et al.  Sensitization and Serological Biomarkers in Knee Osteoarthritis Patients With Different Degrees of Synovitis , 2016, The Clinical journal of pain.

[7]  J. Callaghan,et al.  Pain sensitivity profiles in patients with advanced knee osteoarthritis , 2016, Pain.

[8]  R. Fillingim,et al.  Assessment of Chronic Pain: Domains, Methods, and Mechanisms. , 2016, The journal of pain : official journal of the American Pain Society.

[9]  L. Webster,et al.  Pharmacogenetics and Personalized Medicine in Pain Management. , 2016, Clinics in laboratory medicine.

[10]  M. Versavel,et al.  Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations , 2016, Pain.

[11]  M. Martel,et al.  Variability in conditioned pain modulation predicts response to NSAID treatment in patients with knee osteoarthritis , 2016, BMC Musculoskeletal Disorders.

[12]  R. Treede,et al.  Chronic Widespread Back Pain is Distinct From Chronic Local Back Pain: Evidence From Quantitative Sensory Testing, Pain Drawings, and Psychometrics , 2016, The Clinical journal of pain.

[13]  Jin Fan,et al.  Somatic and vicarious pain are represented by dissociable multivariate brain patterns , 2016, eLife.

[14]  A. Mammen,et al.  Longitudinal Assessment of Small Fiber Neuropathy: Evidence of a Non-Length-Dependent Distal Axonopathy. , 2016, JAMA neurology.

[15]  D. Ranoux,et al.  Safety and efficacy of repeated injections of botulinum toxin A in peripheral neuropathic pain (BOTNEP): a randomised, double-blind, placebo-controlled trial , 2016, The Lancet Neurology.

[16]  Simon B Eickhoff,et al.  Coordinate‐based (ALE) meta‐analysis of brain activation in patients with fibromyalgia , 2016, Human brain mapping.

[17]  Tobias Schmidt-Wilcke,et al.  Pharmacologic attenuation of cross-modal sensory augmentation within the chronic pain insula , 2016, Pain.

[18]  A. Dahan,et al.  Cornea nerve fiber quantification and construction of phenotypes in patients with fibromyalgia , 2016, Scientific Reports.

[19]  L. Becerra,et al.  Rapid treatment-induced brain changes in pediatric CRPS , 2016, Brain Structure and Function.

[20]  Qiuling Shi,et al.  Prechemotherapy Touch Sensation Deficits Predict Oxaliplatin-Induced Neuropathy in Patients with Colorectal Cancer , 2016, Oncology.

[21]  Jonathan G. Lees,et al.  The Pain in Neuropathy Study (PiNS): a cross-sectional observational study determining the somatosensory phenotype of painful and painless diabetic neuropathy , 2016, Pain.

[22]  R. Treede,et al.  Presence of hyperalgesia predicts analgesic efficacy of topically applied capsaicin 8% in patients with peripheral neuropathic pain , 2016, European journal of pain.

[23]  Irene Tracey,et al.  Disambiguating Pharmacodynamic Efficacy from Behavior with Neuroimaging: Implications for Analgesic Drug Development , 2016, Anesthesiology.

[24]  L. Arendt-Nielsen,et al.  A mechanism‐based pain sensitivity index to characterize knee osteoarthritis patients with different disease stages and pain levels , 2015, European journal of pain.

[25]  R. Baron,et al.  Mechanism-based therapy for neuropathic pain-a concept in danger? , 2015, Pain.

[26]  D. Beales,et al.  Somatosensory nociceptive characteristics differentiate subgroups in people with chronic low back pain: a cluster analysis , 2015, Pain.

[27]  L. Arendt-Nielsen,et al.  Linking altered central pain processing and genetic polymorphism to drug efficacy in chronic low back pain , 2015, BMC Pharmacology and Toxicology.

[28]  A. Drewes,et al.  Pregabalin and placebo responders show different effects on central pain processing in chronic pancreatitis patients , 2015, Journal of Pain Research.

[29]  Whei-Min Lin,et al.  Sudomotor innervation in transthyretin amyloid neuropathy: Pathology and functional correlates , 2015, Annals of neurology.

[30]  D. Yarnitsky,et al.  Recommendations on practice of conditioned pain modulation (CPM) testing , 2015, European journal of pain.

[31]  Steven P. Cohen,et al.  Dynamic Pain Phenotypes are Associated with Spinal Cord Stimulation-Induced Reduction in Pain: A Repeated Measures Observational Pilot Study. , 2015, Pain medicine.

[32]  Richard E. Harris,et al.  Brain White Matter Abnormalities in Female Interstitial Cystitis/Bladder Pain Syndrome: A MAPP Network Neuroimaging Study. , 2015, The Journal of urology.

[33]  D. Seminowicz,et al.  Partial recovery of abnormal insula and dorsolateral prefrontal connectivity to cognitive networks in chronic low back pain after treatment , 2015, Human brain mapping.

[34]  T. Jensen,et al.  Pain relief with lidocaine 5% patch in localized peripheral neuropathic pain in relation to pain phenotype: a randomised, double-blind, and placebo-controlled, phenotype panel study , 2015, Pain.

[35]  Ronald G. García,et al.  The Somatosensory Link in Fibromyalgia: Functional Connectivity of the Primary Somatosensory Cortex Is Altered by Sustained Pain and Is Associated With Clinical/Autonomic Dysfunction , 2015, Arthritis & rheumatology.

[36]  L. Arendt-Nielsen,et al.  Serum Levels of Proinflammatory Cytokines in Painful Knee Osteoarthritis and Sensitization , 2015, International journal of inflammation.

[37]  K. Davis,et al.  Reversal of insular and microstructural nerve abnormalities following effective surgical treatment for trigeminal neuralgia , 2015, Pain.

[38]  Richard E. Harris,et al.  Learning to identify CNS drug action and efficacy using multistudy fMRI data , 2015, Science Translational Medicine.

[39]  T. Hall,et al.  Divergent sensory phenotypes in nonspecific arm pain: comparisons with cervical radiculopathy. , 2015, Archives of physical medicine and rehabilitation.

[40]  D. Walsh,et al.  A cross-sectional study of pain sensitivity, disease-activity assessment, mental health, and fibromyalgia status in rheumatoid arthritis , 2015, Arthritis Research & Therapy.

[41]  L. Arendt-Nielsen,et al.  Presurgical assessment of temporal summation of pain predicts the development of chronic postoperative pain 12 months after total knee replacement , 2015, Pain.

[42]  T. Wager,et al.  Distinct Brain Systems Mediate the Effects of Nociceptive Input and Self-Regulation on Pain , 2015, PLoS biology.

[43]  L. Arendt-Nielsen,et al.  Identifying specific profiles in patients with different degrees of painful knee osteoarthritis based on serological biochemical and mechanistic pain biomarkers: a diagnostic approach based on cluster analysis , 2015, Pain.

[44]  M. Karsdal,et al.  Association Between Experimental Pain Biomarkers and Serologic Markers in Patients With Different Degrees of Painful Knee Osteoarthritis , 2014, Arthritis & rheumatology.

[45]  Tor D Wager,et al.  Altered Functional Magnetic Resonance Imaging Responses to Nonpainful Sensory Stimulation in Fibromyalgia Patients , 2014, Arthritis & rheumatology.

[46]  C. S. Hubbard,et al.  Altered Brain Structure and Function Correlate with Disease Severity and Pain Catastrophizing in Migraine Patients , 2014, eNeuro.

[47]  S. Sindrup,et al.  The effect of oxcarbazepine in peripheral neuropathic pain depends on pain phenotype: A randomised, double-blind, placebo-controlled phenotype-stratified study , 2014, PAIN®.

[48]  Richard E. Harris,et al.  Resting state connectivity correlates with drug and placebo response in fibromyalgia patients , 2014, NeuroImage: Clinical.

[49]  C. Orengo,et al.  Sensory, psychological, and metabolic dysfunction in HIV-associated peripheral neuropathy: A cross-sectional deep profiling study , 2014, PAIN®.

[50]  Richard E. Harris,et al.  Alterations in resting state oscillations and connectivity in sensory and motor networks in women with interstitial cystitis/painful bladder syndrome. , 2014, The Journal of urology.

[51]  David Borsook,et al.  Intrinsic brain networks normalize with treatment in pediatric complex regional pain syndrome , 2014, NeuroImage: Clinical.

[52]  David A. Seminowicz,et al.  Altered structure and function in the hippocampus and medial prefrontal cortex in patients with burning mouth syndrome , 2014, PAIN®.

[53]  X. Caro,et al.  Evidence of Abnormal Epidermal Nerve Fiber Density in Fibromyalgia: Clinical and Immunologic Implications , 2014, Arthritis & rheumatology.

[54]  J. Olesen,et al.  Concomitant Persistent Pain in Classical Trigeminal Neuralgia – Evidence for Different Subtypes , 2014, Headache.

[55]  A. Dahan,et al.  Tapentadol potentiates descending pain inhibition in chronic pain patients with diabetic polyneuropathy. , 2014, British journal of anaesthesia.

[56]  S. Sindrup,et al.  Characterization and diagnostic evaluation of chronic polyneuropathies induced by oxaliplatin and docetaxel comparing skin biopsy to quantitative sensory testing and nerve conduction studies , 2014, European journal of neurology.

[57]  G. Cruccu,et al.  Does the epidermal nerve fibre density measured by skin biopsy in patients with peripheral neuropathies correlate with neuropathic pain? , 2014, PAIN®.

[58]  Thomas J. Smith,et al.  The ACTTION-American Pain Society Pain Taxonomy (AAPT): an evidence-based and multidimensional approach to classifying chronic pain conditions. , 2014, The journal of pain : official journal of the American Pain Society.

[59]  R. Fillingim,et al.  Slow Temporal Summation of Pain for Assessment of Central Pain Sensitivity and Clinical Pain of Fibromyalgia Patients , 2014, PloS one.

[60]  L. Arendt-Nielsen,et al.  Translational pain biomarkers in the early development of new neurotherapeutics for pain management , 2014, Expert review of neurotherapeutics.

[61]  S. Mackey,et al.  Complex regional pain syndrome is associated with structural abnormalities in pain-related regions of the human brain. , 2014, The journal of pain : official journal of the American Pain Society.

[62]  R. Freeman,et al.  Sensory profiles of patients with neuropathic pain based on the neuropathic pain symptoms and signs , 2014, PAIN®.

[63]  M. Day,et al.  Gabapentin‐induced pharmacodynamic effects in the spinal nerve ligation model of neuropathic pain , 2014, European journal of pain.

[64]  Irene Tracey,et al.  Pain vulnerability: a neurobiological perspective , 2014, Nature Neuroscience.

[65]  G. Boeckxstaens,et al.  Sensitivity Testing in Irritable Bowel Syndrome With Rectal Capsaicin Stimulations: Role of TRPV1 Upregulation and Sensitization in Visceral Hypersensitivity? , 2014, The American Journal of Gastroenterology.

[66]  P. Furlong,et al.  Psychophysiological responses to visceral and somatic pain in functional chest pain identify clinically relevant pain clusters , 2014, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[67]  D. Herrmann,et al.  Contribution of QSART to the diagnosis of small fiber neuropathy , 2013, Muscle & nerve.

[68]  Tobias Schmidt-Wilcke,et al.  ABSTRACT Background: Chronic pain remains a significant challenge for modern health care as its pathologic mechanisms are largely unknown and preclinical animal models suffer from limitations in assessing this complex subjective experience. However, human brain neuroimaging techniques enable the ass , 2013 .

[69]  Xiping Liu,et al.  Multiphasic modification of intrinsic functional connectivity of the rat brain during increasing levels of propofol , 2013, NeuroImage.

[70]  I. Tracey.  "Seeing" how our drugs work brings translational added value. , 2013, Anesthesiology.

[71]  C. Sommer,et al.  Objective evidence that small-fiber polyneuropathy underlies some illnesses currently labeled as fibromyalgia , 2013, PAIN®.

[72]  L. Becerra,et al.  Analogous responses in the nucleus accumbens and cingulate cortex to pain onset (aversion) and offset (relief) in rats and humans. , 2013, Journal of neurophysiology.

[73]  P. Dieppe,et al.  The association between pre-operative pain sensitisation and chronic pain after knee replacement: an exploratory study. , 2013, Osteoarthritis and cartilage.

[74]  R. Freeman,et al.  Value of quantitative sensory testing in neurological and pain disorders: NeuPSIG consensus , 2013, PAIN®.

[75]  E. Feldman,et al.  Increased axonal regeneration and swellings in intraepidermal nerve fibers characterize painful phenotypes of diabetic neuropathy. , 2013, The journal of pain : official journal of the American Pain Society.

[76]  M. Fava,et al.  Use of functional imaging across clinical phases in CNS drug development , 2013, Translational Psychiatry.

[77]  I. Tracey,et al.  Imaging pain: a potent means for investigating pain mechanisms in patients , 2013, British journal of anaesthesia.

[78]  Daniel Zeller,et al.  Small fibre pathology in patients with fibromyalgia syndrome. , 2013, Brain : a journal of neurology.

[79]  F. Rice,et al.  Excessive peptidergic sensory innervation of cutaneous arteriole-venule shunts (AVS) in the palmar glabrous skin of fibromyalgia patients: implications for widespread deep tissue pain and fatigue. , 2013, Pain medicine.

[80]  M. Lindquist,et al.  An fMRI-based neurologic signature of physical pain. , 2013, The New England journal of medicine.

[81]  Richard E. Harris,et al.  Pressure Pain Sensitivity and Insular Combined Glutamate and Glutamine (Glx) Are Associated with Subsequent Clinical Response to Sham But Not Traditional Acupuncture in Patients Who Have Chronic Pain. , 2013, Medical acupuncture.

[82]  David Borsook,et al.  Parallel Buprenorphine phMRI Responses in Conscious Rodents and Healthy Human Subjects , 2013, The Journal of Pharmacology and Experimental Therapeutics.

[83]  P. Grant,et al.  Transient and Persistent Pain Induced Connectivity Alterations in Pediatric Complex Regional Pain Syndrome , 2013, PloS one.

[84]  W. Miltner,et al.  Somatosensory Abnormalities for Painful and Innocuous Stimuli at the Back and at a Site Distinct from the Region of Pain in Chronic Back Pain Patients , 2013, PloS one.

[85]  C. Graversen,et al.  Quantitative Sensory Testing Predicts Pregabalin Efficacy in Painful Chronic Pancreatitis , 2013, PloS one.

[86]  J. Nyengaard,et al.  Epidermal nerve fiber length density estimation using global spatial sampling in healthy subjects and neuropathy patients. , 2013, Journal of neuropathology and experimental neurology.

[87]  M. Dalakas,et al.  Reduction of Intraepidermal Nerve Fiber Density (IENFD) in the skin biopsies of patients with fibromyalgia: A controlled study , 2013, Journal of the Neurological Sciences.

[88]  J. Lefaucheur,et al.  Neurophysiological markers of small fibre neuropathy in TTR-FAP mutation carriers , 2013, Journal of Neurology.

[89]  Ajay D. Wasan,et al.  Default mode network connectivity encodes clinical pain: An arterial spin labeling study , 2013, PAIN®.

[90]  Michael J. Wald,et al.  Pharmacological modulation of brain activity in a preclinical model of osteoarthritis , 2013, NeuroImage.

[91]  K. Yuan,et al.  Hierarchical Alteration of Brain Structural and Functional Networks in Female Migraine Sufferers , 2012, PloS one.

[92]  T. Schnitzer,et al.  Brain networks predicting placebo analgesia in a clinical trial for chronic back pain , 2012, PAIN®.

[93]  Joachim M. Buhmann,et al.  Decoding the perception of pain from fMRI using multivariate pattern analysis , 2012, NeuroImage.

[94]  M. Dusch,et al.  Skin innervation at different depths correlates with small fibre function but not with pain in neuropathic pain patients , 2012, European journal of pain.

[95]  J. Callaghan,et al.  Predictors of postoperative movement and resting pain following total knee replacement , 2012, PAIN®.

[96]  Richard Rogers,et al.  Baseline reward circuitry activity and trait reward responsiveness predict expression of opioid analgesia in healthy subjects , 2012, Proceedings of the National Academy of Sciences.

[97]  L. Arendt-Nielsen,et al.  Quantitative sensory testing in painful osteoarthritis: a systematic review and meta-analysis. , 2012, Osteoarthritis and cartilage.

[98]  James N. Campbell,et al.  Randomized control trial of topical clonidine for treatment of painful diabetic neuropathy , 2012, PAIN®.

[99]  Neena K Sharma,et al.  The effect of exercise on neuropathic symptoms, nerve function, and cutaneous innervation in people with diabetic peripheral neuropathy. , 2012, Journal of diabetes and its complications.

[100]  Bruce G. Jenkins,et al.  Pharmacologic magnetic resonance imaging (phMRI): Imaging drug action in the brain , 2012, NeuroImage.

[101]  A. Drewes,et al.  Effects of Pregabalin on Central Sensitization in Patients with Chronic Pancreatitis in a Randomized, Controlled Trial , 2012, PloS one.

[102]  Richard E. Harris,et al.  Decreased intrinsic brain connectivity is associated with reduced clinical pain in fibromyalgia. , 2012, Arthritis and rheumatism.

[103]  D. Bouhassira,et al.  Risk factors predictive of chronic postsurgical neuropathic pain: The value of the iliac crest bone harvest model , 2012, PAIN.

[104]  K. Wiech,et al.  Neuroimaging as a tool to investigate how cognitive factors influence analgesic drug outcomes , 2012, Neuroscience Letters.

[105]  Thomas J. Schnitzer,et al.  Corticostriatal functional connectivity predicts transition to chronic back pain , 2012, Nature Neuroscience.

[106]  Mogher Khamaisi,et al.  Conditioned pain modulation predicts duloxetine efficacy in painful diabetic neuropathy , 2012, PAIN.

[107]  M. Struys,et al.  Bilateral Sensory Abnormalities in Patients with Unilateral Neuropathic Pain; A Quantitative Sensory Testing (QST) Study , 2012, PloS one.

[108]  Roland Staud,et al.  Abnormal endogenous pain modulation is a shared characteristic of many chronic pain conditions , 2012, Expert review of neurotherapeutics.

[109]  R. Treede,et al.  Quantitative Sensory Testing of Neuropathic Pain Patients: Potential Mechanistic and Therapeutic Implications , 2012, Current Pain and Headache Reports.

[110]  David Borsook,et al.  Modulation of CNS pain circuitry by intravenous and sublingual doses of buprenorphine , 2012, NeuroImage.

[111]  Richard E. Harris,et al.  Reduced insular γ-aminobutyric acid in fibromyalgia. , 2012, Arthritis and rheumatism.

[112]  C. Sommer,et al.  Small fibers in Fabry disease: baseline and follow‐up data under enzyme replacement therapy , 2011, Journal of the peripheral nervous system : JPNS.

[113]  H. Kehlet,et al.  Mechanosensitivity before and after hysterectomy: a prospective study on the prediction of acute and chronic postoperative pain. , 2011, British journal of anaesthesia.

[114]  Thomas J. Schnitzer,et al.  Brain Morphological Signatures for Chronic Pain , 2011, PloS one.

[115]  F. Rice,et al.  Structural and functional differences between neuropathy with and without pain? , 2011, Experimental Neurology.

[116]  R. Treede,et al.  Quantitative Sensory Testing Profiles in Chronic Back Pain Are Distinct From Those in Fibromyalgia , 2011, The Clinical journal of pain.

[117]  P. Hauer,et al.  Longitudinal assessment of oxaliplatin-induced neuropathy , 2011, Neurology.

[118]  David Borsook,et al.  Imaging Drugs with and without Clinical Analgesic Efficacy , 2011, Neuropsychopharmacology.

[119]  S. Mackey,et al.  Prescription opioid analgesics rapidly change the human brain , 2011, PAIN®.

[120]  V. Napadow,et al.  Neural Correlates of Chronic Low Back Pain Measured by Arterial Spin Labeling , 2011, Anesthesiology.

[121]  Min Zhang,et al.  Awake Rat Pharmacological Magnetic Resonance Imaging as a Translational Pharmacodynamic Biomarker: Metabotropic Glutamate 2/3 Agonist Modulation of Ketamine-Induced Blood Oxygenation Level Dependence Signals , 2011, Journal of Pharmacology and Experimental Therapeutics.

[122]  Irene Tracey,et al.  Can neuroimaging studies identify pain endophenotypes in humans? , 2011, Nature Reviews Neurology.

[123]  A. Vania Apkarian,et al.  Pain and the brain: Specificity and plasticity of the brain in clinical chronic pain , 2011, PAIN.

[124]  Ralf Baron,et al.  Test–retest and interobserver reliability of quantitative sensory testing according to the protocol of the German Research Network on Neuropathic Pain (DFNS): A multi-centre study , 2011, PAIN®.

[125]  K. Wiech,et al.  The Effect of Treatment Expectation on Drug Efficacy: Imaging the Analgesic Benefit of the Opioid Remifentanil , 2011, Science Translational Medicine.

[126]  Tor D Wager,et al.  Predicting Individual Differences in Placebo Analgesia: Contributions of Brain Activity during Anticipation and Pain Experience , 2011, The Journal of Neuroscience.

[127]  R. Treede,et al.  Reference data for quantitative sensory testing (QST): Refined stratification for age and a novel method for statistical comparison of group data , 2010, PAIN®.

[128]  Nicola Filippini,et al.  Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty: a longitudinal voxel-based morphometric study. , 2010, Arthritis and rheumatism.

[129]  C. Schmitz,et al.  Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study , 2010, Journal of the peripheral nervous system : JPNS.

[130]  H. Flor,et al.  Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes , 2010, PAIN.

[131]  Kyungmo Park,et al.  Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity. , 2010, Arthritis and rheumatism.

[132]  G. Wasner,et al.  Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment , 2010, The Lancet Neurology.

[133]  L. Becerra,et al.  Alterations in brain structure and functional connectivity in prescription opioid-dependent patients. , 2010, Brain : a journal of neurology.

[134]  Boris Freidlin,et al.  Randomized clinical trials with biomarkers: design issues. , 2010, Journal of the National Cancer Institute.

[135]  R. Treede,et al.  Somatosensory profiles in subgroups of patients with myogenic temporomandibular disorders and fibromyalgia syndrome , 2009, PAIN®.

[136]  Arne May,et al.  Brain Gray Matter Decrease in Chronic Pain Is the Consequence and Not the Cause of Pain , 2009, The Journal of Neuroscience.

[137]  Vitaly Napadow,et al.  Elevated insular glutamate in fibromyalgia is associated with experimental pain. , 2009, Arthritis and rheumatism.

[138]  A. Carr,et al.  Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients. , 2009, Arthritis and rheumatism.

[139]  David J. Scott,et al.  Traditional Chinese acupuncture and placebo (sham) acupuncture are differentiated by their effects on μ-opioid receptors (MORs) , 2009, NeuroImage.

[140]  R. Fillingim,et al.  Thermal hypersensitivity in a subset of irritable bowel syndrome patients. , 2009, World journal of gastroenterology.

[141]  Lars Arendt-Nielsen,et al.  Experimental and clinical applications of quantitative sensory testing applied to skin, muscles and viscera. , 2009, The journal of pain : official journal of the American Pain Society.

[142]  Shuxing Wang,et al.  Altered quantitative sensory testing outcome in subjects with opioid therapy , 2009, Pain.

[143]  M. C. Bushnell,et al.  Increased gray matter density in young women with chronic vulvar pain , 2008, PAIN.

[144]  David K Menon,et al.  Identifying Brain Activity Specifically Related to the Maintenance and Perceptual Consequence of Central Sensitization in Humans , 2008, The Journal of Neuroscience.

[145]  N. Shenker,et al.  Contralateral hyperalgesia and allodynia following intradermal capsaicin injection in man , 2008, Rheumatology.

[146]  E. Granieri,et al.  The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology , 2008, Brain : a journal of neurology.

[147]  Patrick R Hof,et al.  Functional Trade-Offs in White Matter Axonal Scaling , 2008, The Journal of Neuroscience.

[148]  Irene Tracey,et al.  Investigation into the neural correlates of emotional augmentation of clinical pain , 2008, NeuroImage.

[149]  Giuseppe Lauria,et al.  Skin biopsy as a diagnostic tool in peripheral neuropathy , 2007, Nature Clinical Practice Neurology.

[150]  J. McArthur,et al.  Denervation of skin in neuropathies: the sequence of axonal and Schwann cell changes in skin biopsies. , 2007, Brain : a journal of neurology.

[151]  Nathan Efron,et al.  Surrogate Markers of Small Fiber Damage in Human Diabetic Neuropathy , 2007, Diabetes.

[152]  Richard Rogers,et al.  The anxiolytic effects of midazolam during anticipation to pain revealed using fMRI. , 2007, Magnetic resonance imaging.

[153]  D. Clifford,et al.  Correlates of epidermal nerve fiber densities in HIV-associated distal sensory polyneuropathy , 2007, Neurology.

[154]  G. Wendelschafer‐Crabb,et al.  Concordance between epidermal nerve fiber density and sensory examination in patients with symptoms of idiopathic small fiber neuropathy , 2007, Journal of the Neurological Sciences.

[155]  David A Seminowicz,et al.  Accelerated Brain Gray Matter Loss in Fibromyalgia Patients: Premature Aging of the Brain? , 2007, The Journal of Neuroscience.

[156]  Joseph B. Mandeville,et al.  Remifentanil administration reveals biphasic phMRI temporal responses in rat consistent with dynamic receptor regulation , 2007, NeuroImage.

[157]  S. Landy,et al.  Clarification of Developing and Established Clinical Allodynia and Pain‐Free Outcomes , 2007, Headache.

[158]  Chih-Liang Chin,et al.  Pharmacological MRI in awake rats reveals neural activity in area postrema and nucleus tractus solitarius: Relevance as a potential biomarker for detecting drug-induced emesis , 2006, NeuroImage.

[159]  T. Harrison.  Faculty Opinions recommendation of Lifestyle intervention for pre-diabetic neuropathy. , 2006 .

[160]  F. Birklein,et al.  Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Standardized protocol and reference values , 2006, PAIN.

[161]  Irene Tracey,et al.  An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patients , 2006, NeuroImage.

[162]  M. Max,et al.  Basal Heat Pain Thresholds Predict Opioid Analgesia in Patients with Postherpetic Neuralgia , 2006, Anesthesiology.

[163]  D. Yue,et al.  The relationship among pain, sensory loss, and small nerve fibers in diabetes. , 2006, Diabetes care.

[164]  M. Mcdermott,et al.  Is skin biopsy a predictor of transition to symptomatic HIV neuropathy? , 2006, Neurology.

[165]  G. Wendelschafer‐Crabb,et al.  Morphological features of nerves in skin biopsies , 2006, Journal of the Neurological Sciences.

[166]  J. McArthur,et al.  The utility of skin biopsy for prediction of progression in suspected small fiber neuropathy , 2006, Neurology.

[167]  R. Dworkin,et al.  Skin biopsy and quantitative sensory testing do not predict response to lidocaine patch in painful neuropathies , 2006, Muscle & nerve.

[168]  W Vennart,et al.  Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[169]  G. Wasner,et al.  Postherpetic neuralgia: Topical lidocaine is effective in nociceptor–deprived skin , 2005, Journal of Neurology.

[170]  H. Krämer,et al.  Thermal thresholds predict painfulness of diabetic neuropathies. , 2004, Diabetes care.

[171]  S. Granter,et al.  Monitoring the 3-year efficacy of enzyme replacement therapy in fabry disease by repeated skin biopsies. , 2004, The Journal of investigative dermatology.

[172]  M. Mcdermott,et al.  Epidermal nerve fiber density, axonal swellings and QST as predictors of HIV distal sensory neuropathy , 2004, Muscle & nerve.

[173]  Irene Tracey,et al.  Using fMRI to Quantify the Time Dependence of Remifentanil Analgesia in the Human Brain , 2004, Neuropsychopharmacology.

[174]  Richard Rogers,et al.  An Investigation to Dissociate the Analgesic and Anesthetic Properties of Ketamine Using Functional Magnetic Resonance Imaging , 2004, Anesthesiology.

[175]  D. Bouhassira,et al.  Systemic lidocaine in pain due to peripheral nerve injury and predictors of response , 2004, Neurology.

[176]  R. Burstein,et al.  Defeating migraine pain with triptans: A race against the development of cutaneous allodynia , 2004, Annals of neurology.

[177]  D. Pareyson,et al.  Axonal swellings predict the degeneration of epidermal nerve fibers in painful neuropathies , 2003, Neurology.

[178]  P. Scuffham,et al.  Predicted costs and outcomes from reduced vibration detection in people with diabetes in the U.S. , 2003, Diabetes care.

[179]  D. Herrmann,et al.  Epidermal reinnervation concomitant with symptomatic improvement in a sensory neuropathy , 2003, Muscle & nerve.

[180]  C. Sumner,et al.  The spectrum of neuropathy in diabetes and impaired glucose tolerance , 2003, Neurology.

[181]  Richard G. Wise,et al.  Combining fMRI with a Pharmacokinetic Model to Determine Which Brain Areas Activated by Painful Stimulation Are Specifically Modulated by Remifentanil , 2002, NeuroImage.

[182]  D. Katzenstein,et al.  Reduced intraepidermal nerve fiber density in HIV-associated sensory neuropathy , 2002, Neurology.

[183]  B. Gerdle,et al.  Quantitative Sensory Testing in Fibromyalgia Patients and in Healthy Subjects: Identification of Subgroups , 2001, The Clinical journal of pain.

[184]  S. Tripp,et al.  Epidermal nerve innervation in impaired glucose tolerance and diabetes-associated neuropathy , 2001, Neurology.

[185]  J. Goldstein,et al.  The frequency of undiagnosed diabetes and impaired glucose tolerance in patients with idiopathic sensory neuropathy , 2001, Muscle & nerve.

[186]  M. Bromberg,et al.  Increased prevalence of impaired glucose tolerance in patients with painful sensory neuropathy. , 2001, Diabetes care.

[187]  M. Max,et al.  Mechanism-based Pain Diagnosis: Issues for Analgesic Drug Development , 2001, Anesthesiology.

[188]  D. DeMets,et al.  Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework , 2001, Clinical pharmacology and therapeutics.

[189]  M. Rowbotham,et al.  Capsaicin evoked pain and allodynia in post-herpetic neuralgia , 2000, Pain.

[190]  M. Max.  Is mechanism-based pain treatment attainable? Clinical trial issues. , 2000, The journal of pain : official journal of the American Pain Society.

[191]  Robert A Koeppe,et al.  Buprenorphine-Induced Changes in Mu-Opioid Receptor Availability in Male Heroin-Dependent Volunteers: A Preliminary Study , 2000, Neuropsychopharmacology.

[192]  T. Larson,et al.  Patterns of quantitative sensation testing of hypoesthesia and hyperalgesia are predictive of diabetic polyneuropathy: a study of three cohorts. Nerve growth factor study group. , 2000, Diabetes care.

[193]  J. McArthur,et al.  Epidermal nerve fiber density: normative reference range and diagnostic efficiency. , 1998, Archives of neurology.

[194]  J. McArthur,et al.  Neuropathological alterations in diabetic truncal neuropathy: evaluation by skin biopsy , 1998, Journal of neurology, neurosurgery, and psychiatry.

[195]  M. Rowbotham,et al.  Postherpetic Neuralgia: Irritable Nociceptors and Deafferentation , 1998, Neurobiology of Disease.

[196]  R. Lipton,et al.  Towards a mechanism-based classification of pain? , 1998, Pain.

[197]  T. Crawford,et al.  Small‐fiber sensory neuropathies: Clinical course and neuropathology of idiopathic cases , 1998, Annals of neurology.

[198]  J. McArthur,et al.  Intraepidermal nerve fiber density in patients with painful sensory neuropathy , 1997, Neurology.

[199]  M. Rowbotham,et al.  Cutaneous Innervation Density in the Allodynic Form of Postherpetic Neuralgia , 1996, Neurobiology of Disease.

[200]  K. Davis,et al.  The plasticity of cutaneous hyperalgesia during sympathetic ganglion blockade in patients with neuropathic pain. , 1992, Brain : a journal of neurology.

[201]  E. Torebjörk,et al.  Quantitative sensory testing before and after regional guanethidine block in patients with neuralgia in the hand , 1991, Pain.

[202]  M. Max.  Towards physiologically based treatment of patients with neuropathic pain , 1990, Pain.

[203]  M. Rowbotham,et al.  Post-herpetic neuralgia: the relation of pain complaint, sensory disturbance and skin temperature , 1989, Pain.

[204]  Tor D. Wager,et al.  Towards a neurophysiological signature for fibromyalgia , 2017, Pain.

[205]  J. Nyengaard,et al.  Structural and functional characterization of nerve fibres in polyneuropathy and healthy subjects , 2016, Scandinavian journal of pain.

[206]  Richard E. Harris,et al.  Functional Connectivity is Associated With Altered Brain Chemistry in Women With Endometriosis-Associated Chronic Pelvic Pain. , 2016, The journal of pain : official journal of the American Pain Society.

[207]  Richard E. Harris,et al.  Increased brain gray matter in the primary somatosensory cortex is associated with increased pain and mood disturbance in patients with interstitial cystitis/painful bladder syndrome. , 2015, Journal of Urology.

[208]  M. Baliki,et al.  Chronic pain: the role of learning and brain plasticity. , 2014, Restorative neurology and neuroscience.

[209]  R. Schwartzman,et al.  Thermal pain in complex regional pain syndrome type I. , 2014, Pain physician.

[210]  F. Schlösser,et al.  The Semmes Weinstein monofilament examination is a significant predictor of the risk of foot ulceration and amputation in patients with diabetes mellitus. , 2011, Journal of vascular surgery.

[211]  A. Verma.  Pregabalin for painful HIV neuropathy: A randomized, double-blind, placebo-controlled trial , 2010 .

[212]  S. Abram.  Botulinum Toxin Type A Induces Direct Analgesic Effects in Chronic Neuropathic Pain , 2009 .

[213]  B. Thiers.  Is skin biopsy a predictor of transition to symptomatic HIV neuropathy? A longitudinal studyHerrmann DN, McDermott MP, Sowden JE, et al (Univ of Rochester, NY) Neurology 66:857–861, 2006§ , 2007 .

[214]  Robert A Koeppe,et al.  Effects of Buprenorphine Maintenance Dose on μ-Opioid Receptor Availability, Plasma Concentrations, and Antagonist Blockade in Heroin-Dependent Volunteers , 2003, Neuropsychopharmacology.

[215]  P. Sopp.  Cluster analysis. , 1996, Veterinary immunology and immunopathology.

[216]  T. Westfall,et al.  ALTERATIONS IN THE , 1985 .