New hemostatic agents in the combat setting

BACKGROUND: Hemorrhage is a leading cause of potentially preventable death in both civilian and military trauma patients. Animal data have shown that hemostatic bandages reduce hemorrhage and improve survival. This article reports recent clinical observations regarding the efficacy and evolution of use of two new hemostatic bandages employed in the global war on terrorism.

[1]  M. Robinson,et al.  Case report of uncontrollable pelvic bleeding – managed by a previously unreported method (QuikClot®) , 2009, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[2]  Peter Rhee,et al.  QuikClot use in trauma for hemorrhage control: case series of 103 documented uses. , 2008, The Journal of trauma.

[3]  David G Baer,et al.  Prehospital tourniquet use in Operation Iraqi Freedom: effect on hemorrhage control and outcomes. , 2008, The Journal of trauma.

[4]  John F Kragh,et al.  Practical use of emergency tourniquets to stop bleeding in major limb trauma. , 2008, The Journal of trauma.

[5]  Lisa Pearse,et al.  Injury severity and causes of death from Operation Iraqi Freedom and Operation Enduring Freedom: 2003-2004 versus 2006. , 2008, The Journal of trauma.

[6]  John B Holcomb,et al.  Tactical combat casualty care 2007: evolving concepts and battlefield experience. , 2007, Military medicine.

[7]  W. K. Prusaczyk,et al.  Comparative efficacy of granular and bagged formulations of the hemostatic agent QuikClot. , 2007, The Journal of trauma.

[8]  C. Wade,et al.  The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. , 2007, The Journal of trauma.

[9]  G. Bowlin,et al.  Comparison of a new hemostatic agent to current combat hemostatic agents in a Swine model of lethal extremity arterial hemorrhage. , 2007, The Journal of trauma.

[10]  Charles E. Wade,et al.  Causes of Death in U.S. Special Operations Forces in the Global War on Terrorism: 2001–2004 , 2007, Annals of surgery.

[11]  C. Wade,et al.  Early versus late recombinant factor VIIa in combat trauma patients requiring massive transfusion. , 2007, The Journal of trauma.

[12]  P. Rhee,et al.  Testing of modified zeolite hemostatic dressings in a large animal model of lethal groin injury. , 2006, The Journal of trauma.

[13]  Michael R Hamblin,et al.  Use of chitosan bandage to prevent fatal infections developing from highly contaminated wounds in mice. , 2006, Biomaterials.

[14]  John B Holcomb,et al.  Understanding combat casualty care statistics. , 2006, The Journal of trauma.

[15]  P. Wheatley,et al.  NO-releasing zeolites and their antithrombotic properties. , 2006, Journal of the American Chemical Society.

[16]  Anthony E. Pusateri,et al.  The Chitosan-Based Hemostatic Dressing: Experience in Current Combat Operations. , 2005, The Journal of trauma.

[17]  J. Holcomb,et al.  Comparison of hemorrhage control agents applied to lethal extremity arterial hemorrhages in swine. , 2005, The Journal of trauma.

[18]  K L Mattox,et al.  Mortality from isolated civilian penetrating extremity injury. , 2005, The Journal of trauma.

[19]  Kathy L Ryan,et al.  Hemostatic efficacy of two advanced dressings in an aortic hemorrhage model in Swine. , 2005, The Journal of trauma.

[20]  Joshua S Vayer,et al.  Hemostatic dressings for the first responder: a review. , 2004, Military medicine.

[21]  K. Ryan,et al.  Application of a granular mineral-based hemostatic agent (QuikClot) to reduce blood loss after grade V liver injury in swine. , 2004, The Journal of trauma.

[22]  L. D. Yantis,et al.  Thermal injury resulting from application of a granular mineral hemostatic agent. , 2004, The Journal of trauma.

[23]  Peter Rhee,et al.  Application of a zeolite hemostatic agent achieves 100% survival in a lethal model of complex groin injury in Swine. , 2004, The Journal of trauma.

[24]  Juan Zhou,et al.  Reduction in postoperative adhesion formation and re-formation after an abdominal operation with the use of N, O - carboxymethyl chitosan. , 2004, Surgery.

[25]  Richard A. Harris,et al.  Advanced hemostatic dressing development program: animal model selection criteria and results of a study of nine hemostatic dressings in a model of severe large venous hemorrhage and hepatic injury in Swine. , 2003, The Journal of trauma.

[26]  Yu-dong Gu,et al.  Bridging peripheral nerve defect with chitosan-collagen film. , 2003, Chinese journal of traumatology = Zhonghua chuang shang za zhi.

[27]  Peter Rhee,et al.  Comparative analysis of hemostatic agents in a swine model of lethal groin injury. , 2003, The Journal of trauma.

[28]  J. Synowiecki,et al.  Production, Properties, and Some New Applications of Chitin and Its Derivatives , 2003, Critical reviews in food science and nutrition.

[29]  J. Holcomb,et al.  Comparison of 10 different hemostatic dressings in an aortic injury. , 2003, The Journal of trauma.

[30]  J. Bumgardner,et al.  Chitosan: potential use as a bioactive coating for orthopaedic and craniofacial/dental implants , 2003, Journal of biomaterials science. Polymer edition.

[31]  Richard A. Harris,et al.  Effect of a chitosan-based hemostatic dressing on blood loss and survival in a model of severe venous hemorrhage and hepatic injury in swine. , 2003, The Journal of trauma.

[32]  F. Mi,et al.  Control of wound infections using a bilayer chitosan wound dressing with sustainable antibiotic delivery. , 2002, Journal of biomedical materials research.

[33]  E J Wood,et al.  The effect of chitin and chitosan on the proliferation of human skin fibroblasts and keratinocytes in vitro. , 2001, Biomaterials.

[34]  S. Ko,et al.  Water-soluble chitin as a wound healing accelerator. , 1999, Biomaterials.

[35]  J. Holcomb,et al.  Efficacy of a dry fibrin sealant dressing for hemorrhage control after ballistic injury. , 1998, Archives of surgery.

[36]  J. Holcomb,et al.  New technologies for hemorrhage control , 1997 .

[37]  M. Carey,et al.  Analysis of wounds incurred by U.S. Army Seventh Corps personnel treated in Corps hospitals during Operation Desert Storm, February 20 to March 10, 1991. , 1996, The Journal of trauma.

[38]  R. Muzzarelli,et al.  Osteoconduction exerted by methylpyrrolidinone chitosan used in dental surgery. , 1993, Biomaterials.

[39]  F. Bartone,et al.  Chitosan: effects on wound healing in urogenital tissue: preliminary report. , 1988, The Journal of urology.

[40]  R. Bellamy.  The causes of death in conventional land warfare: implications for combat casualty care research. , 1984, Military medicine.