Involvement of p 21 Waf 1 / Cip 1 in Protein Kinase C Alpha-Induced Cell Cycle Progression

[1]  N. Jones,et al.  Differential control of cyclins D1 and D3 and the cdk inhibitor p27Kip1 by diverse signalling pathways in Swiss 3T3 cells , 1997, Oncogene.

[2]  O. Bachs,et al.  The Protein SET Regulates the Inhibitory Effect of p21Cip1 on Cyclin E-Cyclin-dependent Kinase 2 Activity* , 1999, The Journal of Biological Chemistry.

[3]  J. Antel,et al.  Protein Kinase C Activity Correlates with the Growth Rate of Malignant Gliomas , 1992 .

[4]  V. Sexl,et al.  The Cyclin-dependent Kinase Inhibitor p21 cip1 Mediates the Growth Inhibitory Effect of Phorbol Esters in Human Venous Endothelial Cells* , 1997, The Journal of Biological Chemistry.

[5]  A. Fields,et al.  βII Protein Kinase C Is Required for the G2/M Phase Transition of Cell Cycle* , 1996, The Journal of Biological Chemistry.

[6]  T. Sekiya,et al.  Homozygous deletion of the MTS1/p16 and MTS2/p15 genes and amplification of the CDK4 gene in glioma. , 1995, Oncogene.

[7]  G. Hannon,et al.  p21-containing cyclin kinases exist in both active and inactive states. , 1994, Genes & development.

[8]  K. Münger,et al.  The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2. , 1997, Genes & development.

[9]  R. Martuza,et al.  Treatment of glioblastoma U-87 by systemic administration of an antisense protein kinase C-alpha phosphorothioate oligodeoxynucleotide. , 1996, Molecular pharmacology.

[10]  J. Olson,et al.  Lack of p16INK4 or retinoblastoma protein (pRb), or amplification-associated overexpression of cdk4 is observed in distinct subsets of malignant glial tumors and cell lines. , 1995, Cancer research.

[11]  R. Weichselbaum,et al.  Phorbol ester-induced monocytic differentiation is associated with G2 delay and down-regulation of cdc25 expression. , 1993, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[12]  M L Apuzzo,et al.  Treatment of recurrent malignant gliomas with chronic oral high-dose tamoxifen. , 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

[13]  J. Black,et al.  Protein Kinase C Isozyme-mediated Cell Cycle Arrest Involves Induction of p21waf1/cip1 and p27kip1 and Hypophosphorylation of the Retinoblastoma Protein in Intestinal Epithelial Cells* , 1997, The Journal of Biological Chemistry.

[14]  D. Fishman,et al.  Linking protein kinase C to cell-cycle control. , 1997, European journal of biochemistry.

[15]  B. Stillman,et al.  Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein. , 1997, Genes & development.

[16]  S. Shurtleff,et al.  D-type cyclin-dependent kinase activity in mammalian cells , 1994, Molecular and cellular biology.

[17]  W. Zhou,et al.  Protein kinase C inhibits the CAK-CDK2 cyclin-dependent kinase cascade and G1/S cell cycle progression in human diploid fibroblasts. , 1996, Biochimica et biophysica acta.

[18]  A. Newton,et al.  Regulation of protein kinase C. , 1997, Current opinion in cell biology.

[19]  P. Korkolopoulou,et al.  Expression of retinoblastoma gene product and p21 (WAF1/Cip 1) protein in gliomas: correlations with proliferation markers, p53 expression and survival , 1998, Acta Neuropathologica.

[20]  J. LaBaer,et al.  New functional activities for the p21 family of CDK inhibitors. , 1997, Genes & development.

[21]  D. Sørensen,et al.  A nuclease-resistant protein kinase C alpha ribozyme blocks glioma cell growth. , 1998, Nature Biotechnology.

[22]  C. Delphin,et al.  The protein kinase C activator, phorbol ester, cooperates with the wild-type p53 species of Ras-transformed embryo fibroblasts growth arrest. , 1994, The Journal of biological chemistry.

[23]  D. Louis,et al.  Molecular Genetic Correlates of p16, cdk4, and pRb Immunohistochemistry in Glioblastomas , 1998, Journal of neuropathology and experimental neurology.

[24]  James M. Roberts,et al.  The p21Cip1 and p27Kip1 CDK ‘inhibitors’ are essential activators of cyclin D‐dependent kinases in murine fibroblasts , 1999, The EMBO journal.

[25]  J. Herman,et al.  Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B. , 1996, Cancer research.

[26]  Antonio Iavarone,et al.  Regulation of the cdk inhibitor p21 gene during cell cycle progression is under the control of the transcription factor E2F , 1998, Oncogene.

[27]  P. Dirks,et al.  Cyclin and Cyclin‐Dependent Kinase Expression in Human Astrocytoma Cell Lines , 1997, Journal of neuropathology and experimental neurology.

[28]  Y. Arita,et al.  Regulation of the cell cycle at the G2/M boundary in metastatic melanoma cells by 12-O-tetradecanoyl phorbol-13-acetate (TPA) by blocking p34cdc2 kinase activity. , 1998, Experimental cell research.

[29]  S. Segal,et al.  The role of protein kinase C in G1 and G2/M phases of the cell cycle (review). , 1998, International journal of oncology.

[30]  A. Newton.  Regulation of protein kinase , 1997 .

[31]  H. Mischak,et al.  Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes. , 1993, Molecular pharmacology.

[32]  J. Bruner,et al.  Increased levels of p21WAF1/Cip1 in human brain tumors. , 1995, Oncogene.

[33]  L. Miraglia,et al.  Inhibition of growth of human tumor cell lines in nude mice by an antisense of oligonucleotide inhibitor of protein kinase C-alpha expression. , 1996, Cancer research.

[34]  J. Villemure,et al.  High Dose Tamoxifen in the Treatment of Recurrent High Grade Glioma: A Report of Clinical Stabilization and Tumour Regression , 1993, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[35]  James M. Roberts,et al.  lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin , 1994, Nature.

[36]  G. Condorelli,et al.  The cdc-2-related kinase, PISSLRE, is essential for cell growth and acts in G2 phase of the cell cycle. , 1995, Cancer research.

[37]  I. Schieren,et al.  Linking protein kinase C to the cell cycle: ectopic expression of PKC eta in NIH3T3 cells alters the expression of cyclins and Cdk inhibitors and induces adipogenesis. , 1996, Oncogene.

[38]  P. Parker,et al.  The extended protein kinase C superfamily. , 1998, The Biochemical journal.

[39]  N. Dooley,et al.  Protein kinase C in cultured adult human oligodendrocytes: A potential role for isoform α as a mediator of process outgrowth , 1994, Journal of neuroscience research.

[40]  K. Kinzler,et al.  p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. , 1995, Genes & development.

[41]  T. Sasaguri,et al.  Cell cycle arrest in the G2 phase induced by phorbol ester and diacylglycerol in vascular endothelial cells. , 1996, The American journal of physiology.

[42]  K. Srivenugopal,et al.  Deletions and rearrangements inactivate the p16INK4 gene in human glioma cells. , 1996, Oncogene.

[43]  P. Parker,et al.  Activation of the PKC-isotypes alpha, beta 1, gamma, delta and epsilon by phorbol esters of different biological activities. , 1991, FEBS letters.

[44]  C. Deng,et al.  Involvement of p21cip-1 and p27kip-1 in the molecular mechanisms of steel factor-induced proliferative synergy in vitro and of p21cip-1 in the maintenance of stem/progenitor cells in vivo. , 1996, Blood.

[45]  R. Glazer,et al.  Antisense expression of protein kinase C alpha inhibits the growth and tumorigenicity of human glioblastoma cells. , 1994, Neurosurgery.

[46]  D. Givol,et al.  Induction of WAF1/CIP1 by a p53-independent pathway. , 1994, Cancer research.

[47]  W Arap,et al.  Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA. , 1997, Cancer research.

[48]  J. Villemure,et al.  Protein Kinase C and Growth Regulation of Malignant Gliomas , 1995, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[49]  S. Jaken.  Protein kinase C isozymes and substrates. , 1996, Current opinion in cell biology.

[50]  D. Fabbro,et al.  Inhibition of the growth of glioblastomas by CGP 41251, an inhibitor of protein kinase C, and by a phorbol ester tumor promoter. , 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.