Saturated fatty acids induce NLRP3 activation in human macrophages through K+ efflux resulting from phospholipid saturation and Na, K-ATPase disruption.
暂无分享,去创建一个
J. Piette | S. Legrand-Poels | J. Swinnen | M. Rider | N. Paquot | J. Dehairs | Y. Habraken | N. Esser | Laurent L’homme | G. Herinckx | Olivia Jansen | Marco A. Gianfrancesco | C. Lassence | Cédric Lassence
[1] Zhijian J. Chen,et al. PtdIns4P on Dispersed Trans-Golgi Network Mediates NLRP3 Inflammasome Activation , 2018, Nature.
[2] J. Miller,et al. Role of DGAT enzymes in triacylglycerol metabolism. , 2018, Archives of biochemistry and biophysics.
[3] S. Legrand-Poels,et al. Lipid bilayer stress in obesity‐linked inflammatory and metabolic disorders , 2018, Biochemical pharmacology.
[4] M. Oosting,et al. Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming , 2018, Cell.
[5] N. Shibayama,et al. Saturated Fatty Acids Undergo Intracellular Crystallization and Activate the NLRP3 Inflammasome in Macrophages , 2018, Arteriosclerosis, thrombosis, and vascular biology.
[6] J. Vederas,et al. Diacylglycerol Acyltransferase 1 Is Regulated by Its N-Terminal Domain in Response to Allosteric Effectors1[OPEN] , 2017, Plant Physiology.
[7] G. Hummer,et al. Activation of the Unfolded Protein Response by Lipid Bilayer Stress. , 2017, Molecular cell.
[8] S. Mazères,et al. Using spectral decomposition of the signals from laurdan-derived probes to evaluate the physical state of membranes in live cells , 2017, F1000Research.
[9] N. Hasebe,et al. The cardiac glycoside ouabain activates NLRP3 inflammasomes and promotes cardiac inflammation and dysfunction , 2017, PloS one.
[10] M. Habeck,et al. Specific phospholipid binding to Na,K-ATPase at two distinct sites , 2017, Proceedings of the National Academy of Sciences.
[11] H. Joller-jemelka,et al. Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets. , 2002, The Journal of clinical investigation.
[12] M. Pilon. Revisiting the membrane-centric view of diabetes , 2016, Lipids in Health and Disease.
[13] S. Ryter,et al. NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages , 2016, Nature Medicine.
[14] J. Rathmell,et al. A guide to immunometabolism for immunologists , 2016, Nature Reviews Immunology.
[15] E. Latz,et al. Recent insights into the molecular mechanisms of the NLRP3 inflammasome activation , 2016, F1000Research.
[16] V. Dixit,et al. Inflammasomes: mechanism of assembly, regulation and signalling , 2016, Nature Reviews Immunology.
[17] Charles C. Kim,et al. Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells. , 2016, Cell reports.
[18] G. Núñez,et al. Nek7 is an essential mediator of NLRP3 activation downstream of potassium efflux , 2016, Nature.
[19] J. Hamilton,et al. Disorder Amidst Membrane Order: Standardizing Laurdan Generalized Polarization and Membrane Fluidity Terms , 2016, Journal of Fluorescence.
[20] M. Habeck,et al. General and specific lipid-protein interactions in Na,K-ATPase. , 2015, Biochimica et biophysica acta.
[21] N. Ridgway,et al. CTP:phosphocholine cytidylyltransferase: Function, regulation, and structure of an amphitropic enzyme required for membrane biogenesis. , 2015, Progress in lipid research.
[22] Haitao Guo,et al. Inflammasomes: mechanism of action, role in disease, and therapeutics , 2015, Nature Medicine.
[23] M. Habeck,et al. Stimulation, Inhibition, or Stabilization of Na,K-ATPase Caused by Specific Lipid Interactions at Distinct Sites , 2014, The Journal of Biological Chemistry.
[24] S. Legrand-Poels,et al. Free fatty acids as modulators of the NLRP3 inflammasome in obesity/type 2 diabetes. , 2014, Biochemical pharmacology.
[25] M. Schulze,et al. Erythrocyte membrane fatty acid fluidity and risk of type 2 diabetes in the EPIC-Potsdam study , 2014, Diabetologia.
[26] S. Akira,et al. Cytosolic Double-Stranded RNA Activates the NLRP3 Inflammasome via MAVS-Induced Membrane Permeabilization and K+ Efflux , 2014, The Journal of Immunology.
[27] Albert Koulman,et al. Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study , 2014, The lancet. Diabetes & endocrinology.
[28] S. Legrand-Poels,et al. Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. , 2014, Diabetes research and clinical practice.
[29] R. Coleman,et al. Acyl-CoA metabolism and partitioning. , 2014, Annual review of nutrition.
[30] T. Horng. Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome. , 2014, Trends in immunology.
[31] N. Ferreirós,et al. Inhibition of macrophage fatty acid β-oxidation exacerbates palmitate-induced inflammatory and endoplasmic reticulum stress responses , 2014, Diabetologia.
[32] Andrés Miranda-Merchak,et al. Modulation of (Na,K)-ATPase activity by membrane fatty acid composition: therapeutic implications in human hypertension , 2014, Clinical and experimental hypertension.
[33] L. Riva,et al. Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages[S] , 2013, Journal of Lipid Research.
[34] S. Legrand-Poels,et al. Obesity phenotype is related to NLRP3 inflammasome activity and immunological profile of visceral adipose tissue , 2013, Diabetologia.
[35] G. Núñez,et al. K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. , 2013, Immunity.
[36] M. Donath,et al. Inflammation in obesity and diabetes: islet dysfunction and therapeutic opportunity. , 2013, Cell metabolism.
[37] A. J. Hulbert,et al. Fatty acid composition of membrane bilayers: importance of diet polyunsaturated fat balance. , 2012, Biochimica et biophysica acta.
[38] D. Philpott,et al. Downregulation of the Na/K-ATPase Pump by Leptospiral Glycolipoprotein Activates the NLRP3 Inflammasome , 2012, The Journal of Immunology.
[39] Denis Gris,et al. Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling , 2011, Nature Immunology.
[40] E. Ravussin,et al. The NALP3/NLRP3 Inflammasome Instigates Obesity-Induced Autoinflammation and Insulin Resistance , 2010, Nature Medicine.
[41] Sebastian Munck,et al. De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation. , 2010, Cancer research.
[42] J. Girard,et al. Increased Mitochondrial Fatty Acid Oxidation Is Sufficient to Protect Skeletal Muscle Cells from Palmitate-induced Apoptosis* , 2010, The Journal of Biological Chemistry.
[43] J. Tschopp,et al. The Inflammasomes , 2010, Cell.
[44] D. Lingwood,et al. Order of lipid phases in model and plasma membranes , 2009, Proceedings of the National Academy of Sciences.
[45] F. Tinahones,et al. Changes in the Serum Composition of Free‐fatty Acids During an Intravenous Glucose Tolerance Test , 2009, Obesity.
[46] R. Rodrigo,et al. Relationship between (Na + K)-ATPase activity, lipid peroxidation and fatty acid profile in erythrocytes of hypertensive and normotensive subjects , 2007, Molecular and Cellular Biochemistry.
[47] M. F. Polat,et al. Effects of type 2 diabetes mellitus on plasma fatty acid composition and cholesterol content of erythrocyte and leukocyte membranes , 2006, Acta Diabetologica.
[48] Y. Le Marchand-Brustel,et al. Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression. , 2007, Endocrinology.
[49] S. Grundy,et al. The metabolic syndrome , 2003, The Lancet.
[50] Gerd Schmitz,et al. High-throughput quantification of phosphatidylcholine and sphingomyelin by electrospray ionization tandem mass spectrometry coupled with isotope correction algorithm. , 2004, Biochimica et biophysica acta.
[51] J. Freed,et al. Enrichment of Endoplasmic Reticulum with Cholesterol Inhibits Sarcoplasmic-Endoplasmic Reticulum Calcium ATPase-2b Activity in Parallel with Increased Order of Membrane Lipids , 2004, Journal of Biological Chemistry.
[52] M. Jensen. Fate of fatty acids at rest and during exercise: regulatory mechanisms. , 2003, Acta physiologica Scandinavica.
[53] A. Mokdad,et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. , 2003, JAMA.
[54] B. Vessby,et al. Fatty acid composition of skeletal muscle reflects dietary fat composition in humans. , 2002, The American journal of clinical nutrition.
[55] H. Joller-jemelka,et al. Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. , 2002, The Journal of clinical investigation.
[56] Thomas D. Schmittgen,et al. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.
[57] S. Kersten. Mechanisms of nutritional and hormonal regulation of lipogenesis , 2001, EMBO reports.
[58] I. Johnson,et al. Effects of Dietary Fish Oil Supplementation on the Phospholipid Composition and Fluidity of Cell Membranes from Human Volunteers , 1999, Annals of Nutrition and Metabolism.
[59] P. Clifton,et al. Relationship between plasma insulin and erythrocyte fatty acid composition. , 1998, Prostaglandins, leukotrienes, and essential fatty acids.
[60] D. Chisholm,et al. The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids. , 1993, The New England journal of medicine.