CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer

[1]  C. Reis e Sousa,et al.  The Role of Type 1 Conventional Dendritic Cells in Cancer Immunity , 2018, Trends in cancer.

[2]  M. Cattral,et al.  Tumor Dendritic Cells (DCs) Derived from Precursors of Conventional DCs Are Dispensable for Intratumor CTL Responses , 2018, The Journal of Immunology.

[3]  Laura G. Dubois,et al.  The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells , 2017, Nature Communications.

[4]  H. Nakaya,et al.  Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration , 2017, Cell Death and Disease.

[5]  A. Edelman,et al.  Akt activation by Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) in ovarian cancer cells , 2017, The Journal of Biological Chemistry.

[6]  Daniel M. Corey,et al.  PD-1 expression by tumor-associated macrophages inhibits phagocytosis and tumor immunity , 2017, Nature.

[7]  E. Martinelli,et al.  3D Microfluidic model for evaluating immunotherapy efficacy by tracking dendritic cell behaviour toward tumor cells , 2017, Scientific Reports.

[8]  D. Gabrilovich,et al.  Dendritic cells in cancer: the role revisited. , 2017, Current opinion in immunology.

[9]  L. Boon,et al.  The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity , 2016, Nature Communications.

[10]  A. Means,et al.  The Ca2+/Calmodulin/CaMKK2 Axis: Nature's Metabolic CaMshaft , 2016, Trends in Endocrinology & Metabolism.

[11]  Tao Zhang,et al.  Tumor-infiltrating lymphocytes in breast cancer predict the response to chemotherapy and survival outcome: A meta-analysis , 2016, Oncotarget.

[12]  M. Rantalainen,et al.  Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis. , 2016, Cell reports.

[13]  L. Que,et al.  A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues , 2016, PloS one.

[14]  E. Mohit,et al.  Antitumor Effect of IP-10 by Using Two Different Approaches: Live Delivery System and Gene Therapy , 2016, Journal of breast cancer.

[15]  E. Yeh,et al.  Tumor-associated macrophages: unwitting accomplices in breast cancer malignancy , 2016, npj Breast Cancer.

[16]  K. Moore,et al.  MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis. , 2015, The Journal of clinical investigation.

[17]  Z. Guo,et al.  CXCL11-Armed oncolytic poxvirus elicits potent antitumor immunity and shows enhanced therapeutic efficacy , 2015, Oncoimmunology.

[18]  Kathleen R. Cho,et al.  Epigenetic silencing of Th1 type chemokines shapes tumor immunity and immunotherapy , 2015, Nature.

[19]  S. Ugel,et al.  Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages. , 2015, The Journal of clinical investigation.

[20]  K. Rajapakshe,et al.  The camKK2/camKIV relay is an essential regulator of hepatic cancer , 2015, Hepatology.

[21]  K. Odunsi,et al.  Non-redundant Requirement for CXCR3 Signaling during Tumoricidal T Cell Trafficking across Tumor Vascular Checkpoints , 2015, Nature Communications.

[22]  Ash A. Alizadeh,et al.  Robust enumeration of cell subsets from tissue expression profiles , 2015, Nature Methods.

[23]  J. Suttles,et al.  Deficiency of AMPK in CD8+ T cells suppresses their anti-tumor function by inducing protein phosphatase-mediated cell death , 2015, Oncotarget.

[24]  Nandini A. Sahasrabuddhe,et al.  Calcium calmodulin dependent kinase kinase 2 - a novel therapeutic target for gastric adenocarcinoma , 2015, Cancer biology & therapy.

[25]  J. Suttles,et al.  Adenosine 5′-Monophosphate–Activated Protein Kinase Regulates IL-10–Mediated Anti-Inflammatory Signaling Pathways in Macrophages , 2015, The Journal of Immunology.

[26]  Vivien W. Chan,et al.  Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells. , 2014, Cancer cell.

[27]  Jeffrey W Pollard,et al.  Tumor-associated macrophages: from mechanisms to therapy. , 2014, Immunity.

[28]  Will Liao,et al.  The cellular and molecular origin of tumor-associated macrophages , 2014, Science.

[29]  B. Viollet,et al.  AMPKα1 deficiency amplifies proinflammatory myeloid APC activity and CD40 signaling , 2013, Journal of leukocyte biology.

[30]  Jeff S. Jasper,et al.  27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology , 2013, Science.

[31]  K. Schäkel,et al.  Low-dose irradiation programs macrophage differentiation to an iNOS⁺/M1 phenotype that orchestrates effective T cell immunotherapy. , 2013, Cancer cell.

[32]  B. Viollet,et al.  AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration. , 2013, Cell metabolism.

[33]  L. Racioppi CaMKK2: a novel target for shaping the androgen-regulated tumor ecosystem. , 2013, Trends in molecular medicine.

[34]  Karin Jirström,et al.  The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients , 2012, BMC Cancer.

[35]  A. Means,et al.  Calcium/Calmodulin-dependent Protein Kinase Kinase 2: Roles in Signaling and Pathophysiology* , 2012, The Journal of Biological Chemistry.

[36]  A. Means,et al.  Calcium/Calmodulin-dependent Protein Kinase Kinase 2 Regulates Macrophage-mediated Inflammatory Responses* , 2012, The Journal of Biological Chemistry.

[37]  Daniel G. Anderson,et al.  Origins of tumor-associated macrophages and neutrophils , 2012, Proceedings of the National Academy of Sciences.

[38]  A. Means,et al.  Characterization of the CaMKKβ-AMPK signaling complex. , 2011, Cellular signalling.

[39]  B. Kemp,et al.  Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity. , 2011, The Journal of clinical investigation.

[40]  I. Ellis,et al.  Tumour-infiltrating macrophages and clinical outcome in breast cancer , 2011, Journal of Clinical Pathology.

[41]  A. Means,et al.  A cell‐intrinsic role for CaMKK2 in granulocyte lineage commitment and differentiation , 2011, Journal of leukocyte biology.

[42]  Jinyan Wang,et al.  Transition of tumor-associated macrophages from MHC class IIhi to MHC class IIlow mediates tumor progression in mice , 2011, BMC Immunology.

[43]  I. Mills,et al.  The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis , 2011, The EMBO journal.

[44]  Karin Jirström,et al.  Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. , 2011, Cancer discovery.

[45]  R. Schreiber,et al.  Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion , 2011, Science.

[46]  A. Means,et al.  CaM kinase kinase beta-mediated activation of the growth regulatory kinase AMPK is required for androgen-dependent migration of prostate cancer cells. , 2011, Cancer research.

[47]  Z. Szallasi,et al.  An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients , 2010, Breast Cancer Research and Treatment.

[48]  Wei Xu,et al.  Integrating individual functional moieties of CXCL10 and CXCL11 into a novel chimeric chemokine leads to synergistic antitumor effects: a strategy for chemokine-based multi-target-directed cancer therapy , 2010, Cancer Immunology, Immunotherapy.

[49]  P. De Baetselier,et al.  Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes. , 2010, Cancer research.

[50]  Zhenggang Yang,et al.  Macrophage α1 AMP-activated Protein Kinase (α1AMPK) Antagonizes Fatty Acid-induced Inflammation through SIRT1* , 2010, The Journal of Biological Chemistry.

[51]  Jeffrey W. Pollard,et al.  Macrophage Diversity Enhances Tumor Progression and Metastasis , 2010, Cell.

[52]  P. Allavena,et al.  Tumor‐associated macrophages (TAM) as major players of the cancer‐related inflammation , 2009, Journal of leukocyte biology.

[53]  Michael I Hanzly,et al.  Antitumor/antiestrogenic effect of the chemokine interferon inducible protein 10 (IP-10) involves suppression of VEGF expression in mammary tissue. , 2009, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[54]  J. Suttles,et al.  Adenosine 5′-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype1 , 2008, The Journal of Immunology.

[55]  A. Means,et al.  Calcium/calmodulin-dependent kinase IV in immune and inflammatory responses: novel routes for an ancient traveller. , 2008, Trends in immunology.

[56]  A. Cerwenka,et al.  Natural killer cell accumulation in tumors is dependent on IFN-gamma and CXCR3 ligands. , 2008, Cancer research.

[57]  A. Means,et al.  Hypothalamic CaMKK2 contributes to the regulation of energy balance. , 2008, Cell metabolism.

[58]  Anna Maria Masci,et al.  Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells. , 2008, Blood.

[59]  F. Schmidt Meta-Analysis , 2008 .

[60]  J. Geradts,et al.  Expression characteristics of prostate-derived Ets factor support a role in breast and prostate cancer progression. , 2007, Human pathology.

[61]  F. Robert,et al.  Nuclear receptor ERR alpha and coactivator PGC-1 beta are effectors of IFN-gamma-induced host defense. , 2007, Genes & development.

[62]  W. Berger,et al.  Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer , 2007, Breast Cancer Research and Treatment.

[63]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[64]  Shiaoching Gong,et al.  A gene expression atlas of the central nervous system based on bacterial artificial chromosomes , 2003, Nature.

[65]  A. Means,et al.  Defective Signaling in a Subpopulation of CD4+ T Cells in the Absence of Ca2+/Calmodulin-Dependent Protein Kinase IV , 2002, Molecular and Cellular Biology.

[66]  R. Steinman,et al.  Isolation of Dendritic Cells , 1998, Current protocols in immunology.

[67]  A. Harris,et al.  Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. , 1996, Cancer research.

[68]  R. Cardiff,et al.  Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease , 1992, Molecular and cellular biology.

[69]  C. Stock,et al.  Studies in a tumor spectrum. I. Comparison of the action of methylbis(2‐chloroethyl)amine and 3‐bis(2‐chloroethyl)aminomethyl‐4‐methoxymethyl‐5‐hydroxy‐6‐methylpyridine on the growth of a variety of mouse and rat tumors , 1952, Cancer.

[70]  A. Means,et al.  Physiological roles of the Ca2+/CaM-dependent protein kinase cascade in health and disease. , 2007, Sub-cellular biochemistry.