Global levels of H3K27me3 track with differentiation in vivo and are deregulated by MYC in prostate cancer.

[1]  Yong Jiang,et al.  Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27) , 2012, Proceedings of the National Academy of Sciences.

[2]  J. Maciejewski,et al.  Polycomb segment myeloid malignancies. , 2012, Blood.

[3]  R. Büttner,et al.  Global histone H3 lysine 27 (H3K27) methylation levels and their prognostic relevance in renal cell carcinoma , 2012, BJU international.

[4]  A. D. De Marzo,et al.  Myc Enforces Overexpression of EZH2 in Early Prostatic Neoplasia via Transcriptional and Post-transcriptional Mechanisms , 2011, Oncotarget.

[5]  S. McDade,et al.  Evidence for Alteration of EZH2, BMI1, and KDM6A and Epigenetic Reprogramming in Human Papillomavirus Type 16 E6/E7-Expressing Keratinocytes , 2011, Journal of Virology.

[6]  C. Iacobuzio-Donahue,et al.  Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers , 2011, Oncotarget.

[7]  K. Zeller,et al.  Alterations in nucleolar structure and gene expression programs in prostatic neoplasia are driven by the MYC oncogene. , 2011, The American journal of pathology.

[8]  A. Chase,et al.  Aberrations of EZH2 in Cancer , 2011, Clinical Cancer Research.

[9]  C. Bieberich,et al.  Prostate cancer: New answers prompt new questions regarding cell of origin , 2010, Nature Reviews Urology.

[10]  Stuart H. Orkin,et al.  A Myc Network Accounts for Similarities between Embryonic Stem and Cancer Cell Transcription Programs , 2010, Cell.

[11]  M. Diehn,et al.  The Myc Connection: ES Cells and Cancer , 2010, Cell.

[12]  R. Kuiper,et al.  Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes , 2010, Nature Genetics.

[13]  Jiaoti Huang,et al.  Identification of a Cell of Origin for Human Prostate Cancer , 2010, Science.

[14]  C. Bieberich,et al.  MYC and Prostate Cancer. , 2010, Genes & cancer.

[15]  S. Murray,et al.  myc maintains embryonic stem cell pluripotency and self-renewal. , 2010, Differentiation; research in biological diversity.

[16]  C. Bieberich,et al.  MYC Overexpression Induces Prostatic Intraepithelial Neoplasia and Loss of Nkx3.1 in Mouse Luminal Epithelial Cells , 2010, PloS one.

[17]  J. Licht,et al.  Deregulation of H3K27 methylation in cancer , 2010, Nature Genetics.

[18]  S. Memarzadeh,et al.  Basal epithelial stem cells are efficient targets for prostate cancer initiation , 2010, Proceedings of the National Academy of Sciences.

[19]  M. Rubin,et al.  Human Prostate Sphere-Forming Cells Represent a Subset of Basal Epithelial Cells Capable of Glandular Regeneration in Vivo , 2009, The Prostate.

[20]  P. Knoepfler,et al.  Acting locally and globally: Myc's ever-expanding roles on chromatin. , 2009, Cancer research.

[21]  Lily Wu,et al.  Polycomb Group Protein Enhancer of Zeste 2 Is an Oncogene That Promotes the Neoplastic Transformation of a Benign Prostatic Epithelial Cell Line , 2009, Molecular Cancer Research.

[22]  M. Shen,et al.  A luminal epithelial stem cell that is a cell of origin for prostate cancer , 2009, Nature.

[23]  L. Penn,et al.  Reflecting on 25 years with MYC , 2008, Nature Reviews Cancer.

[24]  P. Farnham,et al.  N-Myc regulates a widespread euchromatic program in the human genome partially independent of its role as a classical transcription factor. , 2008, Cancer research.

[25]  E. Guccione,et al.  Analysis of Myc-Induced Histone Modifications on Target Chromatin , 2008, PloS one.

[26]  Jun Luo,et al.  Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis , 2008, Modern Pathology.

[27]  Gordon B Mills,et al.  Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers , 2008, Molecular carcinogenesis.

[28]  Howard Y. Chang,et al.  Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3. , 2008, Genes & development.

[29]  Eran Segal,et al.  Module map of stem cell genes guides creation of epithelial cancer stem cells. , 2008, Cell stem cell.

[30]  R. Young,et al.  Stem Cells, the Molecular Circuitry of Pluripotency and Nuclear Reprogramming , 2008, Cell.

[31]  T. Ichisaka,et al.  Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors , 2007, Cell.

[32]  T. Graf.  Faculty Opinions recommendation of Induction of pluripotent stem cells from adult human fibroblasts by defined factors. , 2007 .

[33]  Jing Liang,et al.  Integration of Estrogen and Wnt Signaling Circuits by the Polycomb Group Protein EZH2 in Breast Cancer Cells , 2007, Molecular and Cellular Biology.

[34]  F. Hamdy,et al.  EZH2 promotes proliferation and invasiveness of prostate cancer cells , 2007, The Prostate.

[35]  Jianfeng Xu,et al.  Inflammation in prostate carcinogenesis , 2007, Nature Reviews Cancer.

[36]  Philip R. Gafken,et al.  Myc influences global chromatin structure , 2006, The EMBO journal.

[37]  S. Horvath,et al.  Global histone modification patterns predict risk of prostate cancer recurrence , 2005, Nature.

[38]  S. Dalton,et al.  LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism , 2005, Development.

[39]  Daniele Zink,et al.  Nuclear structure in cancer cells , 2004, Nature Reviews Cancer.

[40]  Debashis Ghosh,et al.  EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[41]  T. Graeber,et al.  Myc-driven murine prostate cancer shares molecular features with human prostate tumors. , 2003, Cancer cell.

[42]  S. Dhanasekaran,et al.  The polycomb group protein EZH2 is involved in progression of prostate cancer , 2002, Nature.

[43]  D. Bostwick,et al.  Molecular biology of prostatic intraepithelial neoplasia , 1996, The Prostate.

[44]  D. Bostwick,et al.  Interobserver variability in the diagnosis of high-grade prostatic intraepithelial neoplasia and adenocarcinoma. , 1996, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

[45]  D. Hanahan,et al.  Regulation of Myc and Mad during epidermal differentiation and HPV-associated tumorigenesis. , 1995, Oncogene.

[46]  Fred H. Gage,et al.  BRCA1 tumor suppression occurs via heterochromatin mediated silencing , 2011, Nature.

[47]  M. Ramalho-Santos,et al.  Open chromatin in pluripotency and reprogramming , 2010, Nature Reviews Molecular Cell Biology.

[48]  S. Baylin,et al.  Role of nuclear architecture in epigenetic alterations in cancer. , 2010, Cold Spring Harbor symposia on quantitative biology.

[49]  Hans Clevers,et al.  The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. , 2002, Cell.