Bioactive Sesquiterpenoids and Diterpenoids from the Liverwort Bazzania albifolia

One undescribed 6,7‐secofusicoccane‐type diterpene, albifolione (1), and one new aromadendrane‐type sesquiterpenoid ketone, methyl 2‐oxoaromadendra‐1(10),3‐dien‐12‐oate (2), along with four known compounds, δ‐cuparenol (3), fusicoauritone (4), chiloscyphenols A and B (5 and 6, resp.), were isolated from the liverwort Bazzania albifolia Horik. The structures and relative configurations of 1 and 2 were established unequivocally on the basis of spectroscopic data analysis. Preliminary bioassay revealed that compound 5 showed quite strong cytotoxicity against the human tumor cell line MCF‐7, with an IC50 value of 5.6 μM.

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