Smokeless tobacco topography and toxin exposure.

This study examined the relationship between oral smokeless tobacco (ST) topographical measures and biomarkers of tobacco and carcinogen exposure. During 2 weeks of baseline ad libitum ST use, 54 male participants (mean age=32.1+/-7.5 years) were required to record the time each dip was placed in and removed from their mouths. Urine samples were collected twice during baseline and analyzed for nicotine, cotinine, and their glucuronides (total nicotine and total cotinine) and for metabolites of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides (total NNAL). The results suggest that frequency and duration measures of ST use (p<.01 to p<.001), particularly total dip duration, are significantly correlated with total cotinine, total nicotine, and total NNAL. These results suggest that how long a ST user has tobacco in his mouth is most predictive of tobacco toxin exposure.

[1]  B. Grant,et al.  Patterns of DSM-IV alcohol abuse and dependence criteria among adolescents and adults: results from the 2001 National Household Survey on Drug Abuse. , 2005, Alcoholism, clinical and experimental research.

[2]  Laura Kann,et al.  Youth risk behavior surveillance--United States, 2003. , 2004, Morbidity and mortality weekly report. Surveillance summaries.

[3]  Connie Lim,et al.  Youth Risk Behavior Surveillance--United States, 2009. Morbidity and Mortality Weekly Report. Surveillance Summaries. Volume 59, Number SS-5. , 2004 .

[4]  Dorothy K Hatsukami,et al.  Smokeless tobacco use: harm reduction or induction approach? , 2004, Preventive medicine.

[5]  D. Hatsukami,et al.  Situational factors and patterns associated with smokeless tobacco use , 1991, Journal of Behavioral Medicine.

[6]  D. Hatsukami,et al.  Topographical features of smokeless tobacco use , 1988, Psychopharmacology.

[7]  S. Hecht,et al.  Analysis of total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human urine. , 2003, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[8]  D. Hatsukami,et al.  Preliminary study on reducing oral moist snuff use. , 2003, Drug and alcohol dependence.

[9]  E. Weiderpass,et al.  Smokeless tobacco: harm reduction or nicotine overload? , 2003, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

[10]  S. Hecht,et al.  Human urinary carcinogen metabolites: biomarkers for investigating tobacco and cancer. , 2002, Carcinogenesis.

[11]  D. Hatsukami,et al.  Quantitation of metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone after cessation of smokeless tobacco use. , 2002, Cancer research.

[12]  D. Hatsukami,et al.  Quantitation of urinary metabolites of a tobacco-specific lung carcinogen after smoking cessation. , 1999, Cancer research.

[13]  S. Hecht,et al.  Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines. , 1998, Chemical research in toxicology.

[14]  Tobacco,et al.  Nicotine safety and toxicity , 1998 .

[15]  S. Hecht,et al.  Metabolites of a tobacco-specific nitrosamine, 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone (NNK), in the urine of smokeless tobacco users: relationship between urinary biomarkers and oral leukoplakia. , 1996, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[16]  G. Connolly,et al.  Five leading U.S. commercial brands of moist snuff in 1994: assessment of carcinogenic N-nitrosamines. , 1995, Journal of the National Cancer Institute.

[17]  V. Stevens,et al.  The inside scoop on the stuff called snuff: an interview study of 94 adult male smokeless tobacco users. , 1990, Journal of substance abuse.

[18]  D Hoffmann,et al.  The relevance of tobacco-specific nitrosamines to human cancer. , 1989, Cancer surveys.

[19]  S. Hecht,et al.  Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke. , 1988, Carcinogenesis.

[20]  D. Hatsukami,et al.  Physiologic and subjective changes from smokeless tobacco withdrawal , 1987, Clinical pharmacology and therapeutics.

[21]  W. Blot,et al.  Health consequences of using smokeless tobacco: summary of the Advisory Committee's report to the Surgeon General. , 1986, Public health reports.

[22]  Tobacco habits other than smoking; betel-quid and areca-nut chewing; and some related nitrosamines. IARC Working Group. Lyon, 23-30 October 1984. , 1985, IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans.

[23]  P. Udani,et al.  Morbidity and mortality. , 1962, The Indian journal of child health.