Loneliness, social network size, and immune response to influenza vaccination in college freshmen.

Antibody response to the influenza immunization was investigated in 83 1st-semester healthy university freshmen. Elevated levels of loneliness throughout the semester and small social networks were independently associated with poorer antibody response to 1 component of the vaccine. Those with both high levels of loneliness and a small social network had the lowest antibody response. Loneliness was also associated with greater psychological stress and negative affect, less positive affect, poorer sleep efficiency and quality, and elevations in circulating levels of cortisol. However, only the stress data were consistent with mediation of the loneliness-antibody response relation. None of these variables were associated with social network size, and hence none were potential mediators of the relation between network size and immunization response.

[1]  M. Rosenberg.  Society and the adolescent self-image , 1966 .

[2]  J. Douglas.  The social meanings of suicide , 1968 .

[3]  R. Weiss,et al.  Loneliness: The Experience of Emotional and Social Isolation. , 1975 .

[4]  W. F. Gross,et al.  Loneliness and Locus of Control for Alcoholic Males: Validity Against Murray Need and Cattell Trait Dimensions. , 1976 .

[5]  W. Gove,et al.  Overcrowding isolation and human behavior: exploring the extremes in population distribution. , 1978 .

[6]  L. Berkman,et al.  Social networks, host resistance, and mortality: a nine-year follow-up study of Alameda County residents. , 1979, American journal of epidemiology.

[7]  Isolation, desolation and loneliness , 1980 .

[8]  D. Trout,et al.  The role of social isolation in suicide. , 1980, Suicide & life-threatening behavior.

[9]  D. Russell,et al.  The revised UCLA Loneliness Scale: concurrent and discriminant validity evidence. , 1980, Journal of personality and social psychology.

[10]  D. Mellström,et al.  Loneliness in the Swedish aged. , 1981, Journal of gerontology.

[11]  P. Gunby.  The Anatomy of Loneliness , 1981 .

[12]  Personal Relationships in Disorder , 1981 .

[13]  C E Speicher,et al.  Urinary Cortisol Levels, Cellular Immunocompetency, and Loneliness in Psychiatric Inpatients , 1984, Psychosomatic medicine.

[14]  Letitia Anne Peplau,et al.  Loneliness: A Sourcebook of Current Theory, Research and Therapy. , 1984 .

[15]  J. Kiecolt-Glaser,et al.  Psychosocial Modifiers of Immunocompetence in Medical Students , 1984, Psychosomatic medicine.

[16]  K. Rook.  Research on social support, loneliness, and social isolation: Toward an integration. , 1984 .

[17]  I. Levin,et al.  An examination of the relation of individual difference variables to loneliness. , 1986, Journal of personality.

[18]  D. A. Kenny,et al.  The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. , 1986, Journal of personality and social psychology.

[19]  H Akiyama,et al.  Social networks in adult life and a preliminary examination of the convoy model. , 1987, Journal of gerontology.

[20]  P. Östergren,et al.  Different social network and social support characteristics, nervous problems and insomnia: theoretical and methodological aspects on some results from the population study 'men born in 1914', Malmö, Sweden. , 1987, Social science & medicine.

[21]  Sheldon Cohen,et al.  Psychosocial models of the role of social support in the etiology of physical disease. , 1988, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[22]  J. House,et al.  Social relationships and health. , 1988, Science.

[23]  H. Thomas,et al.  Role of support networks in maintenance of improved cardiovascular health status. , 1989, Social science & medicine.

[24]  Daniel J Buysse,et al.  The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research , 1989, Psychiatry Research.

[25]  R B Williams,et al.  The Cook‐Medley hostility scale: item content and ability to predict survival. , 1989, Psychosomatic medicine.

[26]  P. Reynolds,et al.  Social connections and risk for cancer: prospective evidence from the Alameda County Study. , 1990, Behavioral medicine.

[27]  W. Malarkey,et al.  Stress‐induced modulation of the immune response to recombinant hepatitis B vaccine. , 1992, Psychosomatic medicine.

[28]  L. R. Goldberg.  THE DEVELOPMENT OF MARKERS FOR THE BIG-FIVE FACTOR STRUCTURE , 1992 .

[29]  A. Yarcheski,et al.  Health consequences of loneliness in adolescents. , 1993, Research in nursing & health.

[30]  R S Paffenbarger,et al.  Measurement of physical activity to assess health effects in free-living populations. , 1993, Medicine and science in sports and exercise.

[31]  V. Vaccarino,et al.  Gender differences in cardiovascular morbidity and mortality: The contribution of social networks and support. , 1993 .

[32]  A. Vingerhoets,et al.  Influence of perceived psychological stress and distress on antibody response to low dose rDNA hepatitis B vaccine. , 1993, Journal of psychosomatic research.

[33]  S. Shiffman,et al.  Ecological Momentary Assessment (Ema) in Behavioral Medicine , 1994 .

[34]  D L Patrick,et al.  Screening for depression in well older adults: evaluation of a short form of the CES-D (Center for Epidemiologic Studies Depression Scale). , 1994, American journal of preventive medicine.

[35]  D. Russell.  UCLA Loneliness Scale (Version 3): reliability, validity, and factor structure. , 1996, Journal of personality assessment.

[36]  Shelley E. Taylor,et al.  Social relationships and immune processes in HIV seropositive gay and bisexual men , 1997, Annals of behavioral medicine : a publication of the Society of Behavioral Medicine.

[37]  W. Edmunds,et al.  Social ties and susceptibility to the common cold , 1998, JAMA.

[38]  J. M. Lipton,et al.  Neuroimmunomodulation : molecular aspects, integrative systems, and clinical advances , 1998 .

[39]  S. Maier,et al.  Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition. , 1998, Psychological review.

[40]  J. Sheridan,et al.  The Influence of Psychological Stress on the Immune Response to Vaccines a , 1998, Annals of the New York Academy of Sciences.

[41]  I. Wiklund,et al.  The feeling of loneliness prior to coronary artery bypass grafting might be a predictor of short-and long-term postoperative mortality. , 1998, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[42]  W. Doyle,et al.  The impact of personality on the reporting of unfounded symptoms and illness. , 1999, Journal of personality and social psychology.

[43]  J. Chibnall,et al.  Chronic stress in elderly carers of dementia patients and influenza vaccine , 1999, The Lancet.

[44]  Sheldon Cohen,et al.  Personality and Tonic Cardiovascular, Neuroendocrine, and Immune Parameters , 1999, Brain, Behavior, and Immunity.

[45]  L W Poon,et al.  A model of loneliness in older adults. , 1999, The journals of gerontology. Series B, Psychological sciences and social sciences.

[46]  K. Vedhara,et al.  Chronic stress in elderly carers of dementia patients and antibody response to influenza vaccination , 1999, The Lancet.

[47]  J A Hobson,et al.  Lonely traits and concomitant physiological processes: the MacArthur social neuroscience studies. , 2000, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[48]  E. Fano,et al.  Social behavior, cortisol, and sIgA levels in preschool children. , 2001, Journal of psychosomatic research.

[49]  Sheldon Cohen,et al.  Psychological Stress and Antibody Response to Immunization: A Critical Review of the Human Literature , 2001, Psychosomatic medicine.

[50]  D. Gold,et al.  Disability as a function of social networks and support in elderly African Americans and Whites: the Duke EPESE 1986--1992. , 2001, The journals of gerontology. Series B, Psychological sciences and social sciences.

[51]  S. Manuck,et al.  Associations between stress, trait negative affect, acute immune reactivity, and antibody response to hepatitis B injection in healthy young adults. , 2001, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[52]  K. Rook,et al.  Loneliness, lack of emotional support, lack of companionship, and the likelihood of having a heart condition in an elderly sample , 2002, Annals of behavioral medicine : a publication of the Society of Behavioral Medicine.

[53]  D. Birx,et al.  Cellular immune assays for evaluation of vaccine efficacy in developing countries , 2002 .

[54]  C. Ring,et al.  Stress, Coping, and Hepatitis B Antibody Status , 2002, Psychosomatic medicine.

[55]  L. Hawkley,et al.  Loneliness and Health: Potential Mechanisms , 2002, Psychosomatic medicine.

[56]  Noel R. Rose,et al.  Manual of clinical laboratory immunology , 2002 .

[57]  C. Ring,et al.  Perceived Stress and Psychological Well-Being Are Associated With Antibody Status After Meningitis C Conjugate Vaccination , 2002, Psychosomatic medicine.

[58]  John T. Cacioppo,et al.  Do Lonely Days Invade the Nights? Potential Social Modulation of Sleep Efficiency , 2002, Psychological science.

[59]  Douglas Carroll,et al.  Life events, perceived stress and antibody response to influenza vaccination in young, healthy adults. , 2003, Journal of psychosomatic research.

[60]  B. Penninx,et al.  The influence of differing social ties on decline in physical functioning among older people with and without chronic diseases: The Longitudinal Aging Study Amsterdam , 2003, Aging clinical and experimental research.

[61]  Sheldon Cohen,et al.  Sociability and Susceptibility to the Common Cold , 2003, Psychological science.

[62]  William J Doyle,et al.  Emotional Style and Susceptibility to the Common Cold , 2003, Psychosomatic medicine.

[63]  Louise C Hawkley,et al.  Loneliness and pathways to disease , 2003, Brain, Behavior, and Immunity.

[64]  Ronald Glaser,et al.  Stress, loneliness, and changes in herpesvirus latency , 1985, Journal of Behavioral Medicine.

[65]  John J. Treanor,et al.  Psychological Stress and Antibody Response to Influenza Vaccination: When Is the Critical Period for Stress, and How Does It Get Inside the Body? , 2004, Psychosomatic medicine.