Cancer risk evaluation of brick kiln workers exposed to dust bound PAHs in Punjab province (Pakistan).

Principal objective of this study was to evaluate the health risks of brick kiln workers to dust bound PAHs exposure in Punjab province (Pakistan). To this aim, surface dust samples were collected from brick kiln units located in Chung Khurd (Lahore city), Gujranwala city and Sohra village (in the vicinity of Gujranwala). The highest ΣPAH levels were measured in the dust samples collected in Sohdra village (mean 2578 ng g(-1) d.w., range 302-6757 ng g(-1) d.w.) followed by Gujranwala city (mean 957, range 16.1-1963 ng g(-1) d.w.) and Chung Khurd (mean 882, range 692-1007 ng g(-1) d.w.). Source identification using diagnostic ratios and principal component analysis identified coal and wood combustion as the major PAHs sources. The cancer risk model (CR-Model 1) and the Incremental Lifetime Cancer Risk model (ILCR-Model 2) were used to evaluate the cancer risk assessment via ingestion, inhalation and dermal contact pathways. Both models suggested that brick kiln workers (including adults and children) were exposed to high-potential carcinogenic risk via both ingestion and dermal contact pathways during the brick making process. This study also emphasizes the need for pollution control in the brick kiln industry of Pakistan.

[1]  B. Mahler,et al.  Cancer risk from incidental ingestion exposures to PAHs associated with coal-tar-sealed pavement. , 2013, Environmental science & technology.

[2]  Qixing Zhou,et al.  Source, distribution, and health risk assessment of polycyclic aromatic hydrocarbons in urban street dust from Tianjin, China , 2014, Environmental Science and Pollution Research.

[3]  R. Burnett,et al.  Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. , 2002, JAMA.

[4]  M. Tobiszewski,et al.  PAH diagnostic ratios for the identification of pollution emission sources. , 2012, Environmental pollution.

[5]  Ranjeet S. Sokhi,et al.  Atmospheric polycyclic aromatic hydrocarbons: Source attribution, emission factors and regulation , 2008 .

[6]  T. D. Zaiacomo,et al.  Mutagenic activity of total and particle-sized fractions of urban particulate matter , 1996 .

[7]  Jiping Zhu,et al.  Mutagenic and carcinogenic hazards of settled house dust. I: Polycyclic aromatic hydrocarbon content and excess lifetime cancer risk from preschool exposure. , 2008, Environmental science & technology.

[8]  F. Prahl,et al.  Polycyclic aromatic hydrocarbon (PAH)-phase associations in Washington coastal sediment , 1983 .

[9]  Bonnie B. Potocki,et al.  Exposure to carcinogenic PAHs in the environment , 1992 .

[10]  Andrea Gambaro,et al.  Gas-particle concentration and distribution of n-alkanes and polycyclic aromatic hydrocarbons in the atmosphere of Prato (Italy). , 2007, Chemosphere.

[11]  Athanasios Katsoyiannis,et al.  PAH molecular diagnostic ratios applied to atmospheric sources: a critical evaluation using two decades of source inventory and air concentration data from the UK. , 2011, Environmental science & technology.

[12]  Aramandla Ramesh,et al.  Modulation of neurotoxic behavior in F-344 rats by temporal disposition of benzo(a)pyrene. , 2002, Toxicology letters.

[13]  Alessandra Cincinelli,et al.  Characterization of n-alkanes and PAHs in PM10 samples in Prato (Italy). , 2004, Annali di chimica.

[14]  P. Oleszczuk,et al.  Influence of Agricultural Land Use and Management on the Contents of Polycyclic Aromatic Hydrocarbons in Selected Silty Soils , 2007 .

[15]  Athanasios Katsoyiannis,et al.  One year intensive PM2.5 bound polycyclic aromatic hydrocarbons monitoring in the area of Tuscany, Italy. Concentrations, source understanding and implications. , 2012, Environmental pollution.

[16]  Wei Wang,et al.  Polycyclic aromatic hydrocarbons (PAHs) in urban surface dust of Guangzhou, China: Status, sources and human health risk assessment. , 2011, The Science of the total environment.

[17]  C. Marvin,et al.  Source apportionment of PAH in Hamilton Harbour suspended sediments: comparison of two factor analysis methods. , 2008, Environmental science & technology.

[18]  P. Koutrakis,et al.  Source apportionment of urban particulate aliphatic and polynuclear aromatic hydrocarbons (PAHs) using multivariate methods. , 2001, Environmental science & technology.

[19]  Ruben Gamboa,et al.  Genotoxicity in child populations exposed to Polycyclic Aromatic Hydrocarbons (PAHs) in the air from Tabasco, Mexico , 2008, International journal of environmental research and public health.

[20]  Casimiro Pio,et al.  Size distribution of polycyclic aromatic hydrocarbons in a roadway tunnel in Lisbon, Portugal. , 2011, Chemosphere.

[21]  Yang Bai,et al.  Polycyclic aromatic hydrocarbons in urban soils of Beijing: status, sources, distribution and potential risk. , 2011, Environmental pollution.

[22]  Hui Li,et al.  Cancer risk assessments of Hong Kong soils contaminated by polycyclic aromatic hydrocarbons. , 2013, Journal of hazardous materials.

[23]  Jianfu Zhao,et al.  Polycyclic aromatic hydrocarbons in the surface soil of Shanghai, China: Concentrations, distribution and sources , 2010 .

[24]  Peter Höppe,et al.  Health effects of particles in ambient air. , 2004, International journal of hygiene and environmental health.

[25]  B. Ostro,et al.  Fine Particulate Air Pollution and Mortality in Nine California Counties: Results from CALFINE , 2005, Environmental health perspectives.

[26]  Andrea Gambaro,et al.  Transport of gas-phase polycyclic aromatic hydrocarbons to the Venice lagoon. , 2004, Environmental science & technology.

[27]  B. Maliszewska-Kordybach,et al.  Polycyclic aromatic hydrocarbons in agricultural soils in Poland : preliminary proposals for criteria to evaluate the level of soil contamination , 1996 .

[28]  Maria Rosaria Mannino,et al.  Polycyclic aromatic hydrocarbons (PAHs) in indoor dust matter of Palermo (Italy) area: Extraction, GC–MS analysis, distribution and sources , 2008 .

[29]  Bruce J Poitrast,et al.  Polynuclear Aromatic Hydrocarbons (PAH). , 1986 .

[30]  Chung-Min Liao,et al.  Health risk assessment on human exposed to environmental polycyclic aromatic hydrocarbons pollution sources. , 2006, The Science of the total environment.

[31]  Ruonan Wang,et al.  Occurrence and exposure evaluation of perchlorate in outdoor dust and soil in mainland China. , 2014, The Science of the total environment.

[32]  Athanasios Katsoyiannis,et al.  Model-based evaluation of the use of polycyclic aromatic hydrocarbons molecular diagnostic ratios as a source identification tool. , 2014, Environmental pollution.

[33]  Yuan Zhang,et al.  Polycyclic aromatic hydrocarbons (PAHs) in urban soils of the megacity Shanghai: occurrence, source apportionment and potential human health risk. , 2013, The Science of the total environment.

[34]  Tariq Masood,et al.  Hydrogen fluoride damage to vegetation from peri-urban brick kilns in Asia: a growing but unrecognised problem? , 2012, Environmental pollution.

[35]  Jan Topinka,et al.  Urinary 8-oxodeoxyguanosine levels in children exposed to air pollutants. , 2009, Mutation research.

[36]  Asaad Ahmed Nafees,et al.  Respiratory symptoms and illnesses among brick kiln workers: a cross sectional study from rural districts of Pakistan , 2012, BMC Public Health.

[37]  Cheng-Nan Chang,et al.  Characteristic of polycyclic aromatic hydrocarbon concentrations and source identification for fine and coarse particulates at Taichung Harbor near Taiwan Strait during 2004-2005. , 2006, The Science of the total environment.

[38]  A S Alaamer,et al.  Biomass fuel burning and its implications: deforestation and greenhouse gases emissions in Pakistan. , 2010, Environmental pollution.

[39]  Armin Keller,et al.  PAH and PCB in soils of Switzerland--status and critical review. , 2008, Journal of environmental monitoring : JEM.

[40]  Minghui Zheng,et al.  Distribution of polycyclic aromatic hydrocarbons in sediments from Yellow River Estuary and Yangtze River Estuary, China. , 2009, Journal of environmental sciences.

[41]  I. Nisbet,et al.  Toxic equivalency factors (TEFs) for polycyclic aromatic hydrocarbons (PAHs). , 1992, Regulatory toxicology and pharmacology : RTP.

[42]  D. Meza-Figueroa,et al.  Heavy metal distribution in dust from elementary schools in Hermosillo, Sonora, México , 2007 .

[43]  S. R. Wild,et al.  Polynuclear aromatic hydrocarbons in the United Kingdom environment: a preliminary source inventory and budget. , 1995, Environmental pollution.

[44]  G. Fang,et al.  Atmospheric polycyclic aromatic hydrocarbons (PAHs) in Asia: a review from 1999 to 2004. , 2006, Environmental pollution.

[45]  R. Macdonald,et al.  PAHs in the Fraser River basin: a critical appraisal of PAH ratios as indicators of PAH source and composition , 2002 .

[46]  H. Furumai,et al.  Size- and density-distributions and sources of polycyclic aromatic hydrocarbons in urban road dust. , 2005, Chemosphere.

[47]  Jun Wang,et al.  Concentrations, Source and Risk Assessment of Polycyclic Aromatic Hydrocarbons in Soils from Midway Atoll, North Pacific Ocean , 2014, PloS one.

[48]  P. Abrahams.  Soils: their implications to human health. , 2002, The Science of the total environment.

[49]  Joakim Pagels,et al.  Health effects of residential wood smoke particles: the importance of combustion conditions and physicochemical particle properties , 2009, Particle and Fibre Toxicology.