The FBMD-1 stroma cell line secretes a unique moiety which can increase retroviral transduction of lineage-committed and primitive human peripheral blood progenitor cells

[1]  B. Schiedlmeier,et al.  Human multidrug resistance-1 gene transfer to long-term repopulating human mobilized peripheral blood progenitor cells , 2000, Bone Marrow Transplantation.

[2]  D. Jackson,et al.  Heparan Sulfate Proteoglycan Isoforms of the CD44 Hyaluronan Receptor Induced in Human Inflammatory Macrophages Can Function as Paracrine Regulators of Fibroblast Growth Factor Action* , 2000, The Journal of Biological Chemistry.

[3]  C. Shih,et al.  A secreted and LIF-mediated stromal cell-derived activity that promotes ex vivo expansion of human hematopoietic stem cells. , 2000, Blood.

[4]  B. Schiedlmeier,et al.  Quantitative assessment of retroviral transfer of the human multidrug resistance 1 gene to human mobilized peripheral blood progenitor cells engrafted in nonobese diabetic/severe combined immunodeficient mice. , 2000, Blood.

[5]  Y. Hung,et al.  Improved retroviral transduction of hematopoietic progenitors by combining methods to enhance virus–cell interaction , 2000, Leukemia.

[6]  T. Oegema,et al.  Human LTC-IC can be maintained for at least 5 weeks in vitro when interleukin-3 and a single chemokine are combined with O-sulfated heparan sulfates: requirement for optimal binding interactions of heparan sulfate with early-acting cytokines and matrix proteins. , 2000, Blood.

[7]  P. V. van Hennik,et al.  Seeding efficiency of primitive human hematopoietic cells in nonobese diabetic/severe combined immune deficiency mice: implications for stem cell frequency assessment. , 1999, Blood.

[8]  J. Nolta,et al.  Molecular control of cell cycle progression in primary human hematopoietic stem cells: methods to increase levels of retroviral-mediated transduction , 1999, Leukemia.

[9]  R. Storb,et al.  The use of granulocyte colony-stimulating factor during retroviral transduction on fibronectin fragment CH-296 enhances gene transfer into hematopoietic repopulating cells in dogs. , 1999, Blood.

[10]  I. Pastan,et al.  Retroviral transfer of human MDR1 gene to hematopoietic cells: effects of drug selection and of transcript splicing on expression of encoded P-glycoprotein. , 1999, Human gene therapy.

[11]  S. Forestell,et al.  Optimization of retroviral gene transduction of mobilized primitive hematopoietic progenitors by using thrombopoietin, Flt3, and Kit ligands and RetroNectin culture. , 1999, Human gene therapy.

[12]  I. Pastan,et al.  Engraftment of MDR1 and NeoR gene-transduced hematopoietic cells after breast cancer chemotherapy. , 1999, Blood.

[13]  E. Buss,et al.  Soluble bone marrow stroma factors improve the efficiency of retroviral transfer of the human multidrug resistance 1 gene to human mobilized peripheral blood progenitor cells. , 1999, Human gene therapy.

[14]  A. Ho,et al.  Peripheral blood progenitor cell (PBPC) counts during steady‐state haemopoiesis enable the estimation of the yield of mobilized PBPC after granulocyte colony‐stimulating factor supported cytotoxic chemotherapy: an update on 100 patients , 1999, British journal of haematology.

[15]  M. Yarmush,et al.  Differential Inhibition of Retrovirus Transduction by Proteoglycans and Free Glycosaminoglycans , 1999, Biotechnology progress.

[16]  I. Kato,et al.  Adhesion to fibronectin maintains regenerative capacity during ex vivo culture and transduction of human hematopoietic stem and progenitor cells. , 1998, Blood.

[17]  T. Oegema,et al.  Structurally specific heparan sulfates support primitive human hematopoiesis by formation of a multimolecular stem cell niche. , 1998, Blood.

[18]  C. Verfaillie.  Adhesion receptors as regulators of the hematopoietic process. , 1998, Blood.

[19]  R. Hawley,et al.  Stroma-conditioned medium and sufficient prestimulation improve fibronectin fragment-mediated retroviral gene transfer into human primitive mobilized peripheral blood stem cells through effects on their recovery and transduction efficiency , 1998, Leukemia.

[20]  P. Herman,et al.  Stromal factors support the expansion of the whole hemopoietic spectrum from bone marrow CD34+DR− cells and of some hemopoietic subsets from CD34+ and CD34+DR+ cells , 1998, Leukemia.

[21]  Lesley J. Murray,et al.  Thrombopoietin, kit ligand, and flk2/flt3 ligand together induce increased numbers of primitive hematopoietic progenitors from human CD34+Thy-1+Lin- cells with preserved ability to engraft SCID-hu bone. , 1998, Blood.

[22]  A. Kaubisch,et al.  Phase I trial of retroviral-mediated transfer of the human MDR1 gene as marrow chemoprotection in patients undergoing high-dose chemotherapy and autologous stem-cell transplantation. , 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[23]  P. Jagodziński,et al.  The V3 region of gp120 is responsible for anti-HIV-1 activity of heparin sulphate. , 1998, Acta biochimica Polonica.

[24]  David A. Williams,et al.  Optimization of fibronectin-assisted retroviral gene transfer into human CD34+ hematopoietic cells. , 1997, Human gene therapy.

[25]  J. Dick,et al.  Quantitative Analysis Reveals Expansion of Human Hematopoietic Repopulating Cells After Short-term Ex Vivo Culture , 1997, The Journal of experimental medicine.

[26]  J. Olsen,et al.  Retroviral Gene Transfer Is Inhibited by Chondroitin Sulfate Proteoglycans/Glycosaminoglycans in Malignant Pleural Effusions* , 1997, The Journal of Biological Chemistry.

[27]  L. Coulombel,et al.  Expression and function of integrins on hematopoietic progenitor cells. , 1997, Acta haematologica.

[28]  R. Ploemacher,et al.  Stroma-conditioned media improve expansion of human primitive hematopoietic stem cells and progenitor cells , 1997, Leukemia.

[29]  S. Hegewisch-Becker,et al.  High-dose multidrug resistance in primary human hematopoietic progenitor cells transduced with optimized retroviral vectors. , 1996, Blood.

[30]  D. Valerio,et al.  Frequency analysis of multidrug resistance-1 gene transfer into human primitive hematopoietic progenitor cells using the cobblestone area-forming cell assay and detection of vector-mediated P-glycoprotein expression by rhodamine-123. , 1996, Human gene therapy.

[31]  David A. Williams,et al.  Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells , 1996, Nature Medicine.

[32]  S. Hegewisch-Becker,et al.  Novel retroviral vectors for efficient expression of the multidrug resistance (mdr-1) gene in early hematopoietic cells , 1995, Journal of virology.

[33]  S. Hegewisch-Becker,et al.  Chemotherapy resistance to taxol in clonogenic progenitor cells following transduction of CD34 selected marrow and peripheral blood cells with a retrovirus that contains the MDR-1 chemotherapy resistance gene. , 1995, Gene therapy.

[34]  K. McDonagh,et al.  Expression of retroviral vectors containing the human multidrug resistance 1 cDNA in hematopoietic cells of transplanted mice. , 1995, Blood.

[35]  C. Verfaillie,et al.  Direct adhesion to bone marrow stroma via fibronectin receptors inhibits hematopoietic progenitor proliferation. , 1995, The Journal of clinical investigation.

[36]  G. Hospers,et al.  Introduction of the Human MDR 1 Gene into Hematopoietic Stem Cells to Improve Cancer Chemotherapy , 1995 .

[37]  S. Luikart,et al.  Marrow-derived heparan sulfate proteoglycan mediates the adhesion of hematopoietic progenitor cells to cytokines. , 1995, Experimental hematology.

[38]  S. Neben,et al.  Frequency analysis of human primitive haematopoietic stem cell subsets using a cobblestone area forming cell assay. , 1994, Leukemia.

[39]  H. Goldschmidt,et al.  Patient characteristics associated with successful mobilizing and autografting of peripheral blood progenitor cells in malignant lymphoma. , 1994, Blood.

[40]  P. Dörmer,et al.  Establishment of two permanent human bone marrow stromal cell lines with long-term post irradiation feeder capacity. , 1994, Blood.

[41]  R. V. van Oers,et al.  Alpha 4 beta 1 and alpha 5 beta 1 are differentially expressed during myelopoiesis and mediate the adherence of human CD34+ cells to fibronectin in an activation-dependent way. , 1993, Blood.

[42]  I. Pastan,et al.  Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1. , 1992, Science.

[43]  David A. Williams,et al.  Fibronectin and VLA-4 in haematopoietic stem cell–microenvironment interactions , 1991, Nature.

[44]  A. Miller,et al.  Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection , 1990, Molecular and cellular biology.

[45]  C. Eaves,et al.  Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[46]  I. Pastan,et al.  Expression of a human multidrug resistance cDNA (MDR1) in the bone marrow of transgenic mice: resistance to daunomycin-induced leukopenia , 1989, Molecular and cellular biology.