Caspase Recruitment Domain (Card-Dependent) Cytoplasmic Filaments Mediate Bcl10-Induced Nf-κb Activation

Mucosa-associated lymphoid tissue (MALT) lymphomas are associated with overexpression and constitutive activity of bcl10, a caspase recruitment domain (CARD)-containing protein that activates NF-κB. Here, we show that arrangement of overexpressed bcl10 protein in cytoplasmic filaments is essential for recruitment of signal transducer molecules-involved NF-κB activation. We also show that cytoskeleton elements regulate bcl10 signaling. Thus, organized assemblage of proteins in ordered structures linked to the cytoskeleton network may represent a general mechanism for intracellular signaling.

[1]  A. Costanzo,et al.  c-E10 Is a Caspase-recruiting Domain-containing Protein That Interacts with Components of Death Receptors Signaling Pathway and Activates Nuclear Factor-κB* , 1999, The Journal of Biological Chemistry.

[2]  S. Srinivasula,et al.  CLAP, a Novel Caspase Recruitment Domain-containing Protein in the Tumor Necrosis Factor Receptor Pathway, Regulates NF-κB Activation and Apoptosis* , 1999, The Journal of Biological Chemistry.

[3]  Bernd Hinzmann,et al.  Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32) , 1999, Nature Genetics.

[4]  V. Dixit,et al.  mE10, a Novel Caspase Recruitment Domain-containing Proapoptotic Molecule* , 1999, The Journal of Biological Chemistry.

[5]  G. Nabel,et al.  CIPER, a Novel NF κB-activating Protein Containing a Caspase Recruitment Domain with Homology to Herpesvirus-2 Protein E10* , 1999, The Journal of Biological Chemistry.

[6]  F. Martinon,et al.  Equine Herpesvirus-2 E10 Gene Product, but Not Its Cellular Homologue, Activates NF-κB Transcription Factor and c-Jun N-terminal Kinase* , 1999, The Journal of Biological Chemistry.

[7]  M. Dyer,et al.  Bcl10 Is Involved in t(1;14)(p22;q32) of MALT B Cell Lymphoma and Mutated in Multiple Tumor Types , 1999, Cell.

[8]  Sharad Kumar,et al.  Prodomain-dependent Nuclear Localization of the Caspase-2 (Nedd2) Precursor , 1998, The Journal of Biological Chemistry.

[9]  J. Bertin,et al.  Death-effector Filaments: Novel Cytoplasmic Structures that Recruit Caspases and Trigger Apoptosis , 1998, The Journal of cell biology.

[10]  E. White,et al.  E1B 19K Inhibits Fas-mediated Apoptosis through FADD-dependent Sequestration of FLICE , 1998, The Journal of cell biology.

[11]  Stefan Grimm,et al.  The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal , 1998 .

[12]  Vishva M. Dixit,et al.  RAIDD is a new 'death' adaptor molecule , 1997, Nature.

[13]  D. Goeddel,et al.  TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. , 1996, Immunity.

[14]  H. Horvitz,et al.  Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities. , 1996, Genes & development.

[15]  D. Goeddel,et al.  The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation , 1995, Cell.

[16]  M. Karin,et al.  Cytoskeletal control of gene expression: depolymerization of microtubules activates NF-kappa B , 1995, The Journal of cell biology.

[17]  P. Leder,et al.  The death domain kinase RIP mediates the TNF-induced NF-kappaB signal. , 1998, Immunity.

[18]  M. Dyer,et al.  Bcl 10 Is Involved in t ( 1 ; 14 ) ( p 22 ; q 32 ) of MALT B Cell Lymphoma and Mutated in Multiple Tumor , 1998 .

[19]  D. Goeddel,et al.  The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. , 1995, Cell.