Fine needle aspiration cytology (FNAC), a handy tool for metastatic lymphadenopathy

Aim: To establish the role of fine needle aspiration cytology (FNAC) as a diagnostic tool in the interpretation of metastatic lymphadenopathyMaterial and Methods: The present study was conducted on 275 patients attending various clinics over a period of 2 Ω years. FNAC of the enlarged lymph nodes was performed and biopsy, special stains and immunohistochemical staining was done in selected cases.Observations: Metastatic lymphadenopathy was the commonest lesion in 221 (80.4%) cases. Squamous cell carcinoma was the most common primary tumor metastasizing to lymph nodes. Cervical lymph nodes were the most commonly involved and the commonest primary site was head and neck. Cyto-histological correlation showed 97.9% diagnostic accuracy, 97.9% sensitivity and 100% specificity. Conclusion: FNAC is a rapid, safe, easy and non-expensive diagnostic technique which can be used for initial diagnosis of metastatic lymphadenopathy, in a resource challenged environment, confirm secondaries where primary tumor is evident, and for response to treatment.

[1]  Nazima Haider,et al.  FNA diagnosis of Hutchison Pepper syndrome and metastatic neuroblastoma: A report of two cases , 2008, Diagnostic cytopathology.

[2]  Min Jung Kim,et al.  Sonographically Guided Core Needle Biopsy of Cervical Lymphadenopathy in Patients Without Known Malignancy , 2007, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[3]  B. Ojo,et al.  Surgical lymph node biopsies in University of Ilorin Teaching Hospital, Ilorin, Nigeria. , 2005, The Nigerian postgraduate medical journal.

[4]  G. O'leary,et al.  Efficacy and pitfalls of fine needle aspiration in the diagnosis of neck masses. , 2004, The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland.

[5]  E. Ravinsky,et al.  Transmission Electron Microscopy of Fine Needle Aspiration Biopsies of Metastases , 2003, Acta Cytologica.

[6]  Haque Ma,et al.  Evaluation of fine needle aspiration cytology (FNAC) of lymph node in Mymensingh. , 2003 .

[7]  E. Ravinsky,et al.  Transmission electron microscopy of fine needle aspiration biopsies of metastases. Accuracy of both techniques as established by biopsy diagnoses. , 2003, Acta cytologica.

[8]  M. A. Haque,et al.  Evaluation of fine needle aspiration cytology (FNAC) of lymph node in Mymensingh. , 2003, Mymensingh medical journal : MMJ.

[9]  M. Pitman,et al.  Aspiration cytology of malignant neoplasms associated with granulomas and granuloma‐like features , 1998, Cancer.

[10]  N. A. Ansari,et al.  Fine needle aspiration cytology. , 1997, Journal of clinical pathology.

[11]  I. Ramzy,et al.  Fine needle aspiration biopsy in the diagnosis of lymphadenopathy in 1,103 patients. Role, limitations and analysis of diagnostic pitfalls. , 1995, Acta cytologica.

[12]  C. Bartoli,et al.  Diagnostic assessment of enlarged superficial lymph nodes by fine needle aspiration. , 1993, Acta cytologica.

[13]  A. Sophian,et al.  Lymph node examination by fine needle aspiration in patients with known or suspected malignancy. , 1987, Acta cytologica.

[14]  Chhotray Gp,et al.  Fine needle aspiration cytology in diagnosis of metastatic lymphadenopathies. , 1987 .

[15]  G. P. Chhotray,et al.  Fine needle aspiration cytology in diagnosis of metastatic lymphadenopathies. , 1987, The Indian journal of medical research.

[16]  T. Kline,et al.  Lymphadenopathy and aspiration biopsy cytology. Review of 376 superficial nodes , 1984, Cancer.

[17]  G. Hutchins,et al.  Nonrandom distribution of metastases in neuroblastic tumors , 1983, Cancer.

[18]  W. Frable Fine-needle aspiration biopsy: a review. , 1983, Human pathology.

[19]  S. Hajdu,et al.  Percutaneous aspiration biopsy of lymph nodes. , 1980, American journal of clinical pathology.

[20]  M. Friedman,et al.  Appraisal of aspiration cytology in management of Hodgkin's disease , 1980, Cancer.

[21]  W. Frable Thin-needle aspiration biopsy. A personal experience with 469 cases. , 1976, American journal of clinical pathology.

[22]  I TOEROE,et al.  [ON THE LYMPH NODES]. , 1964, Verhandlungen der Anatomischen Gesellschaft.