Age of alcoholism onset. I. Relationship to psychopathology.

Numerous attempts have been made to subdivide populations of alcoholics into homogeneous subgroups. Although no consensus has been reached about the characteristics of these subgroups, a number of classification schemes have identified a subgroup of patients with a high genetic loading for alcoholism, an early onset of alcoholism, a severe course, and coexisting psychiatric problems consisting of aggressive tendencies or criminality. In a recent typology proposed by Cloninger on the basis of adoption studies, this subgroup has been classified as type 2. Another group of patients who were found to differ in their mode of inheritance and clinical characteristics was classified as type 1. The identification of etiologically homogeneous subgroups is easier in studies of adoptees than in studies of individuals who were not adopted. In an attempt to divide alcoholics into two groups of individuals presenting type 1 and type 2 characteristics, we used as a criterion the age of alcoholism onset because type 2 alcoholics as well as their fathers had been found to abuse alcohol at a younger age than type 1 patients. Patients with an onset of alcoholism before their 20th birthday were found to have a significantly higher incidence of paternal alcoholism and were twice as likely to have been incarcerated for crimes involving physical violence. We also observed other features not previously described in this patient subgroup. Patients who started abusing alcohol in their teens were three times as likely to be depressed and four times as likely to have attempted suicide as patients with a later onset of alcohol abuse.

[1]  C. Lieber,et al.  Age of alcoholism onset. II. Relationship to susceptibility to serotonin precursor availability. , 1989, Archives of general psychiatry.

[2]  T. Babor,et al.  Alcoholics, aggression and antisocial personality. , 1988, Journal of studies on alcohol.

[3]  L. Knorring,et al.  Personality traits in subtypes of alcoholics. , 1987, Journal of studies on alcohol.

[4]  C. Robert Cloninger,et al.  Neurogenetic adaptive mechanisms in alcoholism. , 1987, Science.

[5]  L. Kofoed,et al.  Alcoholism and Antisocial Personality: The Sociobiology of an Addiction , 1986, The Journal of nervous and mental disease.

[6]  C. Naranjo,et al.  Modulation of ethanol intake by serotonin uptake inhibitors. , 1986, The Journal of clinical psychiatry.

[7]  M A Schuckit,et al.  Genetic and clinical implications of alcoholism and affective disorder. , 1986, The American journal of psychiatry.

[8]  M. Hesselbrock,et al.  Psychopathology in hospitalized alcoholics. , 1985, Archives of general psychiatry.

[9]  L. von Knorring,et al.  Relationship between treatment outcome and subtype of alcoholism in men. , 1985, Journal of studies on alcohol.

[10]  G. Lee,et al.  Age of onset versus duration of problem drinking on the Alcohol Use Inventory. , 1985, Journal of studies on alcohol.

[11]  L. Robins,et al.  Association of Alcoholism with Antisocial Personality in Urban Men , 1985, The Journal of nervous and mental disease.

[12]  R. Cadoret,et al.  Alcoholism and antisocial personality. Interrelationships, genetic and environmental factors. , 1985, Archives of general psychiatry.

[13]  D. W. Goodwin Studies of familial alcoholism: a review. , 1984, The Journal of clinical psychiatry.

[14]  M Linnoila,et al.  Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. , 1983, Life sciences.

[15]  R. Cadoret,et al.  DEPRESSION IN ALCOHOLISM * , 1974, Annals of the New York Academy of Sciences.

[16]  S. Guze,et al.  Delinquency, social malad justment, and crime: the role of alcoholism. (A study of first-degree relatives of convicted criminals). , 1968, Diseases of the nervous system.

[17]  E. Jellinek,et al.  Alcohol addiction and its treatment , 1941 .

[18]  W. Filstead,et al.  Definition of onset in the development of onset-based alcoholism typologies. , 1988, Journal of studies on alcohol.

[19]  C. Robert Cloninger,et al.  Etiologic heterogeneity in alcoholism , 1987, Genetic epidemiology.

[20]  R. Frances,et al.  Suicide and alcoholism. , 1986, Annals of the New York Academy of Sciences.

[21]  A. Alterman,et al.  An examination of selected typologies. Hyperactivity, familial, and antisocial alcoholism. , 1986, Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism.

[22]  R. Gerner,et al.  The dexamethasone suppression test and response to somatic treatment: a review. , 1986, The Journal of clinical psychiatry.

[23]  R. Lauerman,et al.  Classification and forms of inebriety. Historical antecedents of alcoholic typologies. , 1986, Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism.

[24]  M. Hesselbrock,et al.  Antisocial Behavior, Psychopathology and Problem Drinking in the Natural History of Alcoholism , 1984 .

[25]  R. Kendall Alcohol and suicide. , 1983, Substance and alcohol actions/misuse.

[26]  D. W. Goodwin Alcoholism and heredity. A review and hypothesis. , 1979, Archives of general psychiatry.

[27]  J. Endicott,et al.  Use of the Research Diagnostic Criteria and the Schedule for Affective Disorders and Schizophrenia to study affective disorders. , 1979, The American journal of psychiatry.

[28]  S. Guze,et al.  Alcoholism and depression. , 1973, Archives of general psychiatry.

[29]  A. Buss,et al.  An inventory for assessing different kinds of hostility. , 1957, Journal of consulting psychology.