THE STRUCTURE OF EOSINOPHIL LEUKOCYTE GRANULES IN RODENTS AND IN MAN

The structure of the specific granules of eosinophil leukocytes has been studied by electron microscopy in sections of tissues, buffy coats, and sediments of peritoneal washings of rats, mice, guinea pigs, and men. The core of eosinophil granules is a crystal which has a cubic lattice with a repeat of ∼30 A in rodents and ∼40 A in man. The chemical composition of the core is discussed in connection with recent cell fractionation studies, and the hypothesis that the core is a crystal of peroxidase is considered.

[1]  P. Seeman,et al.  ACID PHOSPHATASE LOCALIZATION IN RABBIT EOSINOPHILS , 1967, The Journal of cell biology.

[2]  J. Ghidoni,et al.  Light and electron microscopic localization of acid phosphatase activity in human eosinophils. , 1966, American journal of clinical pathology.

[3]  J. G. Hirsch,et al.  CRYSTALLOID STRUCTURE IN GRANULES OF GUINEA PIG BASOPHILS AND HUMAN MAST CELLS , 1965, The Journal of cell biology.

[4]  G. Palade,et al.  CELL JUNCTIONS IN AMPHIBIAN SKIN , 1965, The Journal of cell biology.

[5]  P. Baudhuin,et al.  COMBINED BIOCHEMICAL AND MORPHOLOGICAL STUDY OF PARTICULATE FRACTIONS FROM RAT LIVER , 1965, The Journal of cell biology.

[6]  W. Davidson.  The Eosinophil Leucocytes , 1964 .

[7]  J. G. Hirsch,et al.  ISOLATION OF GRANULES FROM EOSINOPHIL LEUCOCYTES AND STUDY OF THEIR ENZYME CONTENT , 1963, The Journal of experimental medicine.

[8]  E. Reynolds.  THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPY , 1963, The Journal of cell biology.

[9]  John H. Luft,et al.  IMPROVEMENTS IN EPOXY RESIN EMBEDDING METHODS , 1961, The Journal of biophysical and biochemical cytology.

[10]  M. L. Watson.  Staining of Tissue Sections for Electron Microscopy with Heavy Metals , 1958, The Journal of biophysical and biochemical cytology.

[11]  É. de Harven.  A New Technique for Carbon Films , 1958, The Journal of biophysical and biochemical cytology.

[12]  R. Moore,et al.  Electron microscopy of formed elements of normal human blood. , 1957, Blood.

[13]  H. Braunsteiner,et al.  [Electron microscopic studies of granules of human leukocytes]. , 1957, Acta haematologica.

[14]  D. Pease,et al.  An electron microscopic study of red bone marrow. , 1956, Blood.

[15]  H. Sheldon,et al.  Internal ultrastructure in granules of white blood cells of the mouse; a preliminary note. , 1955, Bulletin of the Johns Hopkins Hospital.

[16]  R. Vercauteren.  The properties of the isolated granules from blood eosinophiles. , 1953, Enzymologia.

[17]  G. Air,et al.  STUDIES ON RAT EOSINOPHIL PEROXIDASE. , 1965, Biochimica et biophysica acta.

[18]  Robert D. Heidenreich,et al.  Fundamentals of Transmission Electron Microscopy , 1964 .

[19]  J. Thiery,et al.  Electron microscopy of human white blood cells and their stem cells. , 1961, International review of cytology.

[20]  D. Pease.  Marrow cells seen with the electron microscopy after ultrathin sectioning. , 1955, Revue d'hematologie.

[21]  Pease Dc.  Marrow cells seen with the electron microscopy after ultrathin sectioning. , 1955 .

[22]  G. B. Wislocki,et al.  The localization of lipids in human blood and bone marrow cells. , 1950, Blood.