Asthma severity, polymorphisms in 20p13 and their interaction with tobacco smoke exposure

We investigated the association between genetic variation in chromosomal region 20p13‐p12 (ADAM33 and flanking genes ATRN, GFRA4, SIGLEC1 and HSPA12B) and asthma. Amongst asthmatics, we then investigated the association between genetic variants and asthma severity. We evaluated the effect of environmental tobacco smoke (ETS) exposure in the context of genetic variants.

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