Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes

[1]  F. Guilak,et al.  Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesis , 2021, Nature Communications.

[2]  Raphael Gottardo,et al.  Integrated analysis of multimodal single-cell data , 2020, Cell.

[3]  I. Weissman,et al.  Articular cartilage regeneration by activated skeletal stem cells , 2020, Nature Medicine.

[4]  D. Kaufman,et al.  Lineage‐specific differentiation of osteogenic progenitors from pluripotent stem cells reveals the FGF1‐RUNX2 association in neural crest‐derived osteoprogenitors , 2020, Stem cells.

[5]  S. Salati,et al.  Bone Morphogenetic Protein-2 Signaling in the Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells Induced by Pulsed Electromagnetic Fields , 2020, International journal of molecular sciences.

[6]  P. D. Kraan.  The Interaction between Joint Inflammation and Cartilage Repair. , 2019 .

[7]  G. Daley,et al.  Stem Cells in the Treatment of Disease. , 2019, The New England journal of medicine.

[8]  J. Ernst,et al.  Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes , 2018, Nature Communications.

[9]  G. Keller,et al.  Effective repair of joint cartilage using human pluripotent stem cell-derived tissue , 2018, bioRxiv.

[10]  C. Laurencin,et al.  The Paracrine Effect of Adipose-Derived Stem Cells Inhibits IL-1β-induced Inflammation in Chondrogenic Cells through the Wnt/β-Catenin Signaling Pathway , 2018, Regenerative Engineering and Translational Medicine.

[11]  K. Vadivel,et al.  Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair , 2018, Annals of the rheumatic diseases.

[12]  M. Chesselet,et al.  Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice , 2017, Stem cell reports.

[13]  A. Goodship,et al.  The Wnt5a Receptor, Receptor Tyrosine Kinase‐Like Orphan Receptor 2, Is a Predictive Cell Surface Marker of Human Mesenchymal Stem Cells with an Enhanced Capacity for Chondrogenic Differentiation , 2017, Stem cells.

[14]  G. R. Dodge,et al.  Age-Dependent Subchondral Bone Remodeling and Cartilage Repair in a Minipig Defect Model. , 2017, Tissue engineering. Part C, Methods.

[15]  Ling Wu,et al.  Kappa opioid receptor signaling protects cartilage tissue against posttraumatic degeneration. , 2017, JCI insight.

[16]  A. Beekman,et al.  A 2-year prospective study , 2017 .

[17]  Runo,et al.  Receptor, Receptor Tyrosine Kinase-Like Orphan Receptor 2, Is a Predictive Cell Surface Marker of Human Mesenchymal Stem Cells with an Enhanced Capacity for Chondrogenic Differentiation. , 2017 .

[18]  D. Steinberg,et al.  Effects of Mesenchymal Stem Cell and Growth Factor Delivery on Cartilage Repair in a Mini-Pig Model , 2015, Cartilage.

[19]  P. Behrens,et al.  Nanofractured autologous matrix induced chondrogenesis (NAMIC©)--Further development of collagen membrane aided chondrogenesis combined with subchondral needling: A technical note. , 2015, The Knee.

[20]  K A Athanasiou,et al.  Cartilage immunoprivilege depends on donor source and lesion location. , 2015, Acta biomaterialia.

[21]  B. Alman,et al.  Generation of articular chondrocytes from human pluripotent stem cells , 2015, Nature Biotechnology.

[22]  S. Matsuda,et al.  Generation of Scaffoldless Hyaline Cartilaginous Tissue from Human iPSCs , 2015, Stem cell reports.

[23]  D. Steinberg,et al.  Cartilage repair and subchondral bone remodeling in response to focal lesions in a mini-pig model: implications for tissue engineering. , 2015, Tissue engineering. Part A.

[24]  Xavier Moles Lopez,et al.  Immunohistochemical toolkit for tracking and quantifying xenotransplanted human stem cells. , 2014, Regenerative medicine.

[25]  J. Farr,et al.  Clinical, Radiographic, and Histological Outcomes After Cartilage Repair With Particulated Juvenile Articular Cartilage , 2014, The American journal of sports medicine.

[26]  Cole Trapnell,et al.  Pseudo-temporal ordering of individual cells reveals dynamics and regulators of cell fate decisions , 2014, Nature Biotechnology.

[27]  K. Lyons,et al.  Human Developmental Chondrogenesis as a Basis for Engineering Chondrocytes from Pluripotent Stem Cells , 2013, Stem cell reports.

[28]  J. Hart,et al.  Preliminary results of a novel single-stage cartilage restoration technique: particulated juvenile articular cartilage allograft for chondral defects of the patella. , 2013, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[29]  T. Aoyama,et al.  The layered structure of the articular surface. , 2013, Osteoarthritis and cartilage.

[30]  D. Ornitz,et al.  Development of the endochondral skeleton. , 2013, Cold Spring Harbor perspectives in biology.

[31]  Jangwoo Lee,et al.  BMP2 induces segment-specific skeletal regeneration from digit and limb amputations by establishing a new endochondral ossification center. , 2012, Developmental biology.

[32]  B. Fleming,et al.  A comparative anatomical study of the human knee and six animal species. , 2012, The Knee.

[33]  E. Mohammadi,et al.  Barriers and facilitators related to the implementation of a physiological track and trigger system: A systematic review of the qualitative evidence , 2017, International journal for quality in health care : journal of the International Society for Quality in Health Care.

[34]  E. Piek,et al.  Catabolic factors and osteoarthritis-conditioned medium inhibit chondrogenesis of human mesenchymal stem cells. , 2012, Tissue engineering. Part A.

[35]  H. Fang,et al.  Tissue engineering‐based cartilage repair with mesenchymal stem cells in a porcine model , 2011, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[36]  Jie Li,et al.  Regenerative phenotype in mice with a point mutation in transforming growth factor β type I receptor (TGFBR1) , 2011, Proceedings of the National Academy of Sciences.

[37]  P. Neyret,et al.  MACI - a new era? , 2011, Sports medicine, arthroscopy, rehabilitation, therapy & technology : SMARTT.

[38]  Haeshin Lee,et al.  Hyaline cartilage regeneration by combined therapy of microfracture and long-term bone morphogenetic protein-2 delivery. , 2011, Tissue engineering. Part A.

[39]  S. Kimber,et al.  Directed differentiation of human embryonic stem cells toward chondrocytes , 2010, Nature Biotechnology.

[40]  K. Schenke-Layland,et al.  Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells , 2010, Proceedings of the National Academy of Sciences.

[41]  R. Kandel,et al.  A New Histology Scoring System for the Assessment of the Quality of Human Cartilage Repair: ICRS II , 2010, The American journal of sports medicine.

[42]  Georg Bachmann,et al.  Matrix-induced autologous chondrocyte implantation versus microfracture in the treatment of cartilage defects of the knee: a 2-year randomised study , 2010, Knee Surgery, Sports Traumatology, Arthroscopy.

[43]  Kyriacos A Athanasiou,et al.  Success rates and immunologic responses of autogenic, allogenic, and xenogenic treatments to repair articular cartilage defects. , 2009, Tissue engineering. Part B, Reviews.

[44]  Stefano Zaffagnini,et al.  Arthroscopic Second-Generation Autologous Chondrocyte Implantation Compared with Microfracture for Chondral Lesions of the Knee , 2009, The American journal of sports medicine.

[45]  R. Boston,et al.  Preclinical animal models in single site cartilage defect testing: a systematic review. , 2008, Osteoarthritis and cartilage.

[46]  E. Geissler,et al.  Immunosuppression for liver transplantation , 2008, Gut.

[47]  W. Alkema,et al.  BioVenn – a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams , 2008, BMC Genomics.

[48]  Masahiro Iwamoto,et al.  A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis. , 2008, Developmental biology.

[49]  Andrzej Galat,et al.  Technical note , 2008, Comput. Biol. Chem..

[50]  T. Ichisaka,et al.  Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors , 2007, Cell.

[51]  E. Schwarz,et al.  Transforming growth factor-beta and Wnt signals regulate chondrocyte differentiation through Twist1 in a stage-specific manner. , 2007, Molecular endocrinology.

[52]  Lars Engebretsen,et al.  A randomized trial comparing autologous chondrocyte implantation with microfracture. Findings at five years. , 2007, The Journal of bone and joint surgery. American volume.

[53]  A. Nixon,et al.  Enhanced early chondrogenesis in articular defects following arthroscopic mesenchymal stem cell implantation in an equine model , 2007, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[54]  E. Solheim,et al.  A Randomized Trial Comparing Autologous Chondrocyte Implantation with Microfracture , 2007 .

[55]  G. Burmester,et al.  Synovitis score: discrimination between chronic low‐grade and high‐grade synovitis , 2006, Histopathology.

[56]  Mark Ende,et al.  Hematopoietic stem-cell transplantation. , 2006, The New England journal of medicine.

[57]  S. Smith,et al.  Reliability and responsiveness of the lower extremity functional scale and the anterior knee pain scale in patients with anterior knee pain. , 2005, The Journal of orthopaedic and sports physical therapy.

[58]  A. Osyczka,et al.  Different Effects of BMP-2 on Marrow Stromal Cells from Human and Rat Bone , 2004, Cells Tissues Organs.

[59]  E. Ehlers,et al.  [New therapy procedure for localized cartilage defects. Encouraging results with autologous chondrocyte implantation]. , 1999, MMW Fortschritte der Medizin.

[60]  J. Thomson,et al.  Embryonic stem cell lines derived from human blastocysts. , 1998, Science.

[61]  J. Dayer,et al.  Interleukin (IL)-6 and Its Soluble Receptor Induce TIMP-1 Expression in Synoviocytes and Chondrocytes, and Block IL-1-induced Collagenolytic Activity* , 1998, The Journal of Biological Chemistry.

[62]  C. Ohlsson,et al.  Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. , 1994, The New England journal of medicine.

[63]  T. Cawston,et al.  The prevention of collagen breakdown in bovine nasal cartilage by TIMP, TIMP-2 and a low molecular weight synthetic inhibitor. , 1994, Biochemical and biophysical research communications.

[64]  K. Muneoka,et al.  FGF-2 induces regeneration of the chick limb bud. , 1994, Developmental biology.