Occupational exposure to hydrazine and subsequent risk of cancer.

OBJECTIVES--The aim was to examine the cause specific mortality of men exposed to hydrazine. METHODS--Hydrazine was produced at a factory in the east midlands between 1945 and 1971. The cohort of all 427 men who were employed there for at least six months with varying degrees of occupational exposure to hydrazine were followed up until the end of January 1992. RESULTS--By the end of July 1982 49 deaths had occurred and the observed mortality was found to be close to that expected at each level of exposure. By the end of January 1992 a further 37 deaths had occurred. Again the observed mortality was close to that expected for all causes and also for lung cancer, cancers of the digestive system, other cancers, and all other causes, irrespective of the level of exposure. CONCLUSIONS--The results weigh against there having been any material hazard of occupational exposure to hydrazine. The small number of men studied means, however, that a relative risk as high as 3.5 for lung cancer cannot confidently be excluded.

[1]  B. Tóth.  Tumorigenesis studies with 1,2-dimethylhydrazine dihydrochloride, hydrazine sulfate, and isonicotinic acid in golden hamsters. , 1972, Cancer research.

[2]  K. Austen,et al.  Cold urticaria: release into the circulation of histamine and eosinophil chemotactic factor of anaphylaxis during cold challenge. , 1976, The New England journal of medicine.

[3]  E. H. Vernot,et al.  Long-term inhalation toxicity of hydrazine. , 1985, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[4]  American Conference Of Governmental Industrial Hygienists 1998 Ventilation A O , 2019 .

[5]  B. Terracini.  Evaluation of Carcinogenic Risk of Chemicals to Man , 1972 .

[6]  S. Bhide,et al.  Lung tumour incidence in mice treated with hydrazine sulphate , 1976, International journal of cancer.

[7]  B. Szende,et al.  Tumour-inducing Effect of Hydrazine in Mice , 1966, Nature.

[8]  L. Severi,et al.  Hepatic carcinogenesis in CBA-Cb-Se mice and Cb-Se rats by isonicotinic acid hydrazide and hydrazine sulfate. , 1968, Journal of the National Cancer Institute.

[9]  J. Houštěk,et al.  Occurrence of a Specific Foetal Protein in a Primary Liver Carcinoma , 1966, Nature.

[10]  W. Fritz,et al.  WHO‐IARC‐Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. International Agency for Research on Cancer. Bd. 6 u. 7. Lyon 1974 , 1976 .

[11]  E. H. Vernot,et al.  Chronic Inhalation Toxicity of Hydrazine: Oncogenic Effects , 1981 .

[12]  Occupational exposure to hydrazine and subsequent risk of cancer. , 1984, British journal of industrial medicine.

[13]  L. Severi,et al.  Pulmonary Tumours in Rats induced by Oral Hydrazine Sulphate , 1966, Nature.

[14]  C. Biancifiori.  Hepatomas in CBA/Cb/Se mice and liver lesions in golden hamsters induced by hydrazine sulfate. , 1970, Journal of the National Cancer Institute.