Highly regioselective biotransformation of ginsenoside Rg1 to 25-OH derivatives of 20(S/R)-Rh1 by Cordyceps Sinensis.

[1]  Jincai Lu,et al.  Purification of ginseng rare sapogenins 25-OH-PPT and its hypoglycemic, antiinflammatory and lipid-lowering mechanisms , 2019, Journal of ginseng research.

[2]  Chong-Zhi Wang,et al.  Microbial Conversion of Protopanaxadiol-Type Ginsenosides by the Edible and Medicinal Mushroom Schizophyllum commune: A Green Biotransformation Strategy , 2019, ACS omega.

[3]  Longquan Xu,et al.  Conversion of Ginsenoside Rb1 into Six Types of Highly Bioactive Ginsenoside Rg3 and Its Derivatives by FeCl3 Catalysis. , 2018, Chemical & pharmaceutical bulletin.

[4]  Yuqing Zhao,et al.  25-Hydroxyl-protopanaxatriol protects against H2O2-induced H9c2 cardiomyocytes injury via PI3K/Akt pathway and apoptotic protein down-regulation. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[5]  Huimin Zhao,et al.  Biocatalysis for the synthesis of pharmaceuticals and pharmaceutical intermediates. , 2017, Bioorganic & medicinal chemistry.

[6]  Jia Liu,et al.  The structure-activity relationship of ginsenosides on hypoxia-reoxygenation induced apoptosis of cardiomyocytes. , 2017, Biochemical and biophysical research communications.

[7]  Akansha Srivastava,et al.  Strategies for Fermentation Medium Optimization: An In-Depth Review , 2017, Front. Microbiol..

[8]  J. Kim,et al.  Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases , 2016, Journal of ginseng research.

[9]  D. Oh,et al.  Classification of glycosidases that hydrolyze the specific positions and types of sugar moieties in ginsenosides , 2016, Critical reviews in biotechnology.

[10]  Shuying Liu,et al.  Chemical transformation of ginsenoside Re by a heteropoly acid investigated using HPLC-MSn/HRMS , 2016 .

[11]  Z. Wang,et al.  Inhibitory effects and mechanism of 25-OH-PPD on glomerular mesangial cell proliferation induced by high glucose. , 2016, Environmental toxicology and pharmacology.

[12]  Seockmo Ku.  Finding and Producing Probiotic Glycosylases for the Biocatalysis of Ginsenosides: A Mini Review , 2016, Molecules.

[13]  R. W. Hoffmann.  Markovnikov free radical addition reactions, a sleeping beauty kissed to life. , 2016, Chemical Society reviews.

[14]  Wei Li,et al.  Semi-synthesis and anti-tumor evaluation of novel 25-hydroxyprotopanaxadiol derivatives as apoptosis inducing agents , 2015 .

[15]  Deok-Chun Yang,et al.  Biosynthesis and biotechnological production of ginsenosides. , 2015, Biotechnology advances.

[16]  Chen Zhao,et al.  Antitumor activity of ginseng sapogenins, 25-OH-PPD and 25-OCH3-PPD, on gastric cancer cells , 2015, Biotechnology Letters.

[17]  Y. Qiu,et al.  Highly Selective Bioconversion of Ginsenoside Rb1 to Compound K by the Mycelium of Cordyceps sinensis under Optimized Conditions , 2015, Molecules.

[18]  Lian‐Wen Qi,et al.  Rapid preparation of rare ginsenosides by acid transformation and their structure-activity relationships against cancer cells , 2015, Scientific Reports.

[19]  Usama A. Mahalel,et al.  Microbial biotransformation as a tool for drug development based on natural products from mevalonic acid pathway: A review , 2014, Journal of advanced research.

[20]  Y. Hadar,et al.  The ligninolytic peroxidases in the genus Pleurotus: divergence in activities, expression, and potential applications , 2015, Applied Microbiology and Biotechnology.

[21]  Jia-qing Cao,et al.  Novel 25-hydroxyprotopanaxadiol derivatives incorporating chloroacetyl chloride and their anti-tumor evaluation. , 2014, Bioorganic & medicinal chemistry letters.

[22]  Jeom-Yong Kim,et al.  Complete 1H-NMR and 13C-NMR spectral analysis of the pairs of 20(S) and 20(R) ginsenosides , 2014, Journal of ginseng research.

[23]  P. Hu,et al.  Transformation of ginsenosides from notoginseng by artificial gastric juice can increase cytotoxicity toward cancer cells. , 2014, Journal of agricultural and food chemistry.

[24]  Wei Liu,et al.  Anti-tumor activity of three novel derivatives of ginsenoside on colorectal cancer cells , 2014, Steroids.

[25]  H. Piao,et al.  Semi-synthesis and anti-tumor evaluation of novel 25-hydroxyprotopanaxadiol derivatives. , 2012, European journal of medicinal chemistry.

[26]  Hui Wang,et al.  Ginsenosides as Anticancer Agents: In vitro and in vivo Activities, Structure–Activity Relationships, and Molecular Mechanisms of Action , 2012, Front. Pharmacol..

[27]  Jianfeng Jin,et al.  The selective addition of water to C=C bonds; enzymes are the best chemists. , 2011, Chemical communications.

[28]  D. Bae,et al.  Change of ginsenoside composition in red ginseng processed with citric acid , 2010 .

[29]  K. Leung,et al.  Pharmacology of ginsenosides: a literature review , 2010, Chinese medicine.

[30]  D. Oh,et al.  Biotransformation of ginsenosides by hydrolyzing the sugar moieties of ginsenosides using microbial glycosidases , 2010, Applied Microbiology and Biotechnology.

[31]  Hui Wang,et al.  Pharmacokinetics and tissue distribution of 25-hydroxyprotopanaxadiol, an anti-cancer compound isolated from Panax ginseng, in athymic mice bearing xenografts of human pancreatic tumors , 2010, European Journal of Drug Metabolism and Pharmacokinetics.

[32]  Hui Wang,et al.  Novel ginsenosides 25-OH-PPD and 25-OCH3-PPD as experimental therapy for pancreatic cancer: anticancer activity and mechanisms of action. , 2009, Cancer letters.

[33]  Mirjana Stajic´,et al.  Biology of Pleurotus eryngii and role in biotechnological processes: a review , 2009 .

[34]  Mirjana Stajić,et al.  Biology of Pleurotus eryngii and role in biotechnological processes: a review. , 2009, Critical reviews in biotechnology.

[35]  Hui Wang,et al.  Experimental therapy of prostate cancer with novel natural product anti‐cancer ginsenosides , 2008, The Prostate.

[36]  D. Guo,et al.  Microbial transformation of 20(S)-protopanaxatriol-type saponins by Absidia coerulea. , 2007, Journal of natural products.

[37]  R. Teng,et al.  Hydrolytic reaction of plant extracts to generate molecular diversity: New dammarane glycosides from the mild acid hydrolysate of root saponins of Panax notoginseng , 2004 .

[38]  H. Hasegawa.  Proof of the mysterious efficacy of ginseng: basic and clinical trials: metabolic activation of ginsenoside: deglycosylation by intestinal bacteria and esterification with fatty acid. , 2004, Journal of pharmacological sciences.

[39]  M. Schubert-Zsilavecz,et al.  Degradation of ginsenosides in humans after oral administration. , 2003, Drug metabolism and disposition: the biological fate of chemicals.

[40]  M. Legiša,et al.  The influence of metal ions on malic enzyme activity and lipid synthesis in Aspergillus niger. , 2002, FEMS microbiology letters.

[41]  M. Yohda,et al.  Fe-type nitrile hydratase. , 2001, Journal of Inorganic Biochemistry.