Relationships among norepinephrine levels, exercise capacity, and chronotropic responses in heart failure patients

[1]  M. Emdin,et al.  The ergoreflex: how the skeletal muscle modulates ventilation and cardiovascular function in health and disease , 2021, European journal of heart failure.

[2]  B. Merkely,et al.  Impact of closed loop stimulation on prognostic cardiopulmonary variables in patients with chronic heart failure and severe chronotropic incompetence: a pilot, randomized, crossover study , 2021, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

[3]  A. Garay,et al.  Sympathetic activation and outcomes in chronic heart failure: Does the neurohormonal hypothesis apply to mid-range and preserved ejection fraction patients? , 2020, European journal of internal medicine.

[4]  Snehal R. Patel,et al.  Rate Response Pacing in Left Ventricular Assist Device Patients , 2020, ASAIO journal.

[5]  H. Saner,et al.  A new algorithm for optimization of rate‐adaptive pacing improves exercise tolerance in patients with HFpEF , 2019, Pacing and clinical electrophysiology : PACE.

[6]  M. Emdin,et al.  Central and Obstructive Apneas in Heart Failure With Reduced, Mid-Range and Preserved Ejection Fraction , 2019, Front. Cardiovasc. Med..

[7]  O. Wever-Pinzon,et al.  Characterization of Sympathetic Innervation in Heart Failure With Preserved Ejection Fraction. , 2019, Journal of cardiac failure.

[8]  G. Mancia,et al.  Sympathetic and baroreflex alterations in congestive heart failure with preserved, midrange and reduced ejection fraction , 2019, Journal of hypertension.

[9]  Under What Circumstances Do Rostral Ventrolateral Medulla Neurons Support Blood Pressure? , 2017, The Journal of Neuroscience.

[10]  A. Capucci,et al.  Effect of fixed-rate vs. rate-RESPONSIve pacing on exercise capacity in patients with permanent, refractory atrial fibrillation and left ventricular dysfunction treated with atrioventricular junction aBLation and bivEntricular pacing (RESPONSIBLE): a prospective, multicentre, randomized, single-blin , 2016, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

[11]  J. Kobashigawa,et al.  Early Denervation and Later Reinnervation of the Heart Following Cardiac Transplantation: A Review , 2016, Journal of the American Heart Association.

[12]  J. Cohn,et al.  Heart Failure With Improved Ejection Fraction: Clinical Characteristics, Correlates of Recovery, and Survival Results From the Valsartan Heart Failure Trial , 2016, Circulation. Heart failure.

[13]  M. Kearney,et al.  Chronotropic Incompetence Does Not Limit Exercise Capacity in Chronic Heart Failure. , 2016, Journal of the American College of Cardiology.

[14]  A. Gupte,et al.  Exercise Intolerance In Heart Failure With Preserved Ejection Fraction. , 2016, Methodist DeBakey cardiovascular journal.

[15]  T. Berg β1-Blockers Lower Norepinephrine Release by Inhibiting Presynaptic, Facilitating β1-Adrenoceptors in Normotensive and Hypertensive Rats , 2014, Front. Neurol..

[16]  L. Gullestad,et al.  Exercise after heart transplantation: An overview. , 2013, World journal of transplantation.

[17]  J. Kautzner,et al.  Resting heart rate and heart rate reserve in advanced heart failure have distinct pathophysiologic correlates and prognostic impact: a prospective pilot study. , 2013, JACC. Heart failure.

[18]  W. Spitzer,et al.  Clinical observations with Closed Loop Stimulation pacemakers in a large patient cohort: the CYLOS routine documentation registry (RECORD). , 2012, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

[19]  A. Natale,et al.  Closed Loop Stimulation is Effective in Improving Heart Rate and Blood Pressure Response to Mental Stress: Report of a Single‐Chamber Pacemaker Study in Patients with Chronotropic Incompetent Atrial Fibrillation , 2012, Pacing and clinical electrophysiology : PACE.

[20]  T. Saruta,et al.  Importance of rostral ventrolateral medulla neurons in determining efferent sympathetic nerve activity and blood pressure , 2011, Hypertension Research.

[21]  N. Uriel,et al.  Rate responsive pacing using cardiac resynchronization therapy in patients with chronotropic incompetence and chronic heart failure. , 2011, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

[22]  D. Kitzman,et al.  Chronotropic Incompetence: Causes, Consequences, and Management , 2011, Circulation.

[23]  D. Kitzman,et al.  Exercise intolerance. , 2011, Cardiology clinics.

[24]  D. Mele,et al.  Exercise intolerance in chronic heart failure: mechanisms and therapies. Part I , 2010, European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology.

[25]  E. Bocchi,et al.  Norepinephrine Remains Increased in the Six-Minute Walking Test after Heart Transplantation , 2010, Clinics.

[26]  Javed Butler,et al.  The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications. , 2009, Journal of the American College of Cardiology.

[27]  R. Passman,et al.  The Effects of Rate‐Adaptive Atrial Pacing Versus Ventricular Backup Pacing on Exercise Capacity in Patients with Left Ventricular Dysfunction , 2009, Pacing and clinical electrophysiology : PACE.

[28]  C. Vrints,et al.  Rate response and cardiac resynchronisation therapy in chronic heart failure: higher cardiac output does not acutely improve exercise performance: a pilot trial , 2008, European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology.

[29]  M. Emdin,et al.  Clinical significance of chemosensitivity in chronic heart failure: influence on neurohormonal derangement, Cheyne-Stokes respiration and arrhythmias. , 2008, Clinical science.

[30]  Dietmar Schmitz,et al.  Closed loop stimulation and accelerometer-based rate adaptation: results of the PROVIDE study. , 2008, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

[31]  David S. Hirsh,et al.  Chronotropic incompetence, beta‐blockers, and functional capacity in advanced congestive heart failure: Time to pace? , 2008, European journal of heart failure.

[32]  D. Kitzman,et al.  Exercise intolerance. , 2008, Heart failure clinics.

[33]  J. Myers Principles of exercise prescription for patients with chronic heart failure , 2008, Heart Failure Reviews.

[34]  Shanker Chandiramani,et al.  Heart Rate Changes during Acute Mental Stress with Closed Loop Stimulation: Report on Two Single‐Blinded, Pacemaker Studies , 2007, Pacing and clinical electrophysiology : PACE.

[35]  D. Kitzman,et al.  Prevalence and management of chronotropic incompetence in heart failure , 2007, Current cardiology reports.

[36]  T. Takano,et al.  Relationship between plasma norepinephrine at peak exercise and 123I-MIBG imaging of the heart and lower limbs in heart failure. , 2007, Journal of Nippon Medical School = Nippon Ika Daigaku zasshi.

[37]  D. Kass,et al.  Impaired Chronotropic and Vasodilator Reserves Limit Exercise Capacity in Patients With Heart Failure and a Preserved Ejection Fraction , 2006, Circulation.

[38]  M. Emdin,et al.  Aerobic training decreases B-type natriuretic peptide expression and adrenergic activation in patients with heart failure. , 2006, Journal of the American College of Cardiology.

[39]  D. Kitzman,et al.  Chronotropic incompetence and its contribution to exercise intolerance in older heart failure patients. , 2006, Journal of cardiopulmonary rehabilitation.

[40]  M. Emdin,et al.  Neuro‐hormonal activation predicts ventilatory response to exercise and functional capacity in patients with heart failure , 2006, European journal of heart failure.

[41]  Hung-Fat Tse,et al.  The incremental benefit of rate-adaptive pacing on exercise performance during cardiac resynchronization therapy. , 2005, Journal of the American College of Cardiology.

[42]  Kae Itoh,et al.  Relationship between exercise intolerance and levels of neurohormonal factors and proinflammatory cytokines in patients with stable chronic heart failure. , 2005, International heart journal.

[43]  M. Cicoira,et al.  Ischemic etiology of heart failure identifies patients with more severely impaired exercise capacity. , 2005, International journal of cardiology.

[44]  P. Picton,et al.  Vagal heart rate responses to chronic beta‐blockade in human heart failure relate to cardiac norepinephrine spillover , 2005, European journal of heart failure.

[45]  L. Lund,et al.  Validation of peak exercise oxygen consumption and the Heart Failure Survival Score for serial risk stratification in advanced heart failure. , 2005, The American journal of cardiology.

[46]  P. Giannuzzi,et al.  Cardiopulmonary exercise testing and prognosis in chronic heart failure: a prognosticating algorithm for the individual patient. , 2004, Chest.

[47]  N. Lamblin,et al.  Is hormonal activation during exercise useful for risk stratification in patients with moderate congestive heart failure? , 2004, American heart journal.

[48]  Daniel S Berman,et al.  The incremental prognostic value of percentage of heart rate reserve achieved over myocardial perfusion single-photon emission computed tomography in the prediction of cardiac death and all-cause mortality: superiority over 85% of maximal age-predicted heart rate. , 2004, Journal of the American College of Cardiology.

[49]  M. Pfisterer,et al.  Rate Response of a Closed‐Loop Stimulation Pacing System to Changing Preload and Afterload Conditions , 2003, Pacing and clinical electrophysiology : PACE.

[50]  Kae Itoh,et al.  Relationship between impaired chronotropic response, cardiac output during exercise, and exercise tolerance in patients with chronic heart failure. , 2003, Japanese heart journal.

[51]  L. Pinai,et al.  EXERCISE AND HEART FAILURE: A STATEMENT FROM THE AMERICAN HEART ASSOCIATION COMMITTEE ON EXERCISE, REHABILITATION, AND PREVENTION , 2003 .

[52]  A. Michelucci,et al.  A New Algorithm for Closed‐Loop Stimulation: A Feasibility Study , 2003, Pacing and clinical electrophysiology : PACE.

[53]  W. Levy,et al.  The role of norepinephrine in exercise impairment in congestive heart failure. , 2003, Congestive heart failure.

[54]  W. Hundley,et al.  Pathophysiological characterization of isolated diastolic heart failure in comparison to systolic heart failure. , 2002, JAMA.

[55]  A. Capucci,et al.  Muscle Ergoreceptor Overactivity Reflects Deterioration in Clinical Status and Cardiorespiratory Reflex Control in Chronic Heart Failure , 2001, Circulation.

[56]  George P. Noon,et al.  Inflammatory Response after Implantation of a Left Ventricular Assist Device: Comparison between the Axial Flow MicroMed DeBakey VAD and the Pulsatile Novacor Device , 2001, ASAIO journal.

[57]  Norepinephrine alters exercise oxygen consumption in heart failure patients. , 2000, Medicine and science in sports and exercise.

[58]  J. Hill,et al.  Rate-responsive pacing improves exercise tolerance in heart transplant recipients: a pilot study. , 2000, Journal of cardiopulmonary rehabilitation.

[59]  W. Abraham,et al.  Hormones and hemodynamics in heart failure. , 1999, The New England journal of medicine.

[60]  S. Keteyian,et al.  Effects of exercise training on chronotropic incompetence in patients with heart failure. , 1999, American heart journal.

[61]  P M Okin,et al.  Impaired chronotropic response to exercise stress testing as a predictor of mortality. , 1999, JAMA.

[62]  F. Follath,et al.  Oxygen uptake kinetics during low level exercise in patients with heart failure: relation to neurohormones, peak oxygen consumption, and clinical findings , 1999, Heart.

[63]  D. Pimentel,et al.  Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the beta-adrenergic pathway. , 1998, Circulation.

[64]  G. Santostasi,et al.  Early reduction in plasma norepinephrine during beta-blocking therapy with metoprolol in chronic heart failure. , 1998, Journal of cardiac failure.

[65]  C. Lang,et al.  Effect of sympathoinhibition on exercise performance in patients with heart failure. , 1997, Circulation.

[66]  K. Ogino,et al.  Effects of enalapril on the exercise capacity and neurohumoral factors during exercise in patients with chronic heart failure. , 1997, Cardiology.

[67]  P M Okin,et al.  Impaired heart rate response to graded exercise. Prognostic implications of chronotropic incompetence in the Framingham Heart Study. , 1996, Circulation.

[68]  P. Hanrath,et al.  [Chronic frequency-adaptive pacemaker therapy in patients with heart failure]. , 1995, Zeitschrift fur Kardiologie.

[69]  Jos R. T. C. Roelandt,et al.  In Vivo Measurement of Regional Large Artery Compliance by Intravascular Ultrasound Under Pentobarbital Anesthesia , 1995, Angiology.

[70]  A. Coats,et al.  Chronotropic incompetence in chronic heart failure. , 1995, International journal of cardiology.

[71]  J. Polak,et al.  Carotid arterial compliance in patients with congestive heart failure secondary to idiopathic dilated cardiomyopathy. , 1994, The American journal of cardiology.

[72]  F. Tristani,et al.  Ejection Fraction, Peak Exercise Oxygen Consumption, Cardiothoracic Ratio, Ventricular Arrhythmias, and Plasma Norepinephrine as Determinants of Prognosis in Heart Failure , 1993, Circulation.

[73]  M. Pollock,et al.  Abnormal Neuroendocrine Responses During Exercise in Heart Transplant Recipients , 1992, Circulation.

[74]  B. Parsons,et al.  Adrenergic Effects on the Biology of the Adult Mammalian Cardiocyte , 1992, Circulation.

[75]  Y. Chandrashekhar,et al.  Relation between major indices of prognosis in patients with chronic congestive heart failure: studies of maximal exercise oxygen consumption, neurohormones and ventricular function. , 1992, Indian heart journal.

[76]  A. Mattioli,et al.  [Neurohumoral changes in patients with heart failure treated chronically with beta-blockers]. , 1991, Cardiologia.

[77]  J R Wilson,et al.  Value of Peak Exercise Oxygen Consumption for Optimal Timing of Cardiac Transplantation in Ambulatory Patients With Heart Failure , 1991, Circulation.

[78]  J. Port,et al.  Beta-adrenergic pathways in nonfailing and failing human ventricular myocardium. , 1990, Circulation.

[79]  J. Ribeiro,et al.  Impaired chronotropic response to exercise in patients with congestive heart failure. Role of postsynaptic beta-adrenergic desensitization. , 1989, Circulation.

[80]  P. Binkley,et al.  Neurohumoral profile in congestive heart failure: response to beta-blockade. , 1988, The Journal of laboratory and clinical medicine.

[81]  P. van Brummelen,et al.  Alpha-adrenergic receptors in human blood vessels. , 1986, British journal of clinical pharmacology.

[82]  J. Cohn,et al.  Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. , 1984, The New England journal of medicine.

[83]  P. Simpson Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response. , 1983, The Journal of clinical investigation.

[84]  J. Cohn,et al.  Relationship of exercise capacity to resting left ventricular performance and basal plasma norepinephrine levels in patients with congestive heart failure. , 1982, American heart journal.

[85]  D C Harrison,et al.  Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts. , 1982, The New England journal of medicine.