A novel relationship between creatine transport at the blood-brain and blood-retinal barriers, creatine biosynthesis, and its use for brain and retinal energy homeostasis.

[1]  T. Terasaki,et al.  Hyperammonemia induces transport of taurine and creatine and suppresses claudin-12 gene expression in brain capillary endothelial cells in vitro , 2007, Neurochemistry International.

[2]  T. Terasaki,et al.  Modulation and compensation of the mRNA expression of energy related transporters in the brain of glucose transporter 1-deficient mice. , 2006, Biological & pharmaceutical bulletin.

[3]  P. Magistretti.  Neuron–glia metabolic coupling and plasticity , 2006, Journal of Experimental Biology.

[4]  A. Ribes,et al.  X-Linked creatine transporter deficiency in two patients with severe mental retardation and autism , 2006, Journal of Inherited Metabolic Disease.

[5]  Masahiko Watanabe,et al.  Evidence for creatine biosynthesis in Müller glia , 2005, Glia.

[6]  M. Kalloniatis,et al.  Creatine transporter localization in developing and adult retina: importance of creatine to retinal function. , 2005, American journal of physiology. Cell physiology.

[7]  T. Terasaki,et al.  Vascular EndotheliumSelective Gene Induction by Tie2 Promoter/Enhancer in the Brain and Retina of a Transgenic Rat , 2005, Pharmaceutical Research.

[8]  T. Conrad,et al.  A clinical trial of creatine in ALS , 2004, Neurology.

[9]  S. Ohtsuki.  New aspects of the blood-brain barrier transporters; its physiological roles in the central nervous system. , 2004, Biological & pharmaceutical bulletin.

[10]  Masahiko Watanabe,et al.  Distinct cellular expressions of creatine synthetic enzyme GAMT and creatine kinases uCK‐Mi and CK‐B suggest a novel neuron–glial relationship for brain energy homeostasis , 2004, The European journal of neuroscience.

[11]  M. L. Cardoso,et al.  Creatine and guanidinoacetate: diagnostic markers for inborn errors in creatine biosynthesis and transport. , 2004, Molecular genetics and metabolism.

[12]  Masahiko Watanabe,et al.  Blood‐to‐retina transport of creatine via creatine transporter (CRT) at the rat inner blood–retinal barrier , 2004, Journal of neurochemistry.

[13]  Emi Nakashima,et al.  New approaches to in vitro models of blood-brain barrier drug transport. , 2003, Drug discovery today.

[14]  Bradley E. Enerson,et al.  Molecular features, regulation, and function of monocarboxylate transporters: implications for drug delivery. , 2003, Journal of pharmaceutical sciences.

[15]  S. Kahler,et al.  Metabolic disorders and mental retardation , 2003, American journal of medical genetics. Part C, Seminars in medical genetics.

[16]  A. Schulze.  Creatine deficiency syndromes , 2003, Molecular and Cellular Biochemistry.

[17]  Masahiko Watanabe,et al.  The Blood–Brain Barrier Creatine Transporter is a Major Pathway for Supplying Creatine to the Brain , 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[18]  M. Schapiro,et al.  Congenital creatine transporter deficiency. , 2002, Neuropediatrics.

[19]  A. Bizzi,et al.  X‐linked creatine deficiency syndrome: A novel mutation in creatine transporter gene SLC6A8 , 2002, Annals of neurology.

[20]  M. Tosetti,et al.  Arginine:glycine amidinotransferase deficiency: the third inborn error of creatine metabolism in humans. , 2001, American journal of human genetics.

[21]  A. Persky,et al.  Clinical pharmacology of the dietary supplement creatine monohydrate. , 2001, Pharmacological reviews.

[22]  William S. Ball,et al.  X-linked creatine-transporter gene (SLC6A8) defect: a new creatine-deficiency syndrome. , 2001, American journal of human genetics.

[23]  B. Wong,et al.  Irreversible brain creatine deficiency with elevated serum and urine creatine: A creatine transporter defect? , 2001, Annals of neurology.

[24]  C Bachmann,et al.  Endogenous synthesis and transport of creatine in the rat brain: an in situ hybridization study. , 2001, Brain research. Molecular brain research.

[25]  T. Rauen,et al.  Fine tuning of glutamate uptake and degradation in glial cells: common transcriptional regulation of GLAST1 and GS , 2000, Neurochemistry International.

[26]  M. Wyss,et al.  Creatine and creatinine metabolism. , 2000, Physiological reviews.

[27]  G J Brewer,et al.  Protective Effect of the Energy Precursor Creatine Against Toxicity of Glutamate and β‐Amyloid in Rat Hippocampal Neurons , 2000, Journal of neurochemistry.

[28]  M. Tosetti,et al.  Reversible brain creatine deficiency in two sisters with normal blood creatine level , 2000, Annals of neurology.

[29]  P. Dechent,et al.  Increase of total creatine in human brain after oral supplementation of creatine-monohydrate. , 1999, American journal of physiology. Regulatory, integrative and comparative physiology.

[30]  L. Drewes,et al.  Distribution of monocarboxylate transporters MCT1 and MCT2 in rat retina , 1999, Neuroscience.

[31]  Ole A. Andreassen,et al.  Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis , 1999, Nature Medicine.

[32]  M. Balestrino,et al.  Exogenous creatine delays anoxic depolarization and protects from hypoxic damage: dose–effect relationship , 1999, Brain Research.

[33]  M. Beal,et al.  Creatine and Cyclocreatine Attenuate MPTP Neurotoxicity , 1998, Experimental Neurology.

[34]  D. Leibfritz,et al.  Metabolism of Glycine in Primary Astroglial Cells: Synthesis of Creatine, Serine, and Glutathione , 1998, Journal of neurochemistry.

[35]  D. Bentley,et al.  Arginine Kinase Expression and Localization in Growth Cone Migration , 1998, The Journal of Neuroscience.

[36]  Bruce R. Rosen,et al.  Neuroprotective Effects of Creatine and Cyclocreatine in Animal Models of Huntington’s Disease , 1998, The Journal of Neuroscience.

[37]  Jens Frahm,et al.  Creatine replacement therapy in guanidineoacetate methyltransferase deficiency, a novel inborn error of metabolism , 1996, The Lancet.

[38]  Peter N. Campbell,et al.  Biochemistry (2nd edn) , 1995 .

[39]  M. Tsacopoulos,et al.  Lactate released by Muller glial cells is metabolized by photoreceptors from mammalian retina , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[40]  I. Sora,et al.  The cloning and expression of a human creatine transporter. , 1994, Biochemical and biophysical research communications.

[41]  G Helms,et al.  Creatine Deficiency in the Brain: A New, Treatable Inborn Error of Metabolism , 1994, Pediatric Research.

[42]  M. Kilimann,et al.  A Na(+)-dependent creatine transporter in rabbit brain, muscle, heart, and kidney. cDNA cloning and functional expression. , 1993, The Journal of biological chemistry.

[43]  P. D. De Deyn,et al.  Guanidino compounds in serum, urine, liver, kidney, and brain of man and some ureotelic animals. , 1992, Metabolism: clinical and experimental.

[44]  O. Ezaki,et al.  Ultracytochemical localization of the erythrocyte/HepG2-type glucose transporter (GLUT1) in cells of the blood-retinal barrier in the rat. , 1992, Investigative ophthalmology & visual science.

[45]  W. Pardridge,et al.  Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and in situ hybridization. , 1990, The Journal of biological chemistry.

[46]  P. Detwiler,et al.  Intracellular biochemical manipulation of phototransduction in detached rod outer segments. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[47]  S. Lightman,et al.  Quantitative assessment of the permeability of the rat blood‐retinal barrier to small water‐soluble non‐electrolytes. , 1987, The Journal of physiology.

[48]  S. W. Hall,et al.  Purification and properties of guanylate kinase from bovine retinas and rod outer segments. , 1986, European journal of biochemistry.

[49]  H. Eppenberger,et al.  High content of creatine kinase in chicken retina: compartmentalized localization of creatine kinase isoenzymes in photoreceptor cells. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[50]  A. Lowenthal,et al.  Comparative Study of Guanidino Compounds in Serum and Brain of Mouse, Rat, Rabbit, and Man , 1986, Journal of neurochemistry.

[51]  O. Simell,et al.  Gyrate atrophy of the choroid and retina. A five-year follow-up of creatine supplementation. , 1985, Ophthalmology.

[52]  O. Simell,et al.  Gyrate atrophy of the choroid and retina with hyperornithinemia. Deficient formation of guanidinoacetic acid from arginine. , 1980, The Journal of clinical investigation.

[53]  E. Marliss,et al.  Gyrate atrophy of the choroid and retina with hyperornithinemia. , 1975, American journal of ophthalmology.

[54]  Manjit,et al.  Neurology , 1912, NeuroImage.

[55]  S. Stockler,et al.  Cerebral creatine deficiency syndromes: clinical aspects, treatment and pathophysiology. , 2007, Sub-cellular biochemistry.

[56]  H. Henry,et al.  Expression and function of AGAT, GAMT and CT1 in the mammalian brain. , 2007, Sub-cellular biochemistry.

[57]  M. Tomi,et al.  Advances in the cell biology of transport via the inner blood-retinal barrier: establishment of cell lines and transport functions. , 2005, Biological & pharmaceutical bulletin.

[58]  R. Blakely,et al.  Expression of the rat brain creatine transporter in situ and in transfected HeLa cells. , 1996, Developmental neuroscience.

[59]  Donald Voet,et al.  Biochemistry, 2nd ed. , 1995 .

[60]  M. Wyss,et al.  Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis. , 1992, The Biochemical journal.