Single, high‐dose local injection of bFGF improves thyroarytenoid muscle atrophy after paralysis

Unilateral vocal fold paralysis (UVFP) induces hoarseness due to progressive atrophy of the denervated thyroarytenoid (TA) muscle. Therefore, treatments aimed at regenerating the atrophied TA muscle are required. Basic fibroblast growth factor (bFGF) is involved in muscle development and regeneration. This study aimed to elucidate the effects of bFGF injection on atrophied TA muscle.

[1]  Tatsuo Nakamura,et al.  Regenerative Effects of Basic Fibroblast Growth Factor on Restoration of Thyroarytenoid Muscle Atrophy Caused by Recurrent Laryngeal Nerve Transection. , 2017, Journal of voice : official journal of the Voice Foundation.

[2]  P. Hoffmeyer,et al.  Human myogenic reserve cells are quiescent stem cells that contribute to muscle regeneration after intramuscular transplantation in immunodeficient mice , 2017, Scientific Reports.

[3]  K. Matsushima,et al.  Injection of basic fibroblast growth factor for unilateral vocal cord paralysis* , 2017, Acta Oto-Laryngologica.

[4]  M. Hess,et al.  Laryngeal framework surgery: current strategies , 2016, Current opinion in otolaryngology & head and neck surgery.

[5]  Xiaobing Fu,et al.  Myoprotective effects of bFGF on skeletal muscle injury in pressure-related deep tissue injury in rats , 2016, Burns & Trauma.

[6]  S. Ohno,et al.  Outcome of regenerative therapy for age‐related vocal fold atrophy with basic fibroblast growth factor , 2016, The Laryngoscope.

[7]  E. Yumoto,et al.  Modulation of satellite cells activity and MyoD in rat thyroarytenoid muscle after reinnervation , 2015, The Laryngoscope.

[8]  K. Matsushima,et al.  Single injection of basic fibroblast growth factor to treat severe vocal fold lesions and vocal fold paralysis , 2015, The Laryngoscope.

[9]  Juichi Ito,et al.  Regenerative phonosurgical treatments for vocal fold scar and sulcus with basic fibroblast growth factor , 2013, The Laryngoscope.

[10]  E. Baik,et al.  JAK-STAT pathway and myogenic differentiation , 2013, JAK-STAT.

[11]  Kevin W Eliceiri,et al.  NIH Image to ImageJ: 25 years of image analysis , 2012, Nature Methods.

[12]  J. Ito,et al.  Clinical trial of regeneration of aged vocal folds with growth factor therapy , 2012, The Laryngoscope.

[13]  E. Yumoto,et al.  Nerve-muscle pedicle flap implantation combined with arytenoid adduction. , 2010, Archives of otolaryngology--head & neck surgery.

[14]  D. Montequin,et al.  A rat excised larynx model of vocal fold scar. , 2009, Journal of Speech, Language and Hearing Research.

[15]  J. Ito,et al.  Regeneration of Aged Vocal Fold: First Human Case Treated With Fibroblast Growth Factor , 2008, The Laryngoscope.

[16]  H. Fukuda,et al.  Intracordal injection technique: materials and injection site. , 2008, The Tokai journal of experimental and clinical medicine.

[17]  K. Legerlotz,et al.  Role of MyoD in denervated, disused, and exercised muscle , 2008, Muscle & nerve.

[18]  C. Milstein,et al.  Ansa Cervicalis-to-Recurrent Laryngeal Nerve Anastomosis for Unilateral Vocal Fold Paralysis: Experience of a Single Institution , 2008, The Annals of otology, rhinology, and laryngology.

[19]  D. Bless,et al.  Regeneration of Aged Vocal Folds with Basic Fibroblast Growth Factor in a Rat Model: A Preliminary Report , 2005, The Annals of otology, rhinology, and laryngology.

[20]  P. Claus,et al.  In vivo expression and localization of the fibroblast growth factor system in the intact and lesioned rat peripheral nerve and spinal ganglia , 2001, The Journal of comparative neurology.

[21]  J. Lefaucheur,et al.  Angiogenic and inflammatory responses following skeletal muscle injury are altered by immune neutralization of endogenous basic fibroblast growth factor, insulin-like growth factor-1 and transforming growth factor-β1 , 1996, Journal of Neuroimmunology.

[22]  R. Crumley,et al.  Update: Ansa Cervicalis to Recurrent Laryngeal Nerve Anastomosis for Unilateral Laryngeal Paralysis , 1991, The Laryngoscope.

[23]  H. Peng,et al.  Induction of synaptic development in cultured muscle cells by basic fibroblast growth factor , 1991, Neuron.

[24]  P Aebischer,et al.  Basic fibroblast growth factor released from synthetic guidance channels facilitates peripheral nerve regeneration across long nerve gaps , 1989, Journal of neuroscience research.

[25]  M. May,et al.  Muscle‐Nerve Pedicle Laryngeal Reinnervation , 1986, The Laryngoscope.

[26]  H. Tucker.  Reinnervation of the Unilaterally Paralyzed Larynx , 1977, The Annals of otology, rhinology, and laryngology.

[27]  M. Rudnicki,et al.  Cellular and molecular regulation of muscle regeneration. , 2004, Physiological reviews.

[28]  M. Hearn,et al.  The role of basic fibroblast growth factor in skeletal muscle regeneration. , 1992, Growth factors.