The histopathology of tissue lead retention.

An experimental murine model of chronic lead retention is established. This model excludes joint communication and synovial fluid solubility of lead ions recognized in human gunshot injury. Degenerative changes in the visceral organs and bone appear in these mice 30 days after implantation of lead spheres in the subcutaneous tissues of the posterior body wall. Degeneration, necrosis and interstitial fibrosis of the lung, kidney and remodeling of femoral bone are noted during the course of the experiment (120 days). It is concluded that the systemic diffusion of lead ions from a central focus is related to the development of an absorptive circulatory mechanism around the retained peripheral lead mass.

[1]  R. Slavin,et al.  Lead arthritis and lead poisoning following bullet wounds: a clinicopathologic, ultrastructural, and microanalytic study of two cases. , 1988, Human pathology.

[2]  R. Lees,et al.  Subacute lead poisoning from retained lead shot. , 1988, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

[3]  S. Viegas,et al.  Lead poisoning from a gunshot wound to the hand. , 1986, The Journal of hand surgery.

[4]  S. Greenberg.  A New Method for the Histological Study of Collagen , 1986 .

[5]  W. C. Beazley,et al.  Lead intoxication 18 months after a gunshot wound. , 1984, Clinical orthopaedics and related research.

[6]  R. Bucholz,et al.  Acute lead intoxication from a bullet in an intervertebral disc space. A case report. , 1981, The Journal of bone and joint surgery. American volume.

[7]  C. Crumb,et al.  Lead poisoning from a gunshot wound. Report of a case and review of the literature. , 1979, The American journal of medicine.

[8]  D. M. Switz,et al.  Bullets, joints, And lead intoxication. A remarkable and instructive case. , 1976, Archives of internal medicine.

[9]  R. Goyer,et al.  Lead-Induced Inclusion Bodies: Composition and Probable Role in Lead Metabolism , 1974, Environmental health perspectives.

[10]  F. S. Hsu,et al.  Lead Inclusion Bodies in Osteoclasts , 1973, Science.

[11]  G. Richter,et al.  Lead Poisoning: Rapid Formation of Intranuclear Inclusions , 1972, Science.

[12]  V. Galkin,et al.  [Case of acute lead poisoning developing after a gunshot wound]. , 1972, Klinicheskaia meditsina.

[13]  J. Dingle,et al.  Subcellular distribution of lead in the rat. , 1971, The Journal of laboratory and clinical medicine.

[14]  R. Goyer,et al.  Lead and protein content of isolated intranuclear inclusion bodies from kidneys of lead-poisoned rats. , 1970, Laboratory investigation; a journal of technical methods and pathology.

[15]  Leonard Mh.  The solution of lead by synovial fluid. , 1969 .

[16]  Y. Kress,et al.  Another look at lead inclusion bodies. , 1968, The American journal of pathology.

[17]  Van Rossem,et al.  [ACUTE LEAD POISONING BY LEAD SHOT WOUNDS]. , 1965, Nederlands tijdschrift voor geneeskunde.

[18]  E. Underwood.  Trace Elements in Human and Animal Nutrition , 1956, Agronomy Journal.

[19]  W. Machle.  LEAD ABSORPTION FROM BULLETS LODGED IN TISSUES: REPORT OF TWO CASES , 1940 .

[20]  F. Parker,et al.  Fixing and staining methods for lead and copper in tissues. , 1939, The American journal of pathology.

[21]  L. Teodori,et al.  Report of a Case and Review of the Literature , 2007 .

[22]  J. Garriott,et al.  A fatal case of lead poisoning due to a retained bullet. , 1980, Veterinary and human toxicology.

[23]  Repko Jd,et al.  Critical review and evaluation of the neurological and behavioral sequelae of inorganic lead absorption. , 1979 .

[24]  C. Corum,et al.  Critical review and evaluation of the neurological and behavioral sequelae of inorganic lead absorption. , 1979, CRC critical reviews in toxicology.

[25]  G. W. Woods,et al.  Lead intoxication and traumatic arthritis of the hip secondary to retained bullet fragments. A case report. , 1978, The Journal of bone and joint surgery. American volume.

[26]  M. H. Leonard.  The solution of lead by synovial fluid. , 1969, Clinical orthopaedics and related research.

[27]  R. Wieme.  [A case of acute lead poisoning]. , 1954, Belgisch tijdschrift voor geneeskunde.

[28]  W. Mcnally.  Lead poisoning caused by a bullet embedded for 27 years. , 1949, Industrial medicine & surgery.